Gene: GSTM5

2949
GSTM5-5|GTM5
glutathione S-transferase mu 5
protein-coding
1p13.3
Ensembl:ENSG00000134201 MIM:138385 Vega:OTTHUMG00000011644 UniprotKB:P46439
NC_000001.11
PubMed
0   ANCO-SNPs
ND
2   
5.223e-1 (AD)  9.503e-1 (ND)   (Frontal_Cortex)
7.903e-2 (AD)  7.027e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GSTM20.64
FAH0.56
SELENBP10.558
MMP280.551
EMX20.545
ALDH7A10.543
TNFSF130.541
DECR10.541
AGT0.54
CDC42EP40.539

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NPFFR2-0.364
LRRC55-0.357
FOXP2-0.35
DPP4-0.342
SEMA3E-0.336
GRIK3-0.327
TRABD2A-0.327
QRFPR-0.325
CYP26A1-0.321
RSPO3-0.321

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00143GlutathioneSmall Molecule70-18-8Approved|Investigational|NutraceuticalTarget
ID Drug Name Action PubMed
C0426301-chloro-2,4-dinitrobenzene-glutathione conjugate"GSTM5 protein affects the metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate"11684093
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of GSTM5 mRNA"28433925
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of GSTM5 mRNA"21346803
C0112692,5-hexanedione"2,5-hexanedione results in decreased expression of GSTM5 protein"19033394
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of GSTM5 mRNA"21346803
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of GSTM5 mRNA"15059925
C0303702-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone results in decreased expression of GSTM5 mRNA"20206263
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of GSTM5 mRNA"18723825
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of GSTM5 mRNA"23196670
C0326424-aminophenylarsenoxide4-aminophenylarsenoxide binds to GSTM5 protein26598702
C0326424-aminophenylarsenoxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to GSTM5 protein]26598702
C5213345-(4-dimethylaminobenzoyl)-aminovaleric acid hydroxamate5-(4-dimethylaminobenzoyl)-aminovaleric acid hydroxamate affects the expression of GSTM5 mRNA20932894
D000082AcetaminophenAcetaminophen affects the expression of GSTM5 mRNA17562736
D000643Ammonium ChlorideAmmonium Chloride affects the expression of GSTM5 mRNA16483693
C019257angelica lactoneangelica lactone results in increased expression of GSTM5 protein11309284
C004984apocarotenalapocarotenal results in increased expression of GSTM5 mRNA17034753
D001149ArsenatesArsenates results in increased expression of GSTM5 mRNA15345372
C006632arsenic trioxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to GSTM5 protein]26598702
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of GSTM5 mRNA22228805
D001564Benzo(a)pyrene[chromium hexavalent ion co-treated with Benzo(a)pyrene] affects the expression of GSTM5 mRNA25820237
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of GSTM5 mRNA20061341
D019207beta Carotenebeta Carotene results in increased expression of GSTM5 mRNA17034753
D004958Estradiol[Estradiol co-treated with Plant Preparations] results in decreased expression of GSTM5 mRNA26945725
C095105bexarotenebexarotene results in increased expression of GSTM5 mRNA17630414
C099952bifenthrinbifenthrin results in increased expression of GSTM5 mRNA26071804
C006780bisphenol Abisphenol A results in increased expression of GSTM5 mRNA29275510
C006780bisphenol A"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of GSTM5 mRNA"28433925
C006780bisphenol Abisphenol A affects the expression of GSTM5 mRNA25181051
C006780bisphenol Abisphenol A results in decreased expression of GSTM5 mRNA12075121
D002083Butylated HydroxyanisoleButylated Hydroxyanisole results in increased expression of GSTM5 protein11309284
D020122tert-ButylhydroperoxideGSTM5 protein results in decreased susceptibility to tert-Butylhydroperoxide15003993
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of GSTM5 mRNA14729362|1500399
D002101Cacodylic AcidCacodylic Acid results in increased expression of GSTM5 mRNA15345372
D002104CadmiumCadmium results in decreased expression of GSTM5 mRNA24376830
C053400cafestol[cafestol co-treated with kahweol palmitate] results in increased expression of GSTM5 protein11309284
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of GSTM5 mRNA12734012
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of GSTM5 mRNA24763279
D004390ChlorpyrifosChlorpyrifos results in increased expression of GSTM5 mRNA17452286
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of GSTM5 gene20938992
C074702chromium hexavalent ion[chromium hexavalent ion co-treated with Benzo(a)pyrene] affects the expression of GSTM5 mRNA25820237
D002922CiguatoxinsCiguatoxins affects the expression of GSTM5 mRNA18353800
D002994ClofibrateClofibrate results in decreased expression of GSTM5 mRNA19952500
D002994ClofibrateClofibrate results in increased expression of GSTM5 mRNA18723825
D003033Coal Tar[Vehicle Emissions analog co-treated with Coal Tar analog co-treated with Tobacco Smoke Pollution analog] results in increased expression of GSTM5 mRNA22935520
D003033Coal Tar[Vehicle Emissions analog co-treated with Coal Tar analog] results in increased expression of GSTM5 mRNA22935520
D003300CopperCopper results in increased expression of GSTM5 mRNA22465980
C030123coumarincoumarin results in increased expression of GSTM5 protein11309284
D003407CreosoteCreosote results in increased expression of GSTM5 mRNA19389177
C007164cumene hydroperoxideGSTM5 protein affects the metabolism of cumene hydroperoxide11684093
D003471CuprizoneCuprizone results in decreased expression of GSTM5 mRNA26577399
C057862cyanoginosin LRcyanoginosin LR results in increased expression of GSTM5 mRNA17654400
D000069439DasatinibDasatinib results in increased expression of GSTM5 mRNA20579391
C014347decitabine[decitabine affects the methylation of GSTM5 promoter] which affects the expression of GSTM5 mRNA18664505|1866450
D003907DexamethasoneDexamethasone results in increased expression of GSTM5 mRNA21041162
D003907DexamethasoneDexamethasone results in increased expression of GSTM5 mRNA20032058
D003907DexamethasoneTestosterone inhibits the reaction [Dexamethasone results in increased expression of GSTM5 mRNA]20032058
D003976DiazinonDiazinon results in increased expression of GSTM5 mRNA17452286
C121718dicyclanildicyclanil results in increased expression of GSTM5 mRNA15664270
D004042Dietary Fats, Unsaturated"Dietary Fats, Unsaturated promotes the reaction [perfluorooctanoic acid results in increased expression of GSTM5 mRNA]"23626681
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of GSTM5 mRNA19850644
D004051Diethylhexyl PhthalatePPARA protein promotes the reaction [Diethylhexyl Phthalate results in increased expression of GSTM5 mRNA]19850644
D004051Diethylhexyl Phthalate"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of GSTM5 mRNA"28433925
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of GSTM5 mRNA19638242
D004137DinitrochlorobenzeneGSTM5 protein affects the metabolism of Dinitrochlorobenzene9545290
D004137DinitrochlorobenzeneGSTM5 protein affects the metabolism of Dinitrochlorobenzene9545290
D004237DiuronDiuron results in decreased expression of GSTM5 mRNA25152437
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of GSTM5 mRNA14976129
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GSTM5 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of GSTM5 mRNA12075121|1617478
D005015EthoxyquinEthoxyquin results in increased expression of GSTM5 protein11309284
C436526EUK-189EUK-189 inhibits the reaction [SOD2 gene mutant form results in increased expression of GSTM5 mRNA]15964507
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of GSTM5 gene20938992
D004397FonofosFonofos results in increased methylation of GSTM5 promoter22847954
C069837fullerene C60fullerene C60 results in decreased expression of GSTM5 mRNA19167457
C039281furanfuran results in increased expression of GSTM5 mRNA25539665
D019833GenisteinGenistein results in decreased expression of GSTM5 mRNA12075121
D005978GlutathioneGSTM5 protein affects the metabolism of Glutathione9545290
D005978GlutathioneGSTM5 protein affects the metabolism of Glutathione9545290
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of GSTM5 mRNA24763279
D017313FenretinideFenretinide results in decreased expression of GSTM5 mRNA16467112
D017313FenretinideFenretinide results in increased expression of GSTM5 mRNA28973697
C016517indole-3-carbinolindole-3-carbinol results in increased expression of GSTM5 protein11309284
C033997kahweol palmitate[cafestol co-treated with kahweol palmitate] results in increased expression of GSTM5 protein11309284
C008281limonenelimonene results in increased expression of GSTM5 mRNA12815608
D008094LithiumLithium results in increased expression of GSTM5 mRNA18082333
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of GSTM5 gene20938992
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of GSTM5 mRNA20061341
D009151Mustard GasMustard Gas results in decreased expression of GSTM5 mRNA18955075
C058346N-(4-methoxyphenyl)retinamideN-(4-methoxyphenyl)retinamide results in decreased expression of GSTM5 mRNA16467112
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of GSTM5 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of GSTM5 mRNA"25554681
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of GSTM5 mRNA15913567
C017096n-butoxyethanoln-butoxyethanol results in increased expression of GSTM5 mRNA19812364
D009532NickelNickel results in decreased expression of GSTM5 mRNA25583101
D009532NickelNickel results in decreased expression of GSTM5 mRNA19440498
C002741N-nitrosomorpholineN-nitrosomorpholine results in increased expression of GSTM5 mRNA19716841
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of GSTM5 mRNA25729387
D017239PaclitaxelGSTM5 mRNA results in decreased susceptibility to Paclitaxel16322897
D010278ParathionParathion results in increased methylation of GSTM5 promoter22847954
C023036perfluorooctanoic acid"Dietary Fats, Unsaturated promotes the reaction [perfluorooctanoic acid results in increased expression of GSTM5 mRNA]"23626681
D010634PhenobarbitalPhenobarbital results in decreased expression of GSTM5 mRNA19952500
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of GSTM5 mRNA]19482888
D010634PhenobarbitalPhenobarbital results in increased expression of GSTM5 mRNA19482888
D010634PhenobarbitalPhenobarbital results in increased expression of GSTM5 mRNA19162173
D010695PhlorhizinPhlorhizin results in decreased expression of GSTM5 mRNA22538082
D010695PhlorhizinPhlorhizin results in increased expression of GSTM5 mRNA22538082
C006253pirinixic acid[pirinixic acid co-treated with PPARA] results in decreased expression of GSTM5 mRNA20813756
C006253pirinixic acidpirinixic acid results in decreased expression of GSTM5 mRNA16221962|2081375
C006253pirinixic acidpirinixic acid results in increased expression of GSTM5 mRNA19162173
D028321Plant Preparations[Estradiol co-treated with Plant Preparations] results in decreased expression of GSTM5 mRNA26945725
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of GSTM5 mRNA18723825
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of GSTM5 mRNA19162173
D011374ProgesteroneProgesterone affects the expression of GSTM5 mRNA17251523
D011794QuercetinQuercetin results in increased expression of GSTM5 protein14750173
D011794QuercetinQuercetin results in decreased expression of GSTM5 mRNA16455785
D012524SarinSarin results in increased expression of GSTM5 mRNA19522546
C017947sodium arsenitesodium arsenite results in increased expression of GSTM5 mRNA17451858
C016104sodium bichromatesodium bichromate results in increased expression of GSTM5 mRNA22155349
D012969Sodium FluorideSodium Fluoride results in decreased expression of GSTM5 mRNA28918527
D012969Sodium FluorideSodium Fluoride results in increased expression of GSTM5 protein28918527
D013148SpironolactoneSpironolactone results in increased expression of GSTM5 mRNA18723825
D013311StreptozocinStreptozocin results in increased expression of GSTM5 mRNA16684804
D013311Streptozocinvanadyl sulfate inhibits the reaction [Streptozocin results in increased expression of GSTM5 mRNA]16684804
C012568terbufosterbufos results in increased methylation of GSTM5 promoter22847954
D013739TestosteroneTestosterone inhibits the reaction [Dexamethasone results in increased expression of GSTM5 mRNA]20032058
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GSTM5 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GSTM5 mRNA21570461
D013749Tetrachlorodibenzodioxin"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of GSTM5 mRNA"28433925
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GSTM5 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GSTM5 mRNA22298810
D013853ThioacetamideThioacetamide results in increased expression of GSTM5 mRNA23411599
C009495titanium dioxidetitanium dioxide results in decreased expression of GSTM5 mRNA23557971
D014028Tobacco Smoke Pollution[Vehicle Emissions analog co-treated with Coal Tar analog co-treated with Tobacco Smoke Pollution analog] results in increased expression of GSTM5 mRNA22935520
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of GSTM5 mRNA25729387
D014635Valproic AcidValproic Acid affects the expression of GSTM5 mRNA17963808
C034028vanadyl sulfatevanadyl sulfate inhibits the reaction [Streptozocin results in increased expression of GSTM5 mRNA]16684804
D001335Vehicle Emissions[Vehicle Emissions analog co-treated with Coal Tar analog co-treated with Tobacco Smoke Pollution analog] results in increased expression of GSTM5 mRNA22935520
D001335Vehicle Emissions[Vehicle Emissions analog co-treated with Coal Tar analog] results in increased expression of GSTM5 mRNA22935520
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of GSTM5 gene25560391
D014810Vitamin EVitamin E results in increased expression of GSTM5 mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004364glutathione transferase activity-IDA10587441  
GO:0004364glutathione transferase activity-TAS-  
GO:0005515protein binding-IPI25416956  
GO:0042802identical protein binding-IPI25416956  
GO ID GO Term Qualifier Evidence PubMed
GO:0006749glutathione metabolic process-IDA10587441  
GO:1901687glutathione derivative biosynthetic process-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0045171intercellular bridge-IDA-  
KEGG ID KEGG Term
hsa00480Glutathione metabolism
hsa00980Metabolism of xenobiotics by cytochrome P450
hsa00982Drug metabolism - cytochrome P450
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-156580Phase II - Conjugation of compoundsTAS
R-HSA-156590Glutathione conjugationTAS
R-HSA-211859Biological oxidationsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23565323Genotype and age at Parkinson disease diagnosis. (2013)Searles Nielsen SInt J Mol Epidemiol Genet
23414319Combined influence of gene-specific cord blood methylation and maternal smoking habit on birth weight. (2013 Feb)Haworth KEEpigenomics