Gene info: ID 29126

Gene: CD274

GENE ID: 29126

Synonyms: B7-H|B7H1|PD-L1|PDCD1L1|PDCD1LG1|PDL1

Description: CD274 molecule

Gene type: protein-coding

Location: 9p24.1

dbXrefs: Ensembl:ENSG00000120217 MIM:605402 Vega:OTTHUMG00000019503 UniprotKB:Q9NZQ7

RefSeq: NC_000009.12

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND|AD

# Publications: 5

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 2.093e-1 (AD) 2.872e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
KRT75	0.778
TAP2	0.773
ETV7	0.772
CCL8	0.767
WARS	0.765
TRIM25	0.748
MX1	0.735
CYP19A1	0.734
CD80	0.726
STAT1	0.723

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
SNX22	-0.39
OLIG1	-0.302
DIAPH3	-0.28
PON1	-0.274
NEU4	-0.268
P2RY14	-0.262
GPR17	-0.256
HPR	-0.25
ALDH1L1-AS2	-0.241
KCNJ16	-0.238

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB11595	Atezolizumab	BiotechDrug	1380723-44-3	Approved\|Investigational	Target
DB11714	Durvalumab	BiotechDrug	1428935-60-7	Approved\|Investigational	Target
DB11945	Avelumab	BiotechDrug	1537032-82-8	Approved\|Investigational	Target

ID	Drug Name	Action	PubMed
C548651	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester	2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of CD274 mRNA	19933214
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in increased expression of CD274 mRNA"	18648102
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CD274 mRNA"	27188386
C029728	4-phenylenediamine	4-phenylenediamine results in increased expression of CD274 protein	20488241
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CD274 mRNA"	27188386
D000082	Acetaminophen	Acetaminophen results in increased expression of CD274 mRNA	29067470
D000082	Acetaminophen	Acetaminophen affects the expression of CD274 mRNA	17562736
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of CD274 gene	27153756
D001241	Aspirin	Aspirin results in increased expression of CD274 mRNA	11906190
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of CD274 mRNA	22228805\|2373587
C006780	bisphenol A	bisphenol A results in decreased expression of CD274 mRNA	29275510
C006780	bisphenol A	bisphenol A results in increased expression of CD274 mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased methylation of CD274 gene	28505145
C018475	butyraldehyde	butyraldehyde results in increased expression of CD274 mRNA	26079696
D002104	Cadmium	Cadmium results in increased expression of CD274 mRNA	21120746
D002185	Cannabidiol	Cannabidiol results in increased expression of CD274 mRNA	21542829
D002738	Chloroquine	Chloroquine results in decreased expression of CD274 protein	27692344
C012843	cinnamic aldehyde	cinnamic aldehyde results in increased expression of CD274 protein	20488241\|2362423
C515055	darinaparsin	darinaparsin results in increased expression of CD274 mRNA	22535156
C515055	darinaparsin	Oxygen deficiency inhibits the reaction [darinaparsin results in increased expression of CD274 mRNA]	22535156
D000069439	Dasatinib	Dasatinib results in decreased expression of CD274 mRNA	20579391
D013759	Dronabinol	Dronabinol results in increased expression of CD274 mRNA	21542829
D003703	Demecolcine	Demecolcine results in increased expression of CD274 mRNA	23649840
D003907	Dexamethasone	Dexamethasone results in increased expression of CD274 mRNA	21041162
D016190	Carboplatin	Carboplatin results in decreased expression of CD274	21765211
D016190	Carboplatin	Carboplatin results in decreased expression of CD274 protein	27692344
D002945	Cisplatin	Cisplatin promotes the reaction [jinfukang results in decreased expression of CD274 mRNA]	27392435
D002945	Cisplatin	Cisplatin results in decreased expression of CD274	21765211
D002945	Cisplatin	jinfukang promotes the reaction [Cisplatin results in decreased expression of CD274 mRNA]	27392435
D002117	Calcitriol	Calcitriol results in increased expression of CD274 mRNA	16002434\|2159239
D002117	Calcitriol	[Testosterone co-treated with Calcitriol] results in increased expression of CD274 mRNA	21592394
D004137	Dinitrochlorobenzene	Dinitrochlorobenzene results in increased expression of CD274 mRNA	28941582
D004137	Dinitrochlorobenzene	Dinitrochlorobenzene results in increased expression of CD274 protein	20488241
C521792	DMU-212	DMU-212 affects the expression of CD274 mRNA	26428916
D004964	Estriol	Estriol results in increased expression of CD274 protein	21317386
D005020	Ethyl Methanesulfonate	Ethyl Methanesulfonate results in increased expression of CD274 mRNA	23649840
D005047	Etoposide	Etoposide results in increased expression of CD274 protein	17920123
D005054	Eugenol	Eugenol results in increased expression of CD274 protein	23624239
D015025	Zearalenone	Zearalenone results in increased expression of CD274 mRNA	27757495
C000499	ferric oxide	ferric oxide analog results in increased expression of CD274 mRNA	25086211
D005472	Fluorouracil	Fluorouracil results in increased expression of CD274 protein	17920123
D005492	Folic Acid	[Folic Acid deficiency co-treated with Methotrexate] results in increased expression of CD274 mRNA	24657277
D005557	Formaldehyde	Formaldehyde results in increased expression of CD274 mRNA	23649840
C039281	furan	furan results in decreased expression of CD274 mRNA	25539665
C546771	gardiquimod	gardiquimod results in increased expression of CD274 mRNA	28003376
C546771	gardiquimod	Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of CD274 mRNA]	28003376
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CD274 mRNA	25613284
C036643	isoeugenol	isoeugenol results in increased expression of CD274 protein	20488241
C544151	jinfukang	Cisplatin promotes the reaction [jinfukang results in decreased expression of CD274 mRNA]	27392435
C544151	jinfukang	jinfukang promotes the reaction [Cisplatin results in decreased expression of CD274 mRNA]	27392435
C544151	jinfukang	jinfukang results in decreased expression of CD274 mRNA	27392435
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of CD274 mRNA	24796395
C011890	kojic acid	kojic acid results in increased expression of CD274 mRNA	16595896
C045463	leflunomide	leflunomide results in decreased expression of CD274 mRNA	28988120
C482199	lipopolysaccharide, E coli O55-B5	"lipopolysaccharide, E coli O55-B5 results in increased expression of CD274 protein"	25673294
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of CD274 mRNA	18192897
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of CD274 mRNA	25890327\|2733941
D058185	Magnetite Nanoparticles	[Succimer binds to Magnetite Nanoparticles] which results in increased expression of CD274 mRNA	21641980
D008727	Methotrexate	[Folic Acid deficiency co-treated with Methotrexate] results in increased expression of CD274 mRNA	24657277
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of CD274 mRNA	23649840
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of CD274 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of CD274 mRNA"	25554681
D009532	Nickel	Nickel results in increased expression of CD274 mRNA	24768652\|2558310
D009532	Nickel	Nickel results in increased expression of CD274 protein	23624239
C029938	nickel sulfate	nickel sulfate results in decreased expression of CD274 mRNA	22714537
C029938	nickel sulfate	nickel sulfate results in increased expression of CD274 protein	25673294
C510784	ormosil	[ormosil binds to Polyethylene Glycols] which results in increased expression of CD274 mRNA	24888373
C030110	oxaliplatin	oxaliplatin results in decreased expression of CD274	21765211
D010100	Oxygen	Oxygen deficiency inhibits the reaction [darinaparsin results in increased expression of CD274 mRNA]	22535156
D017239	Paclitaxel	Paclitaxel results in increased expression of CD274 protein	17920123
D010416	Pentachlorophenol	Pentachlorophenol results in increased expression of CD274 mRNA	23892564
C046012	pentanal	pentanal results in increased expression of CD274 mRNA	26079696
D010634	Phenobarbital	Phenobarbital affects the expression of CD274 mRNA	23091169
D011092	Polyethylene Glycols	[ormosil binds to Polyethylene Glycols] which results in increased expression of CD274 mRNA	24888373
D047428	Protein Kinase Inhibitors	Protein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of CD274 mRNA]	28003376
D012822	Silicon Dioxide	Silicon Dioxide analog results in increased expression of CD274 mRNA	25895662
C017947	sodium arsenite	sodium arsenite results in decreased expression of CD274 mRNA	22714537
D004113	Succimer	[Succimer binds to Magnetite Nanoparticles] which results in increased expression of CD274 mRNA	21641980
D013739	Testosterone	[Testosterone co-treated with Calcitriol] results in increased expression of CD274 mRNA	21592394
D013739	Testosterone	Testosterone results in decreased expression of CD274 mRNA	21592394
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of CD274 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of CD274 mRNA	21041162\|2188995
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CD274 mRNA	25613284
D013853	Thioacetamide	Thioacetamide results in decreased expression of CD274 mRNA	23411599
C009495	titanium dioxide	titanium dioxide results in increased expression of CD274 mRNA	23409001
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of CD274 mRNA	28065790
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution affects the expression of CD274 mRNA	20133372
C012589	trichostatin A	trichostatin A results in increased expression of CD274 mRNA	26705709
D014520	Urethane	Urethane results in increased expression of CD274 mRNA	28818685
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CD274 mRNA"	27188386
D014635	Valproic Acid	Valproic Acid results in decreased methylation of CD274 gene	29154799
D014635	Valproic Acid	Valproic Acid results in increased expression of CD274 mRNA	26272509\|2670570
D001335	Vehicle Emissions	Vehicle Emissions results in decreased methylation of CD274 gene	25560391
C025643	vinclozolin	vinclozolin results in increased expression of CD274 mRNA	23034163
D014750	Vincristine	Vincristine results in increased expression of CD274 mRNA	23649840

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005515	protein binding	-	IPI	18585785 21982860 28813410 28813417

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0002845	positive regulation of tolerance induction to tumor cell	-	IMP	28813410 28813417
GO:0006955	immune response	-	IBA	21873635
GO:0006955	immune response	-	IDA	10581077
GO:0007165	signal transduction	-	IBA	21873635
GO:0007165	signal transduction	-	IDA	10581077
GO:0007166	cell surface receptor signaling pathway	-	IBA	21873635
GO:0007166	cell surface receptor signaling pathway	-	IDA	10581077
GO:0030335	positive regulation of cell migration	-	IEA	-
GO:0031295	T cell costimulation	-	IBA	21873635
GO:0031295	T cell costimulation	-	IDA	10581077
GO:0031295	T cell costimulation	-	TAS	-
GO:0032689	negative regulation of interferon-gamma production	-	IMP	12538684 24187568
GO:0032693	negative regulation of interleukin-10 production	-	IMP	12538684 24187568
GO:0034097	response to cytokine	-	IDA	17489864
GO:0042102	positive regulation of T cell proliferation	-	IBA	21873635
GO:0042102	positive regulation of T cell proliferation	-	TAS	10581077
GO:0042130	negative regulation of T cell proliferation	-	IBA	21873635
GO:0046006	regulation of activated T cell proliferation	NOT	IMP	24187568 25310899
GO:0046007	negative regulation of activated T cell proliferation	-	IMP	12538684
GO:0070232	regulation of T cell apoptotic process	NOT	IMP	25310899
GO:0071222	cellular response to lipopolysaccharide	-	IBA	21873635
GO:1901998	toxin transport	-	IEA	-
GO:1903556	negative regulation of tumor necrosis factor superfamily cytokine production	-	IMP	24187568
GO:1905399	regulation of activated CD4-positive, alpha-beta T cell apoptotic process	NOT	IDA	24187568
GO:1905404	positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process	-	IDA	24187568
GO:2001181	positive regulation of interleukin-10 secretion	-	IDA	10581077
GO:2001186	negative regulation of CD8-positive, alpha-beta T cell activation	-	IMP	28813410 28813417

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005886	plasma membrane	-	IDA	28813410 28813417
GO:0005886	plasma membrane	-	TAS	-
GO:0009897	external side of plasma membrane	-	IBA	21873635
GO:0009897	external side of plasma membrane	-	IEA	-
GO:0009986	cell surface	-	IBA	21873635
GO:0016021	integral component of membrane	-	IEA	-
GO:0031901	early endosome membrane	-	IDA	28813417
GO:0055038	recycling endosome membrane	-	IDA	28813417
GO:0070062	extracellular exosome	-	IDA	17076679

KEGG ID	KEGG Term
hsa04514	Cell adhesion molecules (CAMs)

Reactome ID	Reactome Term	Evidence
R-HSA-1280218	Adaptive Immune System	TAS
R-HSA-168256	Immune System	TAS
R-HSA-388841	Costimulation by the CD28 family	TAS
R-HSA-389948	PD-1 signaling	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
25479137	Blockade of PD1 and TIM3 restores innate and adaptive immunity in patients with acute alcoholic hepatitis. (2015 Mar)	Markwick LJ	Gastroenterology
25662388	Clinicopathological analysis of PD-L1 and PD-L2 expression in pulmonary squamous cell carcinoma: Comparison with tumor-infiltrating T cells and the status of oncogenic drivers. (2015 Apr)	Kim MY	Lung Cancer
29437869	Integrative analysis of exogenous, endogenous, tumour and immune factors for precision medicine. (2018 Jun)	Ogino S	Gut
28024695	Tumor B7-H3 (CD276) expression and smoking history in relation to lung adenocarcinoma prognosis. (2017 Jan)	Inamura K	Lung Cancer
29716923	Interferon Gamma Messenger RNA Signature in Tumor Biopsies Predicts Outcomes in Patients with Non-Small-Cell Lung Carcinoma or Urothelial Cancer Treated with Durvalumab. (2018 May 1)	Higgs BW	Clin Cancer Res