Gene: GRM6

2916
CSNB1B|GPRC1F|MGLUR6|mGlu6
glutamate metabotropic receptor 6
protein-coding
5q35.3
Ensembl:ENSG00000113262 MIM:604096 Vega:OTTHUMG00000130889 UniprotKB:O15303
NG_008105.1
PubMed|SNP Mapped
1   ANCO-SNPs
OD|ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.799e-1 (AD)  2.855e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2645339chr5:178989062 (GRCh38.p7)G>Anicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
QRICH20.676
ZGLP10.671
NXF10.668
ZNF5470.654
ZSCAN220.648
ZNF5510.647
ZNF8140.646
ZNF2020.643
RAD54L0.642
AVIL0.639

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SMIM1-0.265
C9orf92-0.254
CDNF-0.252
PDE11A-0.252
HSF2BP-0.25
OR4F5-0.249
TFPI2-0.247
FUT5-0.241
RPE65-0.24
CD48-0.239

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5234151-amino-2-phosphonomethylcyclopropanecarboxylic acid1-amino-2-phosphonomethylcyclopropanecarboxylic acid analog binds to GRM6 protein17602546
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of GRM6 mRNA"27291303
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl affects the expression of GRM6 mRNA"19114083
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of GRM6 mRNA"18648102
D001151ArsenicArsenic affects the methylation of GRM6 gene25304211
C015001arsenitearsenite results in increased methylation of GRM6 promoter23974009
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to GRM6 promoter]19654925
C006780bisphenol Abisphenol A results in decreased expression of GRM6 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of GRM6 promoter22457795
D004390ChlorpyrifosChlorpyrifos results in decreased expression of GRM6 mRNA19440498
D003300Copper[Copper co-treated with Dietary Sucrose] results in increased expression of GRM6 mRNA26033743
D003300CopperCopper deficiency results in increased expression of GRM6 mRNA26033743
D003471CuprizoneCuprizone results in decreased expression of GRM6 mRNA26577399
D003976DiazinonDiazinon results in increased expression of GRM6 mRNA19440498
D019422Dietary Sucrose[Copper co-treated with Dietary Sucrose] results in increased expression of GRM6 mRNA26033743
D019422Dietary SucroseDietary Sucrose results in increased expression of GRM6 mRNA26033743
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of GRM6 mRNA15620428
D000431EthanolEthanol results in decreased expression of GRM6 mRNA20655511
D000431Ethanol"N-methyl-N-(6-methoxy-1-phenyl-1,2,3,4-tetrahydronaphthalen-2-ylmethyl)aminomethylcarboxylic acid inhibits the reaction [Ethanol results in decreased expression of GRM6 mRNA]"20655511
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of GRM6 exon17430614
D005557FormaldehydeFormaldehyde results in increased expression of GRM6 mRNA12679049
D006861Hydrogen Peroxide[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of GRM6 protein18951874
C098607JP8 aviation fuelJP8 aviation fuel affects the expression of GRM6 mRNA15182950
C008261lead acetatelead acetate results in decreased expression of GRM6 mRNA24260418
C008261lead acetatelead acetate results in increased expression of GRM6 mRNA24260418
C520612N-methyl-N-(6-methoxy-1-phenyl-1,2,3,4-tetrahydronaphthalen-2-ylmethyl)aminomethylcarboxylic acid"N-methyl-N-(6-methoxy-1-phenyl-1,2,3,4-tetrahydronaphthalen-2-ylmethyl)aminomethylcarboxylic acid inhibits the reaction [Ethanol results in decreased expression of GRM6 mRNA]"20655511
C025256nonylphenolnonylphenol results in decreased expression of GRM6 mRNA15620428
D010269ParaquatParaquat results in increased expression of GRM6 mRNA18198484
D011441PropylthiouracilPropylthiouracil results in increased expression of GRM6 mRNA24780913
D012402RotenoneGRM6 protein results in decreased susceptibility to Rotenone16624952
D013806Theophylline[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of GRM6 protein18951874

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001640adenylate cyclase inhibiting G-protein coupled glutamate receptor activity-IEA-  
GO:0001642group III metabotropic glutamate receptor activity-IBA21873635  
GO:0004930G-protein coupled receptor activity-TAS9215706  
GO:0005515protein binding-IPI17405131  
GO:0008066glutamate receptor activity-IBA21873635  
GO:0008066glutamate receptor activity-IMP23452348  
GO:0008066glutamate receptor activity-TAS9215706  
GO:0042803protein homodimerization activity-IPI17405131  
GO ID GO Term Qualifier Evidence PubMed
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007196adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway-IBA21873635  
GO:0007216G-protein coupled glutamate receptor signaling pathway-IBA21873635  
GO:0007216G-protein coupled glutamate receptor signaling pathway-IMP23452348  
GO:0007268chemical synaptic transmission-IEA-  
GO:0007626locomotory behavior-IEA-  
GO:0009584detection of visible light-TAS9215706  
GO:0050908detection of light stimulus involved in visual perception-IMP17405131  
GO:0051966regulation of synaptic transmission, glutamatergic-IBA21873635  
GO:0060041retina development in camera-type eye-IEA-  
GO:0090280positive regulation of calcium ion import-IMP23452348  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-IDA17405131  
GO:0005789endoplasmic reticulum membrane-IDA17405131  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-IDA17405131  
GO:0030425dendrite-IEA-  
GO:0035841new growing cell tip-IEA-  
GO:0042734presynaptic membrane-IBA21873635  
KEGG ID KEGG Term
hsa04080Neuroactive ligand-receptor interaction
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-418594G alpha (i) signalling eventsTAS
R-HSA-420499Class C/3 (Metabotropic glutamate/pheromone receptors)TAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20560679Response to methadone maintenance treatment is associated with the MYOCD and GRM6 genes. (2010 Jun 1)Fonseca FMol Diagn Ther