Gene: UHRF1

29128
ICBP90|Np95|RNF106|TDRD22|hNP95|hUHRF1|huNp95
ubiquitin like with PHD and ring finger domains 1
protein-coding
19p13.3
Ensembl:ENSG00000276043 MIM:607990 Vega:OTTHUMG00000180251 UniprotKB:Q96T88
NG_033256.2
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.255e-1 (AD)  1.048e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LRRC10.744
KIF190.735
CPM0.728
CHST30.708
PLIN30.704
PRKX0.688
IKZF20.683
PHF190.68
ZNF6520.677
PLEKHF10.667

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MARCH4-0.537
C1QTNF2-0.528
FBLN7-0.521
FREM3-0.52
CHRM4-0.516
KHDRBS2-0.514
CNTN5-0.513
PRSS12-0.51
NDST3-0.507
VWC2-0.506

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of UHRF1 mRNA"26377693
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of UHRF1 mRNA"28903501
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in decreased expression of UHRF1 mRNA"20453058
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of UHRF1 mRNA"25510870
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of UHRF1 mRNA"19167446
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of UHRF1 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of UHRF1 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of UHRF1 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of UHRF1 mRNA"25510870
C0369902-amino-3,8-dimethylimidazo(4,5-f)quinoxaline"2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of UHRF1 mRNA"20816883
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of UHRF1 mRNA"23196670
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UHRF1 mRNA"27188386
C517041(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in decreased expression of UHRF1 mRNA"19561079
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of UHRF1 mRNA19191707
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UHRF1 mRNA"27188386
D000111Acetylcysteine[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of UHRF1 mRNA22129741
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of UHRF1 mRNA21641981
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of UHRF1 mRNA22100608
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of UHRF1 mRNA19770486
C103505AM 251AM 251 results in decreased expression of UHRF1 mRNA16500647
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in increased expression of UHRF1 mRNA"22863853
C006632arsenic trioxidearsenic trioxide results in decreased expression of UHRF1 mRNA20458559
C006632arsenic trioxidearsenic trioxide results in increased expression of UHRF1 mRNA20862710
C015001arsenitearsenite results in decreased methylation of UHRF1 promoter23974009
D001205Ascorbic Acid[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone] results in decreased expression of UHRF1 mRNA26424790
D001280AtrazineAtrazine results in increased expression of UHRF1 mRNA25929836
D001280AtrazineAtrazine results in decreased expression of UHRF1 mRNA22378314
C105832auraptenaurapten affects the expression of UHRF1 mRNA23320178
C447119bazedoxifenebazedoxifene results in decreased expression of UHRF1 mRNA19914376
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of UHRF1 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of UHRF1 mRNA20064835|2180250
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of UHRF1 gene25435355
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of UHRF1 mRNA19770486
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of UHRF1 mRNA"19150397|2038263
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of UHRF1 mRNA25566086
D004958EstradiolEstradiol results in increased expression of UHRF1 mRNA16474171|1831028
C031463beta-glycerophosphoric acid[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone] results in decreased expression of UHRF1 mRNA26424790
C044887beta-methylcholinebeta-methylcholine affects the expression of UHRF1 mRNA21179406
C006780bisphenol Abisphenol A affects the expression of UHRF1 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of UHRF1 mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of UHRF1 mRNA16474171
C006780bisphenol Abisphenol A affects the expression of UHRF1 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of UHRF1 mRNA25181051
C584509C646 compoundC646 compound results in decreased expression of UHRF1 mRNA23698071|2619108
D000001CalcimycinCalcimycin results in decreased expression of UHRF1 mRNA15964557
D000001CalcimycinCalcimycin results in decreased expression of UHRF1 protein15964557
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of UHRF1 mRNA17484886
D002706ChlordanChlordan results in increased expression of UHRF1 mRNA20403969
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of UHRF1 mRNA20938992
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of UHRF1 gene20938992
D003033Coal TarCoal Tar results in decreased expression of UHRF1 mRNA27858113
C018021cobaltous chloridecobaltous chloride results in increased expression of UHRF1 mRNA24386269
D003300CopperCopper results in decreased expression of UHRF1 mRNA26293553
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of UHRF1 mRNA20971185
D019327Copper SulfateCopper Sulfate results in decreased expression of UHRF1 mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of UHRF1 mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of UHRF1 mRNA19167446
D003375CoumestrolCoumestrol results in increased expression of UHRF1 mRNA19167446
C408982CPG-oligonucleotideCPG-oligonucleotide results in decreased expression of UHRF1 mRNA21878529
C408982CPG-oligonucleotideCPG-oligonucleotide results in increased expression of UHRF1 mRNA21878529
C030973cupric oxidecupric oxide results in decreased expression of UHRF1 mRNA22077320
D016572CyclosporineCyclosporine results in decreased expression of UHRF1 mRNA19159671
C089595cylindrospermopsincylindrospermopsin results in decreased expression of UHRF1 mRNA23726867
D000069439DasatinibDasatinib results in decreased expression of UHRF1 mRNA20579391
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of UHRF1 mRNA24317228
D013759DronabinolDronabinol affects the expression of UHRF1 mRNA18454173
C007262deoxynivalenoldeoxynivalenol affects the phosphorylation of UHRF1 protein23352502
D003907Dexamethasone[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone] results in decreased expression of UHRF1 mRNA26424790
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of UHRF1 mRNA17361019|2126653
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of UHRF1 mRNA28962523
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of UHRF1 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of UHRF1 mRNA27392435
D002945CisplatinCisplatin results in increased expression of UHRF1 mRNA27594783
D002945CisplatinCisplatin results in increased phosphorylation of UHRF1 protein22006019
D004041Dietary FatsDietary Fats results in increased expression of UHRF1 mRNA22609946
D004041Dietary FatsDietary Fats results in increased expression of UHRF1 mRNA21852083
D004041Dietary Fatsresveratrol inhibits the reaction [Dietary Fats results in increased expression of UHRF1 mRNA]21852083
C014476diethyl maleatediethyl maleate results in increased expression of UHRF1 mRNA21161181
D004052Diethylnitrosamine[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of UHRF1 mRNA22129741
D002117CalcitriolCalcitriol results in decreased expression of UHRF1 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of UHRF1 mRNA21592394
D004391DustDust results in decreased expression of UHRF1 mRNA26342214
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of UHRF1 protein23301498
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of UHRF1 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of UHRF1 mRNA17942748
D005492Folic Acid[Folic Acid deficiency co-treated with Methotrexate] results in decreased expression of UHRF1 mRNA24657277
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of UHRF1 mRNA20938992
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of UHRF1 gene20938992
D004397FonofosFonofos results in increased methylation of UHRF1 promoter22847954
C069837fullerene C60fullerene C60 results in decreased expression of UHRF1 mRNA19167457
C056507gemcitabine[gemcitabine results in decreased susceptibility to gemcitabine] which results in decreased expression of UHRF1 protein25189999
C056507gemcitabineUHRF1 protein inhibits the reaction [gemcitabine results in decreased susceptibility to gemcitabine]25189999
C056507gemcitabine[UHRF1 protein promotes the reaction [DNMT1 protein binds to SFN promoter]] inhibits the reaction [gemcitabine results in decreased susceptibility to gemcitabine]25189999
D019833GenisteinGenistein results in increased expression of UHRF1 mRNA16474171
C031927hydroquinonehydroquinone results in decreased expression of UHRF1 protein27979589
C492448ICG 001ICG 001 results in decreased expression of UHRF1 mRNA26191083
C056493imiquimodimiquimod results in decreased expression of UHRF1 mRNA21878529
C016517indole-3-carbinol[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in decreased expression of UHRF1 mRNA22129741
D007213IndomethacinIndomethacin results in decreased expression of UHRF1 mRNA28201806
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of UHRF1 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of UHRF1 mRNA26911376
C410337K 7174K 7174 results in decreased expression of UHRF1 mRNA24086573
D007854LeadLead affects the expression of UHRF1 mRNA28903495
D008094LithiumLithium results in increased expression of UHRF1 mRNA21711903
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of UHRF1 mRNA20938992
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of UHRF1 gene20938992
D008727Methotrexate[Folic Acid deficiency co-treated with Methotrexate] results in decreased expression of UHRF1 mRNA24657277
D009151Mustard GasMustard Gas results in decreased expression of UHRF1 mRNA25102026
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of UHRF1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of UHRF1 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of UHRF1 mRNA"25554681
D009532NickelNickel results in increased expression of UHRF1 mRNA24768652|2558310
C028007nickel monoxidenickel monoxide results in decreased expression of UHRF1 mRNA19167457
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of UHRF1 mRNA20971185
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of UHRF1 mRNA25729387
C030110oxaliplatinoxaliplatin results in decreased expression of UHRF1 mRNA25729387
D010126Ozone[Ozone co-treated with NOTCH3 gene mutant form] results in increased expression of UHRF1 mRNA25658374
D010126OzoneOzone results in decreased expression of UHRF1 mRNA24336422
D010126OzoneTTPA protein affects the reaction [Ozone results in increased expression of UHRF1 mRNA]19555225
C500026palbociclibpalbociclib results in decreased expression of UHRF1 mRNA22869556
D010278ParathionParathion results in increased methylation of UHRF1 promoter22847954
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of UHRF1 mRNA"25510870
D010416PentachlorophenolPentachlorophenol results in increased expression of UHRF1 mRNA23892564
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of UHRF1 protein26879310
D010634PhenobarbitalPhenobarbital affects the expression of UHRF1 mRNA19136022
D010634PhenobarbitalPhenobarbital results in increased expression of UHRF1 mRNA20403969|2309116
D048789PhytoestrogensPhytoestrogens results in increased expression of UHRF1 mRNA18310284
C006253pirinixic acidpirinixic acid affects the expression of UHRF1 mRNA19136022
C006253pirinixic acid[pirinixic acid co-treated with PPARA] results in increased expression of UHRF1 mRNA20813756
C006253pirinixic acidpirinixic acid results in increased expression of UHRF1 mRNA17950772|2081375
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in increased expression of UHRF1 mRNA]17950772
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls analog results in increased expression of UHRF1 mRNA16474171
D011374ProgesteroneProgesterone results in decreased expression of UHRF1 mRNA23012394|2301818
D011374ProgesteroneProgesterone affects the expression of UHRF1 mRNA17251523
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of UHRF1 mRNA19167446
C059514resveratrolresveratrol results in decreased expression of UHRF1 protein18089832
C059514resveratrolresveratrol results in decreased expression of UHRF1 protein25505154
C059514resveratrolresveratrol inhibits the reaction [Dietary Fats results in increased expression of UHRF1 mRNA]21852083
C064116S-(1,1,2,2-tetrafluoroethyl)cysteine"S-(1,1,2,2-tetrafluoroethyl)cysteine results in decreased expression of UHRF1 mRNA"16678137
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of UHRF1 mRNA25895662
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of UHRF1 mRNA25895662
C017947sodium arsenitesodium arsenite results in increased expression of UHRF1 mRNA28595984
C016104sodium bichromatesodium bichromate affects the expression of UHRF1 mRNA22110744
D012969Sodium FluorideSodium Fluoride results in increased expression of UHRF1 mRNA27862939
D053260SootSoot results in increased expression of UHRF1 mRNA22461453|2655175
C075117squalestatin 1squalestatin 1 results in decreased expression of UHRF1 mRNA27225895
C075117squalestatin 1squalestatin 1 results in decreased expression of UHRF1 mRNA27225895
C012568terbufosterbufos results in increased methylation of UHRF1 promoter22847954
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of UHRF1 mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of UHRF1 mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of UHRF1 mRNA21802500
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of UHRF1 mRNA21496263
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of UHRF1 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of UHRF1 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of UHRF1 mRNA17942748|2149626
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in decreased expression of UHRF1 mRNA15964557
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in decreased expression of UHRF1 protein15964557
D019284ThapsigarginThapsigargin results in decreased expression of UHRF1 mRNA22378314
D019284ThapsigarginThapsigargin results in increased expression of UHRF1 protein24648495
D013853ThioacetamideThioacetamide results in increased expression of UHRF1 mRNA23411599
C009495titanium dioxidetitanium dioxide results in increased expression of UHRF1 mRNA23557971|2776080
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of UHRF1 mRNA20133372
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of UHRF1 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of UHRF1 mRNA25729387
C496197trans-10,cis-12-conjugated linoleic acid"trans-10,cis-12-conjugated linoleic acid results in decreased expression of UHRF1 mRNA"17951470
D014241TrichloroethyleneTrichloroethylene results in increased expression of UHRF1 mRNA25549359|2761814
C012589trichostatin Atrichostatin A affects the expression of UHRF1 mRNA28542535
C012589trichostatin Atrichostatin A results in decreased expression of UHRF1 mRNA15901671
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of UHRF1 mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of UHRF1 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of UHRF1 mRNA19140230
D014415TunicamycinTunicamycin results in decreased expression of UHRF1 mRNA22378314
D014520UrethaneUrethane results in decreased expression of UHRF1 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UHRF1 mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of UHRF1 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased methylation of UHRF1 gene29154799
D014635Valproic AcidValproic Acid results in decreased expression of UHRF1 mRNA15901671
C029297vinylidene chloridevinylidene chloride results in increased expression of UHRF1 mRNA26682919
D024483Vitamin K 3Vitamin K 3 affects the expression of UHRF1 mRNA20044591
D015032ZincZinc deficiency results in increased expression of UHRF1 mRNA22171008
C088658zoledronic acidzoledronic acid results in decreased expression of UHRF1 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000987proximal promoter sequence-specific DNA binding-IDA10646863  
GO:0003700DNA-binding transcription factor activity-TAS1868030  
GO:0004842ubiquitin-protein transferase activity-IDA17967883  21745816  22945642  
GO:0005515protein binding-IPI15361834  17673620  17934516  19798101  21745816  22945642  
GO:0008270zinc ion binding-IDA21777816  
GO:0008327methyl-CpG binding-IDA15361834  21029866  
GO:0031493nucleosomal histone binding-ISS-  
GO:0035064methylated histone binding-IDA17967883  21029866  21489993  
GO:0042393histone binding-IDA21777816  
GO:0042802identical protein binding-ISS-  
GO:0044729hemi-methylated DNA-binding-IDA17673620  
GO:0061630ubiquitin protein ligase activity-IBA21873635  
GO:0061630ubiquitin protein ligase activity-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IDA21777816  
GO:0006281DNA repair-IEA-  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006511ubiquitin-dependent protein catabolic process-IDA22945642  
GO:0007049cell cycle-IEA-  
GO:0008283cell proliferation-IEP15361834  
GO:0010216maintenance of DNA methylation-IBA21873635  
GO:0010216maintenance of DNA methylation-IMP17673620  
GO:0010390histone monoubiquitination-IBA21873635  
GO:0010390histone monoubiquitination-ISS-  
GO:0016567protein ubiquitination-IBA21873635  
GO:0016574histone ubiquitination-IDA17967883  
GO:0032270positive regulation of cellular protein metabolic process-IDA10646863  
GO:0045944positive regulation of transcription by RNA polymerase II-IC10646863  
GO:0051865protein autoubiquitination-IDA17967883  21745816  
GO:2000373positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity-IC10646863  
GO ID GO Term Qualifier Evidence PubMed
GO:0000790nuclear chromatin-IDA17673620  
GO:0000790nuclear chromatin-ISS-  
GO:0000791euchromatin-IDA21777816  
GO:0000792heterochromatin-IDA17967883  21489993  21777816  
GO:0005634nucleus-IDA10646863  
GO:0005657replication fork-IDA17673620  
GO:0005720nuclear heterochromatin-IBA21873635  
GO:0016363nuclear matrix-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-212165Epigenetic regulation of gene expressionIEA
R-HSA-5334118DNA methylationIEA
R-HSA-74160Gene expression (Transcription)IEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

There is no Interaction data for this gene.

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24005809Overexpression of UHRF1 is significantly associated with poor prognosis in laryngeal squamous cell carcinoma. (2013 Dec)Pi JTMed Oncol
20517312UHRF1 is a novel diagnostic marker of lung cancer. (2010 Jul 13)Unoki MBr J Cancer