Gene info: ID 2937

Gene: GSS

GENE ID: 2937

Synonyms: GSHS|HEL-S-64p|HEL-S-88n

Description: glutathione synthetase

Gene type: protein-coding

Location: 20q11.22

dbXrefs: Ensembl:ENSG00000100983 MIM:601002 Vega:OTTHUMG00000032315 UniprotKB:P48637

RefSeq: NG_008848.2

Retrived from: PubMed|SNP Mapped

SNPs: 1 ANCO-SNPs

Phenotype: ND|AD

# Publications: 3

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 1.386e-1 (AD) 8.914e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs6060124	chr20:34949094 (GRCh38.p7)	C>A	alcohol dependence	SNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ACAD9	0.945
ACP2	0.944
GSTA4	0.94
AARSD1	0.932
MAN1B1	0.931
VPS33B	0.93
ARFGAP2	0.927
TCF25	0.927
SPG7	0.927
C16orf58	0.926

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.643
OR4F29	-0.596
MTRNR2L6	-0.421
MTRNR2L9	-0.414
MTRNR2L10	-0.371
EVC2	-0.361
CYP39A1	-0.349
CLEC2B	-0.348
CCDC102A	-0.342
PPBP	-0.33

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00143	Glutathione	Small Molecule	70-18-8	Approved\|Investigational\|Nutraceutical	Target
DB00145	Glycine	Small Molecule	56-40-6	Approved\|Nutraceutical	Target
DB00151	L-Cysteine	Small Molecule	52-90-4	Approved\|Nutraceutical	Target
DB03408	gamma-Glutamylcysteine	Small Molecule	636-58-8	Experimental	Target
DB04395	Phosphoaminophosphonic Acid-Adenylate Ester	Small Molecule		Experimental	Target
DB06151	Acetylcysteine	Small Molecule	616-91-1	Approved\|Investigational	Target
DB09130	Copper	Small Molecule	7440-50-8	Approved\|Investigational	Target

ID	Drug Name	Action	PubMed
C049325	1,2-dithiol-3-thione	"1,2-dithiol-3-thione results in increased expression of GSS mRNA"	19162173
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of GSS mRNA"	25614096
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of GSS mRNA"	19114083
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of GSS mRNA"	21346803
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ursodeoxycholic Acid results in increased expression of GSS mRNA]	19073151
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of GSS mRNA	19073151
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of GSS mRNA"	21346803
C049584	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine	"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of GSS mRNA"	12376462
C019499	2-nitrofluorene	2-nitrofluorene results in increased expression of GSS mRNA	15890375
C018855	2-tert-butylhydroquinone	2-tert-butylhydroquinone results in increased expression of GSS mRNA	19183254
C018855	2-tert-butylhydroquinone	2-tert-butylhydroquinone results in increased expression of GSS mRNA	10978506
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of GSS mRNA"	23196670
C050224	3,5,5-trimethylhexanoylferrocene	"3,5,5-trimethylhexanoylferrocene results in increased expression of GSS protein"	22649188
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in increased expression of GSS mRNA"	18648102
C035207	4-amino-2,6-dinitrotoluene	"4-amino-2,6-dinitrotoluene affects the expression of GSS mRNA"	21346803
C027576	4-hydroxy-2-nonenal	4-hydroxy-2-nonenal results in increased expression of GSS mRNA	19191707
C016583	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of GSS mRNA	15890375
D000082	Acetaminophen	Acetaminophen affects the expression of GSS mRNA	25064622
D000082	Acetaminophen	Acetaminophen affects the expression of GSS mRNA	17562736
D000082	Acetaminophen	Acetaminophen results in increased expression of GSS mRNA	25499718
D000082	Acetaminophen	[Clofibrate co-treated with Acetaminophen] affects the expression of GSS mRNA	17585979
D000082	Acetaminophen	PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of GSS mRNA]	17585979
D000082	Acetaminophen	Acetaminophen affects the expression of GSS protein	16687475
D020106	Acrylamide	Acrylamide results in decreased expression of GSS mRNA	22459607
D012436	S-Adenosylmethionine	S-Adenosylmethionine inhibits the reaction [Lithocholic Acid affects the expression of GSS mRNA]	20146260
D012436	S-Adenosylmethionine	S-Adenosylmethionine promotes the reaction [Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid affects the expression of GSS mRNA]]	20146260
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of GSS mRNA	19770486
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of GSS mRNA	15890375
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin analog results in increased expression of GSS protein	26072098
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin results in decreased expression of GSS protein	26072098
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin results in increased expression of GSS protein	26597043
C010845	aluminum chloride	aluminum chloride results in decreased activity of GSS protein	16084594
D000638	Amiodarone	Amiodarone affects the expression of GSS mRNA	25064622
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of GSS mRNA	16483693
D000781	Anethole Trithione	Anethole Trithione results in increased activity of GSS protein	11213483
D001115	Arecoline	Arecoline results in decreased expression of GSS mRNA	17682004
D001151	Arsenic	Arsenic results in increased expression of GSS protein	18487201
D001151	Arsenic	[Arsenic results in increased expression of GSS protein] which results in increased chemical synthesis of Glutathione	18487201
D001379	Azathioprine	Azathioprine results in increased expression of GSS mRNA	18222062
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of GSS mRNA	19770486\|2171566
D001564	Benzo(a)pyrene	"[lipopolysaccharide, E coli O55-B5 co-treated with Benzo(a)pyrene] affects the expression of GSS mRNA"	28987381
C072553	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of GSS mRNA	20061341
D004958	Estradiol	Estradiol results in decreased expression of GSS mRNA	16705744
C006780	bisphenol A	bisphenol A affects the expression of GSS mRNA	21786754
C006780	bisphenol A	bisphenol A results in increased expression of GSS mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased methylation of GSS gene	28505145
D019328	Buthionine Sulfoximine	Buthionine Sulfoximine results in decreased activity of GSS protein	10904027
D019328	Buthionine Sulfoximine	Buthionine Sulfoximine results in increased expression of GSS mRNA	10978506
D019328	Buthionine Sulfoximine	Buthionine Sulfoximine results in decreased activity of GSS protein	18552690
C584509	C646 compound	C646 compound results in increased expression of GSS mRNA	26191083
D002104	Cadmium	Cadmium results in increased expression of GSS mRNA	24603357
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of GSS protein	24527689
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of GSS mRNA	25528414
C034939	cadmium sulfide	cadmium sulfide results in increased expression of GSS mRNA	27866839
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of GSS mRNA	27339419
D000068579	Celecoxib	Celecoxib affects the expression of GSS mRNA	20562220
D002713	Chlorine	Chlorine results in increased expression of GSS mRNA	18636392
D002713	Chlorine	[Ozone co-treated with Chlorine] results in decreased expression of GSS mRNA	18636392
D002737	Chloroprene	Chloroprene results in increased expression of GSS mRNA	23125180
D002746	Chlorpromazine	Chlorpromazine affects the expression of GSS mRNA	25064622
D004390	Chlorpyrifos	Chlorpyrifos affects the expression of GSS mRNA	19440498
C499843	chromium histidinate	chromium histidinate results in increased expression of GSS mRNA	19902159
D002994	Clofibrate	[Clofibrate co-treated with Acetaminophen] affects the expression of GSS mRNA	17585979
D002994	Clofibrate	PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of GSS mRNA]	17585979
C018021	cobaltous chloride	cobaltous chloride results in increased expression of GSS mRNA	24612858
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of GSS mRNA	19376846
D003300	Copper	Copper results in increased expression of GSS mRNA	24603357
D003300	Copper	Copper results in increased expression of GSS mRNA	25119852
D003300	Copper	GSS protein binds to Copper	15359738
D003300	Copper	Copper results in decreased expression of GSS mRNA	22465980
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of GSS mRNA	19549813
D003471	Cuprizone	Cuprizone results in increased expression of GSS mRNA	26577399
D003474	Curcumin	Curcumin results in increased expression of GSS mRNA	19183254
C057862	cyanoginosin LR	cyanoginosin LR results in increased expression of GSS mRNA	17654400
D016572	Cyclosporine	Cyclosporine affects the expression of GSS mRNA	25064622
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of GSS mRNA	21266533
D002945	Cisplatin	[Cisplatin co-treated with jinfukang] results in increased expression of GSS mRNA	27392435
D002945	Cisplatin	Cisplatin results in increased expression of GSS mRNA	27392435\|2759478
C020283	diethanolamine	diethanolamine results in increased expression of GSS mRNA	20537412
C058705	diethyl malate	diethyl malate affects the expression of GSS mRNA	24814887
C058705	diethyl malate	S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of GSS mRNA]	24814887
C014476	diethyl maleate	diethyl maleate results in increased expression of GSS mRNA	10978506
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of GSS mRNA	19638242
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of GSS mRNA	15890375
D015127	9,10-Dimethyl-1,2-benzanthracene	"9,10-Dimethyl-1,2-benzanthracene results in increased expression of GSS mRNA"	12376462
D004128	Dimethylnitrosamine	Dimethylnitrosamine results in increased expression of GSS mRNA	15890375
D004391	Dust	Dust results in increased expression of GSS mRNA	17805423
C045651	epigallocatechin gallate	epigallocatechin gallate results in decreased expression of GSS mRNA	18851785
C045651	epigallocatechin gallate	epigallocatechin gallate results in increased expression of GSS mRNA	25585349
C048498	erdosteine	erdosteine results in increased expression of GSS protein	26193055
D000431	Ethanol	[Ethanol co-treated with Folic Acid deficiency] results in increased activity of GSS protein	16792574
D000431	Ethanol	[Ethanol co-treated with Folic Acid deficiency] results in increased expression of GSS mRNA	16792574
D000431	Ethanol	Ethanol results in increased activity of GSS protein	16792574
D000431	Ethanol	Ethanol results in increased expression of GSS mRNA	16792574
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of GSS mRNA	25064622
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of GSS mRNA	17942748
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GSS mRNA	17942748
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of GSS mRNA	17108234\|2909715
D005020	Ethyl Methanesulfonate	Ethyl Methanesulfonate results in increased expression of GSS mRNA	23649840
C540355	fenamidone	fenamidone results in increased expression of GSS mRNA	27029645
D015073	2-Acetylaminofluorene	2-Acetylaminofluorene results in increased expression of GSS mRNA	17317680
D005485	Flutamide	Flutamide results in decreased expression of GSS mRNA	24793618
D005485	Flutamide	Flutamide results in increased expression of GSS mRNA	24136188
D005492	Folic Acid	[Ethanol co-treated with Folic Acid deficiency] results in increased activity of GSS protein	16792574
D005492	Folic Acid	[Ethanol co-treated with Folic Acid deficiency] results in increased expression of GSS mRNA	16792574
D005557	Formaldehyde	Formaldehyde results in increased expression of GSS mRNA	23649840
C039281	furan	furan results in increased expression of GSS mRNA	25539665\|2740218
D005690	Galactose	Galactose results in decreased expression of GSS mRNA	23274001
D005690	Galactose	sodium bisulfide inhibits the reaction [Galactose results in decreased expression of GSS mRNA]	23274001
C017341	gamma-glutamylcysteine	GSS protein results in increased metabolism of gamma-glutamylcysteine	19073151
D019833	Genistein	Genistein results in decreased expression of GSS mRNA	16705744
D005897	Glafenine	Glafenine results in increased expression of GSS mRNA	24136188
D005978	Glutathione	[Arsenic results in increased expression of GSS protein] which results in increased chemical synthesis of Glutathione	18487201
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased expression of GSS mRNA	19902159
C031927	hydroquinone	hydroquinone results in increased expression of GSS protein	21059386
C031927	hydroquinone	NFE2L2 mRNA affects the reaction [hydroquinone results in increased expression of GSS protein]	21059386
D006997	Hypochlorous Acid	Hypochlorous Acid results in increased expression of GSS mRNA	17980396
D007213	Indomethacin	Indomethacin results in decreased expression of GSS mRNA	28201806
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of GSS mRNA	25613284
D007501	Iron	Iron results in decreased expression of GSS mRNA	19073151
D007501	Iron	Ursodeoxycholic Acid inhibits the reaction [Iron results in decreased expression of GSS mRNA]	19073151
C544151	jinfukang	[Cisplatin co-treated with jinfukang] results in increased expression of GSS mRNA	27392435
C008261	lead acetate	lead acetate results in increased expression of GSS mRNA	25270620
C045463	leflunomide	leflunomide results in increased expression of GSS mRNA	24136188
C482199	lipopolysaccharide, E coli O55-B5	"[lipopolysaccharide, E coli O55-B5 co-treated with Benzo(a)pyrene] affects the expression of GSS mRNA"	28987381
D008095	Lithocholic Acid	Lithocholic Acid affects the expression of GSS mRNA	20146260
D008095	Lithocholic Acid	Lithocholic Acid affects the expression of GSS protein	20146260
D008095	Lithocholic Acid	S-Adenosylmethionine inhibits the reaction [Lithocholic Acid affects the expression of GSS mRNA]	20146260
D008095	Lithocholic Acid	S-Adenosylmethionine promotes the reaction [Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid affects the expression of GSS mRNA]]	20146260
D008095	Lithocholic Acid	Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid affects the expression of GSS mRNA]	20146260
D015122	Mercaptopurine	Mercaptopurine results in increased expression of GSS mRNA	18222062
D008628	Mercury	GSS gene polymorphism affects the abundance of Mercury	21967774
D008701	Methapyrilene	Methapyrilene results in increased expression of GSS mRNA	15890375
D008748	Methylcholanthrene	Methylcholanthrene results in increased activity of GSS protein	23712962
D008748	Methylcholanthrene	Methylcholanthrene results in increased expression of GSS mRNA	23712962
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of GSS protein	27180086
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of GSS mRNA	20061341
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of GSS mRNA	26011545
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased expression of GSS mRNA	23649840
D008769	Methylnitronitrosoguanidine	Methylnitronitrosoguanidine results in decreased expression of GSS mRNA	12634122
D008777	Methyltestosterone	Methyltestosterone results in decreased expression of GSS mRNA	29191790
D015741	Metribolone	Metribolone results in increased expression of GSS protein	17152098
D008920	Misonidazole	GSS gene mutant form results in increased susceptibility to Misonidazole	3874843
D009151	Mustard Gas	Mustard Gas results in increased expression of GSS mRNA	18955075
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate results in increased expression of GSS mRNA	20551477
C051752	nefazodone	nefazodone results in increased expression of GSS mRNA	24136188
C012655	nimesulide	nimesulide results in increased expression of GSS mRNA	24136188
D009585	Nitrogen Dioxide	Nitrogen Dioxide results in decreased expression of GSS mRNA	16049373
C014707	nitrosobenzylmethylamine	nitrosobenzylmethylamine results in increased expression of GSS mRNA	17616710
C002741	N-nitrosomorpholine	N-nitrosomorpholine results in increased expression of GSS protein	19716841
C423264	(N-propargyl-(3R) aminoindan-5-yl)-ethyl methyl carbamate	(N-propargyl-(3R) aminoindan-5-yl)-ethyl methyl carbamate results in increased expression of GSS mRNA	18598687
C025589	ochratoxin A	ochratoxin A results in decreased expression of GSS mRNA	12700408\|1625148
D009842	Oligopeptides	Oligopeptides results in increased activity of GSS protein	23796539
D010126	Ozone	[Ozone co-treated with Chlorine] results in decreased expression of GSS mRNA	18636392
D010261	Paraoxon	Paraoxon results in increased expression of GSS	24486155
D010269	Paraquat	Paraquat affects the expression of GSS mRNA	25064622
D010416	Pentachlorophenol	Pentachlorophenol results in increased expression of GSS mRNA	23892564
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of GSS mRNA	19162173
D010634	Phenobarbital	Phenobarbital affects the expression of GSS mRNA	23091169
D010882	Piperonyl Butoxide	Piperonyl Butoxide results in increased expression of GSS mRNA	15890375\|2248451
C006253	pirinixic acid	pirinixic acid results in decreased expression of GSS mRNA	16940010
C006253	pirinixic acid	pirinixic acid results in increased expression of GSS mRNA	15890375
D010936	Plant Extracts	Plant Extracts results in increased expression of GSS mRNA	23557933
C031280	pyrazole	pyrazole results in increased expression of GSS mRNA	17945193
D011794	Quercetin	Quercetin results in increased expression of GSS mRNA	19183254
C004532	quinone	NFE2L2 mRNA affects the reaction [quinone results in increased expression of GSS protein]	21059386
C004532	quinone	quinone results in increased expression of GSS protein	21059386
D012402	Rotenone	Rotenone results in increased expression of GSS mRNA	23186747
C042431	S-ethyl glutathione	S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of GSS mRNA]	24814887
D018030	Silver Compounds	Silver Compounds results in decreased expression of GSS protein	21182908
C017947	sodium arsenite	sodium arsenite results in decreased expression of GSS mRNA	12634122
C025451	sodium bisulfide	sodium bisulfide inhibits the reaction [Galactose results in decreased expression of GSS mRNA]	23274001
D012969	Sodium Fluoride	Sodium Fluoride results in decreased expression of GSS protein	28918527
D013605	T-2 Toxin	T-2 Toxin affects the expression of GSS protein	26141394
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of GSS mRNA	21570461
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GSS mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of GSS mRNA	15328365\|1816354
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of GSS mRNA	21215274
D013752	Tetracycline	Tetracycline affects the expression of GSS mRNA	25064622
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of GSS mRNA	25613284
D013853	Thioacetamide	Thioacetamide affects the expression of GSS mRNA	25064622
D013853	Thioacetamide	Thioacetamide results in increased expression of GSS mRNA	10978506
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in decreased expression of GSS mRNA	28065790
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution analog results in increased expression of GSS mRNA	26489853
D014050	Toluene	Toluene affects the expression of GSS mRNA	18653662
D014118	Toxins, Biological	"Toxins, Biological affects the expression of GSS mRNA"	19682533
D014303	Trinitrotoluene	Trinitrotoluene affects the expression of GSS mRNA	21346803
C013320	tris(2-butoxyethyl) phosphate	tris(2-butoxyethyl) phosphate results in increased expression of GSS mRNA	25808963
C080163	trovafloxacin	trovafloxacin results in decreased expression of GSS mRNA	24136188
D014580	Ursodeoxycholic Acid	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ursodeoxycholic Acid results in increased expression of GSS mRNA]	19073151
D014580	Ursodeoxycholic Acid	S-Adenosylmethionine promotes the reaction [Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid affects the expression of GSS mRNA]]	20146260
D014580	Ursodeoxycholic Acid	Ursodeoxycholic Acid inhibits the reaction [Iron results in decreased expression of GSS mRNA]	19073151
D014580	Ursodeoxycholic Acid	Ursodeoxycholic Acid inhibits the reaction [Lithocholic Acid affects the expression of GSS mRNA]	20146260
D014580	Ursodeoxycholic Acid	Ursodeoxycholic Acid results in increased expression of GSS mRNA	19073151
C406224	valdecoxib	valdecoxib results in increased expression of GSS mRNA	24136188
D014635	Valproic Acid	Valproic Acid affects the expression of GSS mRNA	25064622
D014635	Valproic Acid	Valproic Acid affects the expression of GSS mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased expression of GSS mRNA	28001369
D014874	Water Pollutants, Chemical	"Water Pollutants, Chemical results in increased expression of GSS mRNA"	23246600

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000287	magnesium ion binding	-	IDA	10369661
GO:0004363	glutathione synthase activity	-	IBA	21873635
GO:0004363	glutathione synthase activity	-	TAS	-
GO:0005515	protein binding	-	IPI	21044950
GO:0005524	ATP binding	-	IDA	10369661
GO:0042802	identical protein binding	-	IPI	21988832 25416956 26871637
GO:0042803	protein homodimerization activity	-	IDA	10369661
GO:0043295	glutathione binding	-	IBA	21873635
GO:0043295	glutathione binding	-	IDA	10369661

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006520	cellular amino acid metabolic process	-	TAS	8896573
GO:0006750	glutathione biosynthetic process	-	IEA	-
GO:0006750	glutathione biosynthetic process	-	TAS	-
GO:0006979	response to oxidative stress	-	TAS	465367
GO:0007399	nervous system development	-	TAS	8896573

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005829	cytosol	-	IBA	21873635
GO:0005829	cytosol	-	TAS	-
GO:0070062	extracellular exosome	-	HDA	19056867 23533145

KEGG ID	KEGG Term
hsa00480	Glutathione metabolism
hsa01100	Metabolic pathways

Reactome ID	Reactome Term	Evidence
R-HSA-1430728	Metabolism	TAS
R-HSA-156580	Phase II - Conjugation of compounds	TAS
R-HSA-156590	Glutathione conjugation	TAS
R-HSA-1643685	Disease	TAS
R-HSA-174403	Glutathione synthesis and recycling	TAS
R-HSA-211859	Biological oxidations	TAS
R-HSA-5579006	Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)	TAS
R-HSA-5579029	Metabolic disorders of biological oxidation enzymes	TAS
R-HSA-5668914	Diseases of metabolism	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
22044695	Genetic variants associated with the risk of chronic obstructive pulmonary disease with and without lung cancer. (2012 Mar)	de Andrade M	Cancer Prev Res (Phila)
28219206	[Correlations between genetic variations of glutathione synthetase gene and the response to platinum-based chemotherapy and prognosis of small cell lung cancer patients]. (2017 Feb 23)	Feng T	Zhonghua Zhong Liu Za Zhi
20439344	Genetic variation in glutathione metabolism and DNA repair genes predicts survival of small-cell lung cancer patients. (2010 Oct)	Sun Z	Ann Oncol