Gene: GSTA4

2941
GSTA4-4|GTA4
glutathione S-transferase alpha 4
protein-coding
6p12.2
Ensembl:ENSG00000170899 MIM:605450 Vega:OTTHUMG00000014868 UniprotKB:O15217
NC_000006.12
PubMed
ND|AD
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.404e-2 (AD)  8.374e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FARSB0.969
OCIAD10.965
DNM1L0.965
MAGED10.959
ATP6AP20.957
ATP6V1E10.956
PPP2R2B0.955
MDH10.955
PEX11B0.954
YWHAZ0.954

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.672
OR4F29-0.623
MTRNR2L6-0.392
MTRNR2L9-0.384
EVC2-0.38
MTRNR2L10-0.373
CNN2-0.371
CSAG1-0.365
AJUBA-0.364
RAI14-0.358

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00143GlutathioneSmall Molecule70-18-8Approved|Investigational|NutraceuticalTarget
ID Drug Name Action PubMed
C52148710-nitro-oleic acid10-nitro-oleic acid results in increased expression of GSTA4 mRNA24140437
C4496731,1,4-tris(acetyloxy)-2-nonene"4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [GSTA4 gene mutant form results in increased susceptibility to 1,1,4-tris(acetyloxy)-2-nonene]"24353929
C4496731,1,4-tris(acetyloxy)-2-nonene"GSTA4 gene mutant form results in increased susceptibility to 1,1,4-tris(acetyloxy)-2-nonene"24353929
C4496731,1,4-tris(acetyloxy)-2-nonene"[GSTA4 gene mutant form results in increased susceptibility to 1,1,4-tris(acetyloxy)-2-nonene] which results in increased activity of CASP8 protein"24353929
C4496731,1,4-tris(acetyloxy)-2-nonene"[GSTA4 gene mutant form results in increased susceptibility to 1,1,4-tris(acetyloxy)-2-nonene] which results in increased activity of CASP9 protein"24353929
C4496731,1,4-tris(acetyloxy)-2-nonene"[GSTA4 gene mutant form results in increased susceptibility to 1,1,4-tris(acetyloxy)-2-nonene] which results in increased cleavage of and results in increased activity of CASP3 protein"24353929
C4496731,1,4-tris(acetyloxy)-2-nonene"pyrazolanthrone inhibits the reaction [GSTA4 gene mutant form results in increased susceptibility to 1,1,4-tris(acetyloxy)-2-nonene]"24353929
C4496731,1,4-tris(acetyloxy)-2-nonene"U 0126 inhibits the reaction [GSTA4 gene mutant form results in increased susceptibility to 1,1,4-tris(acetyloxy)-2-nonene]"24353929
C0283281,2-dichloro-4-nitrobenzene"GSTA4 protein results in increased glutathionylation of 1,2-dichloro-4-nitrobenzene"21876218
C06444113-oxo-9,11-octadecadienoic acid"GSTA4 protein affects the metabolism of 13-oxo-9,11-octadecadienoic acid"12031293
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"[1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased activity of NR1I3 protein] which results in increased expression of GSTA4 mRNA"22496397
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of GSTA4 mRNA"18723825|2249639
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"NR1I3 protein affects the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of GSTA4 mRNA]"22496397
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"NR1I3 protein promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of GSTA4 mRNA]"22698814
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of GSTA4 mRNA"25510870
C0291412,2,5,7,8-pentamethyl-1-hydroxychroman"2,2,5,7,8-pentamethyl-1-hydroxychroman results in increased expression of GSTA4 mRNA"21920950
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of GSTA4 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of GSTA4 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of GSTA4 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of GSTA4 mRNA"25510870
C0312782-chloroethyl ethyl sulfide2-chloroethyl ethyl sulfide results in decreased expression of GSTA4 mRNA20840853
C0517502-hexenal2-hexenal results in increased expression of GSTA4 mRNA9799558
C0517502-hexenal2-hexenal results in increased expression of GSTA4 protein9799558
C0605332-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of GSTA4 protein"17122891
C0303702-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone results in decreased expression of GSTA4 mRNA"20206263
C0188552-tert-butylhydroquinone2-tert-butylhydroquinone results in increased expression of GSTA4 mRNA16014739
C0230353,4,5,3',4'-pentachlorobiphenyl"[3,4,5,3',4'-pentachlorobiphenyl co-treated with Sunphenon] affects the expression of GSTA4 mRNA"24378064
C0502243,5,5-trimethylhexanoylferrocene"3,5,5-trimethylhexanoylferrocene results in increased expression of GSTA4 protein"22649188
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of GSTA4 mRNA"18648102
C0909424-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole"4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [GSTA4 gene mutant form results in increased susceptibility to 1,1,4-tris(acetyloxy)-2-nonene]"24353929
C0441354-hydroxy-2-decenalGSTA4 protein affects the metabolism of 4-hydroxy-2-decenal9461507
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in increased expression of GSTA4 protein12020353
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in increased localization of GSTA4 protein12020353
C0275764-hydroxy-2-nonenalGSTA4 protein affects the metabolism of 4-hydroxy-2-nonenal10514034|1116260
C0275764-hydroxy-2-nonenalGSTA4 protein binds to and affects the metabolism of 4-hydroxy-2-nonenal15829614
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in increased expression of GSTA4 mRNA24423726
C0275764-hydroxy-2-nonenal[APC protein mutant form results in increased expression of GSTA4 mRNA] which affects the metabolism of 4-hydroxy-2-nonenal21967605
C0275764-hydroxy-2-nonenalGSTA4 protein affects the metabolism of 4-hydroxy-2-nonenal11488593|1175532
C0275764-hydroxy-2-nonenalGSTA4 protein inhibits the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of MAPK8 protein]15064094
C0275764-hydroxy-2-nonenalGSTA4 protein mutant form results in decreased glutathionylation of 4-hydroxy-2-nonenal19880816
C0275764-hydroxy-2-nonenal[GSTA4 protein mutant form results in decreased glutathionylation of 4-hydroxy-2-nonenal] which results in increased activity of NFE2L2 protein19880816
C0275764-hydroxy-2-nonenalGSTA4 protein mutant form results in increased susceptibility to 4-hydroxy-2-nonenal19880816
C0275764-hydroxy-2-nonenalGSTA4 protein results in decreased susceptibility to 4-hydroxy-2-nonenal11488593|1506409
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in increased expression of GSTA4 mRNA9799558
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in increased expression of GSTA4 protein9799558
C0275764-hydroxy-2-nonenalGSTA4 protein affects the metabolism of 4-hydroxy-2-nonenal11488593|1260072
C0275764-hydroxy-2-nonenalGSTA4 protein affects the metabolism of 4-hydroxy-2-nonenal analog11256969
C0275764-hydroxy-2-nonenalGSTA4 protein results in increased metabolism of 4-hydroxy-2-nonenal24353929
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of GSTA4 mRNA9774145
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased activity of GSTA4 protein9774145
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of GSTA4 mRNA9774145
C0757734-phenylbutyric acid4-phenylbutyric acid results in increased expression of GSTA4 mRNA14583596
C0293704-toluidine4-toluidine results in increased expression of GSTA4 mRNA27638505
C1174668-isoprostaglandin A2GSTA4 protein affects the metabolism of 8-isoprostaglandin A214727915
C1174668-isoprostaglandin A2GSTA4 protein affects the metabolism of and results in decreased activity of 8-isoprostaglandin A212230403
C1174668-isoprostaglandin A2GSTA4 protein affects the metabolism of 8-isoprostaglandin A214727915
C1174668-isoprostaglandin A2GSTA4 protein affects the metabolism of and results in decreased activity of 8-isoprostaglandin A212230403
D000082AcetaminophenAcetaminophen results in decreased expression of GSTA4 mRNA29067470
D000111Acetylcysteine[Acetylcysteine co-treated with EUK-134] promotes the reaction [[Zinc Sulfate co-treated with Paraquat] results in increased activity of GSTA4 protein]25724285
D000111AcetylcysteineAcetylcysteine promotes the reaction [Maneb results in increased expression of and results in increased activity of GSTA4 protein]23159886
D000111AcetylcysteineAcetylcysteine promotes the reaction [Maneb results in increased expression of GSTA4 mRNA]23159886
D000111AcetylcysteineAcetylcysteine promotes the reaction [[Paraquat co-treated with Maneb] results in increased expression of and results in increased activity of GSTA4 protein]23159886
D000111AcetylcysteineAcetylcysteine promotes the reaction [[Paraquat co-treated with Maneb] results in increased expression of GSTA4 mRNA]23159886
D000111AcetylcysteineAcetylcysteine promotes the reaction [Paraquat results in increased expression of and results in increased activity of GSTA4 protein]23159886
D000111AcetylcysteineAcetylcysteine promotes the reaction [Paraquat results in increased expression of GSTA4 mRNA]23159886
D000111Acetylcysteine[EUK-134 co-treated with Acetylcysteine] promotes the reaction [Paraquat results in increased activity of GSTA4 protein]25724285
D000111Acetylcysteine[EUK-134 co-treated with Acetylcysteine] promotes the reaction [Zinc Sulfate results in increased activity of GSTA4 protein]25724285
D000117AcetylglucosamineAcetylglucosamine results in increased expression of GSTA4 mRNA18047607
D000171AcroleinGSTA4 protein results in decreased susceptibility to Acrolein15064094
D000171AcroleinAcrolein results in increased expression of GSTA4 mRNA9799558
D000171AcroleinAcrolein results in increased expression of GSTA4 protein9799558
D020106AcrylamideAcrylamide results in decreased expression of GSTA4 mRNA28959563
D016604Aflatoxin B1GSTA4 gene SNP affects the susceptibility to Aflatoxin B112907637
D016604Aflatoxin B1GSTA4 gene SNP affects the susceptibility to Aflatoxin B112907637
C006426aflatoxin B1-2,3-oxide"GSTA4 protein results in increased glutathionylation of aflatoxin B1-2,3-oxide"21876218
D000393Air PollutantsAir Pollutants analog results in decreased expression of GSTA4 mRNA21757418
C038491allyl sulfideallyl sulfide results in increased expression of GSTA4 mRNA18723825
C038491allyl sulfideallyl sulfide results in increased expression of GSTA4 mRNA19695238
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of GSTA4 mRNA28522335
D000499AllylamineGSTA4 protein results in decreased susceptibility to Allylamine15064094
D000499AllylamineGSTA4 protein results in decreased susceptibility to Allylamine10406932
C094705amodiaquine quinoneimine[GSTA4 protein co-treated with Glutathione] results in increased metabolism of amodiaquine quinoneimine28478157
C019257angelica lactoneangelica lactone results in increased expression of GSTA4 protein11309284
D047310ApigeninApigenin results in decreased expression of GSTA4 mRNA22359648
C526219apple polyphenol extractapple polyphenol extract results in increased expression of GSTA4 mRNA18351577
D001151Arsenic[APOE protein affects the susceptibility to Arsenic] which affects the expression of GSTA4 mRNA22719926
C015001arsenitearsenite affects the expression of GSTA4 mRNA22959463
C015001arsenitearsenite results in increased methylation of GSTA4 promoter23974009
C015001arsenitearsenite results in increased expression of GSTA4 mRNA18929588
D001205Ascorbic AcidAscorbic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of GSTA4 mRNA]23470461
D019324beta-Naphthoflavonebeta-Naphthoflavone results in increased expression of GSTA4 protein9794803
D001564Benzo(a)pyreneAHR protein promotes the reaction [Benzo(a)pyrene results in increased expression of GSTA4 mRNA]15034205
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of GSTA4 mRNA22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of GSTA4 mRNA14625279|1503420
D001564Benzo(a)pyrene[chromium hexavalent ion co-treated with Benzo(a)pyrene] affects the expression of GSTA4 mRNA25820237
D001564Benzo(a)pyrene[Potassium Dichromate co-treated with potassium chromate(VI)] inhibits the reaction [Benzo(a)pyrene results in increased expression of GSTA4 mRNA]14625279
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of GSTA4 protein9395218
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of GSTA4 mRNA20061341
C038328BEP protocolBEP protocol results in increased expression of GSTA4 mRNA18987330|2320077
D001663BilirubinBilirubin results in decreased expression of GSTA4 mRNA20196124
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in increased expression of GSTA4 protein24793377
C006780bisphenol Abisphenol A affects the expression of GSTA4 mRNA25181051
D002083Butylated HydroxyanisoleButylated Hydroxyanisole results in increased expression of GSTA4 mRNA18723825
D002083Butylated HydroxyanisoleButylated Hydroxyanisole results in increased expression of GSTA4 protein11309284
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of GSTA4 mRNA15336504
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of GSTA4 mRNA14729362|1533650
D002087ButyratesButyrates results in increased expression of GSTA4 mRNA15746163|1582961
D002087ButyratesButyrates results in increased expression of GSTA4 protein15829614
D002087ButyratesButyrates results in increased expression of GSTA4 mRNA14674679
D002101Cacodylic AcidCacodylic Acid results in increased expression of GSTA4 mRNA17720352
D002104CadmiumCadmium results in increased expression of GSTA4 mRNA18522720
D002104CadmiumCadmium results in increased expression of GSTA4 mRNA24067728
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of GSTA4 protein26220685
D019256Cadmium ChlorideCadmium Chloride results in increased expression of GSTA4 mRNA20061341
D019256Cadmium ChlorideCadmium Chloride results in increased expression of GSTA4 protein21699967
C053400cafestol[cafestol co-treated with kahweol palmitate] results in increased expression of GSTA4 protein11309284
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of GSTA4 mRNA17484886
D002635Chenodeoxycholic AcidChenodeoxycholic Acid binds to and results in decreased activity of GSTA4 protein3954743
D002713ChlorineChlorine results in decreased expression of GSTA4 mRNA18636392
D002713Chlorine[Ozone co-treated with Chlorine] affects the expression of GSTA4 mRNA18636392
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of GSTA4 mRNA18178546
D002737ChloropreneChloroprene results in increased expression of GSTA4 mRNA23125180
D004390ChlorpyrifosChlorpyrifos affects the expression of GSTA4 mRNA19440498
D019826Cholic AcidCholic Acid results in increased expression of GSTA4 mRNA17521389
D019826Cholic AcidCholic Acid binds to and results in decreased activity of GSTA4 protein3954743
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of GSTA4 mRNA20938992
C023600chromic oxidechromic oxide results in increased expression of GSTA4 mRNA15003702
C074702chromium hexavalent ion[chromium hexavalent ion co-treated with Benzo(a)pyrene] affects the expression of GSTA4 mRNA25820237
C074702chromium hexavalent ionchromium hexavalent ion results in increased expression of GSTA4 mRNA15003702
C021977chrysene,2-diol-3,4-epoxide-1"GSTA4 protein results in increased glutathionylation of chrysene,2-diol-3,4-epoxide-1"9308905
C012843cinnamic aldehydecinnamic aldehyde results in increased expression of GSTA4 mRNA28219650
D002994ClofibrateClofibrate results in decreased expression of GSTA4 mRNA19952500
D002994ClofibrateClofibrate results in decreased expression of GSTA4 protein16470657
D002994ClofibrateClofibrate results in increased expression of GSTA4 protein20180811
C018021cobaltous chloridecobaltous chloride results in decreased expression of GSTA4 mRNA19376846
D003069CoffeeCoffee results in increased expression of GSTA4 mRNA18028974
D003069CoffeeNFE2L2 protein promotes the reaction [Coffee results in increased expression of GSTA4 mRNA]18028974
D005576ColforsinColforsin affects the localization of GSTA4 protein12646569
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of GSTA4 mRNA20971185
D019327Copper SulfateCopper Sulfate results in decreased expression of GSTA4 mRNA19549813
C030123coumarincoumarin results in increased expression of GSTA4 protein11309284
D003407CreosoteCreosote results in increased expression of GSTA4 mRNA19389177
C007164cumene hydroperoxideGSTA4 protein results in increased glutathionylation of cumene hydroperoxide21876218
D003474CurcuminCurcumin results in increased activity of GSTA4 protein10514034
C057862cyanoginosin LRcyanoginosin LR results in increased expression of GSTA4 mRNA17654400
D016572CyclosporineCyclosporine results in decreased expression of GSTA4 mRNA20106945|2556210
D016572CyclosporineCyclosporine results in decreased expression of GSTA4 mRNA19770486
C017160cypermethrincypermethrin results in increased expression of GSTA4 mRNA20815782
C014347decitabinedecitabine affects the expression of GSTA4 mRNA23300844
C014347decitabine[decitabine co-treated with trichostatin A] results in increased expression of GSTA4 mRNA19444856
C047386desethylamodiaquine[GSTA4 protein co-treated with Glutathione] results in increased metabolism of desethylamodiaquine28478157
D003907Dexamethasone[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of GSTA4 mRNA16054899
D003976DiazinonDiazinon results in decreased expression of GSTA4 mRNA17452286
D003976DiazinonDiazinon results in increased expression of GSTA4 mRNA19440498
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of GSTA4 mRNA17361019|2126653
D003994BucladesineBucladesine results in increased expression of GSTA4 mRNA26049102
D003994BucladesineKT 5720 inhibits the reaction [Bucladesine results in increased expression of GSTA4 mRNA]26049102
D002945CisplatinCisplatin affects the expression of GSTA4 mRNA23300844
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of GSTA4 mRNA27392435
D002945CisplatinCisplatin results in increased expression of GSTA4 mRNA19482077
D004008DiclofenacDiclofenac results in decreased activity of GSTA4 protein27183920
D004008DiclofenacDiclofenac results in decreased expression of GSTA4 mRNA26934552
C000944dicrotophosdicrotophos results in decreased expression of GSTA4 mRNA28302478
C121718dicyclanildicyclanil results in increased expression of GSTA4 mRNA15664270
C036042dicyclohexyl phthalatedicyclohexyl phthalate results in decreased expression of GSTA4 mRNA26924002
D004041Dietary FatsDietary Fats affects the expression of GSTA4 mRNA19680557
D004041Dietary Fats[Dietary Fats co-treated with sodium arsenite] results in decreased expression of GSTA4 mRNA28283972
D004041Dietary FatsDietary Fats results in decreased expression of GSTA4 mRNA28283972
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of GSTA4 mRNA19850644
D004051Diethylhexyl PhthalatePPARA protein promotes the reaction [Diethylhexyl Phthalate results in decreased expression of GSTA4 mRNA]19850644
C014476diethyl maleatediethyl maleate results in increased expression of GSTA4 mRNA25270620
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with kojic acid] results in increased expression of GSTA4 mRNA18544905
D004052Diethylnitrosamine[Phenobarbital co-treated with Diethylnitrosamine] results in increased expression of GSTA4 protein20935162
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in increased expression of GSTA4 mRNA27638505
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of GSTA4 mRNA"22485181
C024629dimethyl phthalatedimethyl phthalate results in decreased expression of GSTA4 mRNA26924002
D004137Dinitrochlorobenzene[GSTA1 protein binds to GSTA4 protein] which affects the metabolism of Dinitrochlorobenzene11851347
D004137Dinitrochlorobenzene[GSTA4 protein binds to GSTA4 protein] which affects the metabolism of Dinitrochlorobenzene11851347
D004137DinitrochlorobenzeneGSTA4 protein results in increased glutathionylation of Dinitrochlorobenzene21876218
D004137DinitrochlorobenzeneDinitrochlorobenzene affects the expression of GSTA4 mRNA28219650
D004137DinitrochlorobenzeneGSTA4 protein affects the metabolism of Dinitrochlorobenzene2619714
C051904dinophysistoxin 1dinophysistoxin 1 results in decreased expression of GSTA4 mRNA28939011
D004237DiuronDiuron results in increased expression of GSTA4 mRNA21551480
D004317DoxorubicinGSTA4 protein affects the susceptibility to Doxorubicin18225754
D004317DoxorubicinGSTA4 protein results in decreased susceptibility to Doxorubicin11488593|8806773
D004610Ellagic AcidEllagic Acid results in increased expression of GSTA4 mRNA12002526
D004785Environmental PollutantsEnvironmental Pollutants results in decreased expression of GSTA4 mRNA12655031
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of GSTA4 mRNA22079256
D004976Ethacrynic AcidGSTA4 protein results in increased glutathionylation of Ethacrynic Acid21876218
D004976Ethacrynic AcidEthacrynic Acid results in increased expression of GSTA4 mRNA9799558
D004976Ethacrynic AcidEthacrynic Acid results in increased expression of GSTA4 protein9799558
D004976Ethacrynic AcidGSTA4 protein affects the metabolism of Ethacrynic Acid2619714
D000431EthanolEthanol results in decreased expression of GSTA4 mRNA28986285
D000431EthanolEthanol results in increased expression of GSTA4 mRNA19167417
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of GSTA4 mRNA14976129
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of GSTA4 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of GSTA4 mRNA15212814
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of GSTA4 mRNA17557909
D005015EthoxyquinEthoxyquin results in increased expression of GSTA4 mRNA18723825
D005015EthoxyquinEthoxyquin results in increased expression of GSTA4 protein11309284
D005015EthoxyquinEthoxyquin results in increased expression of GSTA4 mRNA19695238
D005015EthoxyquinEthoxyquin results in increased expression of GSTA4 protein9794803
C002994ethylene dimethanesulfonateethylene dimethanesulfonate results in increased expression of GSTA4 mRNA22711419
D005047EtoposideEtoposide results in increased expression of GSTA4 mRNA25270620
C433928EUK-134[Acetylcysteine co-treated with EUK-134] promotes the reaction [[Zinc Sulfate co-treated with Paraquat] results in increased activity of GSTA4 protein]25724285
C433928EUK-134[EUK-134 co-treated with Acetylcysteine] promotes the reaction [Paraquat results in increased activity of GSTA4 protein]25724285
C433928EUK-134[EUK-134 co-treated with Acetylcysteine] promotes the reaction [Zinc Sulfate results in increased activity of GSTA4 protein]25724285
C540355fenamidonefenamidone results in increased expression of GSTA4 mRNA27029645
C540355fenamidonesulforafan inhibits the reaction [fenamidone results in increased expression of GSTA4 mRNA]27029645
C020326ferric nitrilotriacetateferric nitrilotriacetate results in increased expression of GSTA4 mRNA19482077
C020326ferric nitrilotriacetateferric nitrilotriacetate results in increased expression of GSTA4 protein19482077
C082360fipronilfipronil results in increased expression of GSTA4 mRNA23962444
D005472FluorouracilGSTA4 protein affects the susceptibility to Fluorouracil16217747
D005485FlutamideFlutamide results in decreased expression of GSTA4 mRNA24793618
D005485FlutamideFlutamide results in increased expression of GSTA4 mRNA24136188
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of GSTA4 mRNA20938992
C050159gamma-glutamyl-glutathioneGSTA4 protein binds to and affects the metabolism of gamma-glutamyl-glutathione2619714
D005839GentamicinsGentamicins results in decreased expression of GSTA4 protein22061828
D005978GlutathioneGSTA4 protein affects the metabolism of Glutathione14727915
D005978Glutathione[GSTA4 protein co-treated with Glutathione] results in increased metabolism of amodiaquine quinoneimine28478157
D005978Glutathione[GSTA4 protein co-treated with Glutathione] results in increased metabolism of desethylamodiaquine28478157
D005978GlutathioneGSTA4 protein affects the metabolism of Glutathione14727915
C412815GW 4064GW 4064 results in increased expression of GSTA4 mRNA26655953
D006427HeminHemin results in increased expression of GSTA4 mRNA19482077
D006861Hydrogen PeroxideGSTA4 gene mutant form results in increased susceptibility to Hydrogen Peroxide24353929
D006861Hydrogen Peroxide[GSTA4 gene mutant form results in increased susceptibility to Hydrogen Peroxide] which results in increased activity of CASP3 protein24353929
D006861Hydrogen PeroxideGSTA4 protein inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein]15064094
D006861Hydrogen PeroxideGSTA4 protein results in decreased susceptibility to Hydrogen Peroxide15064094|1948207
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of GSTA4 mRNA14729362
C016517indole-3-carbinolindole-3-carbinol results in increased expression of GSTA4 protein11309284
C016517indole-3-carbinolindole-3-carbinol affects the expression of GSTA4 mRNA21396975
C016517indole-3-carbinolindole-3-carbinol results in increased expression of GSTA4 protein9794803
D007444Inulin[Inulin metabolite co-treated with oligofructose metabolite] results in increased expression of GSTA4 mRNA23225440
C051890irinotecanirinotecan affects the expression of GSTA4 mRNA20097248
D007501IronIron results in increased expression of GSTA4 mRNA11755321
D007501IronIron results in increased expression of GSTA4 protein11755321
D007501IronIron results in increased expression of and results in increased activity of GSTA4 protein7878679
D0150561-Methyl-3-isobutylxanthine[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of GSTA4 mRNA16054899
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of GSTA4 mRNA27392435
C410337K 7174K 7174 results in decreased expression of GSTA4 mRNA24086573
C033997kahweol palmitate[cafestol co-treated with kahweol palmitate] results in increased expression of GSTA4 protein11309284
C011890kojic acid[Diethylnitrosamine co-treated with kojic acid] results in increased expression of GSTA4 mRNA18544905
C057416KT 5720KT 5720 inhibits the reaction [Bucladesine results in increased expression of GSTA4 mRNA]26049102
D007854LeadLead affects the splicing of GSTA4 mRNA28903495
D007854LeadLead results in decreased expression of GSTA4 protein22129743
D007854LeadPlant Extracts inhibits the reaction [Lead results in decreased expression of GSTA4 protein]22129743
C008261lead acetatelead acetate affects the expression of GSTA4 mRNA21864555
C008261lead acetatelead acetate results in increased expression of GSTA4 protein7878682|9750042
C045463leflunomideleflunomide results in decreased expression of GSTA4 mRNA28988120
C045463leflunomideleflunomide results in increased expression of GSTA4 mRNA24136188
D008054Lipid PeroxidesGSTA4 protein affects the metabolism of and results in decreased susceptibility to Lipid Peroxides9576856
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of GSTA4 mRNA27339419
D008094LithiumLithium results in increased expression of GSTA4 mRNA18082333
D008095Lithocholic AcidLithocholic Acid results in increased expression of GSTA4 mRNA20977460
D008095Lithocholic AcidNFE2L2 protein inhibits the reaction [Lithocholic Acid results in increased expression of GSTA4 mRNA]20977460
D008095Lithocholic AcidLithocholic Acid binds to and results in decreased activity of GSTA4 protein3954743
D008095Lithocholic AcidLithocholic Acid results in increased expression of GSTA4 mRNA21311750
D008344Maneb[Maneb co-treated with Paraquat] results in increased expression of GSTA4 mRNA16510128
D008344ManebMelatonin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of GSTA4 mRNA]20964710
D008344Maneb[Paraquat co-treated with Maneb] results in increased expression of GSTA4 mRNA20964710
D008344ManebSilymarin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of GSTA4 mRNA]20964710
D008344ManebAcetylcysteine promotes the reaction [Maneb results in increased expression of and results in increased activity of GSTA4 protein]23159886
D008344ManebAcetylcysteine promotes the reaction [Maneb results in increased expression of GSTA4 mRNA]23159886
D008344ManebAcetylcysteine promotes the reaction [[Paraquat co-treated with Maneb] results in increased expression of and results in increased activity of GSTA4 protein]23159886
D008344ManebAcetylcysteine promotes the reaction [[Paraquat co-treated with Maneb] results in increased expression of GSTA4 mRNA]23159886
D008344ManebManeb results in increased activity of GSTA4 protein20888808
D008344ManebManeb results in increased expression of and results in increased activity of GSTA4 protein23159886
D008344ManebManeb results in increased expression of GSTA4 mRNA20888808|2315988
D008344ManebManeb results in increased expression of GSTA4 protein20888808
D008344Maneb[Paraquat co-treated with Maneb] results in increased expression of and results in increased activity of GSTA4 protein23159886
D008344Maneb[Paraquat co-treated with Maneb] results in increased expression of GSTA4 mRNA23159886
D008344ManebSilymarin promotes the reaction [Maneb results in increased expression of and results in increased activity of GSTA4 protein]23159886
D008344ManebSilymarin promotes the reaction [Maneb results in increased expression of GSTA4 mRNA]23159886
D008344ManebSilymarin promotes the reaction [[Paraquat co-treated with Maneb] results in increased expression of and results in increased activity of GSTA4 protein]23159886
D008344ManebSilymarin promotes the reaction [[Paraquat co-treated with Maneb] results in increased expression of GSTA4 mRNA]23159886
D008550MelatoninMelatonin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of GSTA4 mRNA]20964710
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of GSTA4 mRNA20938992
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of GSTA4 mRNA28001369
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of GSTA4 mRNA20061341
D008767Methylmercury CompoundsMethylmercury Compounds affects the expression of GSTA4 mRNA18959803
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of GSTA4 mRNA21035857
D020366MethylmethacrylateMethylmethacrylate results in increased expression of GSTA4 mRNA16916219
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GSTA4 mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GSTA4 protein"23933227
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of GSTA4 mRNA"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GSTA4 mRNA]"20230807
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GSTA4 protein]"23933227
C078588microcystinmicrocystin results in increased expression of GSTA4 mRNA19135122
D052998MicrocystinsMicrocystins results in decreased expression of GSTA4 mRNA19790251
D052998MicrocystinsMicrocystins results in increased expression of GSTA4 mRNA19790251
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in decreased expression of GSTA4 mRNA22087261
C406082monomethylarsonous acidmonomethylarsonous acid results in increased expression of GSTA4 mRNA22108045
C517284monomethyl phthalatemonomethyl phthalate results in decreased expression of GSTA4 mRNA26924002
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of GSTA4 mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of GSTA4 mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of GSTA4 mRNA"25554681|2562005
C051752nefazodonenefazodone results in increased expression of GSTA4 mRNA24136188
C022838nickel chloridenickel chloride results in decreased expression of GSTA4 mRNA14645679
D009538Nicotine"[Nicotine co-treated with 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine] results in increased expression of GSTA4 mRNA"20230807
D009538Nicotine"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GSTA4 mRNA]"20230807
D009538Nicotine"Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of GSTA4 protein]"23933227
D009538NicotineNicotine results in decreased expression of GSTA4 mRNA9774145
D009538NicotineNicotine results in increased activity of GSTA4 protein9774145
D009538NicotineNicotine results in increased expression of GSTA4 mRNA9774145
C012655nimesulidenimesulide results in increased expression of GSTA4 mRNA24136188
C002741N-nitrosomorpholineN-nitrosomorpholine results in increased expression of GSTA4 protein19716841
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of GSTA4 mRNA20971185
C025589ochratoxin Aochratoxin A results in decreased expression of GSTA4 mRNA23358140
D019787Linoleic AcidLinoleic Acid metabolite results in increased expression of GSTA4 mRNA26879219
C120489oligofructose[Inulin metabolite co-treated with oligofructose metabolite] results in increased expression of GSTA4 mRNA23225440
D000069463Olive OilOlive Oil analog affects the expression of GSTA4 mRNA17349074
C026209oltiprazNFE2L2 protein affects the reaction [oltipraz results in increased expression of GSTA4 mRNA]22496397
C026209oltipraz[oltipraz results in increased activity of NFE2L2 protein] which results in increased expression of GSTA4 mRNA22496397
C026209oltiprazoltipraz results in increased expression of GSTA4 mRNA18723825|2249639
C026209oltiprazoltipraz results in increased expression of GSTA4 protein11309284
C009618O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate"PON1 protein affects the reaction [O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphate affects the expression of GSTA4 mRNA]"21673326
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of GSTA4 mRNA25729387
C030110oxaliplatinoxaliplatin results in decreased expression of GSTA4 mRNA25729387
D010126Ozone[Ozone co-treated with Chlorine] affects the expression of GSTA4 mRNA18636392
D000073878Palm OilPalm Oil affects the expression of GSTA4 mRNA19680557
C016030pantogabpantogab results in decreased expression of GSTA4 mRNA17379144
D010269ParaquatGSTA4 gene mutant form results in increased susceptibility to Paraquat24353929
D010269ParaquatGSTA4 protein results in decreased susceptibility to Paraquat14761685
D010269Paraquat[Maneb co-treated with Paraquat] results in increased expression of GSTA4 mRNA16510128
D010269ParaquatMelatonin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of GSTA4 mRNA]20964710
D010269Paraquat[Paraquat co-treated with Maneb] results in increased expression of GSTA4 mRNA20964710
D010269ParaquatParaquat results in increased expression of GSTA4 mRNA16128001|1862071
D010269ParaquatSilymarin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of GSTA4 mRNA]20964710
D010269Paraquat[Acetylcysteine co-treated with EUK-134] promotes the reaction [[Zinc Sulfate co-treated with Paraquat] results in increased activity of GSTA4 protein]25724285
D010269ParaquatAcetylcysteine promotes the reaction [[Paraquat co-treated with Maneb] results in increased expression of and results in increased activity of GSTA4 protein]23159886
D010269ParaquatAcetylcysteine promotes the reaction [[Paraquat co-treated with Maneb] results in increased expression of GSTA4 mRNA]23159886
D010269ParaquatAcetylcysteine promotes the reaction [Paraquat results in increased expression of and results in increased activity of GSTA4 protein]23159886
D010269ParaquatAcetylcysteine promotes the reaction [Paraquat results in increased expression of GSTA4 mRNA]23159886
D010269Paraquat[EUK-134 co-treated with Acetylcysteine] promotes the reaction [Paraquat results in increased activity of GSTA4 protein]25724285
D010269Paraquat[Paraquat co-treated with Maneb] results in increased expression of and results in increased activity of GSTA4 protein23159886
D010269Paraquat[Paraquat co-treated with Maneb] results in increased expression of GSTA4 mRNA23159886
D010269ParaquatParaquat promotes the reaction [Zinc Sulfate results in increased expression of GSTA4 mRNA]20553223|2572428
D010269ParaquatParaquat results in increased activity of GSTA4 protein20888808|2572428
D010269ParaquatParaquat results in increased expression of and results in increased activity of GSTA4 protein23159886
D010269ParaquatParaquat results in increased expression of GSTA4 mRNA20553223|2088880
D010269ParaquatParaquat results in increased expression of GSTA4 protein20888808|2452170
D010269ParaquatSilymarin promotes the reaction [[Paraquat co-treated with Maneb] results in increased expression of and results in increased activity of GSTA4 protein]23159886
D010269ParaquatSilymarin promotes the reaction [[Paraquat co-treated with Maneb] results in increased expression of GSTA4 mRNA]23159886
D010269ParaquatSilymarin promotes the reaction [Paraquat results in increased expression of and results in increased activity of GSTA4 protein]23159886
D010269ParaquatSilymarin promotes the reaction [Paraquat results in increased expression of GSTA4 mRNA]23159886
D010269Paraquat[Zinc Sulfate co-treated with Paraquat] results in increased activity of GSTA4 protein25724285
D010269ParaquatZinc Sulfate promotes the reaction [Paraquat results in increased expression of GSTA4 mRNA]20553223|2572428
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of GSTA4 mRNA"25510870
D010416PentachlorophenolPentachlorophenol results in increased expression of GSTA4 mRNA23892564
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in decreased expression of GSTA4 mRNA23602845
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid affects the expression of GSTA4 mRNA19429403
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of GSTA4 protein26178269
C023036perfluorooctanoic acidperfluorooctanoic acid affects the expression of GSTA4 mRNA19429403
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of GSTA4 mRNA19162173
D010634PhenobarbitalPhenobarbital results in decreased expression of GSTA4 mRNA19952500
D010634PhenobarbitalPhenobarbital results in decreased expression of GSTA4 mRNA19084549
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of GSTA4 mRNA]19482888
D010634PhenobarbitalPhenobarbital results in increased expression of GSTA4 mRNA18723825|1927001
D010634Phenobarbital[Phenobarbital co-treated with Diethylnitrosamine] results in increased expression of GSTA4 protein20935162
D010634PhenobarbitalPhenobarbital results in increased expression of GSTA4 mRNA19162173
D010634PhenobarbitalPhenobarbital results in increased expression of GSTA4 protein9794803
D010695PhlorhizinPhlorhizin results in decreased expression of GSTA4 mRNA22538082
C057590phosphatidylcholine hydroperoxideGSTA4 protein results in decreased susceptibility to phosphatidylcholine hydroperoxide9073611
D010882Piperonyl ButoxidePiperonyl Butoxide results in increased expression of GSTA4 mRNA22484513
C006253pirinixic acidpirinixic acid results in decreased expression of GSTA4 mRNA18467677|2005976
C006253pirinixic acidpirinixic acid results in decreased expression of GSTA4 protein15226431
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in decreased expression of GSTA4 mRNA]18467677|2005976
D010936Plant ExtractsPlant Extracts results in increased expression of GSTA4 mRNA18351577
D010936Plant ExtractsPlant Extracts inhibits the reaction [Lead results in decreased expression of GSTA4 protein]22129743
D011084Polycyclic Aromatic HydrocarbonsPolycyclic Aromatic Hydrocarbons affects the expression of GSTA4 mRNA22579512
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of GSTA4 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of GSTA4 mRNA22079256|2271453
C027373potassium chromate(VI)[Potassium Dichromate co-treated with potassium chromate(VI)] inhibits the reaction [Benzo(a)pyrene results in increased expression of GSTA4 mRNA]14625279
D011192Potassium Dichromate[Potassium Dichromate co-treated with potassium chromate(VI)] inhibits the reaction [Benzo(a)pyrene results in increased expression of GSTA4 mRNA]14625279
D011192Potassium DichromateAscorbic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of GSTA4 mRNA]23470461
D011192Potassium DichromatePotassium Dichromate results in decreased expression of GSTA4 mRNA23470461
C071461pregnenolone 16-acetonitrilepregnenolone 16-acetonitrile results in increased expression of GSTA4 mRNA21311750
D011285Pregnenolone CarbonitrileNR1I2 protein affects the reaction [Pregnenolone Carbonitrile results in increased expression of GSTA4 mRNA]22496397
D011285Pregnenolone CarbonitrileNR1I2 protein promotes the reaction [Pregnenolone Carbonitrile results in increased expression of GSTA4 mRNA]22698814
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of GSTA4 mRNA27413110
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of GSTA4 mRNA22496397|2269881
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of GSTA4 mRNA19162173
D011441PropylthiouracilPropylthiouracil results in increased expression of GSTA4 mRNA24780913
D054328Proton Pump InhibitorsProton Pump Inhibitors results in increased expression of GSTA4 mRNA25626140
C513428pyrachlostrobinpyrachlostrobin results in increased expression of GSTA4 mRNA27029645
C432165pyrazolanthrone"pyrazolanthrone inhibits the reaction [GSTA4 gene mutant form results in increased susceptibility to 1,1,4-tris(acetyloxy)-2-nonene]"24353929
D011763Pyrrolizidine AlkaloidsPyrrolizidine Alkaloids results in decreased expression of GSTA4 mRNA26100227
D011794QuercetinQuercetin results in decreased expression of GSTA4 mRNA21632981
D011794QuercetinQuercetin results in decreased expression of GSTA4 mRNA16455785
D017382Reactive Oxygen SpeciesReactive Oxygen Species affects the expression of GSTA4 mRNA25800948
C059514resveratrolresveratrol results in increased expression of GSTA4 mRNA12002526
C089730rosiglitazone[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of GSTA4 mRNA16054899
C089730rosiglitazonerosiglitazone affects the expression of GSTA4 mRNA17245590
D012402RotenoneRotenone results in increased expression of GSTA4 mRNA23186747
C064116S-(1,1,2,2-tetrafluoroethyl)cysteine"S-(1,1,2,2-tetrafluoroethyl)cysteine results in increased expression of GSTA4 mRNA"16678137
C541923sandostatinLARsandostatinLAR results in increased expression of GSTA4 mRNA17210224
D012524SarinSarin results in decreased expression of GSTA4 mRNA19522546
D012643SeleniumSelenium deficiency results in increased expression of GSTA4 mRNA16170372
D012643SeleniumSelenium results in increased expression of GSTA4 mRNA16170372
C009237senecioninesenecionine results in decreased expression of GSTA4 mRNA26100227
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of GSTA4 mRNA25895662
D012834SilverSilver results in decreased expression of GSTA4 mRNA26551752
D012834SilverSilver results in increased expression of GSTA4 mRNA27131904
D012838SilymarinSilymarin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of GSTA4 mRNA]20964710
D012838SilymarinSilymarin promotes the reaction [Maneb results in increased expression of and results in increased activity of GSTA4 protein]23159886
D012838SilymarinSilymarin promotes the reaction [Maneb results in increased expression of GSTA4 mRNA]23159886
D012838SilymarinSilymarin promotes the reaction [[Paraquat co-treated with Maneb] results in increased expression of and results in increased activity of GSTA4 protein]23159886
D012838SilymarinSilymarin promotes the reaction [[Paraquat co-treated with Maneb] results in increased expression of GSTA4 mRNA]23159886
D012838SilymarinSilymarin promotes the reaction [Paraquat results in increased expression of and results in increased activity of GSTA4 protein]23159886
D012838SilymarinSilymarin promotes the reaction [Paraquat results in increased expression of GSTA4 mRNA]23159886
C017947sodium arsenite[Dietary Fats co-treated with sodium arsenite] results in decreased expression of GSTA4 mRNA28283972
C017947sodium arsenitesodium arsenite affects the expression of GSTA4 mRNA16507464
C017947sodium arsenite[sodium arsenite co-treated with Tetradecanoylphorbol Acetate] results in increased expression of GSTA4 mRNA16368122
C017947sodium arsenitesodium arsenite results in increased expression of GSTA4 mRNA17451858|2828397
C016104sodium bichromatesodium bichromate results in increased expression of GSTA4 mRNA22155349
D012969Sodium FluorideSodium Fluoride results in decreased expression of GSTA4 mRNA27257137
D053260SootSoot results in decreased expression of GSTA4 mRNA22461453
C025906stilbene oxidestilbene oxide results in increased expression of GSTA4 protein9794803
D013311StreptozocinStreptozocin results in increased expression of GSTA4 protein14693714
C014202sulfolithocholic acidsulfolithocholic acid binds to and results in decreased activity of GSTA4 protein3954743
C016766sulforafansulforafan inhibits the reaction [fenamidone results in increased expression of GSTA4 mRNA]27029645
C016766sulforafansulforafan results in increased expression of GSTA4 mRNA19071154|1930389
C016766sulforafansulforafan results in increased expression of GSTA4 protein11309284|1930389
C074269Sunphenon"[3,4,5,3',4'-pentachlorobiphenyl co-treated with Sunphenon] affects the expression of GSTA4 mRNA"24378064
C013698tallowtallow affects the expression of GSTA4 mRNA19680557
D013629TamoxifenTamoxifen affects the expression of GSTA4 mRNA20937368
D013749TetrachlorodibenzodioxinAHR protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of GSTA4 mRNA]22496397
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GSTA4 mRNA21570461|2637764
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of GSTA4 mRNA15328365|1580003
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of GSTA4 protein16548065
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of GSTA4 mRNA16054898|1817854
D013755Tetradecanoylphorbol AcetateGSTA4 affects the susceptibility to Tetradecanoylphorbol Acetate16044405
D013755Tetradecanoylphorbol Acetate[sodium arsenite co-treated with Tetradecanoylphorbol Acetate] results in increased expression of GSTA4 mRNA16368122
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate affects the expression of GSTA416044405
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate affects the localization of GSTA4 protein12646569
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of GSTA4 mRNA27865774
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of GSTA4 mRNA27404394
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of GSTA4 mRNA17494027
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of GSTA4 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of GSTA4 mRNA25729387
C012589trichostatin A[decitabine co-treated with trichostatin A] results in increased expression of GSTA4 mRNA19444856
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of GSTA4 mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of GSTA4 mRNA"26179874
D014415TunicamycinTunicamycin results in decreased expression of GSTA4 mRNA17127020
C113580U 0126"U 0126 inhibits the reaction [GSTA4 gene mutant form results in increased susceptibility to 1,1,4-tris(acetyloxy)-2-nonene]"24353929
C112106UAB 30UAB 30 analog results in increased expression of GSTA4 mRNA23292798
D014520UrethaneUrethane results in decreased expression of GSTA4 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of GSTA4 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of GSTA4 mRNA23179753
D014635Valproic AcidValproic Acid affects the expression of GSTA4 mRNA17292431
D014640VancomycinVancomycin results in increased expression of GSTA4 mRNA18930951
C025643vinclozolinvinclozolin results in increased expression of GSTA4 mRNA20566332
D024483Vitamin K 3Vitamin K 3 affects the expression of GSTA4 mRNA20044591
D015032ZincZinc deficiency results in decreased expression of GSTA4 mRNA11717422
D019287Zinc Sulfate[Acetylcysteine co-treated with EUK-134] promotes the reaction [[Zinc Sulfate co-treated with Paraquat] results in increased activity of GSTA4 protein]25724285
D019287Zinc Sulfate[EUK-134 co-treated with Acetylcysteine] promotes the reaction [Zinc Sulfate results in increased activity of GSTA4 protein]25724285
D019287Zinc SulfateParaquat promotes the reaction [Zinc Sulfate results in increased expression of GSTA4 mRNA]20553223|2572428
D019287Zinc Sulfate[Zinc Sulfate co-treated with Paraquat] results in increased activity of GSTA4 protein25724285
D019287Zinc SulfateZinc Sulfate promotes the reaction [Paraquat results in increased expression of GSTA4 mRNA]20553223|2572428
D019287Zinc SulfateZinc Sulfate results in increased activity of GSTA4 protein25724285
D019287Zinc SulfateZinc Sulfate results in increased expression of GSTA4 mRNA20553223|2572428

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004364glutathione transferase activity-IDA10329152  11851347  
GO:0004364glutathione transferase activity-TAS-  
GO:0005515protein binding-IPI25416956  25910212  27107014  
GO:0042802identical protein binding-IPI16189514  25416956  
GO:0042803protein homodimerization activity-IPI10329152  
GO ID GO Term Qualifier Evidence PubMed
GO:0006749glutathione metabolic process-IDA10329152  
GO:0006805xenobiotic metabolic process-IDA10329152  
GO:1901687glutathione derivative biosynthetic process-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa00480Glutathione metabolism
hsa00980Metabolism of xenobiotics by cytochrome P450
hsa00982Drug metabolism - cytochrome P450
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-156580Phase II - Conjugation of compoundsTAS
R-HSA-156590Glutathione conjugationTAS
R-HSA-211859Biological oxidationsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
20097730Antioxidant genes, diabetes and dietary antioxidants in association with risk of pancreatic cancer. (2010 Apr)Tang HCarcinogenesis
25528427Reactive aldehyde-scavenging enzyme activities in atherosclerotic plaques of cigarette smokers and nonsmokers. (2015 Feb)Lapenna DAtherosclerosis
16940154Glutathione-S-transferase expression in the brain: possible role in ethanol preference and longevity. (2006 Sep)Bjork KFASEB J
25892883Polymorphisms of glutathione S-transferase genes and survival of resected hepatocellular carcinoma patients. (2015 Apr 14)Qu KWorld J Gastroenterol