Gene: PDIA3

2923
ER60|ERp57|ERp60|ERp61|GRP57|GRP58|HEL-S-269|HEL-S-93n|HsT17083|P58|PI-PLC
protein disulfide isomerase family A member 3
protein-coding
15q15.3
Ensembl:ENSG00000167004 MIM:602046 Vega:OTTHUMG00000044444 UniprotKB:P30101
NC_000015.10
PubMed
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.875e-1 (AD)  9.650e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HSP90B10.949
KDELR20.937
RPN10.932
P4HB0.927
CAP10.923
RPN20.923
SSR20.915
SURF40.914
KARS0.913
RBM220.912

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.744
OR4F29-0.706
TCL1A-0.177
OR6C74-0.156
HES5-0.146
LYZL2-0.139
PDE11A-0.138
KLRC2-0.133
LCE3A-0.133
C16orf97-0.133

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB01593ZincSmall Molecule7440-66-6Approved|InvestigationalTarget
DB09130CopperSmall Molecule7440-50-8Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of PDIA3 mRNA"19167446
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of PDIA3 mRNA"21346803
C0112692,5-hexanedione"2,5-hexanedione results in decreased expression of PDIA3 protein"19033394
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of PDIA3 mRNA"21346803
C0605332-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine affects the expression of PDIA3 protein"19639176
C0605332-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine"[2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dihydrotestosterone] affects the expression of PDIA3 protein"19639176
C0230353,4,5,3',4'-pentachlorobiphenyl"[3,4,5,3',4'-pentachlorobiphenyl co-treated with Diethylnitrosamine] results in increased expression of PDIA3 protein"23457121
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of PDIA3 mRNA12958071
C0179063-dinitrobenzene3-dinitrobenzene results in increased expression of PDIA3 mRNA21983209
C0179063-dinitrobenzene3-dinitrobenzene results in increased metabolism of PDIA3 protein21402099
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal analog binds to PDIA318232660
D000082AcetaminophenAcetaminophen affects the expression of PDIA3 mRNA17562736
D000082AcetaminophenAcetaminophen results in increased expression of PDIA3 protein16538041
D000517alpha-Chlorohydrinalpha-Chlorohydrin analog results in increased expression of PDIA3 protein26597043
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of PDIA3 protein26072098|2659704
D013196Dihydrotestosterone"[2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine co-treated with Dihydrotestosterone] affects the expression of PDIA3 protein"19639176
D013196DihydrotestosteroneDihydrotestosterone affects the expression of PDIA3 protein19639176
C027876alpha-naphthyl acetatePDIA3 protein results in increased hydrolysis of alpha-naphthyl acetate16798117
D000638AmiodaroneAmiodarone affects the expression of PDIA3 mRNA19483382
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PDIA3 mRNA16483693
D001151ArsenicArsenic results in increased expression of PDIA3 protein19818359
C006632arsenic trioxidearsenic trioxide results in decreased expression of PDIA3 protein19364129
C015001arsenitearsenite results in increased oxidation of PDIA3 protein20196163
D001205Ascorbic AcidAscorbic Acid inhibits the reaction [Fenretinide results in increased expression of PDIA3 mRNA]17353921
D001205Ascorbic AcidAscorbic Acid inhibits the reaction [Fenretinide results in increased expression of PDIA3 protein]17353921
C406592azaspiracidazaspiracid results in increased expression of PDIA3 mRNA28939011
C547126AZM551248AZM551248 results in increased expression of PDIA3 mRNA22323515
D001553BenzbromaroneBenzbromarone affects the expression of PDIA3 mRNA19483382
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with sodium bichromate] results in decreased expression of PDIA3 mRNA21632023
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PDIA3 mRNA22300585
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of PDIA3 mRNA"20018196
C110172BHTOH-QMBHTOH-QM binds to PDIA3 protein16533022
C006780bisphenol Abisphenol A binds to PDIA3 protein21976707
C006780bisphenol Abisphenol A results in increased expression of PDIA3 mRNA25181051
D001761Bleomycin[Bleomycin co-treated with Cisplatin co-treated with Etoposide] results in increased expression of PDIA3 protein24478030
C013418bromfenacoumbromfenacoum results in increased expression of PDIA3 protein28903499
C032036bromobenzenebromobenzene metabolite binds to PDIA3 protein12018992
C515564bromovaninbromovanin results in decreased expression of PDIA3 protein21419150
D019328Buthionine SulfoximineButhionine Sulfoximine results in increased expression of PDIA3 protein23736079
D002104CadmiumCadmium results in increased expression of PDIA3 mRNA24084258
D019256Cadmium ChlorideCadmium Chloride affects the expression of PDIA3 protein24874008
D019256Cadmium ChlorideCadmium Chloride results in increased expression of PDIA3 protein22941245
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of PDIA3 mRNA19031917
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of PDIA3 protein24419708
D019256Cadmium Chloride[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of PDIA3 mRNA19840844
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of PDIA3 mRNA18636176
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of PDIA3 protein16613267
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of PDIA3 protein16845489
D002251Carbon Tetrachloride"Drugs, Chinese Herbal inhibits the reaction [Carbon Tetrachloride affects the expression of PDIA3 protein]"16613267
C099555CD 437CD 437 results in decreased expression of PDIA3 mRNA12958071
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of PDIA3 mRNA23650126
D004390Chlorpyrifos[Copper co-treated with Chlorpyrifos] results in increased expression of PDIA3 mRNA21356183
D002994ClofibrateClofibrate affects the expression of PDIA3 mRNA19483382
D002995Clofibric AcidClofibric Acid affects the expression of PDIA3 mRNA17602206
D003042CocaineCocaine affects the reaction [PTN affects the expression of PDIA3 protein modified form]24096156
D003042CocaineCocaine affects the expression of PDIA3 mRNA20187946
D003300CopperCopper deficiency results in decreased expression of PDIA3 protein25150618
D003300Copper[Copper co-treated with Chlorpyrifos] results in increased expression of PDIA3 mRNA21356183
D003300CopperCopper results in increased expression of PDIA3 mRNA21356183
D003300CopperPDIA3 protein binds to Copper14534351|1535973
D019327Copper SulfateCopper Sulfate results in decreased expression of PDIA3 mRNA19549813
C030123coumarincoumarin results in increased expression of PDIA3 mRNA18480146
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of PDIA3 mRNA"19167446
C030973cupric oxidecupric oxide results in decreased expression of PDIA3 protein25470785
D003520CyclophosphamideCyclophosphamide results in decreased expression of PDIA3 mRNA11906922
D016572CyclosporineCyclosporine results in increased expression of PDIA3 mRNA20106945|2116390
D016572CyclosporineCyclosporine results in decreased expression of PDIA3 protein25047351
D016572CyclosporineCyclosporine results in increased expression of PDIA3 mRNA25047351|2527062
C017160cypermethrincypermethrin results in decreased expression of PDIA3 protein21561882
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of PDIA3 mRNA17361019|2126653
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of PDIA3 mRNA21266533
D002945CisplatinPDIA3 affects the susceptibility to Cisplatin15756446
D002945Cisplatin[Bleomycin co-treated with Cisplatin co-treated with Etoposide] results in increased expression of PDIA3 protein24478030
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of PDIA3 mRNA26924002
D004026DieldrinDieldrin results in decreased expression of PDIA3 mRNA23041725
D004052Diethylnitrosamine"[3,4,5,3',4'-pentachlorobiphenyl co-treated with Diethylnitrosamine] results in increased expression of PDIA3 protein"23457121
D004052Diethylnitrosamine[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of PDIA3 mRNA16158176
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of PDIA3 mRNA14656948
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of PDIA3 mRNA18544905
D004054DiethylstilbestrolDiethylstilbestrol affects the metabolism of PDIA3 protein20932895
D0151279,10-Dimethyl-1,2-benzanthracene"[9,10-Dimethyl-1,2-benzanthracene co-treated with Isoflavones] results in increased expression of PDIA3 protein"22248470
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of PDIA3 protein"22248470
D004298DopamineDopamine results in decreased expression of PDIA3 protein24675778
D004317DoxorubicinDoxorubicin results in increased oxidation of PDIA3 protein28818578
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal inhibits the reaction [Carbon Tetrachloride affects the expression of PDIA3 protein]"16613267
C013525ENNG[ENNG co-treated with Isoflavones] results in increased expression of PDIA3 protein22248470
C013525ENNGENNG results in increased expression of PDIA3 protein22248470
D004785Environmental PollutantsEnvironmental Pollutants results in increased expression of PDIA3 mRNA20064776
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of PDIA3 protein23301498
D000431EthanolEthanol affects the expression of PDIA3 protein22960358
D000431EthanolEthanol results in decreased expression of PDIA3 protein24646710
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of PDIA3 mRNA17108234
D005001EthionineEthionine affects the expression of PDIA3 mRNA19483382
D005047Etoposide[Bleomycin co-treated with Cisplatin co-treated with Etoposide] results in increased expression of PDIA3 protein24478030
D005411Flame RetardantsFlame Retardants results in decreased expression of PDIA3 protein18550172
D005419FlavonoidsFlavonoids results in decreased expression of PDIA3 mRNA18035473
D0150732-Acetylaminofluorene[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of PDIA3 mRNA16158176
D0150732-Acetylaminofluorene[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of PDIA3 mRNA14656948
C039281furanfuran binds to PDIA3 protein22240984
D019833GenisteinGenistein results in increased expression of PDIA3 protein22649256
D005947GlucoseGlucose results in decreased expression of PDIA3 mRNA17178593
D017313FenretinideAscorbic Acid inhibits the reaction [Fenretinide results in increased expression of PDIA3 mRNA]17353921
D017313FenretinideAscorbic Acid inhibits the reaction [Fenretinide results in increased expression of PDIA3 protein]17353921
D017313FenretinideFenretinide results in increased expression of PDIA3 mRNA17353921
D017313FenretinideFenretinide results in increased expression of PDIA3 protein17353921
D006820Hyaluronic AcidHyaluronic Acid analog results in decreased expression of PDIA3 protein23178681
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of PDIA3 protein18603805
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of PDIA3 protein23178681
D002112CalcifediolCalcifediol deficiency results in decreased expression of PDIA3 mRNA17293106
C020758indium trichlorideindium trichloride results in decreased expression of PDIA3 protein19539025
C503753Indolinone AIndolinone A results in increased phosphorylation of PDIA3 protein15838870
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of PDIA3 mRNA25613284
D007529Isoflavones"[9,10-Dimethyl-1,2-benzanthracene co-treated with Isoflavones] results in increased expression of PDIA3 protein"22248470
D007529Isoflavones[ENNG co-treated with Isoflavones] results in increased expression of PDIA3 protein22248470
C011890kojic acid[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of PDIA3 mRNA18544905
C008261lead acetatelead acetate results in increased expression of PDIA3 protein20797405
C029891lead chloridelead chloride results in decreased expression of PDIA3 protein24419708
C008281limonenelimonene results in increased expression of PDIA3 mRNA12815608
D008094LithiumLithium results in increased expression of PDIA3 protein18296634
D008148LovastatinLovastatin results in decreased expression of PDIA3 mRNA20493250
D008148LovastatinLovastatin results in increased expression of PDIA3 mRNA20493250
D008694MethamphetamineMethamphetamine results in decreased expression of PDIA3 protein19826936
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of PDIA3 mRNA"26251327
D008769Methylnitronitrosoguanidine[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in increased expression of PDIA3 mRNA19840844
D008769Methylnitronitrosoguanidine[Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of PDIA3 mRNA19840844
D008769Methylnitronitrosoguanidine[Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of PDIA3 mRNA19840844
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in increased expression of PDIA3 protein24675778
D015741MetriboloneMetribolone results in increased expression of PDIA3 protein17152098
C063855microcystin RRmicrocystin RR results in increased expression of PDIA3 protein19111056
D052998MicrocystinsMicrocystins results in decreased expression of PDIA3 protein22430071
C028577monobutyl phthalatemonobutyl phthalate results in increased expression of PDIA3 protein20553848
C517284monomethyl phthalatemonomethyl phthalate affects the expression of PDIA3 mRNA26924002
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of PDIA3 mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of PDIA3 mRNA"25554681|2562005
C031721naphthalenenaphthalene metabolite binds to PDIA3 protein15892573|1620632
D009532NickelNickel results in increased expression of PDIA3 mRNA24084258
C002741N-nitrosomorpholineN-nitrosomorpholine affects the expression of PDIA3 protein19716841
C025256nonylphenolnonylphenol affects the expression of PDIA3 protein19429228
C025256nonylphenolnonylphenol results in increased expression of PDIA3 protein19260726
C025589ochratoxin Aochratoxin A results in increased expression of PDIA3 protein26861962
D016627OxidopamineOxidopamine results in increased expression of PDIA3 mRNA12486162
D019319Okadaic Acid[Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in increased expression of PDIA3 mRNA19840844
D009853OmeprazoleOmeprazole affects the expression of PDIA3 mRNA19483382
D010100OxygenOxygen results in increased expression of PDIA3 mRNA19747560
D010269ParaquatParaquat results in increased expression of PDIA3 mRNA21371552
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of PDIA3 protein18550172
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in decreased expression of PDIA3 protein19954255
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of PDIA3 protein25616259
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of PDIA3 mRNA19162173
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of PDIA3 mRNA19747560
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of PDIA3 protein22609092
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of PDIA3 mRNA19162173
D010634PhenobarbitalPhenobarbital results in increased expression of PDIA3 protein19952500
D010634PhenobarbitalPhenobarbital affects the expression of PDIA3 mRNA19159669
D010713PhosphatidylcholinesPDIA3 protein results in increased hydrolysis of Phosphatidylcholines16798117
C006253pirinixic acidpirinixic acid affects the expression of PDIA3 mRNA19483382
C006253pirinixic acidpirinixic acid results in decreased expression of PDIA3 mRNA19162173
C035988procymidoneprocymidone results in decreased expression of PDIA3 mRNA15686871
D011374ProgesteroneProgesterone affects the expression of PDIA3 mRNA17251523
C015586propiverinepropiverine binds to PDIA3 protein29273565
D011441PropylthiouracilPropylthiouracil affects the expression of PDIA3 mRNA19483382
C031280pyrazolepyrazole results in increased expression of PDIA3 mRNA17945193
D011748PyrogallolPyrogallol results in increased expression of PDIA3 mRNA20362636
D011794QuercetinQuercetin results in decreased expression of PDIA3 mRNA21632981
C502851quinocetonequinocetone results in increased expression of PDIA3 protein27046791
C059514resveratrolresveratrol affects the expression of PDIA3 protein23255428
C059514resveratrolresveratrol affects the secretion of PDIA3 protein24802182
D012176RetinoidsRetinoids results in decreased expression of PDIA3 protein28886987
C014794retinol palmitatePDIA3 protein results in increased hydrolysis of retinol palmitate16798117
C089730rosiglitazonerosiglitazone affects the expression of PDIA3 protein19556978
D012524SarinSarin affects the expression of PDIA3 protein28973502
D012715Sesame OilSesame Oil results in increased expression of PDIA3 mRNA29191790
C440975silybinsilybin binds to and affects the localization of PDIA3 protein24530445
C440975silybin[silybin binds to PDIA3 protein] promotes the reaction [PDIA3 protein binds to APEX1 protein]24530445
C080703SK&F 83959SK&F 83959 affects the expression of PDIA3 protein25852303
C017947sodium arsenitesodium arsenite affects the expression of PDIA3 protein21925251
C017947sodium arsenitesodium arsenite results in decreased expression of PDIA3 mRNA28595984
C017947sodium arsenitesodium arsenite results in increased expression of PDIA3 protein21925251
C017947sodium arsenitesodium arsenite results in decreased expression of PDIA3 mRNA19822182
C016104sodium bichromate[Benzo(a)pyrene co-treated with sodium bichromate] results in decreased expression of PDIA3 mRNA21632023
D012969Sodium FluorideSodium Fluoride results in decreased expression of PDIA3 protein27548804
D013605T-2 ToxinT-2 Toxin affects the expression of PDIA3 protein26141394
D013739TestosteroneTestosterone affects the expression of PDIA3 mRNA17003280
C534735tetraarsenic tetrasulfidetetraarsenic tetrasulfide results in increased expression of PDIA3 mRNA19208803
C534735tetraarsenic tetrasulfidetetraarsenic tetrasulfide results in increased expression of PDIA3 protein19208803
C534735tetraarsenic tetrasulfidetetraarsenic tetrasulfide results in increased expression of PDIA3 protein19208803
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PDIA3 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PDIA3 mRNA16054898
D013755Tetradecanoylphorbol Acetate[Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in increased expression of PDIA3 mRNA19840844
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of PDIA3 mRNA25613284
D0156472,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine"2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in decreased expression of PDIA3 protein"25852303
D019284ThapsigarginThapsigargin results in increased expression of PDIA3 mRNA17353921
D019284ThapsigarginThapsigargin results in increased expression of PDIA3 protein17353921
D013849ThimerosalThimerosal results in decreased expression of PDIA3 mRNA27188386
D013853ThioacetamideThioacetamide affects the expression of PDIA3 mRNA19483382
C009495titanium dioxidetitanium dioxide results in increased expression of PDIA3 mRNA23557971|2776080
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased metabolism of PDIA3 protein23396223
D014241TrichloroethyleneTrichloroethylene results in decreased expression of PDIA3 mRNA19448997
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in increased expression of PDIA3 mRNA17982090
C057693troglitazonetroglitazone results in increased expression of PDIA3 mRNA28973697
D014415TunicamycinTunicamycin results in increased expression of PDIA3 mRNA17127020
C501517UCF 101UCF 101 results in increased expression of PDIA3 protein19763263
D014635Valproic AcidValproic Acid results in decreased methylation of PDIA3 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of PDIA3 mRNA23179753
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of PDIA3 gene25560391
D000069470Venlafaxine HydrochlorideVenlafaxine Hydrochloride results in decreased expression of PDIA3 mRNA25423262
C025643vinclozolinvinclozolin results in decreased expression of PDIA3 mRNA15686871|2303416
C025643vinclozolinvinclozolin results in increased expression of PDIA3 protein20616205
C111237vorinostatvorinostat results in decreased expression of PDIA3 mRNA27188386
D014859WarfarinWarfarin results in decreased expression of PDIA3 mRNA20493250
D014859WarfarinWarfarin results in increased expression of PDIA3 mRNA20493250
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in increased expression of PDIA3 mRNA"23246600
D015032ZincPDIA3 protein binds to Zinc14534351
D015034Zinc OxideZinc Oxide analog results in increased expression of PDIA3 mRNA25680694

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-HDA22658674  
GO:0003756protein disulfide isomerase activity-IBA21873635  
GO:0004197cysteine-type endopeptidase activity-TAS9399589  
GO:0004629phospholipase C activity-TAS3398923  
GO:0005515protein binding-IPI15896298  16905107  17055437  17170699  20802462  21057456  
21670307  21941299  22665516  23826168  26496610  
GO:0015036disulfide oxidoreductase activity-TAS22013210  
GO:0015037peptide disulfide oxidoreductase activity-IDA16677074  
GO:0042802identical protein binding-IPI16905107  
GO ID GO Term Qualifier Evidence PubMed
GO:0002474antigen processing and presentation of peptide antigen via MHC class I-TAS-  
GO:0002479antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent-TAS-  
GO:0006457protein folding-IBA21873635  
GO:0006457protein folding-TAS-  
GO:0006508proteolysis-IEA-  
GO:0034975protein folding in endoplasmic reticulum-TAS22013210  
GO:0034976response to endoplasmic reticulum stress-IBA21873635  
GO:0045454cell redox homeostasis-IEA-  
GO:0055114oxidation-reduction process-IEA-  
GO:2001238positive regulation of extrinsic apoptotic signaling pathway-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-IDA19995400  
GO:0005634nucleus-HDA21630459  
GO:0005783endoplasmic reticulum-IBA21873635  
GO:0005783endoplasmic reticulum-IDA23826168  
GO:0005783endoplasmic reticulum-TAS16130169  
GO:0005788endoplasmic reticulum lumen-TAS-  
GO:0005925focal adhesion-HDA21423176  
GO:0009986cell surface-IBA21873635  
GO:0009986cell surface-IDA19995400  
GO:0042470melanosome-IEA-  
GO:0043209myelin sheath-IEA-  
GO:0045335phagocytic vesicle-TAS-  
GO:0055038recycling endosome membrane-TAS-  
GO:0070062extracellular exosome-HDA19199708  
KEGG ID KEGG Term
hsa04141Protein processing in endoplasmic reticulum
hsa04612Antigen processing and presentation
Reactome ID Reactome Term Evidence
R-HSA-1236974ER-Phagosome pathwayTAS
R-HSA-1236974ER-Phagosome pathwayIEA
R-HSA-1236975Antigen processing-Cross presentationTAS
R-HSA-1236975Antigen processing-Cross presentationIEA
R-HSA-1280218Adaptive Immune SystemIEA
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-168256Immune SystemIEA
R-HSA-168256Immune SystemTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-446203Asparagine N-linked glycosylationTAS
R-HSA-532668N-glycan trimming in the ER and Calnexin/Calreticulin cycleTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-901042Calnexin/calreticulin cycleTAS
R-HSA-983169Class I MHC mediated antigen processing & presentationIEA
R-HSA-983169Class I MHC mediated antigen processing & presentationTAS
R-HSA-983170Antigen Presentation: Folding, assembly and peptide loading of class I MHCIEA
R-HSA-983170Antigen Presentation: Folding, assembly and peptide loading of class I MHCTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25803269Maternal Smoking Dysregulates Protein Expression in Second Trimester Human Fetal Livers in a Sex-Specific Manner. (2015 Jun)Filis PJ Clin Endocrinol Metab