Gene info: ID 2946

Gene: GSTM2

GENE ID: 2946

Synonyms: GST4|GSTM|GSTM2-2|GTHMUS

Description: glutathione S-transferase mu 2

Gene type: protein-coding

Location: 1p13.3

dbXrefs: Ensembl:ENSG00000213366 MIM:138380 Vega:OTTHUMG00000011638 UniprotKB:P28161

RefSeq: NC_000001.11

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 3

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 2.846e-1 (AD) 9.639e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
SELENBP1	0.866
ACSF2	0.866
EFEMP2	0.863
EZR	0.855
PLTP	0.853
PON2	0.851
FAH	0.839
ITGB5	0.833
PLEKHO2	0.831
STK33	0.828

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.492
GABRG3	-0.462
OR4F29	-0.459
MUM1L1	-0.458
IL12RB2	-0.458
ANKRD34C	-0.428
CALHM1	-0.423
EPHA5	-0.419
KCNH5	-0.418
OPRD1	-0.417

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00143	Glutathione	Small Molecule	70-18-8	Approved\|Investigational\|Nutraceutical	Target
DB02458	S-(2,4-dinitrophenyl)glutathione	Small Molecule	26289-39-4	Experimental	Target
DB03310	Glutathione disulfide	Small Molecule	27025-41-8	Approved\|Experimental\|Investigational	Target
DB04701	S-METHYL-GLUTATHIONE	Small Molecule		Experimental	Target

ID	Drug Name	Action	PubMed
C049325	1,2-dithiol-3-thione	"[1,2-dithiol-3-thione results in increased activity of NFE2L2 protein] which results in increased expression of GSTM2 mRNA"	22495766
C049325	1,2-dithiol-3-thione	"1,2-dithiol-3-thione results in increased expression of GSTM2 mRNA"	19162173
C576882	1-(2-trifluoromethoxyphenyl)-2-nitroethanone	1-(2-trifluoromethoxyphenyl)-2-nitroethanone results in increased expression of GSTM2 protein	22527513
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"[1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased activity of NR1I3 protein] which results in increased expression of GSTM2 mRNA"	22496397
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of GSTM2 mRNA"	18723825\|2249639
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"CTNNB1 protein affects the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of GSTM2 mRNA]"	23578392
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"NR1I3 protein affects the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of GSTM2 mRNA]"	22496397
C042630	1-chloro-2,4-dinitrobenzene-glutathione conjugate	"GSTM2 protein affects the metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate"	11684093
C029790	2,2',3',4,4',5-hexachlorobiphenyl	"2,2',3',4,4',5-hexachlorobiphenyl results in decreased expression of GSTM2 mRNA"	23829299
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of GSTM2 mRNA"	20056577
C014211	2,3,7,8-tetrachlorodibenzofuran	"2,3,7,8-tetrachlorodibenzofuran affects the expression of GSTM2 mRNA"	20702594
C573693	2-(4-((4-(6-methoxy-3-pyridinyl)-5-(4-(trifluoromethoxy)phenyl)-2-thiazolyl)methoxy)-2-methylphenoxy)acetic acid	2-(4-((4-(6-methoxy-3-pyridinyl)-5-(4-(trifluoromethoxy)phenyl)-2-thiazolyl)methoxy)-2-methylphenoxy)acetic acid results in decreased expression of GSTM2 mRNA	22193206
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of GSTM2 mRNA"	21851831
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of GSTM2 mRNA"	28433925
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of GSTM2 mRNA"	21346803
C099328	2-allylphenol	2-allylphenol results in decreased activity of GSTM2 protein	8620581
C082398	2-S-glutathionylcaffeic acid	2-S-glutathionylcaffeic acid results in decreased activity of GSTM2 protein	8340025
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl affects the expression of GSTM2 mRNA"	20702594
C023035	3,4,5,3',4'-pentachlorobiphenyl	"[3,4,5,3',4'-pentachlorobiphenyl co-treated with Sunphenon] affects the expression of GSTM2 mRNA"	24378064
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of GSTM2 mRNA"	18042819
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of GSTM2 mRNA"	23196670
C050224	3,5,5-trimethylhexanoylferrocene	"3,5,5-trimethylhexanoylferrocene results in increased expression of GSTM2 protein"	22649188
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in decreased expression of GSTM2 mRNA"	18648102
C009505	4,4'-diaminodiphenylmethane	"4,4'-diaminodiphenylmethane results in decreased expression of GSTM2 mRNA"	18289764
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GSTM2 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GSTM2 mRNA"	27188386
C010407	4-chloronitrobenzene	GSTM2 protein affects the metabolism of [4-chloronitrobenzene analog co-treated with Glutathione]	8973562
C027576	4-hydroxy-2-nonenal	[GSTM1 protein binds to GSTM2 protein] which affects the metabolism of 4-hydroxy-2-nonenal analog	11256969
C027576	4-hydroxy-2-nonenal	GSTM2 protein results in decreased susceptibility to 4-hydroxy-2-nonenal	15829614
C027576	4-hydroxy-2-nonenal	[GSTM1 protein binds to GSTM2 protein] which affects the metabolism of 4-hydroxy-2-nonenal analog	11256969
C027576	4-hydroxy-2-nonenal	GSTM2 protein affects the metabolism of 4-hydroxy-2-nonenal analog	11256969
C065250	4-hydroxy-equilenin	4-hydroxy-equilenin results in decreased expression of GSTM2 mRNA	15135645
C099327	4-propylphenol	4-propylphenol results in decreased activity of GSTM2 protein	8620581
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GSTM2 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GSTM2 mRNA"	27188386
D000082	Acetaminophen	Acetaminophen affects the expression of GSTM2 mRNA	17562736
D000082	Acetaminophen	Acetaminophen results in decreased expression of GSTM2 mRNA	16611625
D000082	Acetaminophen	[Clofibrate co-treated with Acetaminophen] affects the expression of GSTM2 mRNA	17585979
D000082	Acetaminophen	PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of GSTM2 mRNA]	17585979
D000082	Acetaminophen	Acetaminophen results in decreased expression of GSTM2 mRNA	18346771
D000111	Acetylcysteine	[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in increased expression of GSTM2 mRNA	22129741
D012436	S-Adenosylmethionine	S-Adenosylmethionine inhibits the reaction [Dicarbethoxydihydrocollidine results in increased expression of GSTM2 mRNA]	18098314
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of GSTM2 mRNA	19770486
C006426	aflatoxin B1-2,3-oxide	"GSTM2 protein affects the metabolism of [aflatoxin B1-2,3-oxide co-treated with Glutathione]"	10869451
C038491	allyl sulfide	allyl sulfide results in increased expression of GSTM2 mRNA	18723825
C038491	allyl sulfide	allyl sulfide results in increased expression of GSTM2 mRNA	19695238
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin results in increased expression of GSTM2 protein	26072098
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of GSTM2 mRNA	16483693
C094705	amodiaquine quinoneimine	[GSTM2 protein co-treated with Glutathione] results in increased metabolism of amodiaquine quinoneimine	28478157
C030419	andrographolide	[andrographolide co-treated with beta-Naphthoflavone] results in increased expression of GSTM2 mRNA	19737545
C004984	apocarotenal	apocarotenal results in decreased expression of GSTM2 mRNA	17034753
D001151	Arsenic	Arsenic affects the methylation of GSTM2 gene	25304211
D001205	Ascorbic Acid	Ascorbic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of GSTM2 mRNA]	23470461
D001205	Ascorbic Acid	Ascorbic Acid results in increased expression of GSTM2 mRNA	15372504
C005948	astaxanthine	[astaxanthine co-treated with Docosahexaenoic Acids] results in increased expression of GSTM2 mRNA	24157545
C005948	astaxanthine	[astaxanthine co-treated with Eicosapentaenoic Acid] results in increased expression of GSTM2 mRNA	24157545
C005948	astaxanthine	astaxanthine results in increased expression of GSTM2 mRNA	24157545
D001280	Atrazine	Atrazine results in decreased expression of GSTM2 mRNA	22236720
D001280	Atrazine	Atrazine results in increased expression of GSTM2 mRNA	22236720
D001280	Atrazine	[Chlorpyrifos co-treated with Atrazine] results in decreased expression of GSTM2 mRNA	22236720
D001280	Atrazine	[Chlorpyrifos co-treated with Atrazine] results in increased expression of GSTM2 mRNA	22236720
D001280	Atrazine	Atrazine results in increased expression of GSTM2 mRNA	22378314
D001414	Bacitracin	Bacitracin results in increased expression of GSTM2 mRNA	18289764
D019324	beta-Naphthoflavone	[andrographolide co-treated with beta-Naphthoflavone] results in increased expression of GSTM2 mRNA	19737545
D019324	beta-Naphthoflavone	beta-Naphthoflavone results in increased expression of GSTM2 mRNA	19695238
D001564	Benzo(a)pyrene	GSTM2 protein results in decreased susceptibility to Benzo(a)pyrene	19900515
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of GSTM2 mRNA	20127859
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of GSTM2 mRNA	27195522
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of GSTM2 mRNA	21839799
C005465	benzothiazole	benzothiazole results in increased expression of GSTM2 mRNA	8951341
C025383	benzylideneacetone	GSTM2 protein affects the metabolism of benzylideneacetone	1859377
C072553	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of GSTM2 mRNA	20061341
C038328	BEP protocol	BEP protocol results in increased expression of GSTM2 mRNA	18987330\|2320077
D019207	beta Carotene	beta Carotene results in increased expression of GSTM2 mRNA	17034753
C099952	bifenthrin	bifenthrin results in increased expression of GSTM2 mRNA	26071804
C452139	BIRB 796	BIRB 796 results in increased expression of GSTM2 mRNA	21328587
C006780	bisphenol A	bisphenol A results in increased methylation of GSTM2 promoter	27312807
C006780	bisphenol A	"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of GSTM2 mRNA"	28433925
C006780	bisphenol A	bisphenol A affects the expression of GSTM2 mRNA	25181051
C006780	bisphenol A	bisphenol A results in decreased expression of GSTM2 mRNA	15901920
C584056	BMS-764459	BMS-764459 results in increased expression of GSTM2 mRNA	23831372
C032036	bromobenzene	bromobenzene metabolite binds to GSTM2 protein	17305373
D015124	8-Bromo Cyclic Adenosine Monophosphate	8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of GSTM2 mRNA	22079614
D019328	Buthionine Sulfoximine	Buthionine Sulfoximine results in increased expression of GSTM2 mRNA	15878706
D002083	Butylated Hydroxyanisole	Butylated Hydroxyanisole results in increased expression of GSTM2 mRNA	18723825
D002083	Butylated Hydroxyanisole	Butylated Hydroxyanisole results in increased expression of GSTM2 protein	11991805\|1859377
D002084	Butylated Hydroxytoluene	Butylated Hydroxytoluene results in increased expression of GSTM2 mRNA	12082028\|1853937
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in decreased expression of GSTM2 mRNA	15336504
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in decreased expression of GSTM2 protein	24394546
D020122	tert-Butylhydroperoxide	GSTM2 protein results in decreased susceptibility to tert-Butylhydroperoxide	15003993
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in increased expression of GSTM2 mRNA	15003993\|1533650
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in decreased expression of GSTM2 protein	24394546
C018475	butyraldehyde	butyraldehyde results in decreased expression of GSTM2 mRNA	26079696
D002087	Butyrates	Butyrates results in increased expression of and results in increased activity of GSTM2 protein	12896903
D002087	Butyrates	Butyrates results in increased expression of GSTM2 mRNA	12896903\|1574616
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of GSTM2 mRNA	15501611
D019256	Cadmium Chloride	[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of GSTM2 mRNA	19840844
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of GSTM2 mRNA	18636176
C040048	caffeic acid	caffeic acid results in decreased activity of GSTM2 protein	8340025
D002220	Carbamazepine	Carbamazepine results in increased expression of GSTM2 mRNA	17381134
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of GSTM2 mRNA	27339419
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of GSTM2 mRNA	16239168\|1834677
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of GSTM2 mRNA	17805973
D002330	Carmustine	GSTM2 protein results in decreased nitrosation of Carmustine	11841793
D002392	Catechin	Catechin results in decreased expression of GSTM2 mRNA	19838946
D002635	Chenodeoxycholic Acid	Chenodeoxycholic Acid binds to and results in decreased activity of GSTM2 protein	3954743
C084597	chlorcyclizine	chlorcyclizine results in increased expression of GSTM2 mRNA	21058326
D002713	Chlorine	Chlorine results in decreased expression of GSTM2 mRNA	18636392
D002713	Chlorine	[Ozone co-treated with Chlorine] affects the expression of GSTM2 mRNA	18636392
D004390	Chlorpyrifos	Chlorpyrifos affects the expression of GSTM2 mRNA	22236720
D004390	Chlorpyrifos	[Chlorpyrifos co-treated with Atrazine] results in decreased expression of GSTM2 mRNA	22236720
D004390	Chlorpyrifos	[Chlorpyrifos co-treated with Atrazine] results in increased expression of GSTM2 mRNA	22236720
D004390	Chlorpyrifos	Chlorpyrifos results in decreased expression of GSTM2 mRNA	22236720
D004390	Chlorpyrifos	Chlorpyrifos results in increased expression of GSTM2 mRNA	22236720
D004390	Chlorpyrifos	Chlorpyrifos affects the expression of GSTM2 mRNA	19440498
D019826	Cholic Acid	Cholic Acid results in increased expression of GSTM2 mRNA	17521389
D019826	Cholic Acid	Cholic Acid binds to and results in decreased activity of GSTM2 protein	3954743
C012842	Cibacron Blue F 3GA	Cibacron Blue F 3GA results in decreased activity of GSTM2 protein	8968379
C039671	ciglitazone	ciglitazone results in decreased expression of GSTM2 mRNA	22193206
D002994	Clofibrate	[Clofibrate co-treated with Acetaminophen] affects the expression of GSTM2 mRNA	17585979
D002994	Clofibrate	[Clofibrate co-treated with PPARA protein mutant form] results in increased expression of GSTM2 mRNA	22496397
D002994	Clofibrate	PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of GSTM2 mRNA]	17585979
D002994	Clofibrate	Clofibrate results in decreased expression of GSTM2 mRNA	11328961
D002995	Clofibric Acid	Clofibric Acid affects the expression of GSTM2 mRNA	17602206
D002995	Clofibric Acid	[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of GSTM2 mRNA	17602206
D003024	Clozapine	Clozapine results in decreased expression of GSTM2 mRNA	15860345
D003300	Copper	[ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of GSTM2 mRNA	15467011
D003300	Copper	Copper results in decreased expression of GSTM2 mRNA	22465980
D003345	Corticosterone	Corticosterone results in increased expression of GSTM2 mRNA	15755911
D003345	Corticosterone	Corticosterone results in increased expression of GSTM2 protein	15755911
D003407	Creosote	Creosote results in increased expression of GSTM2 mRNA	19389177
C007164	cumene hydroperoxide	GSTM2 protein affects the metabolism of cumene hydroperoxide	11684093
C057862	cyanoginosin LR	cyanoginosin LR results in increased expression of GSTM2 mRNA	17654400
D003520	Cyclophosphamide	Cyclophosphamide results in decreased expression of GSTM2 mRNA	11906922
C089595	cylindrospermopsin	cylindrospermopsin results in decreased expression of GSTM2 mRNA	23726867
C093628	cyproconazole	cyproconazole results in increased expression of GSTM2 mRNA	22334560
C093628	cyproconazole	cyproconazole results in increased expression of GSTM2 mRNA	25182419
C014347	decitabine	[decitabine affects the methylation of GSTM2 promoter] which affects the expression of GSTM2 mRNA	18664505\|1866450
C014347	decitabine	[decitabine affects the methylation of GSTM2 promoter] which affects the expression of GSTM2 protein	18664505\|1866450
C014347	decitabine	decitabine inhibits the reaction [DNMT3B protein binds to GSTM2 promoter]	21246532
C014347	decitabine	decitabine promotes the reaction [SP1 protein binds to GSTM2 promoter]	21246532
C014347	decitabine	decitabine results in increased expression of GSTM2 mRNA	19900515\|2124653
C014347	decitabine	trichostatin A promotes the reaction [[decitabine affects the methylation of GSTM2 promoter] which affects the expression of GSTM2 protein]	18664505\|1866450
C047386	desethylamodiaquine	[GSTM2 protein co-treated with Glutathione] results in increased metabolism of desethylamodiaquine	28478157
D003907	Dexamethasone	Dexamethasone results in increased expression of GSTM2 mRNA	18723825
D003907	Dexamethasone	Dexamethasone affects the expression of GSTM2 mRNA	15102944
D003907	Dexamethasone	Dexamethasone results in increased expression of GSTM2 mRNA	1394205\|20032058
D003907	Dexamethasone	Testosterone inhibits the reaction [Dexamethasone results in increased expression of GSTM2 mRNA]	20032058
D003976	Diazinon	Diazinon results in increased expression of GSTM2 mRNA	19440498
D003993	Dibutyl Phthalate	Dibutyl Phthalate affects the expression of GSTM2 mRNA	21745491
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of GSTM2 mRNA	21266533
D003997	Dicarbethoxydihydrocollidine	Dicarbethoxydihydrocollidine results in increased expression of GSTM2 mRNA	18098314
D003997	Dicarbethoxydihydrocollidine	S-Adenosylmethionine inhibits the reaction [Dicarbethoxydihydrocollidine results in increased expression of GSTM2 mRNA]	18098314
D002945	Cisplatin	GSTM2 protein affects the susceptibility to Cisplatin	16217747
D002945	Cisplatin	Cisplatin affects the expression of GSTM2 mRNA	20623750
D004008	Diclofenac	Diclofenac results in decreased activity of GSTM2 protein	27183920
C121718	dicyclanil	[dicyclanil co-treated with Diethylnitrosamine] results in increased expression of GSTM2 mRNA	19182440
C121718	dicyclanil	dicyclanil results in increased expression of GSTM2 mRNA	15664270
C121718	dicyclanil	Plant Extracts inhibits the reaction [[Diethylnitrosamine co-treated with dicyclanil] results in increased expression of GSTM2 mRNA]	19182440
D004041	Dietary Fats	Dietary Fats affects the expression of GSTM2 mRNA	19680557
D004041	Dietary Fats	[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of GSTM2 mRNA	28433925
D019422	Dietary Sucrose	[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of GSTM2 mRNA	28433925
D004051	Diethylhexyl Phthalate	"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of GSTM2 mRNA"	28433925
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in decreased expression of GSTM2 protein	8914623
D004052	Diethylnitrosamine	[dicyclanil co-treated with Diethylnitrosamine] results in increased expression of GSTM2 mRNA	19182440
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of GSTM2 mRNA	24535843
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of GSTM2 mRNA	17942915
D004052	Diethylnitrosamine	MET protein inhibits the reaction [Diethylnitrosamine results in increased expression of GSTM2 mRNA]	17942915
D004052	Diethylnitrosamine	Plant Extracts inhibits the reaction [[Diethylnitrosamine co-treated with dicyclanil] results in increased expression of GSTM2 mRNA]	19182440
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of GSTM2 mRNA	17602206
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of GSTM2 mRNA	18544905
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with kojic acid] results in increased expression of GSTM2 mRNA	18544905
D004052	Diethylnitrosamine	[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of GSTM2 mRNA	18253720\|1877588
D004052	Diethylnitrosamine	[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in increased expression of GSTM2 mRNA	22129741
D004052	Diethylnitrosamine	[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of GSTM2 mRNA	22129741
D002117	Calcitriol	Calcitriol results in increased expression of GSTM2 mRNA	21592394
D002117	Calcitriol	[Testosterone co-treated with Calcitriol] results in increased expression of GSTM2 mRNA	21592394
D004121	Dimethyl Sulfoxide	Dimethyl Sulfoxide results in increased expression of GSTM2 mRNA	22193206
D004137	Dinitrochlorobenzene	GSTM2 protein affects the metabolism of Dinitrochlorobenzene	3570286
D004137	Dinitrochlorobenzene	GSTM2 protein affects the metabolism of Dinitrochlorobenzene	10869451
D004137	Dinitrochlorobenzene	GSTM2 protein affects the metabolism of [Dinitrochlorobenzene co-treated with Glutathione]	2375757
D004137	Dinitrochlorobenzene	GSTM2 protein affects the metabolism of [Dinitrochlorobenzene co-treated with Glutathione analog]	2375757
D004137	Dinitrochlorobenzene	Dinitrochlorobenzene affects the activity of GSTM2 protein	9794801
D004137	Dinitrochlorobenzene	Dinitrochlorobenzene promotes the reaction [GSTM2 protein affects the metabolism of Glutathione]	9794801
D004137	Dinitrochlorobenzene	Dinitrochlorobenzene results in increased expression of GSTM2 protein	9794801
D004178	Diquat	Diquat results in decreased expression of GSTM2 mRNA	7676460
D004281	Docosahexaenoic Acids	[astaxanthine co-treated with Docosahexaenoic Acids] results in increased expression of GSTM2 mRNA	24157545
D004281	Docosahexaenoic Acids	Docosahexaenoic Acids results in increased expression of GSTM2 mRNA	24157545
D004317	Doxorubicin	Doxorubicin results in increased oxidation of GSTM2 protein	28818578
C042986	ebselen	ebselen binds to and results in decreased activity of [GSTM1 protein binds to GSTM2 protein]	8147899
D015118	Eicosapentaenoic Acid	[astaxanthine co-treated with Eicosapentaenoic Acid] results in increased expression of GSTM2 mRNA	24157545
D015118	Eicosapentaenoic Acid	Eicosapentaenoic Acid results in increased expression of GSTM2 mRNA	24157545
C045651	epigallocatechin gallate	epigallocatechin gallate results in increased expression of GSTM2 mRNA	10927022
C045651	epigallocatechin gallate	epigallocatechin gallate results in increased expression of GSTM2 protein	10927022
C109476	epoxiconazole	epoxiconazole results in increased expression of GSTM2 mRNA	22334560
C109476	epoxiconazole	epoxiconazole results in increased expression of GSTM2 mRNA	25182419
D004852	Epoxy Compounds	GSTM2 protein affects the metabolism of Epoxy Compounds	8924604
D000431	Ethanol	Ethanol results in increased expression of GSTM2 mRNA	19167417
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of GSTM2 mRNA	12655037\|1557682
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of GSTM2 mRNA	12082028
D005015	Ethoxyquin	Ethoxyquin results in increased expression of GSTM2 mRNA	18723825
D005015	Ethoxyquin	Ethoxyquin results in increased expression of GSTM2 mRNA	19695238
C024565	ethylene dichloride	ethylene dichloride results in decreased expression of GSTM2 mRNA	28189721
D005031	Ethylenethiourea	Ethylenethiourea results in increased expression of GSTM2 mRNA	18801409
D005054	Eugenol	Eugenol analog results in decreased activity of GSTM2 protein	8620581
C436526	EUK-189	EUK-189 inhibits the reaction [SOD2 gene mutant form results in increased expression of GSTM2 mRNA]	15964507
C047360	felbamate	felbamate results in increased expression of GSTM2 mRNA	17381134
D011345	Fenofibrate	[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of GSTM2 mRNA	18253720\|1877588
D011345	Fenofibrate	Fenofibrate results in decreased expression of GSTM2 mRNA	18775883
C009264	fenoprop	fenoprop results in decreased expression of GSTM2 protein	8914623
C082360	fipronil	fipronil results in increased expression of GSTM2 mRNA	23962444
D005419	Flavonoids	Flavonoids results in decreased expression of GSTM2 mRNA	18035473
D005485	Flutamide	Flutamide results in increased expression of GSTM2 mRNA	24136188
D005485	Flutamide	Flutamide results in increased expression of GSTM2 protein	17311803
C473894	fujiflavone P40	fujiflavone P40 results in increased expression of GSTM2 mRNA	14656947
C056933	fumonisin B1	fumonisin B1 results in increased expression of GSTM2 mRNA	16221962
C039281	furan	furan results in decreased expression of GSTM2 mRNA	25539665
C007835	geniposide	geniposide results in increased expression of GSTM2 mRNA	14646352
C007835	geniposide	geniposide results in increased expression of GSTM2 protein	14646352
D005912	Gliotoxin	Gliotoxin results in decreased expression of GSTM2 mRNA	18346771
D005938	Glucocorticoids	Glucocorticoids results in increased expression of GSTM2 mRNA	1944302
D005961	Glucosinolates	Glucosinolates results in increased expression of GSTM2 protein	15570060
D005978	Glutathione	Glutathione binds to GSTM2 protein	2337594
D005978	Glutathione	GSTM2 protein affects the metabolism of Glutathione	10858281
D005978	Glutathione	[GSTM2 protein co-treated with Glutathione] results in increased metabolism of amodiaquine quinoneimine	28478157
D005978	Glutathione	[GSTM2 protein co-treated with Glutathione] results in increased metabolism of desethylamodiaquine	28478157
D005978	Glutathione	"GSTM2 protein affects the metabolism of [aflatoxin B1-2,3-oxide co-treated with Glutathione]"	10869451
D005978	Glutathione	GSTM2 protein affects the metabolism of [Dinitrochlorobenzene co-treated with Glutathione]	2375757
D005978	Glutathione	GSTM2 protein affects the metabolism of [Dinitrochlorobenzene co-treated with Glutathione analog]	2375757
D005978	Glutathione	Dinitrochlorobenzene promotes the reaction [GSTM2 protein affects the metabolism of Glutathione]	9794801
D005978	Glutathione	GSTM2 protein affects the metabolism of [4-chloronitrobenzene analog co-treated with Glutathione]	8973562
D005978	Glutathione	GSTM2 protein affects the metabolism of Glutathione	8924604
D005978	Glutathione	GSTM2 protein affects the metabolism of [styrene oxide co-treated with Glutathione]	2604743
D006118	Griseofulvin	Griseofulvin affects the expression of GSTM2 mRNA	12735108
D006220	Haloperidol	Haloperidol results in decreased expression of GSTM2 mRNA	15860345
D006581	Hexachlorobenzene	Hexachlorobenzene results in increased expression of GSTM2 mRNA	15159207
C033550	hexylglutathione	hexylglutathione results in decreased activity of GSTM2 protein	10858281
D017313	Fenretinide	Fenretinide results in increased expression of GSTM2 mRNA	28973697
C029424	hydrazine	hydrazine results in decreased expression of GSTM2 mRNA	15370871
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased expression of GSTM2 mRNA	15003993
C016517	indole-3-carbinol	indole-3-carbinol affects the expression of GSTM2 mRNA	21396975
C016517	indole-3-carbinol	[indole-3-carbinol co-treated with Diethylnitrosamine co-treated with Acetylcysteine] results in increased expression of GSTM2 mRNA	22129741
C016517	indole-3-carbinol	[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of GSTM2 mRNA	22129741
D007213	Indomethacin	Indomethacin results in increased expression of GSTM2 mRNA	18299717
C031050	isomethyleugenol	isomethyleugenol results in decreased activity of GSTM2 protein	8620581
C098607	JP8 aviation fuel	JP8 aviation fuel affects the expression of GSTM2 mRNA	12539871
C006552	kaempferol	[Quercetin co-treated with kaempferol] results in increased expression of GSTM2 mRNA	25111660
D007654	Ketoconazole	Ketoconazole affects the expression of GSTM2 mRNA	18289764
D007659	Ketones	GSTM2 protein affects the metabolism of Ketones	8924604
C011890	kojic acid	[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of GSTM2 mRNA	18544905
C011890	kojic acid	[Diethylnitrosamine co-treated with kojic acid] results in increased expression of GSTM2 mRNA	18544905
C099406	L 742694	L 742694 affects the expression of GSTM2 mRNA	15102944
C008261	lead acetate	lead acetate results in decreased expression of GSTM2 protein	9750042
C008261	lead acetate	lead acetate results in increased expression of GSTM2 protein	9750042
C482199	lipopolysaccharide, E coli O55-B5	"lipopolysaccharide, E coli O55-B5 results in decreased expression of GSTM2 mRNA"	18346771
C482199	lipopolysaccharide, E coli O55-B5	"[Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of GSTM2 mRNA"	20371263
D008095	Lithocholic Acid	Lithocholic Acid binds to and results in decreased activity of GSTM2 protein	3954743
D008095	Lithocholic Acid	Lithocholic Acid results in increased expression of GSTM2 mRNA	21311750
C042720	mercuric bromide	mercuric bromide results in decreased expression of GSTM2 mRNA	26272509
C042720	mercuric bromide	"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GSTM2 mRNA"	27188386
D008701	Methapyrilene	Methapyrilene results in decreased expression of GSTM2 mRNA	16393664
C005223	methyleugenol	methyleugenol results in decreased activity of GSTM2 protein	8620581
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of GSTM2 mRNA	28001369
D008769	Methylnitronitrosoguanidine	[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of GSTM2 mRNA	19840844
D008769	Methylnitronitrosoguanidine	[Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of GSTM2 mRNA	19840844
D008769	Methylnitronitrosoguanidine	[Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of GSTM2 mRNA	19840844
D015655	1-Methyl-4-phenylpyridinium	1-Methyl-4-phenylpyridinium results in decreased expression of GSTM2 protein	24806433
D052998	Microcystins	Microcystins results in decreased expression of GSTM2 mRNA	19790251
D052998	Microcystins	Microcystins results in increased expression of GSTM2 mRNA	19790251
D009151	Mustard Gas	Mustard Gas results in decreased expression of GSTM2 mRNA	18955075
C583365	N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide	"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of GSTM2 mRNA"	29244179
D009255	Nafenopin	Nafenopin results in decreased expression of GSTM2 protein	8914623
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of GSTM2 mRNA"	25554681\|2562005
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of GSTM2 mRNA"	25554681\|2562005
C031721	naphthalene	naphthalene affects the expression of GSTM2 protein	10959795
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate results in increased expression of GSTM2 mRNA	18289764
C051752	nefazodone	nefazodone results in increased expression of GSTM2 mRNA	24136188
D009532	Nickel	Nickel results in decreased expression of GSTM2 mRNA	24768652\|2558310
D009532	Nickel	Nickel results in decreased expression of GSTM2 mRNA	19440498
C022838	nickel chloride	nickel chloride results in decreased expression of GSTM2 mRNA	14645679
C028007	nickel monoxide	nickel monoxide results in decreased expression of GSTM2 mRNA	19167457
D009569	Nitric Oxide	Nitric Oxide deficiency results in increased expression of GSTM2 mRNA	15878706
D005996	Nitroglycerin	GSTM2 protein affects the metabolism of Nitroglycerin	8968379
C025589	ochratoxin A	ochratoxin A results in increased expression of GSTM2 mRNA	24120684
D019319	Okadaic Acid	[Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of GSTM2 mRNA	19840844
C026209	oltipraz	NFE2L2 protein affects the reaction [oltipraz results in increased expression of GSTM2 mRNA]	22496397
C026209	oltipraz	[oltipraz results in increased activity of NFE2L2 protein] which results in increased expression of GSTM2 mRNA	22496397
C026209	oltipraz	oltipraz results in increased expression of GSTM2 mRNA	18723825\|2249639
C016340	o,p'-DDT	"o,p'-DDT affects the expression of GSTM2 mRNA"	18925944
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in increased expression of GSTM2 mRNA	25729387
C030110	oxaliplatin	oxaliplatin results in increased expression of GSTM2 mRNA	25729387
D010126	Ozone	[Ozone co-treated with Chlorine] affects the expression of GSTM2 mRNA	18636392
D010126	Ozone	Ozone results in decreased expression of GSTM2 mRNA	16716893
D000073878	Palm Oil	Palm Oil affects the expression of GSTM2 mRNA	19680557
D010261	Paraoxon	Paraoxon results in increased expression of GSTM2	24486155
D010269	Paraquat	Paraquat results in increased expression of GSTM2 mRNA	16128001\|2137155
D010269	Paraquat	Paraquat results in decreased expression of GSTM2 mRNA	17935786
D010269	Paraquat	Paraquat results in increased expression of GSTM2 mRNA	16555045
D052638	Particulate Matter	Particulate Matter results in increased expression of GSTM2 mRNA	22352393
D010416	Pentachlorophenol	Pentachlorophenol results in increased expression of GSTM2 mRNA	23892564
C494474	perchlorate	perchlorate results in increased expression of GSTM2 mRNA	18801409
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in decreased expression of GSTM2 mRNA	19162173
C023036	perfluorooctanoic acid	perfluorooctanoic acid affects the expression of GSTM2 mRNA	18281256
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of GSTM2 mRNA	20118188
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of GSTM2 mRNA	20936131
C023036	perfluorooctanoic acid	PPARA promotes the reaction [perfluorooctanoic acid results in increased expression of GSTM2 mRNA]	20118188
C023036	perfluorooctanoic acid	PPARA protein promotes the reaction [perfluorooctanoic acid results in increased expression of GSTM2 mRNA]	20936131
D015232	Dinoprostone	GSTM2 protein affects the chemical synthesis of Dinoprostone	10905636
D044262	Prostaglandin H2	GSTM2 protein affects the metabolism of Prostaglandin H2	10905636
D010634	Phenobarbital	[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of GSTM2 mRNA	24535843
D010634	Phenobarbital	NR1I3 protein affects the reaction [Phenobarbital results in increased expression of GSTM2 mRNA]	19482888
D010634	Phenobarbital	[Phenobarbital co-treated with CTNNB1 protein mutant form] results in increased expression of GSTM2 mRNA	20118494
D010634	Phenobarbital	Phenobarbital results in increased expression of GSTM2 mRNA	19270015\|1948288
D010634	Phenobarbital	Phenobarbital results in increased expression of GSTM2 mRNA	12082028\|1283266
D010634	Phenobarbital	Phenobarbital results in increased expression of GSTM2 protein	8242872
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GSTM2 mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in decreased expression of GSTM2 mRNA	26272509
D010672	Phenytoin	Phenytoin results in increased expression of GSTM2 mRNA	17381134
D010695	Phlorhizin	Phlorhizin results in increased expression of GSTM2 mRNA	22538082
D010795	Phthalic Acids	Phthalic Acids results in decreased expression of GSTM2 mRNA	15728792
C006253	pirinixic acid	pirinixic acid results in decreased expression of GSTM2 mRNA	16221962\|1742611
C006253	pirinixic acid	PPARA protein promotes the reaction [pirinixic acid results in decreased expression of GSTM2 mRNA]	20059764
D010936	Plant Extracts	Plant Extracts inhibits the reaction [[Diethylnitrosamine co-treated with dicyclanil] results in increased expression of GSTM2 mRNA]	19182440
D010936	Plant Extracts	Plant Extracts results in increased expression of GSTM2 mRNA	22178802
D010936	Plant Extracts	Plant Extracts results in increased expression of GSTM2 protein	15570060
D011192	Potassium Dichromate	Ascorbic Acid inhibits the reaction [Potassium Dichromate results in decreased expression of GSTM2 mRNA]	23470461
D011192	Potassium Dichromate	Potassium Dichromate results in decreased expression of GSTM2 mRNA	23470461
C071461	pregnenolone 16-acetonitrile	pregnenolone 16-acetonitrile results in increased expression of GSTM2 mRNA	21311750
D011285	Pregnenolone Carbonitrile	NR1I2 protein affects the reaction [Pregnenolone Carbonitrile results in increased expression of GSTM2 mRNA]	22496397
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile promotes the reaction [NR1I2 protein binds to GSTM2 gene]	20693526
D011285	Pregnenolone Carbonitrile	[Pregnenolone Carbonitrile results in increased activity of NR1I2 protein] which results in increased expression of GSTM2 mRNA	22496397
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in increased expression of GSTM2 mRNA	18723825\|2249639
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in increased expression of GSTM2 mRNA	19162173
D011374	Progesterone	Progesterone affects the expression of GSTM2 mRNA	17251523
C045950	propiconazole	propiconazole results in increased expression of GSTM2 mRNA	16730040\|2127805
D011458	Prostaglandins E	GSTM2 protein affects the chemical synthesis of Prostaglandins E	10905636
D011794	Quercetin	[Quercetin co-treated with kaempferol] results in increased expression of GSTM2 mRNA	25111660
C052785	rebamipide	rebamipide results in increased expression of GSTM2 mRNA	18299717
C013672	riddelliine	riddelliine results in decreased expression of GSTM2 mRNA	18047727
D012402	Rotenone	Rotenone results in increased expression of GSTM2 mRNA	23186747
C058186	S-hexylglutathione-sepharose	S-hexylglutathione-sepharose binds to GSTM2 protein	2337594
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased expression of GSTM2 mRNA	25895662
D012834	Silver	Silver results in increased expression of GSTM2 mRNA	27131904
C017947	sodium arsenite	sodium arsenite results in increased expression of GSTM2 mRNA	25879800
C017947	sodium arsenite	sodium arsenite results in increased expression of GSTM2 mRNA	14691202
C016104	sodium bichromate	sodium bichromate results in decreased expression of GSTM2 mRNA	22155349
C016104	sodium bichromate	sodium bichromate results in increased expression of GSTM2 mRNA	22155349
C016104	sodium bichromate	sodium bichromate results in increased expression of GSTM2 mRNA	12325037
D012969	Sodium Fluoride	Sodium Fluoride results in decreased expression of GSTM2 protein	28918527
D013148	Spironolactone	Spironolactone results in increased expression of GSTM2 mRNA	18723825
D013311	Streptozocin	Streptozocin results in increased expression of GSTM2 mRNA	16684804
D013311	Streptozocin	vanadyl sulfate inhibits the reaction [Streptozocin results in increased expression of GSTM2 mRNA]	16684804
C041711	St. Thomas' Hospital cardioplegic solution	St. Thomas' Hospital cardioplegic solution results in increased expression of GSTM2 mRNA	16214533
C013690	styrene oxide	GSTM2 protein affects the metabolism of styrene oxide	1638515
C013690	styrene oxide	GSTM2 protein affects the metabolism of [styrene oxide co-treated with Glutathione]	2604743
D013448	Sulfobromophthalein	Sulfobromophthalein results in decreased activity of GSTM2 protein	8968379
C014202	sulfolithocholic acid	sulfolithocholic acid binds to and results in decreased activity of GSTM2 protein	3954743
D013467	Sulindac	"[Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of GSTM2 mRNA"	20371263
C074269	Sunphenon	"[3,4,5,3',4'-pentachlorobiphenyl co-treated with Sunphenon] affects the expression of GSTM2 mRNA"	24378064
D013619	Tacrine	Tacrine results in increased expression of GSTM2 mRNA	12832660
C013698	tallow	tallow affects the expression of GSTM2 mRNA	19680557
C030141	taurine-ursodeoxycholate conjugate	taurine-ursodeoxycholate conjugate inhibits the reaction [LEP gene mutant form results in increased expression of GSTM2 mRNA]	21079772
D013739	Testosterone	[Testosterone co-treated with Calcitriol] results in increased expression of GSTM2 mRNA	21592394
D013739	Testosterone	Testosterone results in decreased expression of GSTM2 mRNA	21592394
D013739	Testosterone	Testosterone results in decreased expression of GSTM2 mRNA	20403060
D013739	Testosterone	Testosterone inhibits the reaction [Dexamethasone results in increased expression of GSTM2 mRNA]	20032058
D013749	Tetrachlorodibenzodioxin	AHR protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of GSTM2 mRNA]	22496397
D013749	Tetrachlorodibenzodioxin	NFE2L2 protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of GSTM2 mRNA]	19474220
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of GSTM2 mRNA	20702594\|2637764
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of GSTM2 mRNA	16214954
D013749	Tetrachlorodibenzodioxin	"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of GSTM2 mRNA"	28433925
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of GSTM2 mRNA	18172886\|1879615
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of GSTM2 protein	12361703
D013755	Tetradecanoylphorbol Acetate	[Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of GSTM2 mRNA	19840844
D015647	2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine	"2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in increased expression of GSTM2 protein"	25852303
D013806	Theophylline	Theophylline results in decreased expression of GSTM2 mRNA	16083514
D013844	Thiazoles	Thiazoles results in increased expression of GSTM2 mRNA	8951341
D013844	Thiazoles	Thiazoles results in increased expression of GSTM2 protein	8951341
D013849	Thimerosal	Thimerosal results in decreased expression of GSTM2 mRNA	27188386
D013853	Thioacetamide	Thioacetamide results in increased expression of GSTM2 mRNA	15497818
D014050	Toluene	Toluene affects the expression of GSTM2 mRNA	18653662
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in increased expression of GSTM2 mRNA	25729387
D019772	Topotecan	Topotecan results in increased expression of GSTM2 mRNA	25729387
D014212	Tretinoin	Tretinoin results in decreased expression of GSTM2 mRNA	16604517
C012589	trichostatin A	trichostatin A affects the expression of GSTM2 mRNA	18664505
C012589	trichostatin A	trichostatin A promotes the reaction [[decitabine affects the methylation of GSTM2 promoter] which affects the expression of GSTM2 protein]	18664505\|1866450
C010360	triethyllead	triethyllead results in decreased expression of GSTM2 mRNA	9020200
D014302	Trinitrobenzenesulfonic Acid	Trinitrobenzenesulfonic Acid results in decreased expression of GSTM2 mRNA	17982090
D014303	Trinitrotoluene	Trinitrotoluene affects the expression of GSTM2 mRNA	21346803
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of GSTM2 mRNA"	26179874
D014635	Valproic Acid	Valproic Acid affects the expression of GSTM2 mRNA	17292431\|1796380
D014635	Valproic Acid	Valproic Acid results in increased expression of GSTM2 mRNA	17381134
C034028	vanadyl sulfate	vanadyl sulfate inhibits the reaction [Streptozocin results in increased expression of GSTM2 mRNA]	16684804
D001335	Vehicle Emissions	Vehicle Emissions results in increased expression of GSTM2 mRNA	22352393
C025643	vinclozolin	vinclozolin affects the expression of GSTM2 mRNA	19015723
D015032	Zinc	Zinc deficiency results in decreased expression of GSTM2 mRNA	11717422

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004364	glutathione transferase activity	-	IDA	2034681 8373352 16549767
GO:0004364	glutathione transferase activity	-	TAS	-
GO:0004602	glutathione peroxidase activity	-	IDA	16624487
GO:0005102	signaling receptor binding	-	IPI	22406107
GO:0005515	protein binding	-	IPI	24965446
GO:0019899	enzyme binding	-	IPI	8373352
GO:0042803	protein homodimerization activity	-	IPI	8373352
GO:0043295	glutathione binding	-	IDA	2034681 8373352

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006749	glutathione metabolic process	-	IDA	2034681 8373352 16549767
GO:0010880	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	-	IDA	17023043
GO:0010881	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion	-	IC	17023043 22406107
GO:0014809	regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion	-	IC	17023043
GO:0018916	nitrobenzene metabolic process	-	IDA	2034681 8373352
GO:0042178	xenobiotic catabolic process	-	IDA	2034681 8373352 16549767
GO:0043651	linoleic acid metabolic process	-	IDA	16624487
GO:0055119	relaxation of cardiac muscle	-	TAS	21323602
GO:0060315	negative regulation of ryanodine-sensitive calcium-release channel activity	-	IDA	17023043 22406107
GO:0060316	positive regulation of ryanodine-sensitive calcium-release channel activity	-	IDA	17023043
GO:0070458	cellular detoxification of nitrogen compound	-	IDA	2034681 8373352
GO:0071313	cellular response to caffeine	-	IDA	22406107
GO:0098869	cellular oxidant detoxification	-	IEA	-
GO:1901687	glutathione derivative biosynthetic process	-	TAS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005737	cytoplasm	-	IDA	2034681 8373352
GO:0005829	cytosol	-	IDA	-
GO:0005829	cytosol	-	TAS	-
GO:0016529	sarcoplasmic reticulum	-	IDA	22406107
GO:0045171	intercellular bridge	-	IDA	-
GO:0070062	extracellular exosome	-	HDA	19056867 23533145

KEGG ID	KEGG Term
hsa00480	Glutathione metabolism
hsa00980	Metabolism of xenobiotics by cytochrome P450
hsa00982	Drug metabolism - cytochrome P450

Reactome ID	Reactome Term	Evidence
R-HSA-1430728	Metabolism	TAS
R-HSA-156580	Phase II - Conjugation of compounds	TAS
R-HSA-156590	Glutathione conjugation	TAS
R-HSA-211859	Biological oxidations	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
19859803	No evidence for glutathione S-transferases GSTA2, GSTM2, GSTO1, GSTO2, and GSTZ1 in breast cancer risk. (2010 Jun)	Andonova IE	Breast Cancer Res Treat
20044584	Dietary quercetin, quercetin-gene interaction, metabolic gene expression in lung tissue and lung cancer risk. (2010 Apr)	Lam TK	Carcinogenesis
25892883	Polymorphisms of glutathione S-transferase genes and survival of resected hepatocellular carcinoma patients. (2015 Apr 14)	Qu K	World J Gastroenterol