Gene: GRPR

2925
BB2|BB2R
gastrin releasing peptide receptor
protein-coding
Xp22.2
Ensembl:ENSG00000126010 MIM:305670 Vega:OTTHUMG00000021189 UniprotKB:P30550
NG_012512.1
PubMed
0   ANCO-SNPs
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NPR30.693
IGF10.674
THSD7A0.67
ADAMTS50.664
CHRNA60.647
SP80.629
NDNF0.611
ALK0.609
KIAA12110.578
CNTNAP50.568

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NRN1L-0.382
IGFALS-0.368
UCN-0.322
DRD4-0.32
MCM7-0.311
ANKRD23-0.308
MXD3-0.306
KIF19-0.306
MAL-0.302
IZUMO4-0.3

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5727231-(1,3-carboxypropyl)-4,7-carboxymethyl-1,4,7-triazacyclononane"[2-(3-(1,3-dicarboxypropyl)ureido)pentanedioic acid binds to Aminocaproic Acid binds to 1-(1,3-carboxypropyl)-4,7-carboxymethyl-1,4,7-triazacyclononane binds to Valerates binds to bombesin (7-14) binds to Copper] inhibits the reaction [bombesin, Tyr(4)- binds to GRPR protein]"24508213
C5443802-(3-(1,3-dicarboxypropyl)ureido)pentanedioic acid"[2-(3-(1,3-dicarboxypropyl)ureido)pentanedioic acid binds to Aminocaproic Acid binds to 1-(1,3-carboxypropyl)-4,7-carboxymethyl-1,4,7-triazacyclononane binds to Valerates binds to bombesin (7-14) binds to Copper] inhibits the reaction [bombesin, Tyr(4)- binds to GRPR protein]"24508213
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of GRPR gene27153756
D015119Aminocaproic Acid"[2-(3-(1,3-dicarboxypropyl)ureido)pentanedioic acid binds to Aminocaproic Acid binds to 1-(1,3-carboxypropyl)-4,7-carboxymethyl-1,4,7-triazacyclononane binds to Valerates binds to bombesin (7-14) binds to Copper] inhibits the reaction [bombesin, Tyr(4)- binds to GRPR protein]"24508213
D000643Ammonium ChlorideAmmonium Chloride affects the expression of GRPR mRNA16483693
D000728AndrogensAndrogens affects the expression of GRPR protein17204703
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of GRPR mRNA22228805
C006780bisphenol Abisphenol A results in decreased methylation of GRPR promoter27312807
C006780bisphenol Abisphenol A results in decreased expression of GRPR mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of GRPR gene28505145
D001761BleomycinBleomycin results in decreased expression of GRPR mRNA15808516
C071363bombesin (6-14), Tpi(6)-Leu(13)-psi(CH2NH)-Leu(14)-"bombesin (6-14), Tpi(6)-Leu(13)-psi(CH2NH)-Leu(14)- binds to and results in decreased activity of GRPR protein"17097693
C118536bombesin (7-14)"[2-(3-(1,3-dicarboxypropyl)ureido)pentanedioic acid binds to Aminocaproic Acid binds to 1-(1,3-carboxypropyl)-4,7-carboxymethyl-1,4,7-triazacyclononane binds to Valerates binds to bombesin (7-14) binds to Copper] inhibits the reaction [bombesin, Tyr(4)- binds to GRPR protein]"24508213
C035891bombesin, Tyr(4)-"[2-(3-(1,3-dicarboxypropyl)ureido)pentanedioic acid binds to Aminocaproic Acid binds to 1-(1,3-carboxypropyl)-4,7-carboxymethyl-1,4,7-triazacyclononane binds to Valerates binds to bombesin (7-14) binds to Copper] inhibits the reaction [bombesin, Tyr(4)- binds to GRPR protein]"24508213
C035891bombesin, Tyr(4)-"bombesin, Tyr(4)- binds to GRPR protein"24508213
D002110CaffeineCaffeine results in decreased expression of GRPR mRNA20864626
D002994ClofibrateClofibrate results in increased expression of GRPR mRNA17585979
D003042CocaineCocaine affects the expression of GRPR mRNA20187946
D003300Copper"[2-(3-(1,3-dicarboxypropyl)ureido)pentanedioic acid binds to Aminocaproic Acid binds to 1-(1,3-carboxypropyl)-4,7-carboxymethyl-1,4,7-triazacyclononane binds to Valerates binds to bombesin (7-14) binds to Copper] inhibits the reaction [bombesin, Tyr(4)- binds to GRPR protein]"24508213
D003561CytarabineCytarabine results in decreased expression of GRPR mRNA21198554
D003999Dichloroacetic AcidGRPR mutant form results in increased susceptibility to Dichloroacetic Acid25630799
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of GRPR gene16495775
D019833Genistein[Genistein co-treated with Methoxychlor] results in decreased expression of GRPR mRNA21782745
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of GRPR mRNA24796395
C095194kuwanon Gkuwanon G binds to and results in decreased activity of GRPR protein7646517
C095194kuwanon Gkuwanon G inhibits the reaction [GRP protein binds to GRPR protein]7646517
C095195kuwanon Hkuwanon H binds to and results in decreased activity of GRPR protein7646517
C095195kuwanon Hkuwanon H inhibits the reaction [GRP protein binds to GRPR protein]7646517
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of GRPR mRNA12057914
C013598methoxyacetic acidmethoxyacetic acid results in decreased expression of GRPR mRNA20864626
D008731Methoxychlor[Genistein co-treated with Methoxychlor] results in decreased expression of GRPR mRNA21782745
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of GRPR mRNA28001369
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of GRPR mRNA20864626
C028577monobutyl phthalatemonobutyl phthalate results in decreased expression of GRPR mRNA20864626
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of GRPR mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of GRPR mRNA"25554681
C025256nonylphenolnonylphenol results in decreased expression of GRPR mRNA15620428
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of GRPR mRNA19710929
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of GRPR mRNA25895662
C017947sodium arsenitesodium arsenite affects the methylation of GRPR gene28589171
D014415TunicamycinTunicamycin results in increased expression of GRPR mRNA17127020
D014631Valerates"[2-(3-(1,3-dicarboxypropyl)ureido)pentanedioic acid binds to Aminocaproic Acid binds to 1-(1,3-carboxypropyl)-4,7-carboxymethyl-1,4,7-triazacyclononane binds to Valerates binds to bombesin (7-14) binds to Copper] inhibits the reaction [bombesin, Tyr(4)- binds to GRPR protein]"24508213
D014635Valproic AcidValproic Acid results in increased expression of GRPR mRNA28001369

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004930G-protein coupled receptor activity-IBA21873635  
GO:0008188neuropeptide receptor activity-ISS-  
GO:0008528G-protein coupled peptide receptor activity-IDA1655761  
GO:0042923neuropeptide binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007166cell surface receptor signaling pathway-IBA21873635  
GO:0007186G-protein coupled receptor signaling pathway-IBA21873635  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007200phospholipase C-activating G-protein coupled receptor signaling pathway-ISS-  
GO:0007218neuropeptide signaling pathway-IEA-  
GO:0007611learning or memory-IEA-  
GO:0008283cell proliferation-TAS1655761  
GO:0035176social behavior-ISS-  
GO:0036343psychomotor behavior-IEA-  
GO:0042127regulation of cell proliferation-IEA-  
GO:0043207response to external biotic stimulus-IEA-  
GO:0061744motor behavior-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IDA-  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-IMP1655761  
GO:0005887integral component of plasma membrane-ISS-  
KEGG ID KEGG Term
hsa04020Calcium signaling pathway
hsa04080Neuroactive ligand-receptor interaction
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-375276Peptide ligand-binding receptorsTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-416476G alpha (q) signalling eventsTAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26361040HIF-1alpha Plays a Critical Role in the Gestational Sidestream Smoke-Induced Bronchopulmonary Dysplasia in Mice. (2015)Singh SPPLoS One
10620630Sex-specific expression of gastrin-releasing peptide receptor: relationship to smoking history and risk of lung cancer. (2000 Jan 5)Shriver SPJ Natl Cancer Inst
22296774Gastrin-releasing peptide receptor expression in non-cancerous bronchial epithelia is associated with lung cancer: a case-control study. (2012 Feb 1)Egloff AMRespir Res