Gene: GRM5

2915
GPRC1E|MGLUR5|PPP1R86|mGlu5
glutamate metabotropic receptor 5
protein-coding
11q14.2-q14.3
Ensembl:ENSG00000168959 MIM:604102 Vega:OTTHUMG00000134306 UniprotKB:P41594
NG_052831.1
PubMed|SNP Mapped
ND|AD
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.102e-2 (AD)  5.690e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1391875chr11:88714478 (GRCh38.p7)G>Calcohol dependenceSNV(Single Nucleotide Variation)
rs6483362chr11:88679283 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs2131068chr11:88548038 (GRCh38.p7)T>Anicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PCDHAC20.942
PPM1E0.941
KCNH10.94
SCN8A0.936
CDKL50.932
PLEKHM30.927
KLHL110.923
HS6ST30.919
RGS7BP0.918
PCDHA50.912

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RAB13-0.593
COPZ2-0.58
ROM1-0.57
HEY2-0.561
BCL7C-0.549
S100A16-0.542
RARRES2-0.538
RNF135-0.538
GNG5-0.537
CSAG1-0.536

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00659AcamprosateSmall Molecule77337-76-9Approved|InvestigationalTarget
DB05070ADX10059Small Molecule-InvestigationalTarget
DB06201RufinamideSmall Molecule106308-44-5ApprovedTarget
DB12733DipraglurantSmall Molecule872363-17-2InvestigationalTarget
ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of GRM5 mRNA"25510870
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of GRM5 mRNA"19114083
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of GRM5 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of GRM5 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of GRM5 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of GRM5 mRNA"25510870
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in increased expression of GRM5 mRNA"20406850
C1073492-chloro-5-hydroxyphenylglycine2-chloro-5-hydroxyphenylglycine binds to and results in increased activity of GRM5 protein14556238
C1073492-chloro-5-hydroxyphenylglycine[2-chloro-5-hydroxyphenylglycine binds to and results in increased activity of GRM5 protein] which results in increased hydrolysis of Phosphatidylinositols14556238
C1073492-chloro-5-hydroxyphenylglycineAmphetamine promotes the reaction [[2-chloro-5-hydroxyphenylglycine binds to and results in increased activity of GRM5 protein] which results in increased hydrolysis of Phosphatidylinositols]14556238
C1073492-chloro-5-hydroxyphenylglycine2-chloro-5-hydroxyphenylglycine binds to and results in increased activity of GRM5 protein10854901
C5756373-((2-fluorothiazol-4-yl)ethynyl)-5-fluorobenzonitrile3-((2-fluorothiazol-4-yl)ethynyl)-5-fluorobenzonitrile binds to GRM5 protein21207959
C5756363-((2-fluorothiazol-4-yl)ethynyl)benzonitrile3-((2-fluorothiazol-4-yl)ethynyl)benzonitrile binds to GRM5 protein21207959
C5756353-((2-iodothiazol)-4-ethynyl)-5-fluorobenzonitrile3-((2-iodothiazol)-4-ethynyl)-5-fluorobenzonitrile binds to GRM5 protein21207959
C5414283-((2-methyl-1,3-thiazol-4-yl)ethynyl)piperidine"3-((2-methyl-1,3-thiazol-4-yl)ethynyl)piperidine binds to and results in decreased activity of GRM5 protein"20231306
C4723653-((2-methyl-1,3-thiazol-4-yl)ethynyl)pyridine"3-((2-methyl-1,3-thiazol-4-yl)ethynyl)pyridine binds to and results in decreased activity of GRM5 protein"19463707
C4723653-((2-methyl-1,3-thiazol-4-yl)ethynyl)pyridine"3-((2-methyl-1,3-thiazol-4-yl)ethynyl)pyridine binds to and results in decreased activity of GRM5 protein"15919101|1645107
C4723653-((2-methyl-1,3-thiazol-4-yl)ethynyl)pyridine"3-((2-methyl-1,3-thiazol-4-yl)ethynyl)pyridine results in decreased activity of GRM5 protein"18690408
C0792153,5-dihydroxyphenylglycine"[3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide binds to GRM5 protein] promotes the reaction [3,5-dihydroxyphenylglycine binds to and results in increased activity of GRM5 protein]"15608073
C0792153,5-dihydroxyphenylglycine"3,5-dihydroxyphenylglycine results in increased activity of GRM5 protein"17179862
C0792153,5-dihydroxyphenylglycine"[3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide binds to GRM5 protein] promotes the reaction [3,5-dihydroxyphenylglycine binds to and results in increased activity of GRM5 protein]"15608073
C0792153,5-dihydroxyphenylglycine"6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [3,5-dihydroxyphenylglycine results in increased activity of GRM5 protein]"17179862
C4945533-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide"[3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide binds to GRM5 protein] promotes the reaction [3,5-dihydroxyphenylglycine binds to and results in increased activity of GRM5 protein]"15608073
C4945533-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide"[3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide binds to GRM5 protein] promotes the reaction [Quisqualic Acid binds to and results in increased activity of GRM5 protein]"15608073
C4945533-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide"3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide inhibits the reaction [6-methyl-2-(phenylethynyl)pyridine analog binds to GRM5 protein]"15608073
C4945533-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide"[3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide binds to GRM5 protein] promotes the reaction [3,5-dihydroxyphenylglycine binds to and results in increased activity of GRM5 protein]"15608073
C4945533-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide"[3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide binds to GRM5 protein] promotes the reaction [Quisqualic Acid binds to and results in increased activity of GRM5 protein]"15608073
C5228443-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethynyl)benzonitrile3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethynyl)benzonitrile binds to GRM5 protein21207959
C0652504-hydroxy-equilenin4-hydroxy-equilenin results in decreased expression of GRM5 mRNA15135645
C5710086,6-dimethyl-2-phenylethynyl-7,8-dihydro-6H-quinolin-5-one"6,6-dimethyl-2-phenylethynyl-7,8-dihydro-6H-quinolin-5-one affects the activity of GRM5 protein"21161716
C1214656-methyl-2-(phenylethynyl)pyridine6-methyl-2-(phenylethynyl)pyridine binds to and results in decreased activity of GRM5 protein17592669
C1214656-methyl-2-(phenylethynyl)pyridine"3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide inhibits the reaction [6-methyl-2-(phenylethynyl)pyridine analog binds to GRM5 protein]"15608073
C1214656-methyl-2-(phenylethynyl)pyridine6-methyl-2-(phenylethynyl)pyridine binds to and results in decreased activity of GRM5 protein19812363
C1214656-methyl-2-(phenylethynyl)pyridine6-methyl-2-(phenylethynyl)pyridine binds to GRM5 protein20393458
C1214656-methyl-2-(phenylethynyl)pyridineFMR1 gene mutant form promotes the reaction [6-methyl-2-(phenylethynyl)pyridine binds to GRM5 protein]20393458
C1214656-methyl-2-(phenylethynyl)pyridineGRM5 affects the susceptibility to 6-methyl-2-(phenylethynyl)pyridine18377703
C1214656-methyl-2-(phenylethynyl)pyridine6-methyl-2-(phenylethynyl)pyridine binds to and results in decreased activity of GRM5 protein15010207|1946370
C1214656-methyl-2-(phenylethynyl)pyridine[6-methyl-2-(phenylethynyl)pyridine binds to and results in decreased activity of GRM5 protein] inhibits the reaction [Methamphetamine results in decreased abundance of Dopamine]12907309
C1214656-methyl-2-(phenylethynyl)pyridine[6-methyl-2-(phenylethynyl)pyridine binds to and results in decreased activity of GRM5 protein] inhibits the reaction [Methamphetamine results in increased secretion of Dopamine]12907309
C1214656-methyl-2-(phenylethynyl)pyridine[6-methyl-2-(phenylethynyl)pyridine binds to and results in decreased activity of GRM5 protein] inhibits the reaction [Veratridine results in increased secretion of Dopamine]12907309
C1214656-methyl-2-(phenylethynyl)pyridine[6-methyl-2-(phenylethynyl)pyridine binds to and results in decreased activity of GRM5 protein] which results in decreased secretion of Dopamine12907309
C1214656-methyl-2-(phenylethynyl)pyridine[6-methyl-2-(phenylethynyl)pyridine binds to and results in decreased activity of GRM5 protein] which results in decreased susceptibility to Pilocarpine15009663
C1214656-methyl-2-(phenylethynyl)pyridine6-methyl-2-(phenylethynyl)pyridine binds to GRM5 protein16890937|2120795
C1214656-methyl-2-(phenylethynyl)pyridine"6-methyl-2-(phenylethynyl)pyridine inhibits the reaction [3,5-dihydroxyphenylglycine results in increased activity of GRM5 protein]"17179862
C1214656-methyl-2-(phenylethynyl)pyridine6-methyl-2-(phenylethynyl)pyridine binds to and results in decreased activity of GRM5 protein10854901|1154376
C043877acamprosateGRM5 affects the susceptibility to acamprosate18377703
D000082AcetaminophenAcetaminophen results in decreased expression of GRM5 mRNA22230336
D000111AcetylcysteineAcetylcysteine results in increased activity of GRM5 protein19136971
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of GRM5 gene27153756
D000641AmmoniaAmmonia inhibits the reaction [GRM5 protein results in increased phosphorylation of MAP2 protein]15893642
D003913DextroamphetamineCycloheximide inhibits the reaction [Dextroamphetamine results in increased expression of GRM5 mRNA]11665859
D003913DextroamphetamineCycloheximide inhibits the reaction [Dextroamphetamine results in increased expression of GRM5 protein]11665859
D003913DextroamphetamineDactinomycin inhibits the reaction [Dextroamphetamine results in increased expression of GRM5 mRNA]11665859
D003913DextroamphetamineDactinomycin inhibits the reaction [Dextroamphetamine results in increased expression of GRM5 protein]11665859
D003913DextroamphetamineDextroamphetamine results in decreased expression of GRM5 mRNA11303782
D003913DextroamphetamineDextroamphetamine results in increased expression of GRM5 mRNA11303782|1166585
D003913DextroamphetamineDextroamphetamine results in increased expression of GRM5 protein11665859
D000661AmphetamineAmphetamine promotes the reaction [[2-chloro-5-hydroxyphenylglycine binds to and results in increased activity of GRM5 protein] which results in increased hydrolysis of Phosphatidylinositols]14556238
D000661AmphetamineAmphetamine results in decreased expression of GRM5 mRNA11418936
D000661AmphetamineAmphetamine results in increased expression of GRM5 mRNA14556238
D000661AmphetamineGRM5 protein promotes the reaction [Amphetamine results in increased expression of FOS mRNA]15010207
D001280AtrazineAtrazine results in decreased expression of GRM5 mRNA25929836
C083095azetidine-2,4-dicarboxylic acid"[azetidine-2,4-dicarboxylic acid results in increased activity of GRM5 protein] which results in increased phosphorylation of MAP2 protein"15893642
C547126AZM551248AZM551248 results in decreased expression of GRM5 mRNA22323515
D001549BenzamidesBenzamides binds to and results in decreased activity of GRM5 protein21126874
D004958EstradiolEstradiol results in decreased expression of GRM5 mRNA20068009
C006780bisphenol Abisphenol A results in decreased expression of GRM5 mRNA25181051
C006780bisphenol Abisphenol A results in increased expression of GRM5 mRNA29097150
D001966BromineBromine results in increased expression of GRM5 mRNA18790026
D0200011-Butanol1-Butanol affects the localization of GRM5 protein15470141
D0200011-ButanolPLD2 protein affects the reaction [1-Butanol affects the localization of GRM5 protein]15470141
D004390ChlorpyrifosChlorpyrifos affects the expression of GRM5 mRNA19440498
D003042CocaineCocaine affects the expression of GRM5 mRNA9886066
D003042CocaineCocaine affects the localization of GRM5 protein15295029
D003042CocaineGRM5 mutant form results in decreased susceptibility to Cocaine20826661
D003042CocaineCocaine affects the expression of GRM5 protein19105975|1911859
D003042CocaineCocaine results in decreased expression of and results in decreased activity of GRM5 protein20416862
D003042CocaineCocaine results in increased expression of GRM5 mRNA17898221|2481066
D003300CopperCopper inhibits the reaction [zinc chloride results in increased expression of GRM5 protein]25007851
D003513CycloheximideCycloheximide inhibits the reaction [Dextroamphetamine results in increased expression of GRM5 mRNA]11665859
D003513CycloheximideCycloheximide inhibits the reaction [Dextroamphetamine results in increased expression of GRM5 protein]11665859
D003609DactinomycinDactinomycin inhibits the reaction [Dextroamphetamine results in increased expression of GRM5 mRNA]11665859
D003609DactinomycinDactinomycin inhibits the reaction [Dextroamphetamine results in increased expression of GRM5 protein]11665859
D013759DronabinolDronabinol results in increased expression of GRM5 mRNA21955143
D004026DieldrinDieldrin results in decreased expression of GRM5 protein19812363
D007980Levodopa"[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Levodopa] results in increased expression of GRM5 mRNA"20132464
D007980Levodopa"[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Levodopa] results in increased expression of GRM5 protein"20132464
D004298Dopamine[6-methyl-2-(phenylethynyl)pyridine binds to and results in decreased activity of GRM5 protein] inhibits the reaction [Methamphetamine results in decreased abundance of Dopamine]12907309
D004298Dopamine[6-methyl-2-(phenylethynyl)pyridine binds to and results in decreased activity of GRM5 protein] inhibits the reaction [Methamphetamine results in increased secretion of Dopamine]12907309
D004298Dopamine[6-methyl-2-(phenylethynyl)pyridine binds to and results in decreased activity of GRM5 protein] inhibits the reaction [Veratridine results in increased secretion of Dopamine]12907309
D004298Dopamine[6-methyl-2-(phenylethynyl)pyridine binds to and results in decreased activity of GRM5 protein] which results in decreased secretion of Dopamine12907309
D000431EthanolEthanol results in increased expression of GRM5 mRNA21955143
D000431EthanolEthanol results in increased expression of GRM5 mRNA20655511
D000431Ethanol"N-methyl-N-(6-methoxy-1-phenyl-1,2,3,4-tetrahydronaphthalen-2-ylmethyl)aminomethylcarboxylic acid inhibits the reaction [Ethanol results in increased expression of GRM5 mRNA]"20655511
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of GRM5 mRNA29097150
C032794fenobamfenobam binds to and results in decreased activity of GRM5 protein20452425
C094503glyceryl 2-arachidonate[GRM5 results in increased activity of DAGLA protein] which results in increased secretion of glyceryl 2-arachidonate20393458
D007854LeadLead results in decreased expression of GRM5 mRNA19747533
D007854LeadLead results in decreased expression of GRM5 protein19747533
C008261lead acetatelead acetate affects the expression of GRM5 mRNA22160880
D008694Methamphetamine[6-methyl-2-(phenylethynyl)pyridine binds to and results in decreased activity of GRM5 protein] inhibits the reaction [Methamphetamine results in decreased abundance of Dopamine]12907309
D008694Methamphetamine[6-methyl-2-(phenylethynyl)pyridine binds to and results in decreased activity of GRM5 protein] inhibits the reaction [Methamphetamine results in increased secretion of Dopamine]12907309
D008694MethamphetamineMethamphetamine results in increased expression of GRM5 mRNA18419818
D008694MethamphetamineMethamphetamine results in increased expression of GRM5 protein23711322
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Levodopa] results in increased expression of GRM5 mRNA"20132464
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"[1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine co-treated with Levodopa] results in increased expression of GRM5 protein"20132464
D009020MorphineMorphine results in increased expression of GRM5 mRNA21955143
D009538NicotineNicotine results in increased expression of GRM5 mRNA21955143
C520612N-methyl-N-(6-methoxy-1-phenyl-1,2,3,4-tetrahydronaphthalen-2-ylmethyl)aminomethylcarboxylic acid"N-methyl-N-(6-methoxy-1-phenyl-1,2,3,4-tetrahydronaphthalen-2-ylmethyl)aminomethylcarboxylic acid inhibits the reaction [Ethanol results in increased expression of GRM5 mRNA]"20655511
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of GRM5 mRNA"25510870
D010634PhenobarbitalPhenobarbital results in increased expression of GRM5 mRNA19162173
D010716Phosphatidylinositols[2-chloro-5-hydroxyphenylglycine binds to and results in increased activity of GRM5 protein] which results in increased hydrolysis of Phosphatidylinositols14556238
D010716PhosphatidylinositolsAmphetamine promotes the reaction [[2-chloro-5-hydroxyphenylglycine binds to and results in increased activity of GRM5 protein] which results in increased hydrolysis of Phosphatidylinositols]14556238
D010862Pilocarpine[6-methyl-2-(phenylethynyl)pyridine binds to and results in decreased activity of GRM5 protein] which results in decreased susceptibility to Pilocarpine15009663
D010862PilocarpinePilocarpine results in decreased expression of GRM5 mRNA17634364
D010862PilocarpinePilocarpine results in decreased expression of GRM5 protein17634364
C006253pirinixic acidpirinixic acid results in increased expression of GRM5 mRNA20813756
D011441PropylthiouracilPropylthiouracil results in increased expression of GRM5 mRNA24780913
D016318Quisqualic Acid"[3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide binds to GRM5 protein] promotes the reaction [Quisqualic Acid binds to and results in increased activity of GRM5 protein]"15608073
D016318Quisqualic Acid"[3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide binds to GRM5 protein] promotes the reaction [Quisqualic Acid binds to and results in increased activity of GRM5 protein]"15608073
D012110ReserpineReserpine results in decreased expression of GRM5 mRNA16890937
D012110ReserpineReserpine results in increased expression of GRM5 protein16890937
D012402RotenoneRotenone results in decreased expression of GRM5 mRNA19013527
C120148SIB 1893SIB 1893 binds to and results in decreased activity of GRM5 protein10854901
C017947sodium arsenitesodium arsenite results in decreased expression of GRM5 mRNA24759735
C017947sodium arsenitesodium arsenite results in decreased expression of GRM5 protein24759735
C017947sodium arseniteSodium Fluoride promotes the reaction [sodium arsenite results in decreased expression of GRM5 mRNA]24759735
C017947sodium arseniteSodium Fluoride promotes the reaction [sodium arsenite results in decreased expression of GRM5 protein]24759735
D012969Sodium FluorideSodium Fluoride promotes the reaction [sodium arsenite results in decreased expression of GRM5 mRNA]24759735
D012969Sodium FluorideSodium Fluoride promotes the reaction [sodium arsenite results in decreased expression of GRM5 protein]24759735
D013311StreptozocinStreptozocin results in increased expression of GRM5 protein19840219
D014635Valproic AcidValproic Acid results in decreased expression of GRM5 mRNA24896083
D014701Veratridine[6-methyl-2-(phenylethynyl)pyridine binds to and results in decreased activity of GRM5 protein] inhibits the reaction [Veratridine results in increased secretion of Dopamine]12907309
D015032ZincZinc deficiency results in decreased expression of GRM5 mRNA18356318
C016837zinc chlorideCopper inhibits the reaction [zinc chloride results in increased expression of GRM5 protein]25007851
C016837zinc chloridezinc chloride results in increased expression of GRM5 protein25007851

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004930G-protein coupled receptor activity-IMP7908515  
GO:0005515protein binding-IPI19694902  24012003  
GO:0008066glutamate receptor activity-IBA21873635  
GO:0008066glutamate receptor activity-IDA7908515  
GO:0030296protein tyrosine kinase activator activity-TAS24012003  
GO:0099530G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential-IBA21873635  
GO:0099530G-protein coupled receptor activity involved in regulation of postsynaptic membrane potential-IEA-  
GO:0099583neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration-IBA21873635  
GO:0099583neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration-IEA-  
GO:1990782protein tyrosine kinase binding-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001932regulation of protein phosphorylation-IGI24012003  
GO:0006417regulation of translation-TAS24012003  
GO:0006448regulation of translational elongation-IGI24012003  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007206phospholipase C-activating G-protein coupled glutamate receptor signaling pathway-TAS7908515  
GO:0007216G-protein coupled glutamate receptor signaling pathway-IBA21873635  
GO:0007216G-protein coupled glutamate receptor signaling pathway-IMP7908515  
GO:0007268chemical synaptic transmission-TAS7908515  
GO:0007611learning or memory-ISS-  
GO:0007612learning-IEA-  
GO:0007626locomotory behavior-IEA-  
GO:0035584calcium-mediated signaling using intracellular calcium source-IGI24012003  
GO:0048169regulation of long-term neuronal synaptic plasticity-IEA-  
GO:0050808synapse organization-ISS-  
GO:0050890cognition-IMP23227193  
GO:0051966regulation of synaptic transmission, glutamatergic-IBA21873635  
GO:0060078regulation of postsynaptic membrane potential-IEA-  
GO:0061098positive regulation of protein tyrosine kinase activity-ISS-  
GO:0090647modulation of age-related behavioral decline-ISS-  
GO:0099553trans-synaptic signaling by endocannabinoid, modulating synaptic transmission-IBA21873635  
GO:0099566regulation of postsynaptic cytosolic calcium ion concentration-IEA-  
GO:1902938regulation of intracellular calcium activated chloride channel activity-IGI24012003  
GO:1904646cellular response to amyloid-beta-IGI24012003  
GO:1904646cellular response to amyloid-beta-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IEA-  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-IMP7908515  
GO:0043005neuron projection-IEA-  
GO:0098839postsynaptic density membrane-IBA21873635  
KEGG ID KEGG Term
hsa04020Calcium signaling pathway
hsa04080Neuroactive ligand-receptor interaction
hsa04540Gap junction
hsa04720Long-term potentiation
hsa04730Long-term depression
hsa05016Huntington's disease
Reactome ID Reactome Term Evidence
R-HSA-112316Neuronal SystemTAS
R-HSA-112316Neuronal SystemIEA
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-416476G alpha (q) signalling eventsTAS
R-HSA-420499Class C/3 (Metabotropic glutamate/pheromone receptors)TAS
R-HSA-500792GPCR ligand bindingTAS
R-HSA-6794361Neurexins and neuroliginsTAS
R-HSA-6794361Neurexins and neuroliginsIEA
R-HSA-6794362Protein-protein interactions at synapsesTAS
R-HSA-6794362Protein-protein interactions at synapsesIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25921801Eye color: A potential indicator of alcohol dependence risk in European Americans. (2015 Jul)Sulovari AAm J Med Genet B Neuropsychiatr Genet
29032150Functional analysis of schizophrenia genes using GeneAnalytics program and integrated databases. (2018 Jan 30)Sundararajan TGene
25939814CREB-BDNF pathway influences alcohol cue-elicited activation in drinkers. (2015 Aug)Chen JHum Brain Mapp