Gene info: ID 2947

Gene: GSTM3

GENE ID: 2947

Synonyms: GST5|GSTB|GSTM3-3|GTM3

Description: glutathione S-transferase mu 3

Gene type: protein-coding

Location: 1p13.3

dbXrefs: Ensembl:ENSG00000134202 MIM:138390 Vega:OTTHUMG00000011640 UniprotKB:P21266

RefSeq: NC_000001.11

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 36

Sherlock p-value : 3.799e-1 (AD) 9.353e-1 (ND) (Frontal_Cortex)

Pascal p-value : 1.222e-1 (AD) 7.789e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ADH5	0.766
CPE	0.741
CTNNA2	0.739
CASC4	0.738
ALDH5A1	0.735
NEBL	0.733
BBS2	0.726
FAM213A	0.725
DDAH1	0.723
SCP2	0.72

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.623
OR4F29	-0.577
TMEM236	-0.219
OR6C74	-0.217
CETP	-0.211
TRPV5	-0.204
NANOGNB	-0.203
SPOCD1	-0.195
TNFRSF13B	-0.194
KEL	-0.193

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00143	Glutathione	Small Molecule	70-18-8	Approved\|Investigational\|Nutraceutical	Target
DB00163	Vitamin E	Small Molecule	59-02-9	Approved\|Nutraceutical	Enzyme
DB14001	alpha-Tocopherol succinate	Small Molecule	4345-03-3	Approved\|Nutraceutical	Enzyme
DB14002	D-alpha-Tocopherol acetate	Small Molecule	58-95-7	Approved\|Nutraceutical	Enzyme

ID	Drug Name	Action	PubMed
C028328	1,2-dichloro-4-nitrobenzene	"GSTM3 protein affects the metabolism of 1,2-dichloro-4-nitrobenzene"	3169012
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"[1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased activity of NR1I3 protein] which results in increased expression of GSTM3 mRNA"	22496397
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of GSTM3 mRNA"	18723825\|2249639
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"CTNNB1 protein affects the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of GSTM3 mRNA]"	23578392
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"NR1I3 protein affects the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of GSTM3 mRNA]"	22496397
C042630	1-chloro-2,4-dinitrobenzene-glutathione conjugate	"GSTM3 protein affects the metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate"	11684093
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"[2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylnitrosamine] results in increased expression of GSTM3 mRNA"	23457121
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of GSTM3 mRNA"	28433925
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of GSTM3 mRNA"	21346803
C009497	2-(4-toluidino)-6-naphthalenesulfonic acid	2-(4-toluidino)-6-naphthalenesulfonic acid binds to GSTM3 protein	7725348
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of GSTM3 mRNA"	21346803
C013166	2-nonenal	GSTM3 protein polymorphism results in decreased metabolism of 2-nonenal	15247628
C013166	2-nonenal	GSTM3 protein polymorphism results in increased metabolism of 2-nonenal	15247628
C572491	3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol	3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol results in increased expression of GSTM3 protein	26194647
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of GSTM3 mRNA"	24378064
C023035	3,4,5,3',4'-pentachlorobiphenyl	"Sunphenon promotes the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of GSTM3 mRNA]"	24378064
C023035	3,4,5,3',4'-pentachlorobiphenyl	"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of GSTM3 mRNA"	23196670
C050224	3,5,5-trimethylhexanoylferrocene	"3,5,5-trimethylhexanoylferrocene results in increased expression of GSTM3 protein"	22649188
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GSTM3 mRNA"	27188386
C027576	4-hydroxy-2-nonenal	[GSTM1 protein binds to GSTM3 protein] which affects the metabolism of 4-hydroxy-2-nonenal analog	11256969
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GSTM3 mRNA"	27188386
D000082	Acetaminophen	Acetaminophen results in decreased expression of GSTM3 mRNA	16611625
D000082	Acetaminophen	Acetaminophen results in decreased expression of GSTM3 mRNA	17522070
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of GSTM3 mRNA	19770486
D000447	Aldehydes	Aldehydes results in increased expression of GSTM3 mRNA	25014914
C038491	allyl sulfide	allyl sulfide results in increased expression of GSTM3 mRNA	18723825
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin analog results in decreased expression of GSTM3 protein	26597043
D000517	alpha-Chlorohydrin	alpha-Chlorohydrin results in increased expression of GSTM3 protein	26072098
D006710	Homocysteine	[Methionine deficiency co-treated with Homocysteine] affects the expression of GSTM3 protein	17116298
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of GSTM3 mRNA	16483693
C030419	andrographolide	[andrographolide co-treated with beta-Naphthoflavone] results in increased expression of GSTM3 mRNA	19737545
C030419	andrographolide	andrographolide results in increased expression of GSTM3 mRNA	19737545
C000228	aristolochic acid I	aristolochic acid I results in increased expression of GSTM3 mRNA	17483316
D034341	Aristolochic Acids	Aristolochic Acids results in increased expression of GSTM3 mRNA	21834575
D001151	Arsenic	Arsenic affects the methylation of GSTM3 gene	25304211
D001151	Arsenic	Arsenic results in increased expression of GSTM3 mRNA	19945496
C006632	arsenic trioxide	arsenic trioxide results in increased expression of GSTM3 mRNA	22521957
D001194	Asbestos	Asbestos affects the expression of GSTM3 protein	7614465
D017636	Asbestos, Amphibole	"Asbestos, Amphibole affects the expression of GSTM3 protein"	20855422
D001280	Atrazine	[Atrazine co-treated with Chlorpyrifos co-treated with Endosulfan] results in increased expression of GSTM3 mRNA	22515965
D019324	beta-Naphthoflavone	[andrographolide co-treated with beta-Naphthoflavone] results in increased expression of GSTM3 mRNA	19737545
D019324	beta-Naphthoflavone	beta-Naphthoflavone results in increased expression of GSTM3 protein	9794803
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of GSTM3 protein	22138271
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of GSTM3 mRNA	20064835
D001564	Benzo(a)pyrene	Methionine inhibits the reaction [Benzo(a)pyrene results in decreased expression of GSTM3 protein]	22138271
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of GSTM3 mRNA	21569818\|2196490
C031403	benzyl isothiocyanate	benzyl isothiocyanate results in increased expression of GSTM3 protein	9794803
C072553	benzyloxycarbonylleucyl-leucyl-leucine aldehyde	benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of GSTM3 mRNA	20061341
C038328	BEP protocol	BEP protocol results in increased expression of GSTM3 mRNA	23200778
D004958	Estradiol	Estradiol results in increased expression of GSTM3 mRNA	11331657
D004958	Estradiol	Estradiol results in decreased expression of GSTM3 mRNA	14664709
D004958	Estradiol	Estradiol results in decreased expression of GSTM3 mRNA	17522070
C452139	BIRB 796	BIRB 796 results in increased expression of GSTM3 mRNA	21328587
C006780	bisphenol A	bisphenol A affects the expression of GSTM3 mRNA	21786754
C006780	bisphenol A	"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of GSTM3 mRNA"	28433925
C006780	bisphenol A	bisphenol A affects the expression of GSTM3 mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased expression of GSTM3 mRNA	26794494
C000611646	bisphenol F	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of GSTM3 mRNA	28628672
D002083	Butylated Hydroxyanisole	Butylated Hydroxyanisole results in increased expression of GSTM3 mRNA	18723825\|6822548
D002083	Butylated Hydroxyanisole	Butylated Hydroxyanisole results in increased expression of GSTM3 protein	11991805
D002083	Butylated Hydroxyanisole	Butylated Hydroxyanisole results in increased expression of GSTM3 protein	9794803
C018475	butyraldehyde	butyraldehyde results in increased expression of GSTM3 mRNA	26079696
D002104	Cadmium	Cadmium results in increased expression of GSTM3 mRNA	24376830
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of GSTM3 protein	24527689
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of GSTM3 mRNA	27339419
D002251	Carbon Tetrachloride	PLG gene mutant form promotes the reaction [Carbon Tetrachloride results in increased expression of GSTM3 mRNA]	16006527
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of GSTM3 mRNA	17522070
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of GSTM3 mRNA	16239168
D002259	Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone	Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased expression of GSTM3 mRNA	16039398
D002330	Carmustine	GSTM3 protein affects the metabolism of Carmustine	15247628
D002330	Carmustine	GSTM3 protein results in decreased nitrosation of and results in decreased activity of Carmustine	8395980
D002330	Carmustine	GSTM3 protein results in decreased nitrosation of Carmustine	11841793
D002725	Chloroform	Chloroform results in decreased expression of GSTM3 mRNA	17522070
D002737	Chloroprene	Chloroprene results in increased expression of GSTM3 mRNA	23125180
D004390	Chlorpyrifos	[Atrazine co-treated with Chlorpyrifos co-treated with Endosulfan] results in increased expression of GSTM3 mRNA	22515965
D004390	Chlorpyrifos	Chlorpyrifos results in decreased expression of GSTM3 mRNA	17452286
D019826	Cholic Acid	Cholic Acid results in increased expression of GSTM3 mRNA	17521389
D002994	Clofibrate	Clofibrate results in increased expression of GSTM3 mRNA	22496397
D002994	Clofibrate	PPARA protein affects the reaction [Clofibrate results in increased expression of GSTM3 mRNA]	22496397
D002995	Clofibric Acid	Clofibric Acid affects the expression of GSTM3 mRNA	17602206
D003035	Cobalt	Cobalt results in increased expression of GSTM3 mRNA	22147119
D003300	Copper	[Copper co-treated with Diethylnitrosamine co-treated with Iron] results in increased expression of GSTM3 mRNA	20302851
D003300	Copper	[Copper co-treated with Diethylnitrosamine] results in increased expression of GSTM3 mRNA	20302851
C030123	coumarin	coumarin results in increased expression of GSTM3 protein	9794803
C007164	cumene hydroperoxide	GSTM3 protein polymorphism results in decreased metabolism of cumene hydroperoxide	15247628
C007164	cumene hydroperoxide	GSTM3 protein polymorphism results in increased metabolism of cumene hydroperoxide	15247628
C007164	cumene hydroperoxide	GSTM3 protein affects the metabolism of cumene hydroperoxide	11684093
C057862	cyanoginosin LR	cyanoginosin LR results in increased expression of GSTM3 mRNA	17654400
D016572	Cyclosporine	Cyclosporine results in decreased expression of GSTM3 mRNA	25562108\|2798913
D016572	Cyclosporine	Cyclosporine results in decreased expression of GSTM3 mRNA	19770486
C089595	cylindrospermopsin	cylindrospermopsin results in increased expression of GSTM3 mRNA	23726867
C093628	cyproconazole	cyproconazole results in increased expression of GSTM3 mRNA	22334560\|2397080
C014347	decitabine	[decitabine affects the methylation of GSTM3 promoter] which affects the expression of GSTM3 mRNA	18664505\|1866450
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of GSTM3 mRNA	28628672
D003907	Dexamethasone	Dexamethasone results in increased expression of GSTM3 mRNA	18723825
D003907	Dexamethasone	Dexamethasone results in decreased expression of GSTM3 mRNA	17522070
D003976	Diazinon	Diazinon results in increased methylation of GSTM3 gene	22964155
D003976	Diazinon	Diazinon results in decreased expression of GSTM3 mRNA	17452286\|1944049
C061481	dibenzoylmethane	dibenzoylmethane results in increased expression of GSTM3 mRNA	17942926
C061481	dibenzoylmethane	[sulforafan co-treated with dibenzoylmethane] results in increased expression of GSTM3 mRNA	17942926
D003999	Dichloroacetic Acid	Dichloroacetic Acid results in increased expression of GSTM3 mRNA	28962523
D002945	Cisplatin	Cisplatin results in increased expression of GSTM3 mRNA	27594783
D002945	Cisplatin	GSTM3 gene polymorphism affects the susceptibility to Cisplatin	11081456
D002945	Cisplatin	GSTM3 protein affects the susceptibility to Cisplatin	16217747
D004008	Diclofenac	Diclofenac results in increased expression of GSTM3 mRNA	26934552
C000944	dicrotophos	dicrotophos results in decreased expression of GSTM3 mRNA	28302478
C121718	dicyclanil	dicyclanil results in increased expression of GSTM3 mRNA	15664270
D004026	Dieldrin	Dieldrin affects the expression of GSTM3 mRNA	19440498
D004041	Dietary Fats	Dietary Fats affects the expression of GSTM3 mRNA	19680557
D004041	Dietary Fats	[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of GSTM3 mRNA	28433925
D004041	Dietary Fats	Dietary Fats results in increased expression of GSTM3 mRNA	25016146
D004042	Dietary Fats, Unsaturated	"[perfluorooctanoic acid co-treated with Dietary Fats, Unsaturated] results in increased expression of GSTM3 mRNA"	23626681
D019422	Dietary Sucrose	[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of GSTM3 mRNA	28433925
D004051	Diethylhexyl Phthalate	Diethylhexyl Phthalate results in increased expression of GSTM3 mRNA	19850644
D004051	Diethylhexyl Phthalate	PPARA protein inhibits the reaction [Diethylhexyl Phthalate results in increased expression of GSTM3 mRNA]	19850644
D004051	Diethylhexyl Phthalate	"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of GSTM3 mRNA"	28433925
D004052	Diethylnitrosamine	"[2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylnitrosamine] results in increased expression of GSTM3 mRNA"	23457121
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with kojic acid] results in increased expression of GSTM3 mRNA	17917374
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of GSTM3 mRNA	24535843
D004052	Diethylnitrosamine	[Copper co-treated with Diethylnitrosamine co-treated with Iron] results in increased expression of GSTM3 mRNA	20302851
D004052	Diethylnitrosamine	[Copper co-treated with Diethylnitrosamine] results in increased expression of GSTM3 mRNA	20302851
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of GSTM3 mRNA	18544905
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with kojic acid] results in increased expression of GSTM3 mRNA	18544905
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of GSTM3 mRNA	28943392
D004052	Diethylnitrosamine	Diethylnitrosamine results in decreased expression of GSTM3 mRNA	19638242
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of GSTM3 mRNA	14965361
D004052	Diethylnitrosamine	[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of GSTM3 mRNA	18253720\|1877588
D004052	Diethylnitrosamine	[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of GSTM3 mRNA	22129741
D004052	Diethylnitrosamine	[Orphenadrine co-treated with Diethylnitrosamine] results in increased expression of GSTM3 mRNA	23665939
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of GSTM3 mRNA	11331657
C472511	dimethylarsinous acid	dimethylarsinous acid results in increased expression of GSTM3 mRNA	20886546
D015127	9,10-Dimethyl-1,2-benzanthracene	"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of GSTM3 mRNA"	22485181
D004137	Dinitrochlorobenzene	GSTM3 protein affects the metabolism of Dinitrochlorobenzene	9545290
D004137	Dinitrochlorobenzene	GSTM3 protein polymorphism results in decreased metabolism of Dinitrochlorobenzene	15247628
D004137	Dinitrochlorobenzene	GSTM3 protein polymorphism results in increased metabolism of Dinitrochlorobenzene	15247628
D004137	Dinitrochlorobenzene	Dinitrochlorobenzene results in increased expression of GSTM3 protein	9794801
D004137	Dinitrochlorobenzene	GSTM3 protein affects the metabolism of Dinitrochlorobenzene	3169012
C051904	dinophysistoxin 1	dinophysistoxin 1 results in increased expression of GSTM3 mRNA	28939011
D004281	Docosahexaenoic Acids	PPARA protein promotes the reaction [Docosahexaenoic Acids results in increased expression of GSTM3 mRNA]	18489776
D004317	Doxorubicin	Doxorubicin results in increased expression of GSTM3 mRNA	26873546
D004317	Doxorubicin	Doxorubicin results in increased oxidation of GSTM3 protein	28818578
D004365	Drugs, Chinese Herbal	"Drugs, Chinese Herbal results in increased expression of GSTM3 mRNA"	23262642
D004391	Dust	Dust results in increased expression of GSTM3 mRNA	17805423
D015118	Eicosapentaenoic Acid	PPARA protein promotes the reaction [Eicosapentaenoic Acid results in increased expression of GSTM3 mRNA]	18489776
D004642	Emodin	Emodin results in decreased expression of GSTM3 mRNA	16045814
D004726	Endosulfan	[Atrazine co-treated with Chlorpyrifos co-treated with Endosulfan] results in increased expression of GSTM3 mRNA	22515965
D004726	Endosulfan	Endosulfan results in increased expression of GSTM3 mRNA	22515965
D004791	Enzyme Inhibitors	[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of GSTM3 protein	23301498
C109476	epoxiconazole	epoxiconazole results in increased expression of GSTM3 mRNA	22334560\|2397080
D004918	Erythromycin Estolate	Erythromycin Estolate results in decreased expression of GSTM3 mRNA	17522070
C010452	estradiol-17 beta-benzoate	estradiol-17 beta-benzoate results in decreased expression of GSTM3 mRNA	15972882
C015854	estradiol valerate	estradiol valerate results in decreased expression of GSTM3 mRNA	15972882
D000431	Ethanol	Ethanol results in increased expression of GSTM3 mRNA	19167417
D000431	Ethanol	Ethanol results in increased expression of GSTM3 mRNA	16098508
D004997	Ethinyl Estradiol	Ethinyl Estradiol affects the expression of GSTM3 mRNA	17555576
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of GSTM3 mRNA	17942748
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of GSTM3 mRNA	17942748
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of GSTM3 mRNA	15576828\|1583489
D005015	Ethoxyquin	Ethoxyquin results in increased expression of GSTM3 mRNA	18723825
D005015	Ethoxyquin	Ethoxyquin results in increased expression of GSTM3 protein	9794803
C024565	ethylene dichloride	ethylene dichloride results in decreased expression of GSTM3 mRNA	28189721
D011345	Fenofibrate	[Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of GSTM3 mRNA	18253720\|1877588
D011345	Fenofibrate	Fenofibrate results in decreased expression of GSTM3 mRNA	18775883
D005419	Flavonoids	Flavonoids results in decreased expression of GSTM3 mRNA	18035473
D005485	Flutamide	Flutamide results in increased expression of GSTM3 mRNA	24136188
C056933	fumonisin B1	fumonisin B1 results in increased expression of GSTM3 mRNA	16221962
C039281	furan	furan results in increased expression of GSTM3 mRNA	20194422
D005907	Gliclazide	Gliclazide inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of GSTM3 mRNA]	21439372
D005978	Glutathione	GSTM3 protein affects the metabolism of Glutathione	9545290
D006108	Graphite	Graphite results in decreased expression of GSTM3 protein	22157353
C412815	GW 4064	GW 4064 results in increased expression of GSTM3 mRNA	26655953
D017313	Fenretinide	Fenretinide results in increased expression of GSTM3 mRNA	28973697
C016517	indole-3-carbinol	indole-3-carbinol affects the expression of GSTM3 mRNA	21396975
C016517	indole-3-carbinol	[indole-3-carbinol co-treated with Diethylnitrosamine] results in increased expression of GSTM3 mRNA	22129741
C016517	indole-3-carbinol	[indole-3-carbinol co-treated with Phenobarbital] results in increased expression of GSTM3 mRNA	24418717
C016517	indole-3-carbinol	indole-3-carbinol results in increased expression of GSTM3 mRNA	24418717
C016517	indole-3-carbinol	indole-3-carbinol results in increased expression of GSTM3 protein	9794803
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of GSTM3 mRNA	28628672
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of GSTM3 mRNA	25613284
D007501	Iron	[Copper co-treated with Diethylnitrosamine co-treated with Iron] results in increased expression of GSTM3 mRNA	20302851
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of GSTM3 mRNA	28628672
C410337	K 7174	K 7174 results in decreased expression of GSTM3 mRNA	24086573
D007657	Ketone Bodies	Ketone Bodies results in increased expression of GSTM3 mRNA	16807920
C011890	kojic acid	[Diethylnitrosamine co-treated with kojic acid] results in increased expression of GSTM3 mRNA	17917374
C011890	kojic acid	[Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of GSTM3 mRNA	18544905
C011890	kojic acid	[Diethylnitrosamine co-treated with kojic acid] results in increased expression of GSTM3 mRNA	18544905
D008070	Lipopolysaccharides	Lipopolysaccharides results in decreased expression of GSTM3 mRNA	27339419
D008094	Lithium	Lithium results in increased expression of GSTM3 mRNA	18082333
D018021	Lithium Chloride	[Lithium Chloride results in increased activity of CTNNB1 protein] which results in increased expression of GSTM3 mRNA	20118494
D058185	Magnetite Nanoparticles	Magnetite Nanoparticles affects the expression of GSTM3 mRNA	25532727
D017258	Medroxyprogesterone Acetate	Medroxyprogesterone Acetate results in increased expression of GSTM3 mRNA	18497975
D008528	Mefenamic Acid	GSTM3 protein results in increased glutathionylation of Mefenamic Acid analog	25372302
D008628	Mercury	Mercury results in increased expression of GSTM3 mRNA	24788667
D008715	Methionine	[Methionine deficiency co-treated with Homocysteine] affects the expression of GSTM3 protein	17116298
D008715	Methionine	Methionine inhibits the reaction [Benzo(a)pyrene results in decreased expression of GSTM3 protein]	22138271
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of GSTM3 mRNA	23103053
D052998	Microcystins	Microcystins affects the expression of GSTM3 mRNA	19790251
D052998	Microcystins	Microcystins results in decreased expression of GSTM3 mRNA	19790251
C540575	MK2i peptide	[TGFB1 protein co-treated with MK2i peptide] results in decreased expression of GSTM3 protein	20864298
D016686	Monocrotaline	[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of GSTM3 mRNA	21224054
C406082	monomethylarsonous acid	monomethylarsonous acid results in increased expression of GSTM3 mRNA	20886546\|2210804
C583365	N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide	"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of GSTM3 mRNA"	29244179
D009270	Naloxone	Naloxone results in decreased expression of GSTM3 mRNA	17522070
D037742	Nanotubes, Carbon	"Nanotubes, Carbon affects the expression of GSTM3 protein"	22001959
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of GSTM3 protein"	22157353
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of GSTM3 mRNA"	25554681\|2562005
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of GSTM3 mRNA"	25554681\|2562005
D015058	1-Naphthylisothiocyanate	1-Naphthylisothiocyanate results in decreased expression of GSTM3 mRNA	17522070
D009532	Nickel	Nickel affects the expression of GSTM3 mRNA	14575637
D009532	Nickel	Nickel results in decreased expression of GSTM3 mRNA	24768652\|2558310
D009532	Nickel	trichostatin A inhibits the reaction [Nickel affects the expression of GSTM3 mRNA]	14575637
D009532	Nickel	Nickel affects the expression of GSTM3 mRNA	19440498
C014707	nitrosobenzylmethylamine	nitrosobenzylmethylamine results in decreased expression of GSTM3 mRNA	17616710
C025589	ochratoxin A	ochratoxin A results in increased acetylation of GSTM3 promoter	29098329
C025589	ochratoxin A	[ochratoxin A results in increased acetylation of GSTM3 promoter] which results in increased expression of GSTM3 mRNA	29098329\|2909832
C025589	ochratoxin A	ochratoxin A results in increased expression of GSTM3 mRNA	29098329
D019319	Okadaic Acid	Okadaic Acid results in increased expression of GSTM3 mRNA	28939011
D000069463	Olive Oil	Olive Oil analog affects the expression of GSTM3 mRNA	17349074
C026209	oltipraz	NFE2L2 protein affects the reaction [oltipraz results in increased expression of GSTM3 mRNA]	22496397
C026209	oltipraz	[oltipraz results in increased activity of NFE2L2 protein] which results in increased expression of GSTM3 mRNA	22496397
C026209	oltipraz	oltipraz results in increased expression of GSTM3 mRNA	18723825\|2249639
C026209	oltipraz	oltipraz results in increased expression of GSTM3 protein	9794803
D009966	Orphenadrine	Orphenadrine affects the expression of GSTM3 mRNA	23665940
D009966	Orphenadrine	[Orphenadrine co-treated with Diethylnitrosamine] results in increased expression of GSTM3 mRNA	23665939
D009966	Orphenadrine	[Phenobarbital co-treated with Orphenadrine] affects the expression of GSTM3 mRNA	23665940
D010126	Ozone	Ozone results in decreased expression of GSTM3 mRNA	12763052
D000073878	Palm Oil	Palm Oil affects the expression of GSTM3 mRNA	19680557
D010269	Paraquat	Paraquat results in increased expression of GSTM3 mRNA	20883675
D010269	Paraquat	Paraquat results in increased expression of GSTM3 mRNA	16128001
D052638	Particulate Matter	Particulate Matter results in increased expression of GSTM3 mRNA	18952161
D010396	Penicillamine	Penicillamine results in increased expression of GSTM3 mRNA	22843330
D010416	Pentachlorophenol	Pentachlorophenol results in increased expression of GSTM3 mRNA	23892564
C046012	pentanal	pentanal results in increased expression of GSTM3 mRNA	26079696
C471071	perfluorohexanesulfonic acid	perfluorohexanesulfonic acid results in increased expression of GSTM3 mRNA	28558994
C101816	perfluoro-n-nonanoic acid	perfluoro-n-nonanoic acid results in decreased expression of GSTM3 mRNA	21984479
C584865	perfluorononanoic acid	perfluorononanoic acid results in increased expression of GSTM3 mRNA	28558994
C076994	perfluorooctane sulfonic acid	NR1H3 gene mutant form inhibits the reaction [perfluorooctane sulfonic acid results in increased expression of GSTM3 mRNA]	25949234
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid affects the expression of GSTM3 mRNA	19429403
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in decreased expression of GSTM3 mRNA	26300304
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in increased expression of GSTM3 mRNA	20936131\|2594923
C023036	perfluorooctanoic acid	[NR1H3 gene mutant form results in increased susceptibility to perfluorooctanoic acid] which results in increased expression of GSTM3 mRNA	25949234
C023036	perfluorooctanoic acid	perfluorooctanoic acid affects the expression of GSTM3 mRNA	18281256\|1942940
C023036	perfluorooctanoic acid	"[perfluorooctanoic acid co-treated with Dietary Fats, Unsaturated] results in increased expression of GSTM3 mRNA"	23626681
C023036	perfluorooctanoic acid	[perfluorooctanoic acid co-treated with PPARA] results in decreased expression of GSTM3 mRNA	20118188
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of GSTM3 mRNA	18281256\|2011818
C023036	perfluorooctanoic acid	PPARA protein inhibits the reaction [perfluorooctanoic acid results in increased expression of GSTM3 mRNA]	18281256
D015232	Dinoprostone	GSTM3 protein affects the chemical synthesis of Dinoprostone	10905636
D044262	Prostaglandin H2	GSTM3 protein affects the metabolism of Prostaglandin H2	10905636
D010634	Phenobarbital	[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of GSTM3 mRNA	24535843
D010634	Phenobarbital	NR1I3 protein affects the reaction [Phenobarbital results in increased expression of GSTM3 mRNA]	19482888
D010634	Phenobarbital	[Phenobarbital co-treated with CTNNB1 protein mutant form] results in increased expression of GSTM3 mRNA	20118494
D010634	Phenobarbital	Phenobarbital results in increased expression of GSTM3 mRNA	18723825\|1927001
D010634	Phenobarbital	[indole-3-carbinol co-treated with Phenobarbital] results in increased expression of GSTM3 mRNA	24418717
D010634	Phenobarbital	Phenobarbital affects the expression of GSTM3 mRNA	23665940\|2402578
D010634	Phenobarbital	[Phenobarbital co-treated with Orphenadrine] affects the expression of GSTM3 mRNA	23665940
D010634	Phenobarbital	Phenobarbital results in increased expression of GSTM3 mRNA	24418717
D010634	Phenobarbital	Phenobarbital results in increased expression of GSTM3 protein	9794803
D010634	Phenobarbital	Piperonyl Butoxide affects the reaction [Phenobarbital affects the expression of GSTM3 mRNA]	24025784
D010656	Phenylephrine	Phenylephrine results in decreased expression of GSTM3 mRNA	18158353
D010672	Phenytoin	[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of GSTM3 mRNA	21224054
D010882	Piperonyl Butoxide	Piperonyl Butoxide affects the reaction [Phenobarbital affects the expression of GSTM3 mRNA]	24025784
D010882	Piperonyl Butoxide	Piperonyl Butoxide results in increased expression of GSTM3 mRNA	18544911\|2248451
C006253	pirinixic acid	pirinixic acid results in decreased expression of GSTM3 mRNA	16221962\|1742611
D010936	Plant Extracts	Plant Extracts results in increased expression of GSTM3 mRNA	23262642
D011084	Polycyclic Aromatic Hydrocarbons	GSTM3 protein polymorphism results in increased susceptibility to Polycyclic Aromatic Hydrocarbons	11289100\|1174033
D059808	Polyphenols	Polyphenols results in decreased expression of GSTM3 mRNA	16293270
D011285	Pregnenolone Carbonitrile	NR1I2 protein affects the reaction [Pregnenolone Carbonitrile results in increased expression of GSTM3 mRNA]	22496397
D011285	Pregnenolone Carbonitrile	[Pregnenolone Carbonitrile results in increased activity of NR1I2 protein] which results in increased expression of GSTM3 mRNA	22496397
D011285	Pregnenolone Carbonitrile	Pregnenolone Carbonitrile results in increased expression of GSTM3 mRNA	18723825\|2249639
C045950	propiconazole	NR1H3 gene mutant form promotes the reaction [propiconazole results in increased expression of GSTM3 mRNA]	25949234
C045950	propiconazole	propiconazole results in increased expression of GSTM3 mRNA	21278054\|2233456
C045950	propiconazole	propiconazole results in increased expression of GSTM3 mRNA	16643972
C005556	propionaldehyde	propionaldehyde results in increased expression of GSTM3 mRNA	26079696
D011458	Prostaglandins E	GSTM3 protein affects the chemical synthesis of Prostaglandins E	10905636
C030984	pyrene	pyrene results in increased expression of GSTM3 mRNA	26160115
C010423	pyrithione zinc	pyrithione zinc results in increased expression of GSTM3 mRNA	21424779
D011794	Quercetin	Quercetin results in decreased expression of GSTM3 mRNA	16455785
D011802	Quinidine	Quinidine results in decreased expression of GSTM3 mRNA	17522070
C059514	resveratrol	resveratrol inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of GSTM3 mRNA]	21439372
D012293	Rifampin	[Monocrotaline co-treated with Rifampin co-treated with Phenytoin co-treated with PRKDC] results in increased expression of GSTM3 mRNA	21224054
D012312	Ritodrine	Ritodrine results in increased expression of GSTM3 mRNA	23370008
D012822	Silicon Dioxide	Silicon Dioxide analog results in decreased expression of GSTM3 mRNA	25895662
C017947	sodium arsenite	sodium arsenite results in increased expression of GSTM3 mRNA	20886546
C017947	sodium arsenite	sodium arsenite affects the expression of GSTM3 mRNA	16507464
D015086	2,6-Dichloroindophenol	"[2,6-Dichloroindophenol co-treated with NQO1 protein polymorphism] results in increased expression of GSTM3 mRNA"	21034357
D018038	Sodium Selenite	Sodium Selenite results in increased expression of GSTM3 mRNA	24383545
D012999	Soman	Soman results in decreased expression of GSTM3 mRNA	19281266
D053260	Soot	Soot results in decreased expression of GSTM3 mRNA	22461453
D053260	Soot	Soot results in decreased expression of GSTM3 mRNA	21914721
D013148	Spironolactone	Spironolactone results in increased expression of GSTM3 mRNA	18723825
C025906	stilbene oxide	stilbene oxide results in increased expression of GSTM3 protein	9794803
D013311	Streptozocin	Gliclazide inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of GSTM3 mRNA]	21439372
D013311	Streptozocin	resveratrol inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of GSTM3 mRNA]	21439372
D013311	Streptozocin	[Streptozocin co-treated with Niacinamide] results in decreased expression of GSTM3 mRNA	21439372
C016766	sulforafan	[sulforafan co-treated with dibenzoylmethane] results in increased expression of GSTM3 mRNA	17942926
C016766	sulforafan	sulforafan results in increased expression of GSTM3 mRNA	17942926
C074269	Sunphenon	"Sunphenon promotes the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of GSTM3 mRNA]"	24378064
C446685	systhane	systhane results in increased expression of GSTM3 mRNA	23970803
C446685	systhane	systhane results in increased expression of GSTM3 mRNA	16643972
C013698	tallow	tallow affects the expression of GSTM3 mRNA	19680557
D013629	Tamoxifen	Tamoxifen affects the expression of GSTM3 mRNA	17555576
C030141	taurine-ursodeoxycholate conjugate	taurine-ursodeoxycholate conjugate inhibits the reaction [LEP gene mutant form results in increased expression of GSTM3 mRNA]	21079772
C031655	tauroursodeoxycholic acid	tauroursodeoxycholic acid results in decreased expression of GSTM3 mRNA	15885361
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of GSTM3 mRNA	16039398
D013749	Tetrachlorodibenzodioxin	AHR protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of GSTM3 mRNA]	22496397
D013749	Tetrachlorodibenzodioxin	NFE2L2 protein affects the reaction [Tetrachlorodibenzodioxin results in increased expression of GSTM3 mRNA]	19474220
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of GSTM3 mRNA	24680724\|2637764
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of GSTM3 mRNA	16214954
D013749	Tetrachlorodibenzodioxin	"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of GSTM3 mRNA"	28433925
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of GSTM3 mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of GSTM3 mRNA	19465110
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin results in increased activity of AHR protein] which results in increased expression of GSTM3 mRNA	22496397
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of GSTM3 mRNA	18172886\|1879615
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of GSTM3 mRNA	21215274
D013752	Tetracycline	Tetracycline results in decreased activity of GSTM3 protein	11807801
D013752	Tetracycline	Tetracycline results in decreased expression of GSTM3 mRNA	17522070
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of GSTM3 mRNA	25613284
D013806	Theophylline	Theophylline results in decreased expression of GSTM3 mRNA	17522070
D013853	Thioacetamide	[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of GSTM3 mRNA	28943392
D013853	Thioacetamide	Thioacetamide results in increased expression of GSTM3 mRNA	23411599
C009495	titanium dioxide	titanium dioxide results in decreased expression of GSTM3 mRNA	23557971
D014050	Toluene	Toluene affects the expression of GSTM3 mRNA	18653662
D014212	Tretinoin	Tretinoin results in increased expression of GSTM3 mRNA	21934132
C032910	triadimefon	NR1H3 gene mutant form promotes the reaction [triadimefon results in increased expression of GSTM3 mRNA]	25949234
C032910	triadimefon	triadimefon results in increased expression of GSTM3 mRNA	23970803\|2594923
C032910	triadimefon	triadimefon results in increased expression of GSTM3 mRNA	16643972
D014241	Trichloroethylene	Trichloroethylene results in increased expression of GSTM3 mRNA	25549359
C012589	trichostatin A	trichostatin A inhibits the reaction [Nickel affects the expression of GSTM3 mRNA]	14575637
C012589	trichostatin A	trichostatin A results in increased expression of GSTM3 mRNA	24935251
C010360	triethyllead	triethyllead results in decreased expression of GSTM3 mRNA	9020200
C015559	trimellitic anhydride	trimellitic anhydride results in decreased expression of GSTM3 mRNA	19042947
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of GSTM3 mRNA"	26179874
D014315	Triterpenes	Triterpenes results in increased expression of GSTM3 mRNA	18544911
C057693	troglitazone	troglitazone results in decreased expression of GSTM3 mRNA	19631733
C057693	troglitazone	troglitazone results in increased expression of GSTM3 mRNA	19631733
D014415	Tunicamycin	Tunicamycin results in decreased expression of GSTM3 mRNA	17127020
C112106	UAB 30	UAB 30 analog results in decreased expression of GSTM3 mRNA	23292798
C112106	UAB 30	UAB 30 results in increased expression of GSTM3 mRNA	23292798
D014580	Ursodeoxycholic Acid	Ursodeoxycholic Acid results in decreased expression of GSTM3 mRNA	15885361
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GSTM3 mRNA"	27188386
D014635	Valproic Acid	Valproic Acid results in increased expression of GSTM3 mRNA	23179753\|2438349
D001335	Vehicle Emissions	Vehicle Emissions results in increased methylation of GSTM3 gene	25560391
D014800	Vitallium	Vitallium analog results in increased expression of GSTM3 mRNA	23825117
D009536	Niacinamide	Gliclazide inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of GSTM3 mRNA]	21439372
D009536	Niacinamide	resveratrol inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of GSTM3 mRNA]	21439372
D009536	Niacinamide	[Streptozocin co-treated with Niacinamide] results in decreased expression of GSTM3 mRNA	21439372
D015029	Zeranol	Zeranol results in increased expression of GSTM3 mRNA	11331657

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004364	glutathione transferase activity	-	IDA	8373352 9545290 10587441
GO:0004364	glutathione transferase activity	-	TAS	-
GO:0005515	protein binding	-	IPI	23355646
GO:0019899	enzyme binding	-	IPI	8373352
GO:0042802	identical protein binding	-	IPI	16189514 19060904 21516116
GO:0042803	protein homodimerization activity	-	IDA	9545290
GO:0042803	protein homodimerization activity	-	IPI	8373352
GO:0043295	glutathione binding	-	IDA	8373352

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006749	glutathione metabolic process	-	IDA	8373352 10587441
GO:0008065	establishment of blood-nerve barrier	-	TAS	2345169
GO:0018916	nitrobenzene metabolic process	-	IDA	8373352
GO:0042178	xenobiotic catabolic process	-	IDA	8373352
GO:0043627	response to estrogen	-	IEP	10037815
GO:0070458	cellular detoxification of nitrogen compound	-	IDA	8373352
GO:1901687	glutathione derivative biosynthetic process	-	TAS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	HDA	21630459
GO:0005737	cytoplasm	-	IDA	8373352
GO:0005829	cytosol	-	IDA	-
GO:0005829	cytosol	-	TAS	-
GO:0035686	sperm fibrous sheath	-	IEA	-
GO:0045171	intercellular bridge	-	IDA	-
GO:0070062	extracellular exosome	-	HDA	23533145

KEGG ID	KEGG Term
hsa00480	Glutathione metabolism
hsa00980	Metabolism of xenobiotics by cytochrome P450
hsa00982	Drug metabolism - cytochrome P450

Reactome ID	Reactome Term	Evidence
R-HSA-1430728	Metabolism	TAS
R-HSA-156580	Phase II - Conjugation of compounds	TAS
R-HSA-156590	Glutathione conjugation	TAS
R-HSA-211859	Biological oxidations	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
7614465	Pulmonary expression of glutathione S-transferase M3 in lung cancer patients: association with GSTM1 polymorphism, smoking, and asbestos exposure. (1995 Aug 1)	Anttila S	Cancer Res
17565746	Prospective study of urinary excretion of 7-methylguanine and the risk of lung cancer: Effect modification by mu class glutathione-S-transferases. (2007 Oct 1)	Loft S	Int J Cancer
20847076	Genetic susceptibility to asbestos-related fibrotic pleuropulmonary changes. (2011 Sep)	Kukkonen MK	Eur Respir J
18668224	Association of GSTM3 intron 6 variant with cigarette smoking, tobacco chewing and alcohol as modifier factors for prostate cancer risk. (2009 Apr)	Kesarwani P	Arch Toxicol
9592753	[Effect of gene polymorphism on detoxifying glutathione-S-transferase enzymes on chromosomal stability of squamous epithelial carcinomas in the area of the head-neck]. (1998 Apr)	Matthias C	Laryngorhinootologie
22027651	Genetic polymorphisms of xenobiotic-metabolizing enzymes influence the risk of pulmonary emphysema. (2011 Dec)	Kukkonen MK	Pharmacogenet Genomics
15654505	Association of habitual smoking and drinking with single nucleotide polymorphism (SNP) in 40 candidate genes: data from random population-based Japanese samples. (2005)	Liu Y	J Hum Genet
16886896	Glutathione S-transferases mu 1, theta 1, pi 1, alpha 1 and mu 3 genetic polymorphisms and the risk of colorectal and gastric cancers in humans. (2006 Jul)	Martinez C	Pharmacogenomics
15829318	Polymorphisms in genes involved in xenobiotic metabolism and lung cancer risk under the age of 60 years. A pooled study of lung cancer patients in Denmark and Norway. (2005 May)	Skuladottir H	Lung Cancer
10077151	Glutathione S-transferase GSTM1, GSTM3, GSTP1 and GSTT1 genotypes and the risk of smoking-related oral and pharyngeal cancers. (1999 Mar 31)	Jourenkova-Mironova N	Int J Cancer
18569590	The influence of polymorphisms of glutathione S-transferases M1 and M3 on the development of human urothelial cancer. (2008)	Golka K	J Toxicol Environ Health A
10080124	[Genetic predisposition for the development of head and neck carcinomas]. (1999 Jan)	Jahnke V	Laryngorhinootologie
25040976	Susceptibility of lung cancer with polymorphisms of CYP1A1, GSTM1, GSTM3, GSTT1 and GSTP1 genotypes in the population of Inner Mongolia region. (2014)	Jiang XY	Asian Pac J Cancer Prev
25892883	Polymorphisms of glutathione S-transferase genes and survival of resected hepatocellular carcinoma patients. (2015 Apr 14)	Qu K	World J Gastroenterol
10022746	Polymorphism in cytochrome P450 CYP2D6, CYP1A1, CYP2E1 and glutathione S-transferase, GSTM1, GSTM3, GSTT1 and susceptibility to tobacco-related cancers: studies in upper aerodigestive tract cancers. (1998 Apr)	Matthias C	Pharmacogenetics
8988674	Glutathione S-transferase and cytochrome-P-450 polymorphism as risk factors for squamous cell carcinoma of the larynx. (1996 Dec)	Jahnke V	Am J Surg
14735473	Glutathione S-transferase M3 (A/A) genotype as a risk factor for oral cancer and leukoplakia among Indian tobacco smokers. (2004 Mar)	Sikdar N	Int J Cancer
11408349	Glutathione-S-transferase gene polymorphisms in colorectal cancer patients: interaction between GSTM1 and GSTM3 allele variants as a risk-modulating factor. (2001 Jul)	Loktionov A	Carcinogenesis
10493261	The glutathione S-transferases: influence of polymorphism on cancer susceptibility. (1999)	Strange RC	IARC Sci Publ
21513434	Association of genetic polymorphism of GSTT1, GSTM1 and GSTM3 in COPD patients in a north Indian population. (2011 Jun)	Shukla RK	COPD
10676631	High-activity microsomal epoxide hydrolase genotypes and the risk of oral, pharynx, and larynx cancers. (2000 Feb 1)	Jourenkova-Mironova N	Cancer Res
18258609	A comprehensive analysis of phase I and phase II metabolism gene polymorphisms and risk of non-small cell lung cancer in smokers. (2008 Jun)	Zienolddiny S	Carcinogenesis
19407363	GSTM1, GSTM3 and GSTT1 gene variants and risk of benign prostate hyperplasia in North India. (2009)	Mittal RD	Dis Markers
9918133	Role of glutathione S-transferase GSTM1, GSTM3, GSTP1 and GSTT1 genotypes in modulating susceptibility to smoking-related lung cancer. (1998 Dec)	Jourenkova-Mironova N	Pharmacogenetics
11040079	Polymorphic glutathione S-transferase M1 is a risk factor of primary open-angle glaucoma among Estonians. (2000 Nov)	Juronen E	Exp Eye Res
17372252	An international case-control study of glutathione transferase and functionally related polymorphisms and risk of primary adult brain tumors. (2007 Mar)	Schwartzbaum JA	Cancer Epidemiol Biomarkers Prev
7728947	Expression and polymorphism of glutathione S-transferase in human lungs: risk factors in smoking-related lung cancer. (1995 Apr)	Nakajima T	Carcinogenesis
10407823	[Immunohistologic and molecular genetic studies of the effect of glutathione-S-transferases on the development of squamous epithelial carcinomas in the area of the head-neck]. (1999 Apr)	Matthias C	Laryngorhinootologie
22108414	Human GSTs polymorphisms in the Hakka population of south China and their associations with family history of several chronic diseases. (2011 Oct)	Pan S	Biomed Environ Sci
9077484	Truncal tumor site is associated with high risk of multiple basal cell carcinoma and is influenced by glutathione S-transferase, GSTT1, and cytochrome P450, CYP1A1 genotypes, and their interaction. (1997 Apr)	Lear JT	J Invest Dermatol
11548073	Significance of genetic polymorphisms in glutathione S-transferase multigene family and lung cancer risk. (2001)	Reszka E	Int J Occup Med Environ Health
12359356	Microsomal epoxide hydrolase and glutathione S-transferase polymorphisms in relation to laryngeal carcinoma risk. (2002 Dec 10)	To-Figueras J	Cancer Lett
20661821	Association of xenobiotic metabolizing enzymes genetic polymorphisms with esophageal cancer in Kashmir Valley and influence of environmental factors. (2010)	Malik MA	Nutr Cancer
16112301	NAT2 slow acetylation, GSTM1 null genotype, and risk of bladder cancer: results from the Spanish Bladder Cancer Study and meta-analyses. (2005 Aug 20-26)	Garcia-Closas M	Lancet
9679751	Combined effect of polymorphic GST genes on individual susceptibility to lung cancer. (1998 Aug 12)	Saarikoski ST	Int J Cancer
24177223	Significant interactions between maternal PAH exposure and haplotypes in candidate genes on B[a]P-DNA adducts in a NYC cohort of non-smoking African-American and Dominican mothers and newborns. (2014 Jan)	Iyer S	Carcinogenesis