Gene: GRM4

2914
GPRC1D|MGLUR4|mGlu4
glutamate metabotropic receptor 4
protein-coding
6p21.31
Ensembl:ENSG00000124493 MIM:604100 Vega:OTTHUMG00000014538 UniprotKB:Q14833
NG_029677.3
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.128e-1 (AD)  3.925e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg10083824chr6:34102147GRM4Promoter5.451e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
BCL11B0.839
DRD10.838
SEZ60.833
HRH30.815
PTPN50.815
RAP1GAP0.812
KCNA40.809
CPNE50.807
GABRA50.804
TMEM120B0.792

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
COPZ2-0.528
YES1-0.518
REST-0.481
NXT2-0.481
MYL3-0.479
PRKD3-0.479
ASB4-0.479
RAB13-0.477
GNG11-0.474
LYN-0.473

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00142Glutamic AcidSmall Molecule56-86-0Approved|NutraceuticalTarget
ID Drug Name Action PubMed
C0523831,1-bis(4-hydroxyphenyl)-2-phenylbut-1-ene"1,1-bis(4-hydroxyphenyl)-2-phenylbut-1-ene results in decreased expression of GRM4 mRNA"23373633
C5234151-amino-2-phosphonomethylcyclopropanecarboxylic acid1-amino-2-phosphonomethylcyclopropanecarboxylic acid analog binds to GRM4 protein17602546
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of GRM4 mRNA"19114083
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of GRM4 mRNA"20816883
C0127292-amino-4-phosphonobutyric acid2-amino-4-phosphonobutyric acid binds to and results in increased activity of GRM4 protein16806298
C0127292-amino-4-phosphonobutyric acid2-amino-4-phosphonobutyric acid binds to GRM4 protein17602546
C5533444-styrylpyrimidin-2-ylamine4-styrylpyrimidin-2-ylamine binds to GRM420638279
C016601afimoxifeneafimoxifene results in increased expression of GRM4 mRNA23373633
D000447AldehydesAldehydes results in increased expression of GRM4 mRNA25014914
D000643Ammonium ChlorideAmmonium Chloride affects the expression of GRM4 mRNA16483693
D001280AtrazineAtrazine results in increased expression of GRM4 mRNA22378314
D001285AtropineAtropine inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium]18171729
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of GRM4 mRNA21839799
C006780bisphenol Abisphenol A affects the expression of GRM4 mRNA25181051
C013418bromfenacoumbromfenacoum results in decreased expression of GRM4 protein28903499
C018475butyraldehydebutyraldehyde results in increased expression of GRM4 mRNA26079696
D002217CarbacholAtropine inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium]18171729
D002217CarbacholCarbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]18171729
D002217Carbachol[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium18171729
D002217CarbacholPertussis Toxin inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium]18171729
D002217CarbacholScopolamine Hydrobromide inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium]18171729
D002217Carbacholtertiapin inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium]18171729
D002217CarbacholTropicamide inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium]18171729
D004390ChlorpyrifosChlorpyrifos results in increased expression of GRM4 mRNA19440498
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of GRM4 gene20938992
D003300CopperCopper deficiency results in increased expression of GRM4 mRNA26033743
D003976DiazinonDiazinon affects the expression of GRM4 mRNA19440498
D019422Dietary SucroseDietary Sucrose results in increased expression of GRM4 mRNA26033743
D000431EthanolEthanol results in decreased expression of GRM4 mRNA20655511
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of GRM4 gene20938992
C039281furanfuran results in increased expression of GRM4 mRNA25539665
C004312glycidolglycidol results in decreased expression of GRM4 mRNA24915197
C008261lead acetatelead acetate results in increased expression of GRM4 mRNA24260418
C008261lead acetatelead acetate affects the expression of GRM4 mRNA22160880
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of GRM4 gene20938992
C013598methoxyacetic acidmethoxyacetic acid affects the expression of GRM4 mRNA20864626
C587536N-(4-chloro-3-methoxyphenyl)-2-picolinamideN-(4-chloro-3-methoxyphenyl)-2-picolinamide binds to and affects the activity of GRM4 protein21247167
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in increased expression of GRM4 mRNA27935865
C442478N-phenyl-7-(hydroxyimino)cyclopropa(b)chromen-1a-carboxamideN-phenyl-7-(hydroxyimino)cyclopropa(b)chromen-1a-carboxamide affects the activity of GRM4 protein22088953
C442478N-phenyl-7-(hydroxyimino)cyclopropa(b)chromen-1a-carboxamideN-phenyl-7-(hydroxyimino)cyclopropa(b)chromen-1a-carboxamide binds to and affects the activity of GRM4 protein21247167
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"PON1 gene mutant form affects the susceptibility to [O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate affects the expression of GRM4 mRNA]"21673326
C046012pentanalpentanal results in increased expression of GRM4 mRNA26079696
D037342Pertussis ToxinPertussis Toxin inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium]18171729
D010634PhenobarbitalPhenobarbital results in decreased expression of GRM4 mRNA19162173
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in increased expression of GRM4 mRNA27935865
D010936Plant ExtractsPlant Extracts results in decreased expression of GRM4 mRNA23557933
C005556propionaldehydepropionaldehyde results in increased expression of GRM4 mRNA26079696
D011441PropylthiouracilPropylthiouracil results in decreased expression of GRM4 mRNA24780913
D012402RotenoneGRM4 protein results in decreased susceptibility to Rotenone16624952
D012601Scopolamine HydrobromideScopolamine Hydrobromide inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium]18171729
D013605T-2 ToxinT-2 Toxin results in decreased expression of GRM4 mRNA26141394
C029738tertiapintertiapin inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium]18171729
D013793ThalliumAtropine inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium]18171729
D013793Thallium[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium18171729
D013793ThalliumPertussis Toxin inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium]18171729
D013793ThalliumScopolamine Hydrobromide inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium]18171729
D013793Thalliumtertiapin inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium]18171729
D013793ThalliumTropicamide inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium]18171729
D014331TropicamideTropicamide inhibits the reaction [[Carbachol results in increased activity of [GRM4 protein binds to KCNJ3 protein]] which results in increased import of Thallium]18171729
D014635Valproic AcidValproic Acid results in increased methylation of GRM4 gene29154799
C544970VU 0155041VU 0155041 binds to and affects the folding of GRM4 protein21688779

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001642group III metabotropic glutamate receptor activity-IBA21873635  
GO:0004930G-protein coupled receptor activity-IMP8738157  9473604  
GO:0008066glutamate receptor activity-IBA21873635  
GO:0008066glutamate receptor activity-IMP8738157  9473604  
GO ID GO Term Qualifier Evidence PubMed
GO:0000187activation of MAPK activity-IDA15102938  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007196adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway-IBA21873635  
GO:0007196adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway-IMP15102938  
GO:0007216G-protein coupled glutamate receptor signaling pathway-IBA21873635  
GO:0007268chemical synaptic transmission-TAS8738157  
GO:0007269neurotransmitter secretion-TAS15102938  
GO:0043410positive regulation of MAPK cascade-IEP15102938  
GO:0043523regulation of neuron apoptotic process-TAS15102938  
GO:0051966regulation of synaptic transmission, glutamatergic-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005622intracellular-IDA15102938  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-IDA15102938  
GO:0031410cytoplasmic vesicle-IDA15102938  
GO:0042734presynaptic membrane-IBA21873635  
KEGG ID KEGG Term
hsa04080Neuroactive ligand-receptor interaction
hsa04742Taste transduction
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-418594G alpha (i) signalling eventsTAS
R-HSA-420499Class C/3 (Metabotropic glutamate/pheromone receptors)TAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25262781Expression of glutamatergic genes in healthy humans across 16 brain regions; altered expression in the hippocampus after chronic exposure to alcohol or cocaine. (2014 Nov)Enoch MAGenes Brain Behav