Gene info: ID 2923

Gene: PDIA3

GENE ID: 2923

Synonyms: ER60|ERp57|ERp60|ERp61|GRP57|GRP58|HEL-S-269|HEL-S-93n|HsT17083|P58|PI-PLC

Description: protein disulfide isomerase family A member 3

Gene type: protein-coding

Location: 15q15.3

dbXrefs: Ensembl:ENSG00000167004 MIM:602046 Vega:OTTHUMG00000044444 UniprotKB:P30101

RefSeq: NC_000015.10

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 2.875e-1 (AD) 9.650e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
HSP90B1	0.949
KDELR2	0.937
RPN1	0.932
P4HB	0.927
CAP1	0.923
RPN2	0.923
SSR2	0.915
SURF4	0.914
KARS	0.913
RBM22	0.912

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.744
OR4F29	-0.706
TCL1A	-0.177
OR6C74	-0.156
HES5	-0.146
LYZL2	-0.139
PDE11A	-0.138
KLRC2	-0.133
LCE3A	-0.133
C16orf97	-0.133

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB01593	Zinc	Small Molecule	7440-66-6	Approved\|Investigational	Target
DB09130	Copper	Small Molecule	7440-50-8	Approved\|Investigational	Target

ID	Drug Name	Action	PubMed
C029497	2,3-bis(3'-hydroxybenzyl)butyrolactone	"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of PDIA3 mRNA"	19167446
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of PDIA3 mRNA"	21346803
C011269	2,5-hexanedione	"2,5-hexanedione results in decreased expression of PDIA3 protein"	19033394
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of PDIA3 mRNA"	21346803
C060533	2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine	"2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine affects the expression of PDIA3 protein"	19639176
C060533	2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine	"[2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dihydrotestosterone] affects the expression of PDIA3 protein"	19639176
C023035	3,4,5,3',4'-pentachlorobiphenyl	"[3,4,5,3',4'-pentachlorobiphenyl co-treated with Diethylnitrosamine] results in increased expression of PDIA3 protein"	23457121
C472791	3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid	3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of PDIA3 mRNA	12958071
C017906	3-dinitrobenzene	3-dinitrobenzene results in increased expression of PDIA3 mRNA	21983209
C017906	3-dinitrobenzene	3-dinitrobenzene results in increased metabolism of PDIA3 protein	21402099
C027576	4-hydroxy-2-nonenal	4-hydroxy-2-nonenal analog binds to PDIA3	18232660
D000082	Acetaminophen	Acetaminophen affects the expression of PDIA3 mRNA	17562736
D000082	Acetaminophen	Acetaminophen results in increased expression of PDIA3 protein	16538041
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin analog results in increased expression of PDIA3 protein	26597043
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin results in increased expression of PDIA3 protein	26072098\|2659704
D013196	Dihydrotestosterone	"[2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dihydrotestosterone] affects the expression of PDIA3 protein"	19639176
D013196	Dihydrotestosterone	Dihydrotestosterone affects the expression of PDIA3 protein	19639176
C027876	alpha-naphthyl acetate	PDIA3 protein results in increased hydrolysis of alpha-naphthyl acetate	16798117
D000638	Amiodarone	Amiodarone affects the expression of PDIA3 mRNA	19483382
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of PDIA3 mRNA	16483693
D001151	Arsenic	Arsenic results in increased expression of PDIA3 protein	19818359
C006632	arsenic trioxide	arsenic trioxide results in decreased expression of PDIA3 protein	19364129
C015001	arsenite	arsenite results in increased oxidation of PDIA3 protein	20196163
D001205	Ascorbic Acid	Ascorbic Acid inhibits the reaction [Fenretinide results in increased expression of PDIA3 mRNA]	17353921
D001205	Ascorbic Acid	Ascorbic Acid inhibits the reaction [Fenretinide results in increased expression of PDIA3 protein]	17353921
C406592	azaspiracid	azaspiracid results in increased expression of PDIA3 mRNA	28939011
C547126	AZM551248	AZM551248 results in increased expression of PDIA3 mRNA	22323515
D001553	Benzbromarone	Benzbromarone affects the expression of PDIA3 mRNA	19483382
D001564	Benzo(a)pyrene	[Benzo(a)pyrene co-treated with sodium bichromate] results in decreased expression of PDIA3 mRNA	21632023
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of PDIA3 mRNA	22300585
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of PDIA3 mRNA"	20018196
C110172	BHTOH-QM	BHTOH-QM binds to PDIA3 protein	16533022
C006780	bisphenol A	bisphenol A binds to PDIA3 protein	21976707
C006780	bisphenol A	bisphenol A results in increased expression of PDIA3 mRNA	25181051
D001761	Bleomycin	[Bleomycin co-treated with Cisplatin co-treated with Etoposide] results in increased expression of PDIA3 protein	24478030
C013418	bromfenacoum	bromfenacoum results in increased expression of PDIA3 protein	28903499
C032036	bromobenzene	bromobenzene metabolite binds to PDIA3 protein	12018992
C515564	bromovanin	bromovanin results in decreased expression of PDIA3 protein	21419150
D019328	Buthionine Sulfoximine	Buthionine Sulfoximine results in increased expression of PDIA3 protein	23736079
D002104	Cadmium	Cadmium results in increased expression of PDIA3 mRNA	24084258
D019256	Cadmium Chloride	Cadmium Chloride affects the expression of PDIA3 protein	24874008
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of PDIA3 protein	22941245
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of PDIA3 mRNA	19031917
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of PDIA3 protein	24419708
D019256	Cadmium Chloride	[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of PDIA3 mRNA	19840844
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of PDIA3 mRNA	18636176
D002251	Carbon Tetrachloride	Carbon Tetrachloride affects the expression of PDIA3 protein	16613267
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of PDIA3 protein	16845489
D002251	Carbon Tetrachloride	"Drugs, Chinese Herbal inhibits the reaction [Carbon Tetrachloride affects the expression of PDIA3 protein]"	16613267
C099555	CD 437	CD 437 results in decreased expression of PDIA3 mRNA	12958071
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in decreased expression of PDIA3 mRNA	23650126
D004390	Chlorpyrifos	[Copper co-treated with Chlorpyrifos] results in increased expression of PDIA3 mRNA	21356183
D002994	Clofibrate	Clofibrate affects the expression of PDIA3 mRNA	19483382
D002995	Clofibric Acid	Clofibric Acid affects the expression of PDIA3 mRNA	17602206
D003042	Cocaine	Cocaine affects the reaction [PTN affects the expression of PDIA3 protein modified form]	24096156
D003042	Cocaine	Cocaine affects the expression of PDIA3 mRNA	20187946
D003300	Copper	Copper deficiency results in decreased expression of PDIA3 protein	25150618
D003300	Copper	[Copper co-treated with Chlorpyrifos] results in increased expression of PDIA3 mRNA	21356183
D003300	Copper	Copper results in increased expression of PDIA3 mRNA	21356183
D003300	Copper	PDIA3 protein binds to Copper	14534351\|1535973
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of PDIA3 mRNA	19549813
C030123	coumarin	coumarin results in increased expression of PDIA3 mRNA	18480146
D003375	Coumestrol	"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of PDIA3 mRNA"	19167446
C030973	cupric oxide	cupric oxide results in decreased expression of PDIA3 protein	25470785
D003520	Cyclophosphamide	Cyclophosphamide results in decreased expression of PDIA3 mRNA	11906922
D016572	Cyclosporine	Cyclosporine results in increased expression of PDIA3 mRNA	20106945\|2116390
D016572	Cyclosporine	Cyclosporine results in decreased expression of PDIA3 protein	25047351
D016572	Cyclosporine	Cyclosporine results in increased expression of PDIA3 mRNA	25047351\|2527062
C017160	cypermethrin	cypermethrin results in decreased expression of PDIA3 protein	21561882
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of PDIA3 mRNA	17361019\|2126653
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of PDIA3 mRNA	21266533
D002945	Cisplatin	PDIA3 affects the susceptibility to Cisplatin	15756446
D002945	Cisplatin	[Bleomycin co-treated with Cisplatin co-treated with Etoposide] results in increased expression of PDIA3 protein	24478030
C036042	dicyclohexyl phthalate	dicyclohexyl phthalate affects the expression of PDIA3 mRNA	26924002
D004026	Dieldrin	Dieldrin results in decreased expression of PDIA3 mRNA	23041725
D004052	Diethylnitrosamine	"[3,4,5,3',4'-pentachlorobiphenyl co-treated with Diethylnitrosamine] results in increased expression of PDIA3 protein"	23457121
D004052	Diethylnitrosamine	[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of PDIA3 mRNA	16158176
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of PDIA3 mRNA	14656948
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of PDIA3 mRNA	18544905
D004054	Diethylstilbestrol	Diethylstilbestrol affects the metabolism of PDIA3 protein	20932895
D015127	9,10-Dimethyl-1,2-benzanthracene	"[9,10-Dimethyl-1,2-benzanthracene co-treated with Isoflavones] results in increased expression of PDIA3 protein"	22248470
D015127	9,10-Dimethyl-1,2-benzanthracene	"9,10-Dimethyl-1,2-benzanthracene results in increased expression of PDIA3 protein"	22248470
D004298	Dopamine	Dopamine results in decreased expression of PDIA3 protein	24675778
D004317	Doxorubicin	Doxorubicin results in increased oxidation of PDIA3 protein	28818578
D004365	Drugs, Chinese Herbal	"Drugs, Chinese Herbal inhibits the reaction [Carbon Tetrachloride affects the expression of PDIA3 protein]"	16613267
C013525	ENNG	[ENNG co-treated with Isoflavones] results in increased expression of PDIA3 protein	22248470
C013525	ENNG	ENNG results in increased expression of PDIA3 protein	22248470
D004785	Environmental Pollutants	Environmental Pollutants results in increased expression of PDIA3 mRNA	20064776
D004791	Enzyme Inhibitors	[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of PDIA3 protein	23301498
D000431	Ethanol	Ethanol affects the expression of PDIA3 protein	22960358
D000431	Ethanol	Ethanol results in decreased expression of PDIA3 protein	24646710
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of PDIA3 mRNA	17108234
D005001	Ethionine	Ethionine affects the expression of PDIA3 mRNA	19483382
D005047	Etoposide	[Bleomycin co-treated with Cisplatin co-treated with Etoposide] results in increased expression of PDIA3 protein	24478030
D005411	Flame Retardants	Flame Retardants results in decreased expression of PDIA3 protein	18550172
D005419	Flavonoids	Flavonoids results in decreased expression of PDIA3 mRNA	18035473
D015073	2-Acetylaminofluorene	[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of PDIA3 mRNA	16158176
D015073	2-Acetylaminofluorene	[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of PDIA3 mRNA	14656948
C039281	furan	furan binds to PDIA3 protein	22240984
D019833	Genistein	Genistein results in increased expression of PDIA3 protein	22649256
D005947	Glucose	Glucose results in decreased expression of PDIA3 mRNA	17178593
D017313	Fenretinide	Ascorbic Acid inhibits the reaction [Fenretinide results in increased expression of PDIA3 mRNA]	17353921
D017313	Fenretinide	Ascorbic Acid inhibits the reaction [Fenretinide results in increased expression of PDIA3 protein]	17353921
D017313	Fenretinide	Fenretinide results in increased expression of PDIA3 mRNA	17353921
D017313	Fenretinide	Fenretinide results in increased expression of PDIA3 protein	17353921
D006820	Hyaluronic Acid	Hyaluronic Acid analog results in decreased expression of PDIA3 protein	23178681
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased expression of PDIA3 protein	18603805
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in decreased expression of PDIA3 protein	23178681
D002112	Calcifediol	Calcifediol deficiency results in decreased expression of PDIA3 mRNA	17293106
C020758	indium trichloride	indium trichloride results in decreased expression of PDIA3 protein	19539025
C503753	Indolinone A	Indolinone A results in increased phosphorylation of PDIA3 protein	15838870
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of PDIA3 mRNA	25613284
D007529	Isoflavones	"[9,10-Dimethyl-1,2-benzanthracene co-treated with Isoflavones] results in increased expression of PDIA3 protein"	22248470
D007529	Isoflavones	[ENNG co-treated with Isoflavones] results in increased expression of PDIA3 protein	22248470
C011890	kojic acid	[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of PDIA3 mRNA	18544905
C008261	lead acetate	lead acetate results in increased expression of PDIA3 protein	20797405
C029891	lead chloride	lead chloride results in decreased expression of PDIA3 protein	24419708
C008281	limonene	limonene results in increased expression of PDIA3 mRNA	12815608
D008094	Lithium	Lithium results in increased expression of PDIA3 protein	18296634
D008148	Lovastatin	Lovastatin results in decreased expression of PDIA3 mRNA	20493250
D008148	Lovastatin	Lovastatin results in increased expression of PDIA3 mRNA	20493250
D008694	Methamphetamine	Methamphetamine results in decreased expression of PDIA3 protein	19826936
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of PDIA3 mRNA"	26251327
D008769	Methylnitronitrosoguanidine	[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of PDIA3 mRNA	19840844
D008769	Methylnitronitrosoguanidine	[Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of PDIA3 mRNA	19840844
D008769	Methylnitronitrosoguanidine	[Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of PDIA3 mRNA	19840844
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in increased expression of PDIA3 protein	24675778
D015741	Metribolone	Metribolone results in increased expression of PDIA3 protein	17152098
C063855	microcystin RR	microcystin RR results in increased expression of PDIA3 protein	19111056
D052998	Microcystins	Microcystins results in decreased expression of PDIA3 protein	22430071
C028577	monobutyl phthalate	monobutyl phthalate results in increased expression of PDIA3 protein	20553848
C517284	monomethyl phthalate	monomethyl phthalate affects the expression of PDIA3 mRNA	26924002
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of PDIA3 mRNA"	25554681\|2562005
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of PDIA3 mRNA"	25554681\|2562005
C031721	naphthalene	naphthalene metabolite binds to PDIA3 protein	15892573\|1620632
D009532	Nickel	Nickel results in increased expression of PDIA3 mRNA	24084258
C002741	N-nitrosomorpholine	N-nitrosomorpholine affects the expression of PDIA3 protein	19716841
C025256	nonylphenol	nonylphenol affects the expression of PDIA3 protein	19429228
C025256	nonylphenol	nonylphenol results in increased expression of PDIA3 protein	19260726
C025589	ochratoxin A	ochratoxin A results in increased expression of PDIA3 protein	26861962
D016627	Oxidopamine	Oxidopamine results in increased expression of PDIA3 mRNA	12486162
D019319	Okadaic Acid	[Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of PDIA3 mRNA	19840844
D009853	Omeprazole	Omeprazole affects the expression of PDIA3 mRNA	19483382
D010100	Oxygen	Oxygen results in increased expression of PDIA3 mRNA	19747560
D010269	Paraquat	Paraquat results in increased expression of PDIA3 mRNA	21371552
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether results in decreased expression of PDIA3 protein	18550172
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether results in decreased expression of PDIA3 protein	19954255
C086401	pentabromodiphenyl ether	pentabromodiphenyl ether results in increased expression of PDIA3 protein	25616259
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in decreased expression of PDIA3 mRNA	19162173
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in increased expression of PDIA3 mRNA	19747560
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of PDIA3 protein	22609092
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of PDIA3 mRNA	19162173
D010634	Phenobarbital	Phenobarbital results in increased expression of PDIA3 protein	19952500
D010634	Phenobarbital	Phenobarbital affects the expression of PDIA3 mRNA	19159669
D010713	Phosphatidylcholines	PDIA3 protein results in increased hydrolysis of Phosphatidylcholines	16798117
C006253	pirinixic acid	pirinixic acid affects the expression of PDIA3 mRNA	19483382
C006253	pirinixic acid	pirinixic acid results in decreased expression of PDIA3 mRNA	19162173
C035988	procymidone	procymidone results in decreased expression of PDIA3 mRNA	15686871
D011374	Progesterone	Progesterone affects the expression of PDIA3 mRNA	17251523
C015586	propiverine	propiverine binds to PDIA3 protein	29273565
D011441	Propylthiouracil	Propylthiouracil affects the expression of PDIA3 mRNA	19483382
C031280	pyrazole	pyrazole results in increased expression of PDIA3 mRNA	17945193
D011748	Pyrogallol	Pyrogallol results in increased expression of PDIA3 mRNA	20362636
D011794	Quercetin	Quercetin results in decreased expression of PDIA3 mRNA	21632981
C502851	quinocetone	quinocetone results in increased expression of PDIA3 protein	27046791
C059514	resveratrol	resveratrol affects the expression of PDIA3 protein	23255428
C059514	resveratrol	resveratrol affects the secretion of PDIA3 protein	24802182
D012176	Retinoids	Retinoids results in decreased expression of PDIA3 protein	28886987
C014794	retinol palmitate	PDIA3 protein results in increased hydrolysis of retinol palmitate	16798117
C089730	rosiglitazone	rosiglitazone affects the expression of PDIA3 protein	19556978
D012524	Sarin	Sarin affects the expression of PDIA3 protein	28973502
D012715	Sesame Oil	Sesame Oil results in increased expression of PDIA3 mRNA	29191790
C440975	silybin	silybin binds to and affects the localization of PDIA3 protein	24530445
C440975	silybin	[silybin binds to PDIA3 protein] promotes the reaction [PDIA3 protein binds to APEX1 protein]	24530445
C080703	SK&F 83959	SK&F 83959 affects the expression of PDIA3 protein	25852303
C017947	sodium arsenite	sodium arsenite affects the expression of PDIA3 protein	21925251
C017947	sodium arsenite	sodium arsenite results in decreased expression of PDIA3 mRNA	28595984
C017947	sodium arsenite	sodium arsenite results in increased expression of PDIA3 protein	21925251
C017947	sodium arsenite	sodium arsenite results in decreased expression of PDIA3 mRNA	19822182
C016104	sodium bichromate	[Benzo(a)pyrene co-treated with sodium bichromate] results in decreased expression of PDIA3 mRNA	21632023
D012969	Sodium Fluoride	Sodium Fluoride results in decreased expression of PDIA3 protein	27548804
D013605	T-2 Toxin	T-2 Toxin affects the expression of PDIA3 protein	26141394
D013739	Testosterone	Testosterone affects the expression of PDIA3 mRNA	17003280
C534735	tetraarsenic tetrasulfide	tetraarsenic tetrasulfide results in increased expression of PDIA3 mRNA	19208803
C534735	tetraarsenic tetrasulfide	tetraarsenic tetrasulfide results in increased expression of PDIA3 protein	19208803
C534735	tetraarsenic tetrasulfide	tetraarsenic tetrasulfide results in increased expression of PDIA3 protein	19208803
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of PDIA3 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of PDIA3 mRNA	16054898
D013755	Tetradecanoylphorbol Acetate	[Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of PDIA3 mRNA	19840844
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of PDIA3 mRNA	25613284
D015647	2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine	"2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in decreased expression of PDIA3 protein"	25852303
D019284	Thapsigargin	Thapsigargin results in increased expression of PDIA3 mRNA	17353921
D019284	Thapsigargin	Thapsigargin results in increased expression of PDIA3 protein	17353921
D013849	Thimerosal	Thimerosal results in decreased expression of PDIA3 mRNA	27188386
D013853	Thioacetamide	Thioacetamide affects the expression of PDIA3 mRNA	19483382
C009495	titanium dioxide	titanium dioxide results in increased expression of PDIA3 mRNA	23557971\|2776080
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased metabolism of PDIA3 protein	23396223
D014241	Trichloroethylene	Trichloroethylene results in decreased expression of PDIA3 mRNA	19448997
D014302	Trinitrobenzenesulfonic Acid	Trinitrobenzenesulfonic Acid results in increased expression of PDIA3 mRNA	17982090
C057693	troglitazone	troglitazone results in increased expression of PDIA3 mRNA	28973697
D014415	Tunicamycin	Tunicamycin results in increased expression of PDIA3 mRNA	17127020
C501517	UCF 101	UCF 101 results in increased expression of PDIA3 protein	19763263
D014635	Valproic Acid	Valproic Acid results in decreased methylation of PDIA3 gene	29154799
D014635	Valproic Acid	Valproic Acid results in increased expression of PDIA3 mRNA	23179753
D001335	Vehicle Emissions	Vehicle Emissions results in increased methylation of PDIA3 gene	25560391
D000069470	Venlafaxine Hydrochloride	Venlafaxine Hydrochloride results in decreased expression of PDIA3 mRNA	25423262
C025643	vinclozolin	vinclozolin results in decreased expression of PDIA3 mRNA	15686871\|2303416
C025643	vinclozolin	vinclozolin results in increased expression of PDIA3 protein	20616205
C111237	vorinostat	vorinostat results in decreased expression of PDIA3 mRNA	27188386
D014859	Warfarin	Warfarin results in decreased expression of PDIA3 mRNA	20493250
D014859	Warfarin	Warfarin results in increased expression of PDIA3 mRNA	20493250
D014874	Water Pollutants, Chemical	"Water Pollutants, Chemical results in increased expression of PDIA3 mRNA"	23246600
D015032	Zinc	PDIA3 protein binds to Zinc	14534351
D015034	Zinc Oxide	Zinc Oxide analog results in increased expression of PDIA3 mRNA	25680694

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0003723	RNA binding	-	HDA	22658674
GO:0003756	protein disulfide isomerase activity	-	IBA	21873635
GO:0004197	cysteine-type endopeptidase activity	-	TAS	9399589
GO:0004629	phospholipase C activity	-	TAS	3398923
GO:0005515	protein binding	-	IPI	15896298 16905107 17055437 17170699 20802462 21057456 21670307 21941299 22665516 23826168 26496610
GO:0015036	disulfide oxidoreductase activity	-	TAS	22013210
GO:0015037	peptide disulfide oxidoreductase activity	-	IDA	16677074
GO:0042802	identical protein binding	-	IPI	16905107

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	-	TAS	-
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	-	TAS	-
GO:0006457	protein folding	-	IBA	21873635
GO:0006457	protein folding	-	TAS	-
GO:0006508	proteolysis	-	IEA	-
GO:0034975	protein folding in endoplasmic reticulum	-	TAS	22013210
GO:0034976	response to endoplasmic reticulum stress	-	IBA	21873635
GO:0045454	cell redox homeostasis	-	IEA	-
GO:0055114	oxidation-reduction process	-	IEA	-
GO:2001238	positive regulation of extrinsic apoptotic signaling pathway	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005615	extracellular space	-	IDA	19995400
GO:0005634	nucleus	-	HDA	21630459
GO:0005783	endoplasmic reticulum	-	IBA	21873635
GO:0005783	endoplasmic reticulum	-	IDA	23826168
GO:0005783	endoplasmic reticulum	-	TAS	16130169
GO:0005788	endoplasmic reticulum lumen	-	TAS	-
GO:0005925	focal adhesion	-	HDA	21423176
GO:0009986	cell surface	-	IBA	21873635
GO:0009986	cell surface	-	IDA	19995400
GO:0042470	melanosome	-	IEA	-
GO:0043209	myelin sheath	-	IEA	-
GO:0045335	phagocytic vesicle	-	TAS	-
GO:0055038	recycling endosome membrane	-	TAS	-
GO:0070062	extracellular exosome	-	HDA	19199708

KEGG ID	KEGG Term
hsa04141	Protein processing in endoplasmic reticulum
hsa04612	Antigen processing and presentation

Reactome ID	Reactome Term	Evidence
R-HSA-1236974	ER-Phagosome pathway	TAS
R-HSA-1236974	ER-Phagosome pathway	IEA
R-HSA-1236975	Antigen processing-Cross presentation	TAS
R-HSA-1236975	Antigen processing-Cross presentation	IEA
R-HSA-1280218	Adaptive Immune System	IEA
R-HSA-1280218	Adaptive Immune System	TAS
R-HSA-168256	Immune System	IEA
R-HSA-168256	Immune System	TAS
R-HSA-392499	Metabolism of proteins	TAS
R-HSA-446203	Asparagine N-linked glycosylation	TAS
R-HSA-532668	N-glycan trimming in the ER and Calnexin/Calreticulin cycle	TAS
R-HSA-597592	Post-translational protein modification	TAS
R-HSA-901042	Calnexin/calreticulin cycle	TAS
R-HSA-983169	Class I MHC mediated antigen processing & presentation	IEA
R-HSA-983169	Class I MHC mediated antigen processing & presentation	TAS
R-HSA-983170	Antigen Presentation: Folding, assembly and peptide loading of class I MHC	IEA
R-HSA-983170	Antigen Presentation: Folding, assembly and peptide loading of class I MHC	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
25803269	Maternal Smoking Dysregulates Protein Expression in Second Trimester Human Fetal Livers in a Sex-Specific Manner. (2015 Jun)	Filis P	J Clin Endocrinol Metab