Gene: GRP

2922
BN|GRP-10|preproGRP|proGRP
gastrin releasing peptide
protein-coding
18q21.32
Ensembl:ENSG00000134443 MIM:137260 Vega:OTTHUMG00000132760 UniprotKB:P07492
NC_000018.10
PubMed
0   ANCO-SNPs
CD|OD|ND|AD
10   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.880e-1 (AD)  2.628e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DLX10.595
PTHLH0.585
CPLX30.581
VIP0.569
CRH0.562
CAMK2N20.561
DLX20.559
CA40.555
NECAB20.551
PNOC0.54

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CP-0.477
SELL-0.447
RNASE2-0.426
MS4A6A-0.425
AQP1-0.424
SERPINA3-0.414
KIF19-0.413
CSF3R-0.41
EVI2B-0.408
FKBP5-0.4

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in decreased expression of GRP mRNA"26377693
C4656642-(1-(3-dimethylaminopropyl)-5-methoxyindol-3-yl)-3-(1H-indol-3-yl)maleimide2-(1-(3-dimethylaminopropyl)-5-methoxyindol-3-yl)-3-(1H-indol-3-yl)maleimide promotes the reaction [GRP protein modified form results in increased chemical synthesis of Inositol Phosphates]18313772
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of GRP mRNA"19114083
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GRP mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GRP mRNA"27188386
C5258724'-cyanobiphenyl-4-sulfonic acid (6-aminopyridin-2-yl)amide4'-cyanobiphenyl-4-sulfonic acid (6-aminopyridin-2-yl)amide results in decreased expression of GRP mRNA23264615
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GRP mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GRP mRNA"27188386
C469552A 419259A 419259 inhibits the reaction [GRP protein results in increased cleavage of and results in increased secretion of AREG protein]15342401
C469552A 419259A 419259 inhibits the reaction [GRP protein results in increased cleavage of and results in increased secretion of TGFA protein]15342401
C469552A 419259A 419259 inhibits the reaction [GRP protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]15342401
C469552A 419259A 419259 inhibits the reaction [GRP protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]15342401
C469552A 419259A 419259 inhibits the reaction [GRP protein results in increased phosphorylation of EGFR protein]15342401
C496492abrineabrine results in increased expression of GRP mRNA22595364
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of GRP gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of GRP mRNA16483693
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in increased expression of GRP mRNA"22863853
C006632arsenic trioxidearsenic trioxide results in decreased expression of GRP mRNA20458559
C015001arsenitearsenite results in increased methylation of GRP promoter23974009
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of GRP mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of GRP mRNA27858113
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in decreased expression of GRP mRNA26377693
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in decreased expression of GRP mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of GRP mRNA17879257
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of GRP mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of GRP mRNA21569818|2261060
C070515bisindolylmaleimide Ibisindolylmaleimide I promotes the reaction [GRP protein modified form results in increased chemical synthesis of Inositol Phosphates]18313772
C006780bisphenol Abisphenol A results in decreased expression of GRP mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of GRP gene28505145
C018475butyraldehydebutyraldehyde results in increased expression of GRP mRNA26079696
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of GRP mRNA27858113
D003033Coal TarCoal Tar results in decreased expression of GRP mRNA27858113
D019327Copper SulfateCopper Sulfate results in increased expression of GRP mRNA19549813
D003976DiazinonDiazinon results in increased expression of GRP mRNA29108742
C118739entinostatentinostat results in decreased expression of GRP mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GRP mRNA"27188386
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of GRP mRNA23649840
C081021Go 6976Go 6976 promotes the reaction [GRP protein modified form results in increased chemical synthesis of Inositol Phosphates]18313772
D006854HydrocortisoneHydrocortisone results in increased expression of GRP mRNA23264615
C041508indeno(1,2,3-cd)pyrene"indeno(1,2,3-cd)pyrene results in decreased expression of GRP mRNA"26377693
D007295Inositol Phosphates2-(1-(3-dimethylaminopropyl)-5-methoxyindol-3-yl)-3-(1H-indol-3-yl)maleimide promotes the reaction [GRP protein modified form results in increased chemical synthesis of Inositol Phosphates]18313772
D007295Inositol Phosphatesbisindolylmaleimide I promotes the reaction [GRP protein modified form results in increased chemical synthesis of Inositol Phosphates]18313772
D007295Inositol PhosphatesGo 6976 promotes the reaction [GRP protein modified form results in increased chemical synthesis of Inositol Phosphates]18313772
D007295Inositol PhosphatesGRP protein modified form results in increased chemical synthesis of Inositol Phosphates18313772
D007295Inositol PhosphatesRo 31-8220 promotes the reaction [GRP protein modified form results in increased chemical synthesis of Inositol Phosphates]18313772
D007295Inositol Phosphatesrottlerin promotes the reaction [GRP protein modified form results in increased chemical synthesis of Inositol Phosphates]18313772
D007295Inositol PhosphatesStaurosporine promotes the reaction [GRP protein modified form results in increased chemical synthesis of Inositol Phosphates]18313772
D007295Inositol PhosphatesTetradecanoylphorbol Acetate inhibits the reaction [GRP protein modified form results in increased chemical synthesis of Inositol Phosphates]18313772
C095194kuwanon Gkuwanon G inhibits the reaction [GRP protein binds to GRPR protein]7646517
C095195kuwanon Hkuwanon H inhibits the reaction [GRP protein binds to GRPR protein]7646517
C095195kuwanon Hkuwanon H inhibits the reaction [GRP protein binds to NMBR protein]7646517
C100342marimastatmarimastat inhibits the reaction [GRP protein results in increased cleavage of and results in increased secretion of AREG protein]15342401
C100342marimastatmarimastat inhibits the reaction [GRP protein results in increased cleavage of and results in increased secretion of TGFA protein]15342401
C065757meloxicammeloxicam results in decreased expression of GRP mRNA21270428|2326461
D015122MercaptopurineMercaptopurine results in increased expression of GRP mRNA23358152
D008731MethoxychlorMethoxychlor results in decreased expression of GRP mRNA21782745
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of GRP mRNA28001369
D0156551-Methyl-4-phenylpyridiniumGRP protein inhibits the reaction [SNCA protein results in increased susceptibility to 1-Methyl-4-phenylpyridinium]15888489
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of GRP mRNA"25511174
D010126OzoneOzone results in increased expression of GRP mRNA24336422
D010936Plant ExtractsPlant Extracts results in decreased expression of GRP mRNA23557933
D011374ProgesteroneProgesterone results in increased expression of GRP mRNA22238285
D011374Progesterone[Progesterone co-treated with IFNE protein] results in increased expression of GRP mRNA18448839
D011374Progesterone[Progesterone co-treated with IFNE protein] results in increased expression of GRP protein18448839
D011374ProgesteroneProgesterone results in increased expression of GRP mRNA18448839|1969004
D011374ProgesteroneProgesterone results in increased expression of GRP protein18448839
C005556propionaldehydepropionaldehyde results in increased expression of GRP mRNA26079696
D011441PropylthiouracilPropylthiouracil results in increased expression of GRP mRNA24780913
C064758Ro 31-8220Ro 31-8220 promotes the reaction [GRP protein modified form results in increased chemical synthesis of Inositol Phosphates]18313772
C085746rottlerinrottlerin promotes the reaction [GRP protein modified form results in increased chemical synthesis of Inositol Phosphates]18313772
D053260SootSoot affects the expression of GRP mRNA26551751
D019311StaurosporineStaurosporine promotes the reaction [GRP protein modified form results in increased chemical synthesis of Inositol Phosphates]18313772
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate inhibits the reaction [GRP protein modified form results in increased chemical synthesis of Inositol Phosphates]18313772
C009495titanium dioxidetitanium dioxide affects the expression of GRP mRNA23557971
C012589trichostatin Atrichostatin A results in increased expression of GRP mRNA26272509
C057693troglitazonetroglitazone results in increased expression of GRP mRNA21515302
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GRP mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of GRP mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of GRP mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased expression of GRP mRNA28001369
D014635Valproic AcidValproic Acid affects the expression of GRP mRNA17292431
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of GRP gene25560391
C111237vorinostatvorinostat results in increased expression of GRP mRNA26272509

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005102signaling receptor binding-NAS3027901  
GO:0005184neuropeptide hormone activity-IDA8756537  
GO ID GO Term Qualifier Evidence PubMed
GO:0007165signal transduction-NAS3027901  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007218neuropeptide signaling pathway-IDA8756537  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0035176social behavior-IEA-  
GO:0036343psychomotor behavior-IEA-  
GO:0043207response to external biotic stimulus-IEA-  
GO:0090277positive regulation of peptide hormone secretion-ISS-  
GO:1900738positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IDA3211139  8756537  
GO:0034774secretory granule lumen-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-2980736Peptide hormone metabolismTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-375276Peptide ligand-binding receptorsTAS
R-HSA-381771Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)TAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-400508Incretin synthesis, secretion, and inactivationTAS
R-HSA-416476G alpha (q) signalling eventsTAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
17478053Glial-restricted precursors: patterns of expression of opioid receptors and relationship to human immunodeficiency virus-1 Tat and morphine susceptibility in vitro. (2007 Jun 8)Buch SKNeuroscience
24006219Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia with a central and peripheral carcinoid and multiple tumorlets: a case report emphasizing the role of neuropeptide hormones and human gonadotropin-alpha. (2013 Dec)Oba HEndocr Pathol
8959679Clinical correlates of bombesin-like peptide receptor subtype expression in human lung cancer cells. (1996 Nov)Toi-Scott MLung Cancer
21730252Effects of mass media campaign exposure intensity and durability on quit attempts in a population-based cohort study. (2011 Dec)Wakefield MAHealth Educ Res
1706089Gastrin-releasing peptide gene products in midtrimester human fetal lung with and without maternal smoking history during pregnancy. (1991)Chen MFPediatr Pulmonol
28119953Acrolein Is a Pathogenic Mediator of Alcoholic Liver Disease and the Scavenger Hydralazine Is Protective in Mice. (2016 Sep)Chen WYCell Mol Gastroenterol Hepatol
16340837[Lung cancer in women]. (2005 Dec)Quoix ERev Mal Respir
27149479Retrospective Study to Determine Diagnostic Utility of 6 Commonly Used Lung Cancer Biomarkers Among Han and Uygur Population in Xinjiang Uygur Autonomous Region of People's Republic of China. (2016 May)Yang-Chun FMedicine (Baltimore)
10771023Interaction of tobacco-specific toxicants with the neuronal alpha(7) nicotinic acetylcholine receptor and its associated mitogenic signal transduction pathway: potential role in lung carcinogenesis and pediatric lung disorders. (2000 Mar 30)Schuller HMEur J Pharmacol
9279210Expression of mRNA for gastrin-releasing peptide receptor by human bronchial epithelial cells. Association with prolonged tobacco exposure and responsiveness to bombesin-like peptides. (1997 Aug)Siegfried JMAm J Respir Crit Care Med