Gene info: ID 2938

Gene: GSTA1

GENE ID: 2938

Synonyms: GST-epsilon|GST2|GSTA1-1|GTH1

Description: glutathione S-transferase alpha 1

Gene type: protein-coding

Location: 6p12.2

dbXrefs: Ensembl:ENSG00000243955 MIM:138359 Vega:OTTHUMG00000014861 UniprotKB:P08263

RefSeq: NC_000006.12

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 24

Sherlock p-value : 7.569e-1 (AD) 6.132e-1 (ND) (Frontal_Cortex)

Pascal p-value : 8.303e-1 (AD) 2.119e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
NPFFR2	0.637
MCTP2	0.57
TNIP3	0.555
SEMA3E	0.548
THEMIS	0.53
HS3ST5	0.524
FOXP2	0.522
MEI1	0.52
DACH1	0.513
NXPH4	0.512

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
DDR2	-0.339
MRO	-0.33
ARHGAP31	-0.323
TMEM100	-0.319
CMYA5	-0.318
GHRHR	-0.315
AMOT	-0.315
ASB4	-0.314
SYNC	-0.31
KCNJ16	-0.308

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00143	Glutathione	Small Molecule	70-18-8	Approved\|Investigational\|Nutraceutical	Target
DB01915	S-Hydroxycysteine	Small Molecule	-	Experimental	Target
DB02486	2-Hydroxyethyl Disulfide	Small Molecule	1892-29-1	Experimental	Target
DB02943	N-(4-Aminobutanoyl)-S-(4-Methoxybenzyl)-L-Cysteinylglycine	Small Molecule		Experimental	Target
DB03003	Glutathione Sulfonic Acid	Small Molecule		Experimental	Target
DB03602	S-Benzyl-Glutathione	Small Molecule		Experimental	Target
DB04132	S-Hexylglutathione	Small Molecule		Experimental	Target
DB13014	Hypericin	Small Molecule	548-04-9	Investigational	Target
DB00143	Glutathione	Small Molecule	70-18-8	Approved\|Investigational\|Nutraceutical	Enzyme
DB00993	Azathioprine	Small Molecule	446-86-6	Approved	Enzyme
DB01008	Busulfan	Small Molecule	55-98-1	Approved\|Investigational	Enzyme
DB02486	2-Hydroxyethyl Disulfide	Small Molecule	1892-29-1	Experimental	Enzyme
DB02943	N-(4-Aminobutanoyl)-S-(4-Methoxybenzyl)-L-Cysteinylglycine	Small Molecule		Experimental	Enzyme
DB03602	S-Benzyl-Glutathione	Small Molecule		Experimental	Enzyme
DB04132	S-Hexylglutathione	Small Molecule		Experimental	Enzyme

ID	Drug Name	Action	PubMed
C026486	1,2,5,6-dibenzanthracene	"GSTA1 protein affects the metabolism of and results in decreased susceptibility to 1,2,5,6-dibenzanthracene"	11673082
C007318	1,2-dibromo-3-chloropropane	"GSTA1 protein affects the metabolism of 1,2-dibromo-3-chloropropane"	8242859
C007318	1,2-dibromo-3-chloropropane	"GSTA1 protein results in increased susceptibility to 1,2-dibromo-3-chloropropane"	8242859
C028328	1,2-dichloro-4-nitrobenzene	"GSTA1 protein affects the metabolism of 1,2-dichloro-4-nitrobenzene"	12388831
C028328	1,2-dichloro-4-nitrobenzene	"GSTA1 protein results in increased glutathionylation of 1,2-dichloro-4-nitrobenzene"	15946636
C049325	1,2-dithiol-3-thione	"1,2-dithiol-3-thione results in increased expression of GSTA1 mRNA"	18367636\|7568053
C049325	1,2-dithiol-3-thione	"NFE2L2 gene mutant form inhibits the reaction [1,2-dithiol-3-thione results in increased expression of GSTA1 mRNA]"	18367636
C049325	1,2-dithiol-3-thione	"Tetradecanoylphorbol Acetate promotes the reaction [1,2-dithiol-3-thione results in increased expression of GSTA1 mRNA]"	7568053
C064441	13-oxo-9,11-octadecadienoic acid	"GSTA1 protein affects the metabolism of 13-oxo-9,11-octadecadienoic acid"	12031293
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"[1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased activity of NR1I3 protein] which results in increased expression of GSTA1 mRNA"	22496397
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of GSTA1 mRNA"	18692084\|2249639
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"NR1I3 protein affects the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of GSTA1 mRNA]"	18692084\|2249639
C025086	15-hydroperoxy-5,8,11,13-eicosatetraenoic acid	"GSTA1 protein affects the metabolism of 15-hydroperoxy-5,8,11,13-eicosatetraenoic acid"	11716762
C027132	1-anilino-8-naphthalenesulfonate	1-anilino-8-naphthalenesulfonate binds to GSTA1 protein	14690442
C014211	2,3,7,8-tetrachlorodibenzofuran	"2,3,7,8-tetrachlorodibenzofuran affects the expression of GSTA1 mRNA"	18343893
C085911	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [sulforafan results in increased expression of GSTA1 mRNA]	15090468
C096092	2-(acetoxyamino)-1-methyl-6-phenylimidazo(4,5-b)pyridine	"GSTA1 protein affects the metabolism of and results in decreased activity of 2-(acetoxyamino)-1-methyl-6-phenylimidazo(4,5-b)pyridine"	11535243\|1579762
C096092	2-(acetoxyamino)-1-methyl-6-phenylimidazo(4,5-b)pyridine	"GSTA1 protein polymorphism results in increased susceptibility to 2-(acetoxyamino)-1-methyl-6-phenylimidazo(4,5-b)pyridine"	11535243
C099328	2-allylphenol	2-allylphenol results in decreased activity of GSTA1 protein	8620581
C049584	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine	"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of GSTA1 mRNA"	22138251
C049584	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine	"GSTA1 gene polymorphism affects the susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"	14601045
C049584	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine	"[xanthohumol co-treated with 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] results in increased expression of GSTA1 mRNA"	22138251
C036990	2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline	"2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of GSTA1 mRNA"	22138251\|2381079
C546460	2-amino-3-methyl-3H-imidazo(4,5-f)quinoline	"2-amino-3-methyl-3H-imidazo(4,5-f)quinoline results in decreased expression of GSTA1 mRNA"	23810796
C051750	2-hexenal	2-hexenal results in increased expression of GSTA1 mRNA	9799558
C060533	2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine	"2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of GSTA1 protein"	17122891
C122183	2-hydroxymenthofuran	GSTA1 protein affects the metabolism of [2-hydroxymenthofuran co-treated with Glutathione]	10496977
C018855	2-tert-butylhydroquinone	2-tert-butylhydroquinone results in increased activity of GSTA1 protein	15627257
C018855	2-tert-butylhydroquinone	2-tert-butylhydroquinone results in increased expression of GSTA1 mRNA	15627257\|1601473
C018855	2-tert-butylhydroquinone	Tetradecanoylphorbol Acetate promotes the reaction [2-tert-butylhydroquinone results in increased expression of GSTA1 mRNA]	7568053
C023035	3,4,5,3',4'-pentachlorobiphenyl	"[3,4,5,3',4'-pentachlorobiphenyl co-treated with Sunphenon] affects the expression of GSTA1 mRNA"	24378064
C045421	3,4,8-trimethylimidazo(4,5-f)quinoxalin-2-amine	"3,4,8-trimethylimidazo(4,5-f)quinoxalin-2-amine results in decreased expression of GSTA1 mRNA"	23810796
C026137	3-hydroxyacetanilide	3-hydroxyacetanilide results in increased expression of GSTA1 mRNA	18544908
C053603	3-methylpyridine	3-methylpyridine results in decreased expression of GSTA1 protein	7986210
C027576	4-hydroxy-2-nonenal	GSTA1 protein affects the metabolism of 4-hydroxy-2-nonenal analog	11256969
C027576	4-hydroxy-2-nonenal	4-hydroxy-2-nonenal results in increased expression of GSTA1 protein	12020353
C027576	4-hydroxy-2-nonenal	GSTA1 protein results in decreased susceptibility to 4-hydroxy-2-nonenal	15829614
C027576	4-hydroxy-2-nonenal	4-hydroxy-2-nonenal results in increased expression of GSTA1 mRNA	19191707
C027576	4-hydroxy-2-nonenal	GSTA1 protein affects the metabolism of [4-hydroxy-2-nonenal co-treated with Glutathione]	11716762
C027576	4-hydroxy-2-nonenal	4-hydroxy-2-nonenal results in increased expression of GSTA1 mRNA	9799558
C027576	4-hydroxy-2-nonenal	GSTA1 protein affects the metabolism of 4-hydroxy-2-nonenal analog	11256969
C027576	4-hydroxy-2-nonenal	[GSTA1 protein binds to GSTA3 protein] which affects the metabolism of 4-hydroxy-2-nonenal analog	11256969
C066463	4-iodo-tamoxifen	4-iodo-tamoxifen results in decreased expression of GSTA1 mRNA	9744569
C024836	4-nitrophenol	4-nitrophenol results in increased expression of GSTA1 mRNA	27172127
C099327	4-propylphenol	4-propylphenol results in decreased activity of GSTA1 protein	8620581
C003528	5-androstene-3,17-dione	"GSTA1 protein affects the metabolism of 5-androstene-3,17-dione"	11152686
C003528	5-androstene-3,17-dione	"GSTA1 protein results in increased metabolism of 5-androstene-3,17-dione"	16280386
C544471	5-hydroxythalidomide	5-hydroxythalidomide binds to GSTA1 protein	27464947
C544471	5-hydroxythalidomide	5-hydroxythalidomide binds to GSTA1 protein	27464947
C086396	5-S-glutathionyl-alpha-methyldopa	5-S-glutathionyl-alpha-methyldopa results in decreased activity of GSTA1 protein	8131222
C086394	5-S-glutathionyldopamine	5-S-glutathionyldopamine results in decreased activity of GSTA1 protein	8131222
C478192	6-chloroacetyl-2-dimethylaminonaphthalene	GSTA1 protein affects the metabolism of 6-chloroacetyl-2-dimethylaminonaphthalene	12470677
C111984	6-methylsulfinylhexyl isothiocyanate	6-methylsulfinylhexyl isothiocyanate results in increased expression of GSTA1 protein	21382770
C111984	6-methylsulfinylhexyl isothiocyanate	6-methylsulfinylhexyl isothiocyanate results in increased expression of GSTA1 protein	11706044
C037112	9-deoxy-delta-9-prostaglandin D2	GSTA1 protein affects the metabolism of 9-deoxy-delta-9-prostaglandin D2	9084911
D000082	Acetaminophen	Acetaminophen results in increased expression of GSTA1 mRNA	26690555
D000082	Acetaminophen	Acetaminophen affects the expression of GSTA1 mRNA	17562736
D000082	Acetaminophen	Acetaminophen results in decreased expression of GSTA1 mRNA	16611625
D000082	Acetaminophen	Acetaminophen results in increased expression of GSTA1 mRNA	18544908\|2549971
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of GSTA1 mRNA]	9152014
D000171	Acrolein	Acrolein results in increased expression of GSTA1 mRNA	12763045
D000171	Acrolein	Acrolein results in increased expression of GSTA1 mRNA	9799558
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of GSTA1 protein	20106945
D016604	Aflatoxin B1	Aflatoxin B1 binds to GSTA1 protein	9826190
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of GSTA1 mRNA	21632981\|2164198
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin results in increased expression of GSTA1 mRNA	28522335
D017962	alpha-Linolenic Acid	alpha-Linolenic Acid results in increased expression of GSTA1 mRNA	28555106
D017962	alpha-Linolenic Acid	NFE2L2 protein promotes the reaction [alpha-Linolenic Acid results in increased expression of GSTA1 mRNA]	28555106
C005197	alternariol	alternariol affects the localization of GSTA1 mRNA	23154127
C018206	alternariol monomethyl ether	alternariol monomethyl ether affects the localization of GSTA1 mRNA	23154127
D000588	Amines	GSTA1 protein affects the metabolism of and results in decreased activity of Amines metabolite	12505289
D000640	Amitrole	Amitrole inhibits the reaction [cobaltous chloride results in increased expression of GSTA1 mRNA]	25820916
D000640	Amitrole	Amitrole inhibits the reaction [cobaltous chloride results in increased expression of GSTA1 protein]	25820916
D000735	Androstenedione	GSTA1 protein results in increased chemical synthesis of Androstenedione	23650189
C019257	angelica lactone	angelica lactone results in increased expression of GSTA1 protein	11309284
D000968	Antimycin A	Antimycin A results in increased expression of GSTA1 mRNA	19304788
C042140	arachidoyl-coenzyme A	arachidoyl-coenzyme A binds to and results in decreased activity of GSTA1 protein	10542059
C006632	arsenic trioxide	arsenic trioxide results in increased expression of GSTA1 mRNA	11678611\|2045855
C006632	arsenic trioxide	Atrazine promotes the reaction [arsenic trioxide results in increased expression of GSTA1 mRNA]	11678611
C015001	arsenite	arsenite results in increased expression of GSTA1 mRNA	19933842
C031327	artemisinine	artemisinine results in decreased activity of GSTA1 protein	11807801
D001205	Ascorbic Acid	[Quercetin co-treated with Ascorbic Acid] results in decreased expression of GSTA1 mRNA	17639512
D001205	Ascorbic Acid	Ascorbic Acid promotes the reaction [sodium arsenite results in increased expression of GSTA1 mRNA]	16517059
D001280	Atrazine	Atrazine promotes the reaction [arsenic trioxide results in increased expression of GSTA1 mRNA]	11678611
C406592	azaspiracid	azaspiracid results in decreased expression of GSTA1 mRNA	28939011
D001379	Azathioprine	GSTA1 protein affects the metabolism of Azathioprine	18155239
C018003	benzo(a)pyrene-3,6-quinone	"benzo(a)pyrene-3,6-quinone results in increased expression of GSTA1 mRNA"	11008122
C017228	benzo(a)pyrene 7,8-dihydrodiol	"benzo(a)pyrene 7,8-dihydrodiol results in increased expression of GSTA1 mRNA"	11008122
D019324	beta-Naphthoflavone	beta-Naphthoflavone results in decreased expression of GSTA1 mRNA	25218365
D019324	beta-Naphthoflavone	beta-Naphthoflavone results in increased expression of GSTA1 protein	2049074
D019324	beta-Naphthoflavone	Lipopolysaccharides inhibits the reaction [beta-Naphthoflavone results in increased expression of GSTA1 mRNA]	15627257
D019324	beta-Naphthoflavone	beta-Naphthoflavone results in increased expression of GSTA1 mRNA	9020873
D019817	Benzoic Acid	Benzoic Acid results in increased activity of GSTA1 protein mutant form	10329179
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of GSTA1 mRNA	22316170
D001564	Benzo(a)pyrene	[Benzo(a)pyrene co-treated with sodium bichromate] results in decreased expression of GSTA1 mRNA	22613061
D001564	Benzo(a)pyrene	Benzo(a)pyrene promotes the reaction [JUND protein binds to GSTA1 gene]	11961136
D001564	Benzo(a)pyrene	Benzo(a)pyrene promotes the reaction [NFE2L2 protein binds to GSTA1 gene]	11961136
D001564	Benzo(a)pyrene	Benzo(a)pyrene promotes the reaction [NRF1 protein binds to GSTA1 gene]	11961136
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of GSTA1 mRNA	21569818\|2293552
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of GSTA1 mRNA	22300585
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of GSTA1 protein	9395218
D001564	Benzo(a)pyrene	Benzo(a)pyrene metabolite results in increased expression of GSTA1 mRNA	11008122
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of GSTA1 mRNA	11008122
D001564	Benzo(a)pyrene	[Benzo(a)pyrene binds to AHR protein] which results in increased expression of GSTA1	23656968
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"GSTA1 protein affects the metabolism of and results in decreased activity of [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide co-treated with Glutathione]"	11849043
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"GSTA1 protein affects the metabolism of and results in decreased susceptibility to 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"	12557262
D016227	Benzoquinones	Benzoquinones analog results in increased expression of GSTA1 protein	21651925
C025383	benzylideneacetone	benzylideneacetone results in increased expression of GSTA1 mRNA	7568053
C025383	benzylideneacetone	Tetradecanoylphorbol Acetate promotes the reaction [benzylideneacetone results in increased expression of GSTA1 mRNA]	7568053
C072553	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Cycloheximide inhibits the reaction [Lead results in increased expression of GSTA1 mRNA]]	16243960
C072553	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Cycloheximide inhibits the reaction [Mercury results in increased expression of GSTA1 mRNA]]	16243960
C072553	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of GSTA1 mRNA]]	16243960
C072553	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Cycloheximide promotes the reaction [Copper results in decreased expression of GSTA1 mRNA]]	16243960
D004958	Estradiol	Estradiol results in decreased expression of GSTA1 mRNA	23019147
D004958	Estradiol	Estradiol results in decreased expression of GSTA1 mRNA	19484750
C099952	bifenthrin	bifenthrin results in increased expression of GSTA1 mRNA	26071804\|2791626
D001663	Bilirubin	Bilirubin results in increased expression of GSTA1 mRNA	15382119
D001663	Bilirubin	IL1B protein inhibits the reaction [Bilirubin results in increased expression of GSTA1 mRNA]	15382119
D001688	Biological Products	Biological Products results in increased expression of GSTA1 mRNA	22570534
C452139	BIRB 796	BIRB 796 results in increased expression of GSTA1 mRNA	21328587
C006780	bisphenol A	bisphenol A results in increased expression of GSTA1 protein	16284450
C006780	bisphenol A	bisphenol A results in increased expression of GSTA1 mRNA	25181051
D001973	Bromodeoxyuridine	[Bromodeoxyuridine co-treated with furan] results in increased expression of GSTA1 mRNA	24910943
D002066	Busulfan	GSTA1 gene polymorphism affects the abundance of Busulfan	20672371
D002066	Busulfan	GSTA1 gene polymorphism affects the metabolism of Busulfan	21135089\|2121580
D002066	Busulfan	GSTA1 polymorphism affects the susceptibility to Busulfan	21441958
D002066	Busulfan	GSTA1 protein affects the metabolism of Busulfan	10570028\|8886613
D002066	Busulfan	GSTA1 protein affects the metabolism of [Busulfan co-treated with Glutathione]	10437668
D002066	Busulfan	GSTA1 protein results in decreased susceptibility to Busulfan	12429583
D019328	Buthionine Sulfoximine	Buthionine Sulfoximine promotes the reaction [Cadmium Chloride results in increased expression of GSTA1 mRNA]	9152014
D002083	Butylated Hydroxyanisole	Butylated Hydroxyanisole results in increased expression of GSTA1 mRNA	16426233
D002083	Butylated Hydroxyanisole	Butylated Hydroxyanisole results in increased expression of GSTA1 protein	11309284\|1199180
D002087	Butyrates	Butyrates results in increased expression of GSTA1 mRNA	19800383
D002087	Butyrates	Butyrates results in increased expression of GSTA1 protein	12896903
D002104	Cadmium	Cadmium results in increased expression of GSTA1 mRNA	16517059\|2406772
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of GSTA1 mRNA	16517059\|2552841
D019256	Cadmium Chloride	Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of GSTA1 mRNA]	9152014
D019256	Cadmium Chloride	Buthionine Sulfoximine promotes the reaction [Cadmium Chloride results in increased expression of GSTA1 mRNA]	9152014
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of GSTA1 mRNA	9152014
C053400	cafestol	[cafestol co-treated with kahweol palmitate] results in increased expression of GSTA1 protein	11309284
D002220	Carbamazepine	Carbamazepine results in increased expression of GSTA1 mRNA	17112801
D002251	Carbon Tetrachloride	Carbon Tetrachloride affects the expression of GSTA1 mRNA	17484886
D002251	Carbon Tetrachloride	[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in decreased activity of GSTA1 protein	12725062
D002251	Carbon Tetrachloride	Tea inhibits the reaction [[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in decreased activity of GSTA1 protein]	12725062
D002273	Carcinogens	GSTA1 promoter polymorphism affects the susceptibility to Carcinogens	12505289
D002699	Chlorambucil	ABCC2 protein promotes the reaction [GSTA1 protein results in decreased susceptibility to Chlorambucil]	14569069
D002699	Chlorambucil	Chlorambucil analog results in decreased activity of GSTA1 protein	11115505
D002699	Chlorambucil	GSTA1 protein affects the metabolism of [Chlorambucil co-treated with Glutathione]	11115505
D002699	Chlorambucil	GSTA1 protein results in decreased susceptibility to Chlorambucil	11115505\|1456906
D002706	Chlordan	Chlordan results in increased expression of GSTA1 mRNA	20403969
D020111	Chlorodiphenyl (54% Chlorine)	Chlorodiphenyl (54% Chlorine) results in increased expression of GSTA1 mRNA	17851650
D002726	Chlorogenic Acid	Chlorogenic Acid results in increased activity of GSTA1 protein	15944151
D002746	Chlorpromazine	[Chlorpromazine co-treated with Cholic Acids] affects the expression of GSTA1 mRNA	27344345
D004390	Chlorpyrifos	Chlorpyrifos results in increased expression of GSTA1 mRNA	21907274
D004390	Chlorpyrifos	Chlorpyrifos results in increased expression of GSTA1 protein	21907274
D019826	Cholic Acid	Cholic Acid binds to [GSTA1 protein co-treated with GSTA1 protein]	3783048
D019826	Cholic Acid	Cholic Acid binds to [GSTA3 protein co-treated with GSTA1 protein]	3783048
D019826	Cholic Acid	Glutathione inhibits the reaction [Cholic Acid binds to [GSTA3 protein co-treated with GSTA1 protein]]	3783048
D002793	Cholic Acids	[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of GSTA1 mRNA	27344345
D002793	Cholic Acids	[Chlorpromazine co-treated with Cholic Acids] affects the expression of GSTA1 mRNA	27344345
D002793	Cholic Acids	[Cyclosporine co-treated with Cholic Acids] affects the expression of GSTA1 mRNA	27344345
D002922	Ciguatoxins	Ciguatoxins affects the expression of GSTA1 mRNA	18353800
C019304	ciprofibrate	ciprofibrate results in decreased expression of GSTA1 mRNA	7676460
C051514	ciprofibrate-coenzyme A	ciprofibrate-coenzyme A binds to and results in decreased activity of GSTA1 protein	10542059
D002994	Clofibrate	Clofibrate results in increased expression of GSTA1 mRNA	22496397
D002994	Clofibrate	PPARA protein affects the reaction [Clofibrate results in increased expression of GSTA1 mRNA]	22496397
D002994	Clofibrate	Clofibrate results in increased expression of GSTA1 mRNA	22300585
D003022	Clotrimazole	Clotrimazole results in decreased expression of GSTA1 mRNA	22559005
D003024	Clozapine	GSTA1 protein results in decreased activity of Clozapine	20849150
D003024	Clozapine	GSTA1 protein results in increased glutathionylation of Clozapine	20849150
D003033	Coal Tar	[Vehicle Emissions analog co-treated with Coal Tar analog co-treated with Tobacco Smoke Pollution analog] results in increased expression of GSTA1 mRNA	22935520
D003033	Coal Tar	[Vehicle Emissions analog co-treated with Coal Tar analog] results in increased expression of GSTA1 mRNA	22935520
D003035	Cobalt	Cobalt results in increased expression of GSTA1 mRNA	14971665
C018021	cobaltous chloride	Amitrole inhibits the reaction [cobaltous chloride results in increased expression of GSTA1 mRNA]	25820916
C018021	cobaltous chloride	Amitrole inhibits the reaction [cobaltous chloride results in increased expression of GSTA1 protein]	25820916
C018021	cobaltous chloride	cobaltous chloride results in increased expression of GSTA1 mRNA	25820916
C018021	cobaltous chloride	cobaltous chloride results in increased expression of GSTA1 protein	25820916
D003069	Coffee	Coffee results in increased expression of GSTA1 mRNA	22946519\|2560643
D003069	Coffee	GSTA1 polymorphism affects the susceptibility to Coffee	25606436
D003069	Coffee	NFE2L2 promoter SNP affects the reaction [Coffee results in increased expression of GSTA1 mRNA]	25606436
D003069	Coffee	Coffee results in increased expression of GSTA1 mRNA	18028974
D003069	Coffee	Coffee results in increased expression of GSTA1 protein	18028974
D003069	Coffee	NFE2L2 protein promotes the reaction [Coffee results in increased expression of GSTA1 mRNA]	18028974
D003300	Copper	benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Cycloheximide promotes the reaction [Copper results in decreased expression of GSTA1 mRNA]]	16243960
D003300	Copper	Copper inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of GSTA1 mRNA]	16243960
D003300	Copper	Copper promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of GSTA1 protein]	16243960
D003300	Copper	Copper results in decreased expression of GSTA1 mRNA	16243960
D003300	Copper	Copper results in increased activity of GSTA1 protein	16243960
D003300	Copper	Cycloheximide promotes the reaction [Copper results in decreased expression of GSTA1 mRNA]	16243960
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of GSTA1 mRNA	19549813
C030123	coumarin	coumarin results in increased expression of GSTA1 protein	11309284
C007164	cumene hydroperoxide	GSTA1 protein affects the metabolism of cumene hydroperoxide	9211657
C007164	cumene hydroperoxide	GSTA1 protein results in increased metabolism of cumene hydroperoxide	1985777
C007164	cumene hydroperoxide	GSTA1 protein affects the metabolism of cumene hydroperoxide	12388831
C007164	cumene hydroperoxide	GSTA1 protein affects the metabolism of cumene hydroperoxide	15946636
C057862	cyanoginosin LR	GSTA1 protein results in increased glutathionylation of and affects the susceptibility to cyanoginosin LR	21504230
D003513	Cycloheximide	benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Cycloheximide inhibits the reaction [Lead results in increased expression of GSTA1 mRNA]]	16243960
D003513	Cycloheximide	benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Cycloheximide inhibits the reaction [Mercury results in increased expression of GSTA1 mRNA]]	16243960
D003513	Cycloheximide	benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of GSTA1 mRNA]]	16243960
D003513	Cycloheximide	benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Cycloheximide promotes the reaction [Copper results in decreased expression of GSTA1 mRNA]]	16243960
D003513	Cycloheximide	Cycloheximide inhibits the reaction [Lead results in increased expression of GSTA1 mRNA]	16243960
D003513	Cycloheximide	Cycloheximide inhibits the reaction [Mercury results in increased expression of GSTA1 mRNA]	16243960
D003513	Cycloheximide	Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of GSTA1 mRNA]	16243960
D003513	Cycloheximide	Cycloheximide promotes the reaction [Copper results in decreased expression of GSTA1 mRNA]	16243960
D003513	Cycloheximide	Cycloheximide results in decreased expression of GSTA1 mRNA	16243960
D003520	Cyclophosphamide	GSTA1 protein affects the metabolism of [Cyclophosphamide metabolite co-treated with Glutathione]	12516103
D016572	Cyclosporine	[Cyclosporine co-treated with Cholic Acids] affects the expression of GSTA1 mRNA	27344345
D016572	Cyclosporine	Cyclosporine results in decreased expression of GSTA1 mRNA	20106945\|2163298
D003609	Dactinomycin	Dactinomycin inhibits the reaction [Dexamethasone results in increased expression of GSTA1 mRNA]	28483492
D003609	Dactinomycin	Dactinomycin inhibits the reaction [Lead results in increased expression of GSTA1 mRNA]	16243960
D003609	Dactinomycin	Dactinomycin inhibits the reaction [Mercury results in increased expression of GSTA1 mRNA]	16243960
D003609	Dactinomycin	Dactinomycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of GSTA1 mRNA]	16243960
D003907	Dexamethasone	Dactinomycin inhibits the reaction [Dexamethasone results in increased expression of GSTA1 mRNA]	28483492
D003907	Dexamethasone	Dexamethasone promotes the reaction [NR3C1 protein binds to GSTA1 promoter]	28483492
D003907	Dexamethasone	Dexamethasone results in increased expression of GSTA1 mRNA	28483492
D003907	Dexamethasone	Dexamethasone results in increased expression of GSTA1 protein	28483492
C041517	dibenzo(a,l)pyrene	"GSTA1 protein affects the metabolism of and results in decreased activity of [dibenzo(a,l)pyrene co-treated with Glutathione]"	11849043
C041517	dibenzo(a,l)pyrene	"GSTA1 protein binds to and affects the metabolism of and results in decreased susceptibility to dibenzo(a,l)pyrene analog"	12067250
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of GSTA1 mRNA	17379624
D003994	Bucladesine	Bucladesine results in increased expression of GSTA1 mRNA	26049102
D003994	Bucladesine	KT 5720 inhibits the reaction [Bucladesine results in increased expression of GSTA1 mRNA]	26049102
D003999	Dichloroacetic Acid	Dichloroacetic Acid results in increased expression of GSTA1 mRNA	28962523
D002945	Cisplatin	[Cisplatin co-treated with panobinostat] affects the expression of GSTA1 mRNA	21791302
D002945	Cisplatin	GSTA1 results in decreased susceptibility to Cisplatin	21150160
D002945	Cisplatin	Cisplatin results in decreased expression of GSTA1 mRNA	1394205
D002945	Cisplatin	Cisplatin results in decreased expression of GSTA1 protein	1394205
D004008	Diclofenac	Diclofenac results in decreased activity of GSTA1 protein	27183920
C000944	dicrotophos	dicrotophos results in decreased expression of GSTA1 mRNA	28302478
C121718	dicyclanil	dicyclanil results in increased expression of GSTA1 mRNA	15664270
C036042	dicyclohexyl phthalate	dicyclohexyl phthalate results in increased expression of GSTA1 mRNA	26924002
D018119	Stavudine	Stavudine results in increased expression of GSTA1 mRNA	18299183
D004041	Dietary Fats	Dietary Fats affects the expression of GSTA1 mRNA	17086191
D004041	Dietary Fats	Dietary Fats results in increased expression of GSTA1 mRNA	22609946
D004041	Dietary Fats	resveratrol inhibits the reaction [Dietary Fats affects the expression of GSTA1 mRNA]	17086191
D004042	Dietary Fats, Unsaturated	"Dietary Fats, Unsaturated promotes the reaction [perfluorooctanoic acid results in increased expression of GSTA1 mRNA]"	23626681
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in increased expression of GSTA1 mRNA	28412506
C058705	diethyl malate	diethyl malate affects the expression of GSTA1 mRNA	24814887
C058705	diethyl malate	S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of GSTA1 mRNA]	24814887
D004052	Diethylnitrosamine	Diethylnitrosamine results in decreased expression of GSTA1 mRNA	21527772
D004052	Diethylnitrosamine	[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in decreased activity of GSTA1 protein	12725062
D004052	Diethylnitrosamine	Tea inhibits the reaction [[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in decreased activity of GSTA1 protein]	12725062
D004112	Dimercaprol	Dimercaprol results in increased expression of GSTA1 mRNA	7568053
D004112	Dimercaprol	Tetradecanoylphorbol Acetate promotes the reaction [Dimercaprol results in increased expression of GSTA1 mRNA]	7568053
C015835	dimethyl-4-toluidine	dimethyl-4-toluidine results in increased expression of GSTA1 mRNA	27638505
D015127	9,10-Dimethyl-1,2-benzanthracene	"[9,10-Dimethyl-1,2-benzanthracene binds to AHR protein] which results in increased expression of GSTA1"	23656968
C024629	dimethyl phthalate	dimethyl phthalate results in increased expression of GSTA1 mRNA	26924002
D004121	Dimethyl Sulfoxide	Dimethyl Sulfoxide inhibits the reaction [Thioacetamide results in decreased expression of GSTA1 protein]	12370186
D004137	Dinitrochlorobenzene	GSTA1 protein affects the metabolism of Dinitrochlorobenzene	14508638
D004137	Dinitrochlorobenzene	GSTA1 protein affects the metabolism of [Dinitrochlorobenzene co-treated with Glutathione]	14690442
D004137	Dinitrochlorobenzene	GSTA1 protein binds to and affects the metabolism of [Dinitrochlorobenzene co-treated with Glutathione]	12147362
D004137	Dinitrochlorobenzene	[GSTA1 protein binds to GSTA1 protein] which affects the metabolism of Dinitrochlorobenzene	11851347
D004137	Dinitrochlorobenzene	[GSTA1 protein binds to GSTA4 protein] which affects the metabolism of Dinitrochlorobenzene	11851347
D004137	Dinitrochlorobenzene	GSTA1 protein results in increased metabolism of Dinitrochlorobenzene	3138230
D004137	Dinitrochlorobenzene	GSTA1 protein affects the metabolism of Dinitrochlorobenzene	12388831
D004137	Dinitrochlorobenzene	GSTA1 protein affects the metabolism of Dinitrochlorobenzene	15946636
D004137	Dinitrochlorobenzene	Dinitrochlorobenzene results in increased expression of GSTA1 protein	9794801
C051904	dinophysistoxin 1	dinophysistoxin 1 results in decreased expression of GSTA1 mRNA	28939011
D004147	Dioxins	Dioxins results in increased expression of GSTA1 mRNA	18329192
D004178	Diquat	Diquat results in decreased expression of GSTA1 mRNA	7676460
D004298	Dopamine	Dopamine analog results in decreased activity of GSTA1 protein	8131222
D004317	Doxorubicin	GSTA1 protein inhibits the reaction [Doxorubicin results in decreased abundance of Glutathione]	16890185
D004317	Doxorubicin	GSTA1 protein inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]	16890185
D004317	Doxorubicin	GSTA1 protein inhibits the reaction [Doxorubicin results in increased cleavage of and results in increased activity of CASP3 protein]	16890185
D004317	Doxorubicin	GSTA1 protein inhibits the reaction [Doxorubicin results in increased cleavage of PARP1 protein]	16890185
D004317	Doxorubicin	GSTA1 protein inhibits the reaction [Doxorubicin results in increased phosphorylation of MAPK8 protein]	16890185
D004317	Doxorubicin	GSTA1 protein results in decreased susceptibility to Doxorubicin	16890185
D004317	Doxorubicin	Doxorubicin results in increased expression of GSTA1 mRNA	22666520
D004317	Doxorubicin	Doxorubicin results in increased secretion of GSTA1 protein	28885000
D004317	Doxorubicin	Metformin inhibits the reaction [Doxorubicin results in increased expression of GSTA1 mRNA]	22666520
C042986	ebselen	ebselen binds to and results in decreased activity of [GSTA1 protein binds to GSTA3 protein]	8147899
D004791	Enzyme Inhibitors	Enzyme Inhibitors inhibits the reaction [Phenylpropanolamine results in increased expression of GSTA1 protein]	24792324
C045651	epigallocatechin gallate	epigallocatechin gallate results in increased expression of GSTA1 mRNA	25585349
C073539	erucin	erucin results in increased expression of GSTA1 protein	18823965
C045407	estradiol 3,17-disulfate	"estradiol 3,17-disulfate binds to and results in decreased activity of GSTA1 protein"	12206662
D004976	Ethacrynic Acid	GSTA1 protein affects the metabolism of Ethacrynic Acid analog	12781783
D004976	Ethacrynic Acid	GSTA1 protein results in decreased susceptibility to Ethacrynic Acid	1985777
D004976	Ethacrynic Acid	GSTA1 protein affects the metabolism of Ethacrynic Acid	12388831
D004976	Ethacrynic Acid	Ethacrynic Acid results in increased expression of GSTA1 mRNA	9799558
D004976	Ethacrynic Acid	[GSTA1 protein binds to GSTA2 protein] which affects the metabolism of Ethacrynic Acid	9877184
D000431	Ethanol	[Ethanol co-treated with Folic Acid deficiency] results in increased expression of GSTA1 mRNA	16792574
D000431	Ethanol	Ethanol results in increased expression of GSTA1 mRNA	16792574
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of GSTA1 mRNA	12655037\|1583489
D005015	Ethoxyquin	Ethoxyquin results in increased expression of GSTA1 protein	11309284
C024565	ethylene dichloride	GSTA1 protein affects the metabolism of and results in increased activity of and results in increased susceptibility to ethylene dichloride	11673082
D005020	Ethyl Methanesulfonate	Ethyl Methanesulfonate results in increased expression of GSTA1 mRNA	23649840
C098546	ethyl tert-butyl ether	ethyl tert-butyl ether results in increased expression of GSTA1 protein	24090815
D005054	Eugenol	Eugenol analog results in decreased activity of GSTA1 protein	8620581
D005395	Fish Oils	Fish Oils affects the reaction [NR1H4 protein affects the expression of GSTA1 mRNA]	29142166
D015073	2-Acetylaminofluorene	2-Acetylaminofluorene results in increased expression of GSTA1 mRNA	17317680
D005492	Folic Acid	[Ethanol co-treated with Folic Acid deficiency] results in increased expression of GSTA1 mRNA	16792574
D005492	Folic Acid	Folic Acid deficiency results in increased expression of GSTA1 mRNA	16792574
C039281	furan	[Bromodeoxyuridine co-treated with furan] results in increased expression of GSTA1 mRNA	24910943
C039281	furan	furan results in increased expression of GSTA1 mRNA	24183702\|2491094
D005961	Glucosinolates	Glucosinolates results in increased expression of GSTA1 protein	15570060
D005978	Glutathione	"GSTA1 protein affects the metabolism of and results in decreased activity of [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide co-treated with Glutathione]"	11849043
D005978	Glutathione	"GSTA1 protein affects the metabolism of and results in decreased activity of [dibenzo(a,l)pyrene co-treated with Glutathione]"	11849043
D005978	Glutathione	GSTA1 protein affects the metabolism of [Busulfan co-treated with Glutathione]	10437668
D005978	Glutathione	GSTA1 protein affects the metabolism of [Chlorambucil co-treated with Glutathione]	11115505
D005978	Glutathione	GSTA1 protein affects the metabolism of [Cyclophosphamide metabolite co-treated with Glutathione]	12516103
D005978	Glutathione	GSTA1 protein affects the metabolism of [Dinitrochlorobenzene co-treated with Glutathione]	14690442
D005978	Glutathione	GSTA1 protein affects the metabolism of Glutathione	8886613\|9084911
D005978	Glutathione	GSTA1 protein affects the metabolism of [hydratropic aldehyde co-treated with Glutathione]	11368548
D005978	Glutathione	GSTA1 protein affects the metabolism of [Thiotepa co-treated with Glutathione]	7712478
D005978	Glutathione	GSTA1 protein binds to and affects the metabolism of [Dinitrochlorobenzene co-treated with Glutathione]	12147362
D005978	Glutathione	GSTA1 protein inhibits the reaction [Doxorubicin results in decreased abundance of Glutathione]	16890185
D005978	Glutathione	GSTA1 protein affects the metabolism of [4-hydroxy-2-nonenal co-treated with Glutathione]	11716762
D005978	Glutathione	GSTA1 protein affects the metabolism of Glutathione	15946636
D005978	Glutathione	Glutathione binds to GSTA1 protein	10751412
D005978	Glutathione	Glutathione inhibits the reaction [Cholic Acid binds to [GSTA3 protein co-treated with GSTA1 protein]]	3783048
D005978	Glutathione	GSTA1 protein affects the metabolism of [2-hydroxymenthofuran co-treated with Glutathione]	10496977
D005978	Glutathione	[GSTA1 protein binds to GSTA2 protein] which affects the metabolism of Glutathione	9877184
D005999	Glycochenodeoxycholic Acid	Glycochenodeoxycholic Acid binds to [GSTA1 protein co-treated with GSTA1 protein]	3783048
D005999	Glycochenodeoxycholic Acid	Glycochenodeoxycholic Acid binds to [GSTA3 protein co-treated with GSTA1 protein]	3783048
D006016	Glycolates	Glycolates analog binds to and results in decreased activity of GSTA1 protein	6686184
D006062	Gonadotropins	Gonadotropins results in increased expression of GSTA1 mRNA	10433206
C115992	GS-Succ-BP	GS-Succ-BP binds to and results in decreased activity of GSTA1 protein	10681528
C412815	GW 4064	GW 4064 results in increased expression of GSTA1 mRNA	26655953
D006540	Herbicides	Herbicides binds to and results in decreased activity of GSTA1 protein	6686184
D006571	Heterocyclic Compounds	GSTA1 protein affects the metabolism of and results in decreased activity of Heterocyclic Compounds metabolite	12505289
C033550	hexylglutathione	hexylglutathione binds to GSTA1 protein	12211029\|1589376
C013026	hydratropic aldehyde	GSTA1 protein affects the metabolism of [hydratropic aldehyde co-treated with Glutathione]	11368548
C013026	hydratropic aldehyde	GSTA1 protein results in decreased activity of hydratropic aldehyde	11368548
D006854	Hydrocortisone	Hydrocortisone results in increased expression of and results in increased activity of GSTA1 protein	11297599
D006854	Hydrocortisone	Hydrocortisone results in increased expression of GSTA1 mRNA	11297599
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the expression of GSTA1 mRNA	20044591
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased expression of GSTA1 mRNA	11008122
C004965	hypericin	hypericin binds to and results in decreased activity of GSTA1 protein	15461448
D007052	Ibuprofen	Ibuprofen results in increased expression of GSTA1 mRNA	22559005
C071362	idoxifene	idoxifene results in decreased expression of GSTA1 mRNA	9744569
C016517	indole-3-carbinol	indole-3-carbinol results in increased expression of GSTA1 protein	11309284
D007306	Insecticides	GSTA1 protein affects the metabolism of and results in decreased alkylation of Insecticides	15103050
C057937	iomeprol	palmidrol analog inhibits the reaction [[Streptozocin co-treated with iomeprol] results in increased expression of GSTA1 protein]	26474837
C057937	iomeprol	[Streptozocin co-treated with iomeprol] results in increased expression of GSTA1 protein	26474837
C023359	iproplatin	iproplatin results in decreased expression of GSTA1 mRNA	1394205
C023359	iproplatin	iproplatin results in decreased expression of GSTA1 protein	1394205
D007501	Iron	Iron results in decreased expression of GSTA1 protein	11755321
D007501	Iron	Iron results in increased expression of GSTA1 mRNA	11755321
D007501	Iron	Iron results in increased expression of GSTA1 protein	11755321
C031050	isomethyleugenol	isomethyleugenol results in decreased activity of GSTA1 protein	8620581
C015304	isopimpinellin	isopimpinellin results in increased expression of GSTA1 mRNA	18692084
D017879	Isothiocyanates	Isothiocyanates results in increased expression of GSTA1 protein	15570060
D017879	Isothiocyanates	Isothiocyanates results in increased expression of GSTA1 protein	15570060
C098607	JP8 aviation fuel	JP8 aviation fuel results in increased expression of GSTA1 mRNA	15618438
C410337	K 7174	K 7174 results in decreased expression of GSTA1 mRNA	24086573
C006552	kaempferol	kaempferol results in increased expression of GSTA1 mRNA	21256954
C033997	kahweol palmitate	[cafestol co-treated with kahweol palmitate] results in increased expression of GSTA1 protein	11309284
D007654	Ketoconazole	Ketoconazole inhibits the reaction [Phenobarbital results in increased expression of GSTA1 mRNA]	16608920
D007654	Ketoconazole	Ketoconazole inhibits the reaction [Rifampin results in increased expression of GSTA1 mRNA]	16608920
D007654	Ketoconazole	Ketoconazole results in decreased expression of GSTA1 mRNA	16608920
C057416	KT 5720	KT 5720 inhibits the reaction [Bucladesine results in increased expression of GSTA1 mRNA]	26049102
C050466	lauroyl-coenzyme A	lauroyl-coenzyme A binds to and results in decreased activity of GSTA1 protein	10542059
D007854	Lead	benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Cycloheximide inhibits the reaction [Lead results in increased expression of GSTA1 mRNA]]	16243960
D007854	Lead	Cycloheximide inhibits the reaction [Lead results in increased expression of GSTA1 mRNA]	16243960
D007854	Lead	Dactinomycin inhibits the reaction [Lead results in increased expression of GSTA1 mRNA]	16243960
D007854	Lead	Lead inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of GSTA1 protein]	16243960
D007854	Lead	Lead promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of GSTA1 mRNA]	16243960
D007854	Lead	Lead results in increased expression of GSTA1 mRNA	16243960
D007854	Lead	NFE2L2 protein affects the reaction [Lead results in increased expression of GSTA1 mRNA]	16243960
C008261	lead acetate	lead acetate results in increased expression of GSTA1 mRNA	26498409
C008261	lead acetate	NFE2L2 mutant form inhibits the reaction [lead acetate results in increased expression of GSTA1 mRNA]	26498409
C008261	lead acetate	lead acetate results in decreased expression of GSTA1 protein	9750042
C008261	lead acetate	lead acetate results in increased expression of GSTA1 protein	9750042
C008285	linoleic acid hydroperoxide	GSTA1 protein affects the metabolism of linoleic acid hydroperoxide	11716762
C026562	linoleoyl-coenzyme A	linoleoyl-coenzyme A binds to and results in decreased activity of GSTA1 protein	10542059
D008054	Lipid Peroxides	GSTA1 protein affects the metabolism of and results in decreased susceptibility to Lipid Peroxides	9576856
D008054	Lipid Peroxides	GSTA1 protein results in decreased abundance of Lipid Peroxides	11818388
C440499	lipopolysaccharide, Escherichia coli O111 B4	"lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of GSTA1 mRNA"	19264136
D008070	Lipopolysaccharides	Lipopolysaccharides inhibits the reaction [beta-Naphthoflavone results in increased expression of GSTA1 mRNA]	15627257
D008070	Lipopolysaccharides	Lipopolysaccharides results in decreased expression of GSTA1	15627257
D008070	Lipopolysaccharides	Lipopolysaccharides results in decreased expression of GSTA1 mRNA	15627257
D008095	Lithocholic Acid	Lithocholic Acid binds to and results in decreased activity of GSTA1 protein	12206662
D008095	Lithocholic Acid	Lithocholic Acid binds to [GSTA1 protein co-treated with GSTA1 protein]	3783048
D008095	Lithocholic Acid	Lithocholic Acid binds to [GSTA3 protein co-treated with GSTA1 protein]	3783048
D058185	Magnetite Nanoparticles	[Succimer binds to Magnetite Nanoparticles] which results in increased expression of GSTA1 mRNA	21641980
D008468	Meclizine	[Meclizine binds to and results in increased activity of NR1I3 protein] which results in increased expression of GSTA1 mRNA	15272053
D008528	Mefenamic Acid	GSTA1 protein results in increased glutathionylation of Mefenamic Acid analog	25372302
D008627	Mercuric Chloride	Mercuric Chloride results in increased expression of GSTA1 mRNA	7568053
D008627	Mercuric Chloride	Mercuric Chloride results in increased expression of GSTA1 protein	9434069
D008627	Mercuric Chloride	Tetradecanoylphorbol Acetate promotes the reaction [Mercuric Chloride results in increased expression of GSTA1 mRNA]	7568053
D008628	Mercury	GSTA1 gene polymorphism affects the abundance of Mercury	19515364
D008628	Mercury	benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Cycloheximide inhibits the reaction [Mercury results in increased expression of GSTA1 mRNA]]	16243960
D008628	Mercury	Cycloheximide inhibits the reaction [Mercury results in increased expression of GSTA1 mRNA]	16243960
D008628	Mercury	Dactinomycin inhibits the reaction [Mercury results in increased expression of GSTA1 mRNA]	16243960
D008628	Mercury	Mercury inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of GSTA1 protein]	16243960
D008628	Mercury	Mercury promotes the reaction and results in increased expression of Tetrachlorodibenzodioxin promotes the reaction and results in increased expression of GSTA1 mRNA	22579925
D008628	Mercury	Mercury promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of and results in increased activity of GSTA1 protein]	22579925
D008628	Mercury	Mercury promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of GSTA1 mRNA]	16243960
D008628	Mercury	Mercury results in increased expression of and results in increased activity of GSTA1 protein	22579925
D008628	Mercury	Mercury results in increased expression of GSTA1 mRNA	16243960\|2257992
D008628	Mercury	NFE2L2 protein affects the reaction [Mercury results in increased expression of GSTA1 mRNA]	16243960
D008687	Metformin	Metformin inhibits the reaction [Doxorubicin results in increased expression of GSTA1 mRNA]	22666520
D008727	Methotrexate	Methotrexate results in increased expression of GSTA1 mRNA	24449571
D008748	Methylcholanthrene	Methylcholanthrene results in decreased expression of GSTA1 mRNA	23712962
D008748	Methylcholanthrene	Methylcholanthrene results in increased expression of GSTA1 protein	9630845
D008750	Methyldopa	Methyldopa analog results in decreased activity of GSTA1 protein	8131222
C005223	methyleugenol	methyleugenol results in decreased activity of GSTA1 protein	8620581
D020366	Methylmethacrylate	Methylmethacrylate results in increased expression of GSTA1 mRNA	19029078
D020366	Methylmethacrylate	Methylmethacrylate results in increased expression of GSTA1 mRNA	16916219
D008743	Methyl Parathion	GSTA1 protein affects the metabolism of and results in decreased alkylation of Methyl Parathion	15103050
D008743	Methyl Parathion	Methyl Parathion results in increased expression of GSTA1 mRNA	21907274
D008743	Methyl Parathion	Methyl Parathion results in increased expression of GSTA1 protein	21907274
D015655	1-Methyl-4-phenylpyridinium	U 0126 affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of GSTA1 mRNA]	12710931
C063855	microcystin RR	GSTA1 protein results in increased glutathionylation of microcystin RR	23538035
D015735	Mifepristone	Mifepristone results in increased expression of GSTA1 mRNA	17584828
C406082	monomethylarsonous acid	monomethylarsonous acid results in increased expression of GSTA1 mRNA	22108045
C517284	monomethyl phthalate	monomethyl phthalate results in increased expression of GSTA1 mRNA	26924002
C583365	N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide	"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of GSTA1 mRNA"	29244179
C051515	nafenopin-coenzyme A	nafenopin-coenzyme A binds to and results in decreased activity of GSTA1 protein	10542059
D037742	Nanotubes, Carbon	"Nanotubes, Carbon affects the expression of GSTA1 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog affects the expression of GSTA1 mRNA"	25620056
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of GSTA1 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of GSTA1 mRNA"	25620056
D015058	1-Naphthylisothiocyanate	[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of GSTA1 mRNA	27344345
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate results in increased expression of GSTA1 mRNA	20551477
D019829	Nevirapine	GSTA1 protein results in increased glutathionylation of Nevirapine metabolite	27989146
D009532	Nickel	Nickel results in increased expression of GSTA1 mRNA	14971665
C044387	N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine	"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of GSTA1 mRNA"	17018880
C025589	ochratoxin A	ochratoxin A results in decreased expression of GSTA1 mRNA	12700408
C025589	ochratoxin A	ochratoxin A inhibits the reaction [sulforafan results in increased expression of GSTA1 mRNA]	18547363
C025589	ochratoxin A	ochratoxin A results in decreased expression of GSTA1 mRNA	18547363
D019787	Linoleic Acid	Linoleic Acid results in increased expression of GSTA1 mRNA	28555106
D019787	Linoleic Acid	NFE2L2 protein promotes the reaction [Linoleic Acid results in increased expression of GSTA1 mRNA]	28555106
D019319	Okadaic Acid	Okadaic Acid results in decreased expression of GSTA1 mRNA	28939011
C017585	oleoyl-coenzyme A	oleoyl-coenzyme A binds to and results in decreased activity of GSTA1 protein	10542059
C026209	oltipraz	NFE2L2 protein affects the reaction [oltipraz results in increased expression of GSTA1 mRNA]	22496397
C026209	oltipraz	[oltipraz results in increased activity of NFE2L2 protein] which results in increased expression of GSTA1 mRNA	22496397
C026209	oltipraz	oltipraz results in increased expression of GSTA1 mRNA	22496397
C026209	oltipraz	oltipraz results in increased expression of GSTA1 protein	11309284
C016340	o,p'-DDT	"o,p'-DDT affects the expression of GSTA1 mRNA"	18925944
D010069	Oxadiazoles	[Oxadiazoles analog co-treated with FGF2 protein] results in increased expression of GSTA1 mRNA	23212921
C030110	oxaliplatin	oxaliplatin results in increased expression of GSTA1 mRNA	25729387
C029341	oxophenylarsine	oxophenylarsine results in increased expression of GSTA1 mRNA	7568053
D010100	Oxygen	Oxygen deficiency results in decreased expression of GSTA1 mRNA	19695866
D010126	Ozone	Ozone results in increased expression of GSTA1 mRNA	17095637
C005958	palmidrol	palmidrol analog inhibits the reaction [[Streptozocin co-treated with iomeprol] results in increased expression of GSTA1 protein]	26474837
D010171	Palmitoyl Coenzyme A	Palmitoyl Coenzyme A binds to and results in decreased activity of GSTA1 protein	10542059
C496932	panobinostat	[Cisplatin co-treated with panobinostat] affects the expression of GSTA1 mRNA	21791302
D010269	Paraquat	Paraquat results in increased expression of GSTA1 mRNA	16128001
D052638	Particulate Matter	Particulate Matter analog results in increased expression of GSTA1 mRNA	15322212
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in increased expression of GSTA1 mRNA	20936131
C023036	perfluorooctanoic acid	"Dietary Fats, Unsaturated promotes the reaction [perfluorooctanoic acid results in increased expression of GSTA1 mRNA]"	23626681
C023036	perfluorooctanoic acid	[perfluorooctanoic acid co-treated with PPARA] results in decreased expression of GSTA1 mRNA	20118188
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of GSTA1 mRNA	20118188\|2093613
C023036	perfluorooctanoic acid	PPARA protein promotes the reaction [perfluorooctanoic acid results in increased expression of GSTA1 mRNA]	20936131
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of GSTA1 mRNA	18804290
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of GSTA1 mRNA	9020873
D020025	Peroxisome Proliferators	Peroxisome Proliferators metabolite binds to and results in decreased activity of GSTA1 protein	10542059
D010634	Phenobarbital	Ketoconazole inhibits the reaction [Phenobarbital results in increased expression of GSTA1 mRNA]	16608920
D010634	Phenobarbital	Phenobarbital results in decreased expression of GSTA1 mRNA	19084549
D010634	Phenobarbital	Phenobarbital results in decreased expression of GSTA1 protein	7986210
D010634	Phenobarbital	Phenobarbital results in increased expression of GSTA1 mRNA	16608920\|1911856
D010634	Phenobarbital	Phenobarbital results in increased expression of GSTA1 mRNA	20403969\|2651995
D010634	Phenobarbital	Phenobarbital results in increased expression of GSTA1 mRNA	10762607\|1496536
D010634	Phenobarbital	Phenobarbital results in increased expression of GSTA1 protein	24090815
D010634	Phenobarbital	Phenobarbital results in increased stability of GSTA1 mRNA	10762607
C033457	phenobarbital quinidine	IL1B protein inhibits the reaction [phenobarbital quinidine results in increased expression of GSTA1 mRNA]	15382119
C033457	phenobarbital quinidine	phenobarbital quinidine results in increased expression of GSTA1 mRNA	15382119
D010665	Phenylpropanolamine	Enzyme Inhibitors inhibits the reaction [Phenylpropanolamine results in increased expression of GSTA1 protein]	24792324
D010665	Phenylpropanolamine	Phenylpropanolamine results in increased expression of GSTA1 mRNA	24792324
D010665	Phenylpropanolamine	Phenylpropanolamine results in increased expression of GSTA1 protein	24792324
D010665	Phenylpropanolamine	S-ethyl glutathione inhibits the reaction [Phenylpropanolamine results in increased expression of GSTA1 mRNA]	24792324
D010665	Phenylpropanolamine	STAT3 mRNA promotes the reaction [Phenylpropanolamine results in increased expression of GSTA1 mRNA]	24792324
D010672	Phenytoin	Phenytoin results in increased expression of GSTA1 mRNA	11134551
C057590	phosphatidylcholine hydroperoxide	GSTA1 protein affects the metabolism of phosphatidylcholine hydroperoxide	11716762
D010795	Phthalic Acids	Phthalic Acids results in decreased expression of GSTA1 mRNA	15728792
D010847	Picolines	Picolines results in decreased expression of GSTA1 protein	7986210
C004479	pimagedine	pimagedine inhibits the reaction [Spermidine results in increased expression of GSTA1 mRNA]	12763045
C014153	pirimiphos methyl	pirimiphos methyl results in decreased expression of GSTA1 mRNA	27845199
C006253	pirinixic acid	pirinixic acid results in increased expression of GSTA1 mRNA	23811191
D010936	Plant Extracts	Plant Extracts results in increased expression of GSTA1 protein	15570060
D010936	Plant Extracts	Plant Extracts results in increased expression of GSTA1 protein	15570060
D011285	Pregnenolone Carbonitrile	NR1I2 protein affects the reaction [Pregnenolone Carbonitrile results in increased expression of GSTA1 mRNA]	22496397
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile promotes the reaction [NR1I2 protein binds to GSTA1 gene]	20693526
D011285	Pregnenolone Carbonitrile	[Pregnenolone Carbonitrile promotes the reaction [NR1I2 protein binds to GSTA1 gene]] which results in increased expression of GSTA1 mRNA	20693526\|2069352
D011285	Pregnenolone Carbonitrile	[Pregnenolone Carbonitrile results in increased activity of NR1I2 protein] which results in increased expression of GSTA1 mRNA	22496397
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in increased expression of GSTA1 mRNA	22496397
D011374	Progesterone	Progesterone results in increased expression of GSTA1 mRNA	23012394
D011374	Progesterone	GSTA1 protein results in increased chemical synthesis of Progesterone	23650189
D011374	Progesterone	Progesterone results in increased expression of GSTA1 mRNA	20726854
C045950	propiconazole	propiconazole affects the expression of GSTA1 mRNA	17383973
C100008	prostaglandin A2	GSTA1 protein affects the metabolism of prostaglandin A2	9084911
D011719	Pyrazines	Pyrazines results in decreased expression of GSTA1 protein	7986210
C031280	pyrazole	pyrazole results in increased expression of GSTA1 mRNA	17945193
D011748	Pyrogallol	Pyrogallol results in decreased expression of GSTA1 mRNA	18789925
D011748	Pyrogallol	resveratrol inhibits the reaction [Pyrogallol results in decreased expression of GSTA1 mRNA]	18789925
D011794	Quercetin	[Quercetin co-treated with Ascorbic Acid] results in decreased expression of GSTA1 mRNA	17639512
D011794	Quercetin	Quercetin results in decreased expression of GSTA1 mRNA	21632981
D011794	Quercetin	Quercetin results in increased expression of GSTA1 mRNA	12756216
D011794	Quercetin	Quercetin affects the expression of GSTA1 mRNA	19270413
C428865	quercetin 3-arabinopyranoside	quercetin 3-arabinopyranoside results in increased expression of GSTA1 protein	16574296
D017382	Reactive Oxygen Species	Reactive Oxygen Species affects the expression of GSTA1 mRNA	25800948
C059514	resveratrol	resveratrol inhibits the reaction [Dietary Fats affects the expression of GSTA1 mRNA]	17086191
C059514	resveratrol	resveratrol inhibits the reaction [Pyrogallol results in decreased expression of GSTA1 mRNA]	18789925
C059514	resveratrol	resveratrol results in increased expression of GSTA1 mRNA	16169743
D012293	Rifampin	Rifampin results in increased expression of GSTA1 mRNA	22559005
D012293	Rifampin	Ketoconazole inhibits the reaction [Rifampin results in increased expression of GSTA1 mRNA]	16608920
D012293	Rifampin	Rifampin results in increased expression of GSTA1 mRNA	16608920\|1911856
D012293	Rifampin	[Tetrachlorodibenzodioxin co-treated with Rifampin] results in increased expression of GSTA1 mRNA	29162470
D012294	Rifamycins	Rifamycins results in increased expression of GSTA1 protein	7986210
D012402	Rotenone	CEBPB protein affects the reaction [Rotenone results in increased expression of GSTA1 mRNA]	19304788
D012402	Rotenone	DDIT3 protein affects the reaction [Rotenone results in increased expression of GSTA1 mRNA]	19304788
D012402	Rotenone	Rotenone results in increased expression of GSTA1 mRNA	19304788\|2318674
C042431	S-ethyl glutathione	S-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of GSTA1 mRNA]	24814887
C042431	S-ethyl glutathione	S-ethyl glutathione inhibits the reaction [Phenylpropanolamine results in increased expression of GSTA1 mRNA]	24792324
C118258	SN50 peptide	SN50 peptide inhibits the reaction [sulforafan results in increased expression of GSTA1 mRNA]	15090468
C017947	sodium arsenite	Ascorbic Acid promotes the reaction [sodium arsenite results in increased expression of GSTA1 mRNA]	16517059
C017947	sodium arsenite	sodium arsenite promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of and results in increased activity of GSTA1 protein]	22535251
C017947	sodium arsenite	sodium arsenite promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of GSTA1 mRNA]	22535251
C017947	sodium arsenite	sodium arsenite results in increased activity of GSTA1 protein	11979426
C017947	sodium arsenite	sodium arsenite results in increased expression of and results in increased activity of GSTA1 protein	22535251
C017947	sodium arsenite	sodium arsenite results in increased expression of GSTA1 mRNA	11979426\|1601473
C017947	sodium arsenite	Tetradecanoylphorbol Acetate promotes the reaction [sodium arsenite results in increased expression of GSTA1 mRNA]	7568053
C016104	sodium bichromate	[Benzo(a)pyrene co-treated with sodium bichromate] results in decreased expression of GSTA1 mRNA	22613061
D012997	Solvents	GSTA1 polymorphism affects the susceptibility to Solvents	24914957
D053260	Soot	Soot results in decreased expression of GSTA1 mRNA	19165387\|2246145
D013095	Spermidine	pimagedine inhibits the reaction [Spermidine results in increased expression of GSTA1 mRNA]	12763045
D013095	Spermidine	Spermidine results in increased expression of GSTA1 mRNA	12763045
C053003	S-phenyl-N-acetylcysteine	GSTA1 gene polymorphism affects the abundance of S-phenyl-N-acetylcysteine	20100551
C053003	S-phenyl-N-acetylcysteine	GSTA1 gene polymorphism affects the reaction [GSTM1 gene polymorphism affects the abundance of S-phenyl-N-acetylcysteine]	20100551
C017725	stearoyl-coenzyme A	stearoyl-coenzyme A binds to and results in decreased activity of GSTA1 protein	10542059
C040349	S-tetradecanoyl-coenzyme A	S-tetradecanoyl-coenzyme A binds to and results in decreased activity of GSTA1 protein	10542059
D013311	Streptozocin	palmidrol analog inhibits the reaction [[Streptozocin co-treated with iomeprol] results in increased expression of GSTA1 protein]	26474837
D013311	Streptozocin	[Streptozocin co-treated with iomeprol] results in increased expression of GSTA1 protein	26474837
C041711	St. Thomas' Hospital cardioplegic solution	St. Thomas' Hospital cardioplegic solution results in decreased expression of GSTA1 mRNA	16214533
D004113	Succimer	[Succimer binds to Magnetite Nanoparticles] which results in increased expression of GSTA1 mRNA	21641980
D013448	Sulfobromophthalein	Sulfobromophthalein binds to and affects the folding of and affects the activity of GSTA1 protein	9826190
D013448	Sulfobromophthalein	Sulfobromophthalein binds to GSTA1 protein	15147239
D013448	Sulfobromophthalein	Sulfobromophthalein binds to [GSTA1 protein co-treated with GSTA1 protein]	3783048
D013448	Sulfobromophthalein	Sulfobromophthalein binds to [GSTA3 protein co-treated with GSTA1 protein]	3783048
C016766	sulforafan	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [sulforafan results in increased expression of GSTA1 mRNA]	15090468
C016766	sulforafan	SN50 peptide inhibits the reaction [sulforafan results in increased expression of GSTA1 mRNA]	15090468
C016766	sulforafan	sulforafan results in decreased expression of GSTA1 mRNA	12949046
C016766	sulforafan	sulforafan results in increased expression of GSTA1 mRNA	12151360\|1275621
C016766	sulforafan	NFE2L2 protein promotes the reaction [sulforafan results in increased expression of GSTA1 mRNA]	20932822
C016766	sulforafan	sulforafan results in increased expression of GSTA1 mRNA	20932822\|7568053
C016766	sulforafan	sulforafan results in increased expression of GSTA1 protein	11309284
C016766	sulforafan	Tetradecanoylphorbol Acetate promotes the reaction [sulforafan results in increased expression of GSTA1 mRNA]	7568053
C016766	sulforafan	sulforafan results in increased expression of GSTA1 mRNA	11264000
C016766	sulforafan	sulforafan results in increased expression of GSTA1 protein	18823965
C016766	sulforafan	ochratoxin A inhibits the reaction [sulforafan results in increased expression of GSTA1 mRNA]	18547363
C016766	sulforafan	sulforafan results in increased expression of GSTA1 mRNA	18547363
C473478	sunitinib	sunitinib affects the expression of GSTA1 mRNA	26797788
C074269	Sunphenon	"[3,4,5,3',4'-pentachlorobiphenyl co-treated with Sunphenon] affects the expression of GSTA1 mRNA"	24378064
C446685	systhane	systhane affects the expression of GSTA1 mRNA	17383973
D013629	Tamoxifen	Tamoxifen metabolite results in decreased expression of GSTA1 mRNA	9744569
D013629	Tamoxifen	Tamoxifen results in decreased activity of GSTA1 protein	8706011
D013629	Tamoxifen	Tamoxifen results in decreased expression of GSTA1 mRNA	8706011\|9744569
D013629	Tamoxifen	Tamoxifen results in decreased expression of GSTA1 protein	8706011
C030141	taurine-ursodeoxycholate conjugate	taurine-ursodeoxycholate conjugate inhibits the reaction [LEP gene mutant form results in increased expression of GSTA1 mRNA]	21079772
D013662	Tea	Tea inhibits the reaction [[Carbon Tetrachloride co-treated with Diethylnitrosamine] results in decreased activity of GSTA1 protein]	12725062
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Rifampin] results in increased expression of GSTA1 mRNA	29162470
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of GSTA1 mRNA	20106945\|2163298
D013749	Tetrachlorodibenzodioxin	AHR protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of GSTA1 mRNA]	22496397
D013749	Tetrachlorodibenzodioxin	benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of GSTA1 mRNA]]	16243960
D013749	Tetrachlorodibenzodioxin	Copper inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of GSTA1 mRNA]	16243960
D013749	Tetrachlorodibenzodioxin	Copper promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of GSTA1 protein]	16243960
D013749	Tetrachlorodibenzodioxin	Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of GSTA1 mRNA]	16243960
D013749	Tetrachlorodibenzodioxin	Dactinomycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of GSTA1 mRNA]	16243960
D013749	Tetrachlorodibenzodioxin	Lead inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of GSTA1 protein]	16243960
D013749	Tetrachlorodibenzodioxin	Lead promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of GSTA1 mRNA]	16243960
D013749	Tetrachlorodibenzodioxin	Mercury inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of GSTA1 protein]	16243960
D013749	Tetrachlorodibenzodioxin	Mercury promotes the reaction and results in increased expression of Tetrachlorodibenzodioxin promotes the reaction and results in increased expression of GSTA1 mRNA	22579925
D013749	Tetrachlorodibenzodioxin	Mercury promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of and results in increased activity of GSTA1 protein]	22579925
D013749	Tetrachlorodibenzodioxin	Mercury promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of GSTA1 mRNA]	16243960
D013749	Tetrachlorodibenzodioxin	NFE2L2 protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of GSTA1 mRNA]	19474220
D013749	Tetrachlorodibenzodioxin	sodium arsenite promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of and results in increased activity of GSTA1 protein]	22535251
D013749	Tetrachlorodibenzodioxin	sodium arsenite promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of GSTA1 mRNA]	22535251
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of GSTA1 mRNA	18343893\|2637764
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to GSTA1 gene]	28213091
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased activity of GSTA1 protein	16243960
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of and results in increased activity of GSTA1 protein	22535251\|2257992
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of GSTA1 mRNA	16243960\|1837239
D013755	Tetradecanoylphorbol Acetate	"Tetradecanoylphorbol Acetate promotes the reaction [1,2-dithiol-3-thione results in increased expression of GSTA1 mRNA]"	7568053
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate promotes the reaction [2-tert-butylhydroquinone results in increased expression of GSTA1 mRNA]	7568053
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate promotes the reaction [benzylideneacetone results in increased expression of GSTA1 mRNA]	7568053
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate promotes the reaction [Dimercaprol results in increased expression of GSTA1 mRNA]	7568053
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate promotes the reaction [Mercuric Chloride results in increased expression of GSTA1 mRNA]	7568053
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate promotes the reaction [sodium arsenite results in increased expression of GSTA1 mRNA]	7568053
D013755	Tetradecanoylphorbol Acetate	Tetradecanoylphorbol Acetate promotes the reaction [sulforafan results in increased expression of GSTA1 mRNA]	7568053
C121030	tetrahydrothiophene	GSTA1 protein results in increased chemical synthesis of tetrahydrothiophene	12429583
D013853	Thioacetamide	Dimethyl Sulfoxide inhibits the reaction [Thioacetamide results in decreased expression of GSTA1 protein]	12370186
D013853	Thioacetamide	Thioacetamide results in decreased expression of GSTA1 protein	12370186
D013853	Thioacetamide	Thioacetamide results in increased expression of GSTA1 mRNA	15497818
D013852	Thiotepa	GSTA1 gene SNP affects the export of Thiotepa	19076156
D013852	Thiotepa	GSTA1 protein affects the metabolism of [Thiotepa co-treated with Glutathione]	7712478
D013852	Thiotepa	GSTA1 protein affects the susceptibility to Thiotepa	19076156
C009495	titanium dioxide	titanium dioxide results in decreased expression of GSTA1 mRNA	23557971\|2776080
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased susceptibility to GSTA1 protein polymorphism	23643483
D014028	Tobacco Smoke Pollution	[Vehicle Emissions analog co-treated with Coal Tar analog co-treated with Tobacco Smoke Pollution analog] results in increased expression of GSTA1 mRNA	22935520
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of GSTA1 mRNA	23038017
D019772	Topotecan	Topotecan results in increased expression of GSTA1 mRNA	25729387
D017312	Toremifene	Toremifene results in decreased expression of GSTA1 mRNA	9744569
C032910	triadimefon	triadimefon affects the expression of GSTA1 mRNA	17383973
D014227	Triazines	Triazines inhibits the reaction [IDH2 protein mutant form results in increased expression of GSTA1 mRNA]	27469509
D014241	Trichloroethylene	Trichloroethylene results in increased expression of GSTA1 mRNA	28973375
D013721	Triethylenephosphoramide	GSTA1 gene SNP affects the export of Triethylenephosphoramide	19076156
D013721	Triethylenephosphoramide	GSTA1 protein affects the susceptibility to Triethylenephosphoramide	19076156
C010360	triethyllead	triethyllead results in decreased expression of GSTA1 mRNA	9020200
C010360	triethyllead	triethyllead results in increased expression of GSTA1 mRNA	9020200
C052920	trimethylarsine oxide	trimethylarsine oxide results in increased expression of GSTA1 mRNA	26144063
C005445	triphenyl phosphate	triphenyl phosphate results in decreased expression of GSTA1 mRNA	26183808
C005445	triphenyl phosphate	triphenyl phosphate results in increased expression of GSTA1 mRNA	26049154
C012085	tris(2,3-dibromopropyl)phosphate	"GSTA1 protein affects the metabolism of tris(2,3-dibromopropyl)phosphate"	8242859
C012085	tris(2,3-dibromopropyl)phosphate	"GSTA1 protein results in increased susceptibility to tris(2,3-dibromopropyl)phosphate"	8242859
C013320	tris(2-butoxyethyl) phosphate	tris(2-butoxyethyl) phosphate affects the expression of GSTA1 mRNA	29024780
C013320	tris(2-butoxyethyl) phosphate	tris(2-butoxyethyl) phosphate results in increased expression of GSTA1 mRNA	25808963
C031324	tris(chloroethyl)phosphate	tris(chloroethyl)phosphate results in decreased expression of GSTA1 mRNA	26183808
C031324	tris(chloroethyl)phosphate	tris(chloroethyl)phosphate results in increased expression of GSTA1 mRNA	26049154
D017973	Tungsten Compounds	Tungsten Compounds results in increased expression of GSTA1 mRNA	14971665
C113580	U 0126	U 0126 affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of GSTA1 mRNA]	12710931
D014520	Urethane	Urethane results in decreased expression of GSTA1 mRNA	28818685
C073339	usnic acid	usnic acid results in increased expression of GSTA1 protein	27369375
D014635	Valproic Acid	Valproic Acid results in decreased expression of GSTA1 mRNA	23179753\|2800136
D014638	Vanadates	Vanadates results in increased expression of GSTA1 mRNA	22714537
D001335	Vehicle Emissions	[Vehicle Emissions analog co-treated with Coal Tar analog co-treated with Tobacco Smoke Pollution analog] results in increased expression of GSTA1 mRNA	22935520
D001335	Vehicle Emissions	[Vehicle Emissions analog co-treated with Coal Tar analog] results in increased expression of GSTA1 mRNA	22935520
D001335	Vehicle Emissions	Vehicle Emissions analog results in increased expression of GSTA1 mRNA	15322212
D001335	Vehicle Emissions	Vehicle Emissions results in increased expression of GSTA1 mRNA	23897985
D024483	Vitamin K 3	Vitamin K 3 affects the expression of GSTA1 mRNA	20044591
C104536	xanthohumol	"[xanthohumol co-treated with 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine] results in increased expression of GSTA1 mRNA"	22138251
C104536	xanthohumol	xanthohumol results in decreased expression of GSTA1 mRNA	22138251

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004364	glutathione transferase activity	-	IDA	11851347 20606271
GO:0004364	glutathione transferase activity	-	NAS	1731620
GO:0004364	glutathione transferase activity	-	TAS	-
GO:0004602	glutathione peroxidase activity	-	IDA	16624487

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006749	glutathione metabolic process	-	IDA	11851347 20606271
GO:0030855	epithelial cell differentiation	-	IEP	21492153
GO:0043651	linoleic acid metabolic process	-	IDA	16624487
GO:0098869	cellular oxidant detoxification	-	IEA	-
GO:1901687	glutathione derivative biosynthetic process	-	TAS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005829	cytosol	-	IDA	-
GO:0005829	cytosol	-	TAS	-
GO:0070062	extracellular exosome	-	HDA	19056867 23533145

KEGG ID	KEGG Term
hsa00480	Glutathione metabolism
hsa00980	Metabolism of xenobiotics by cytochrome P450
hsa00982	Drug metabolism - cytochrome P450

Reactome ID	Reactome Term	Evidence
R-HSA-1430728	Metabolism	TAS
R-HSA-156580	Phase II - Conjugation of compounds	TAS
R-HSA-156590	Glutathione conjugation	TAS
R-HSA-211859	Biological oxidations	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
24919441	Polymorphisms of NRF2 and NRF2 target genes in urinary bladder cancer patients. (2014 Oct)	Reszka E	J Cancer Res Clin Oncol
19440493	PAH-DNA adducts, cigarette smoking, GST polymorphisms, and breast cancer risk. (2009 Apr)	McCarty KM	Environ Health Perspect
14601045	Genetic polymorphisms and modulation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-DNA adducts in human lymphocytes. (2003 Dec 20)	Magagnotti C	Int J Cancer
21432116	Human Glutathione S-transferase A1 polymorphism and susceptibility to oral squamous cell carcinoma in Japanese. (2005 Nov)	Komiya Y	Environ Health Prev Med
18430527	Glutathione S-transferase A1 polymorphism as a risk factor for smoking-related type 2 diabetes among Japanese. (2008 May 30)	Oniki K	Toxicol Lett
24075358	GSTA1, GSTM1, GSTP1, and GSTT1 polymorphisms and susceptibility to smoking-related bladder cancer: a case-control study. (2013 Oct)	Matic M	Urol Oncol
16886896	Glutathione S-transferases mu 1, theta 1, pi 1, alpha 1 and mu 3 genetic polymorphisms and the risk of colorectal and gastric cancers in humans. (2006 Jul)	Martinez C	Pharmacogenomics
25218365	Diversified expression of aryl hydrocarbon receptor dependent genes in human laryngeal squamous cell carcinoma cell lines treated with beta-naphthoflavone. (2014 Nov 18)	Brauze D	Toxicol Lett
20100551	Occupational exposure to low levels of benzene: Biomarkers of exposure and nucleic acid oxidation and their modulation by polymorphic xenobiotic metabolizing enzymes. (2010 Apr 1)	Manini P	Toxicol Lett
16488119	Relationship between genotype and enzyme activity of glutathione S-transferases M1 and P1 in Chinese. (2006 May)	Zhong SL	Eur J Pharm Sci
15797627	Human glutathion S-transferase A1 polymorphism and susceptibility to urothelial cancer in the Japanese population. (2005 Apr 18)	Komiya Y	Cancer Lett
21715529	Maternal smoking and fetal sex significantly affect metabolic enzyme expression in the human fetal liver. (2011 Sep)	O'Shaughnessy PJ	J Clin Endocrinol Metab
24968062	Influence of genetic polymorphism on t,t-MA/S-PMA ratio in 301 benzene exposed subjects. (2014 Dec 1)	Carbonari D	Toxicol Lett
20377137	Genetic polymorphisms in GSTA1, GSTP1, GSTT1, and GSTM1 and gastric cancer risk in a Vietnamese population. (2010)	Nguyen TV	Oncol Res
23643483	Interactive effects of smoking and glutathione S-transferase polymorphisms on the development of non-alcoholic fatty liver disease. (2013 Jul 4)	Oniki K	Toxicol Lett
25892883	Polymorphisms of glutathione S-transferase genes and survival of resected hepatocellular carcinoma patients. (2015 Apr 14)	Qu K	World J Gastroenterol
7728947	Expression and polymorphism of glutathione S-transferase in human lungs: risk factors in smoking-related lung cancer. (1995 Apr)	Nakajima T	Carcinogenesis
22108414	Human GSTs polymorphisms in the Hakka population of south China and their associations with family history of several chronic diseases. (2011 Oct)	Pan S	Biomed Environ Sci
16624829	Effects of glutathione S-transferase A1 (GSTA1) genotype and potential modifiers on breast cancer risk. (2006 Sep)	Ahn J	Carcinogenesis
28714190	Polymorphisms of xenobiotic-metabolizing genes and colorectal cancer risk in patients with lynch syndrome: A retrospective cohort study in Taiwan. (2018 Jan)	Kamiza AB	Environ Mol Mutagen
23570881	GSTM1, GSTT1, GSTP1, and GSTA1 genetic variants are not associated with coronary artery disease in Taiwan. (2013 Jul 1)	Yeh HL	Gene
18414193	Polymorphisms of glutathione S-transferase A1 and O1 and breast cancer among postmenopausal Danish women. (2008 Jun)	Olsen A	Eur J Cancer Prev
15746160	Constitutional short telomeres are strong genetic susceptibility markers for bladder cancer. (2005 Jul)	Broberg K	Carcinogenesis
25524402	Association between plasma selenium level and NRF2 target genes expression in humans. (2015 Apr)	Reszka E	J Trace Elem Med Biol