Gene: GSTT1

2952
-
glutathione S-transferase theta 1
protein-coding
22q11.23
Ensembl:ENSG00000277656 MIM:600436 UniprotKB:P30711
NC_000022.11
PubMed
ND|AD
519   
1.901e-1 (AD)  6.191e-1 (ND)   (Frontal_Cortex)
8.913e-1 (AD)  2.239e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DDT0.376
PCYT20.331
HINT20.324
NT5M0.324
MVK0.321
HDAC110.321
C16orf860.319
PCSK40.314
MRPS280.31
TMEM1870.307

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GSTT2-0.382
MFSD6L-0.358
CXorf49-0.326
GSTT2B-0.324
DNAH11-0.324
FER1L6-0.315
TECRL-0.312
OR51A7-0.312
FCER2-0.308
KRT72-0.306

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00143GlutathioneSmall Molecule70-18-8Approved|Investigational|NutraceuticalTarget
DB00515CisplatinSmall Molecule15663-27-1ApprovedEnzyme
DB00526OxaliplatinSmall Molecule61825-94-3Approved|InvestigationalEnzyme
DB00773EtoposideSmall Molecule33419-42-0ApprovedEnzyme
DB00958CarboplatinSmall Molecule41575-94-4ApprovedEnzyme
DB09221PolaprezincSmall Molecule107667-60-7Approved|InvestigationalEnzyme
ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in increased expression of GSTT1 mRNA"19162173|1969523
C0076061,2-epoxy-3-(p-nitrophenoxy)propane"GSTT1 protein affects the metabolism of 1,2-epoxy-3-(p-nitrophenoxy)propane"14508638
C0076061,2-epoxy-3-(p-nitrophenoxy)propane"GSTT1 gene SNP inhibits the reaction [GSTT1 protein results in increased glutathionylation of 1,2-epoxy-3-(p-nitrophenoxy)propane]"21781954|2178195
C0076061,2-epoxy-3-(p-nitrophenoxy)propane"GSTT1 protein affects the metabolism of 1,2-epoxy-3-(p-nitrophenoxy)propane"15683365|1588275
C0076061,2-epoxy-3-(p-nitrophenoxy)propane"GSTT1 protein results in increased glutathionylation of 1,2-epoxy-3-(p-nitrophenoxy)propane"19664997|2178195
C0076061,2-epoxy-3-(p-nitrophenoxy)propane"GSTT1 protein affects the metabolism of 1,2-epoxy-3-(p-nitrophenoxy)propane"17827337|9854036
C0076061,2-epoxy-3-(p-nitrophenoxy)propane"GSTT1 protein affects the metabolism of 1,2-epoxy-3-(p-nitrophenoxy)propane"1848757
C0076061,2-epoxy-3-(p-nitrophenoxy)propane"GSTT1 protein affects the metabolism of and results in decreased activity of 1,2-epoxy-3-(p-nitrophenoxy)propane"8951341
C0076061,2-epoxy-3-(p-nitrophenoxy)propane"GSTT1 protein affects the metabolism of and results in decreased susceptibility to 1,2-epoxy-3-(p-nitrophenoxy)propane"7578934
C0317631,3-butadiene"GSTT1 affects the abundance of 1,3-butadiene metabolite"16949064
C0317631,3-butadiene"GSTT1 gene polymorphism promotes the reaction [EPHX1 gene polymorphism results in increased susceptibility to 1,3-butadiene]"11238181
C0238911,3-dichloro-1-propene"GSTT1 protein affects the metabolism of and results in increased activity of 1,3-dichloro-1-propene"15790493
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"[1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased activity of NR1I3 protein] which results in increased expression of GSTT1 mRNA"22496397
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of GSTT1 mRNA"18723825|2249639
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"NR1I3 protein affects the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of GSTT1 mRNA]"22496397
C0291412,2,5,7,8-pentamethyl-1-hydroxychroman"2,2,5,7,8-pentamethyl-1-hydroxychroman results in increased expression of GSTT1 mRNA"21920950
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"GSTT1 gene polymorphism affects the susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"22564066
C0369902-amino-3,8-dimethylimidazo(4,5-f)quinoxaline"GSTT1 gene polymorphism affects the susceptibility to 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline"22564066
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Particulate Matter results in decreased expression of GSTT1 mRNA]28655636
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Vehicle Emissions results in decreased expression of GSTT1 mRNA]28655636
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of GSTT1 mRNA"18648102
C0275624-nitrobenzyl chlorideGSTT1 protein affects the metabolism of 4-nitrobenzyl chloride15683365
C0275624-nitrobenzyl chlorideGSTT1 protein results in increased glutathionylation of 4-nitrobenzyl chloride19664997
C0275624-nitrobenzyl chlorideGSTT1 protein results in increased metabolism of 4-nitrobenzyl chloride23505503
C0275624-nitrobenzyl chlorideGSTT1 protein affects the metabolism of 4-nitrobenzyl chloride9854036
C0275624-nitrobenzyl chlorideGSTT1 protein affects the metabolism of 4-nitrobenzyl chloride1848757
C1100574-nitrophenethyl bromideGSTT1 protein affects the metabolism of 4-nitrophenethyl bromide15683365
C1100574-nitrophenethyl bromideGSTT1 protein affects the metabolism of 4-nitrophenethyl bromide1848757
C5225895,6-dihydrocyclopenta-1,2-dithiole-3-thione"5,6-dihydrocyclopenta-1,2-dithiole-3-thione results in increased expression of GSTT1 mRNA"19695238
C0572696-aminochrysene-1,2-dihydrodiol"GSTT1 protein affects the metabolism of and results in decreased activity of 6-aminochrysene-1,2-dihydrodiol metabolite"8951341
C4536817-amino-4-chloromethylcoumarinGSTT1 protein mutant form results in increased metabolism of 7-amino-4-chloromethylcoumarin17011574
C0084507-methylguanineGSTT1 gene polymorphism affects the susceptibility to and affects the metabolism of 7-methylguanine15066569
D000082AcetaminophenAcetaminophen results in increased expression of GSTT1 mRNA29067470
D000082AcetaminophenAcetaminophen affects the expression of GSTT1 mRNA17562736
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of GSTT1 mRNA17585979
D000082Acetaminophen[CTH gene mutant form results in increased susceptibility to Acetaminophen] which results in decreased expression of GSTT1 protein25499718
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of GSTT1 mRNA]17585979
D020106Acrylamide[CYP2E1 gene polymorphism co-treated with GSTM1 gene polymorphism co-treated with GSTT1 gene polymorphism] affects the metabolism of Acrylamide19131562
D020106AcrylamideGSTT1 gene polymorphism affects the metabolism of Acrylamide19131562
D020106AcrylamideAcrylamide results in increased expression of GSTT1 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of GSTT1 mRNA22100608|2715375
D016604Aflatoxin B1GSTT1 gene SNP affects the susceptibility to Aflatoxin B112907637
D016604Aflatoxin B1GSTT1 protein affects the metabolism of and results in decreased activity of Aflatoxin B1 metabolite8951341
D000393Air PollutantsGSTT1 gene polymorphism affects the susceptibility to Air Pollutants22732554
C038491allyl sulfideallyl sulfide results in increased expression of GSTT1 mRNA19695238
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of GSTT1 mRNA28522335
D024502alpha-Tocopherolalpha-Tocopherol results in increased expression of GSTT1 protein9855024
D000638AmiodaroneAmiodarone affects the expression of GSTT1 mRNA19483382
D000643Ammonium ChlorideAmmonium Chloride affects the expression of GSTT1 mRNA16483693
D000666Amphotericin BAmphotericin B results in decreased expression of GSTT1 mRNA20623750
C019257angelica lactoneangelica lactone results in increased expression of GSTT1 protein9855024
D000975AntioxidantsGSTT1 gene mutant form results in increased abundance of Antioxidants25420021
C000228aristolochic acid Iaristolochic acid I results in increased expression of GSTT1 mRNA17483316
D001151ArsenicArsenic affects the methylation of GSTT1 gene25304211
D001151ArsenicGSTT1 gene affects the susceptibility to Arsenic17284320
D001151ArsenicGSTT1 gene polymorphism affects the methylation of Arsenic24511153|2587699
D001151ArsenicGSTT1 gene polymorphism affects the susceptibility to Arsenic16214926
D001151ArsenicGSTT1 mutant form affects the metabolism of Arsenic22136492
D001152ArsenicalsGSTT1 gene polymorphism affects the abundance of and affects the methylation of Arsenicals27084675
C006632arsenic trioxidearsenic trioxide results in decreased expression of GSTT1 mRNA20458559
C015001arsenitearsenite results in increased expression of GSTT1 mRNA15345372
D001194AsbestosGSTT1 gene polymorphism affects the susceptibility to Asbestos20847076
D001194AsbestosGSTT1 protein affects the susceptibility to Asbestos17563610
D001205Ascorbic AcidGSTT1 affects the susceptibility to Ascorbic Acid deficiency19710200
D001241AspirinAspirin results in increased expression of GSTT1 protein9729437
D001280AtrazineAtrazine affects the expression of GSTT1 mRNA22236720
D001280Atrazine[Atrazine co-treated with Chlorpyrifos] results in decreased expression of GSTT1 mRNA22236720
D001280Atrazine[Atrazine co-treated with Chlorpyrifos] results in increased expression of GSTT1 mRNA22236720
D001280AtrazineAtrazine results in decreased expression of GSTT1 mRNA22236720
D001280AtrazineAtrazine results in decreased expression of GSTT1 mRNA22982499
C547126AZM551248AZM551248 results in decreased expression of GSTT1 mRNA22323515
D001553BenzbromaroneBenzbromarone affects the expression of GSTT1 mRNA19483382
D001554BenzeneGSTM1 gene polymorphism affects the reaction [GSTT1 gene polymorphism affects the reaction [NQO1 gene SNP results in increased susceptibility to Benzene]]17178637
D001554BenzeneGSTT1 gene polymorphism affects the susceptibility to Benzene15226677|1525614
D001554BenzeneGSTT1 gene polymorphism results in increased susceptibility to Benzene15226677|1574850
D001554BenzeneGSTT1 polymorphism affects the susceptibility to Benzene18836923
D001554BenzeneGSTT1 protein affects the metabolism of Benzene15226677
D001554BenzeneGSTT1 protein affects the susceptibility to Benzene12460800|2920468
D001554BenzeneGSTT1 protein polymorphism affects the chemical synthesis of Benzene metabolite15935803
D001554BenzeneGSTT1 protein polymorphism affects the metabolism of [Benzene co-treated with Glutathione]15533900
D001554BenzeneGSTT1 protein polymorphism affects the susceptibility to Benzene15533900|1593580
D001554BenzeneGSTT1 protein results in increased metabolism of Benzene17885617
D001554BenzeneGSTT1 gene polymorphism affects the susceptibility to Benzene18848868
C023372benzene oxideGSTT1 protein results in increased metabolism of benzene oxide26554337
C023372benzene oxideGSTT1 protein affects the metabolism of benzene oxide22153878
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of GSTT1 mRNA22228805
D001564Benzo(a)pyrene"[lipopolysaccharide, E coli O55-B5 co-treated with Benzo(a)pyrene] affects the expression of GSTT1 mRNA"28987381
C031403benzyl isothiocyanatebenzyl isothiocyanate results in increased expression of GSTT1 protein9794803
D004958EstradiolEstradiol results in decreased expression of GSTT1 mRNA23019147
D004958Estradiol[Progesterone co-treated with Estradiol] results in decreased expression of GSTT1 mRNA17404688
D004958EstradiolEstradiol results in decreased expression of GSTT1 mRNA14664709
C044887beta-methylcholinebeta-methylcholine affects the expression of GSTT1 mRNA21179406
C006780bisphenol Abisphenol A results in increased expression of GSTT1 mRNA25181051
C032036bromobenzenebromobenzene results in decreased expression of GSTT1 mRNA15056800
C025191bromodichloromethaneGSTT1 protein results in increased metabolism of bromodichloromethane12588193
C025191bromodichloromethaneGSTT1 protein results in increased metabolism of bromodichloromethane12588193
C025191bromodichloromethaneGSTT1 protein affects the metabolism of [bromodichloromethane co-treated with Glutathione]14998683
C025191bromodichloromethaneGSTT1 protein results in increased metabolism of bromodichloromethane12588193
D002066Busulfan[GSTM1 gene polymorphism co-treated with GSTT1 gene polymorphism] affects the metabolism of Busulfan21215809
D002083Butylated HydroxyanisoleButylated Hydroxyanisole results in increased expression of GSTT1 mRNA9794803
D002083Butylated HydroxyanisoleButylated Hydroxyanisole results in increased expression of GSTT1 protein9794803
D002084Butylated HydroxytolueneButylated Hydroxytoluene results in increased expression of GSTT1 mRNA15110098
D020122tert-ButylhydroperoxideGSTT1 protein affects the metabolism of tert-Butylhydroperoxide9854036
D002087ButyratesButyrates results in increased expression of GSTT1 mRNA14674679
D002101Cacodylic AcidGSTT1 gene affects the susceptibility to Cacodylic Acid17431481
D002101Cacodylic AcidGSTT1 protein affects the metabolism of Cacodylic Acid17431481
D002104CadmiumCadmium affects the expression of GSTT1 mRNA21276481
D002104CadmiumCadmium results in decreased expression of GSTT1 mRNA22257444
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of GSTT1 promoter22457795
D002220CarbamazepineCarbamazepine affects the expression of GSTT1 mRNA24752500
D002246Carbon DisulfideGSTT1 gene polymorphism affects the metabolism of Carbon Disulfide17333241
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of GSTT1 mRNA17484886
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of GSTT1 mRNA27339419
D002330CarmustineGSTT1 protein affects the susceptibility to Carmustine16874663
D002330CarmustineGSTT1 protein results in decreased nitrosation of Carmustine11841793
D002330CarmustineGSTT1 protein affects the metabolism of Carmustine17827337
D004390Chlorpyrifos[Atrazine co-treated with Chlorpyrifos] results in decreased expression of GSTT1 mRNA22236720
D004390Chlorpyrifos[Atrazine co-treated with Chlorpyrifos] results in increased expression of GSTT1 mRNA22236720
D004390ChlorpyrifosChlorpyrifos affects the expression of GSTT1 mRNA22236720
D004390ChlorpyrifosChlorpyrifos results in decreased expression of GSTT1 mRNA22236720
D004390ChlorpyrifosChlorpyrifos results in decreased expression of GSTT1 mRNA24581378
D004390ChlorpyrifosChlorpyrifos results in decreased expression of GSTT1 protein24581378
D004390ChlorpyrifosChlorpyrifos results in increased expression of GSTT1 mRNA17452286|1944049
C012843cinnamic aldehydecinnamic aldehyde affects the expression of GSTT1 mRNA28219650
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of GSTT1 mRNA17585979
D002994ClofibrateClofibrate results in increased expression of GSTT1 mRNA18723825
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of GSTT1 mRNA]17585979
D002994ClofibrateClofibrate affects the expression of GSTT1 mRNA19483382
D002994ClofibrateClofibrate results in increased expression of GSTT1 mRNA12883083
D060729Coal AshGSTT1 polymorphism affects the susceptibility to Coal Ash21334974
C018021cobaltous chloridecobaltous chloride results in decreased expression of GSTT1 mRNA24386269
D003069CoffeeCoffee affects the expression of GSTT1 mRNA21448860
D003300CopperCopper results in increased expression of GSTT1 mRNA25646894
D003300CopperCopper results in decreased expression of GSTT1 mRNA22465980
C030123coumarincoumarin results in increased expression of GSTT1 mRNA10413528|9794803
C030123coumarincoumarin results in increased expression of GSTT1 protein10413528|9794803
C007164cumene hydroperoxideGSTT1 protein affects the oxidation of cumene hydroperoxide19664997
C007164cumene hydroperoxideGSTT1 protein affects the metabolism of cumene hydroperoxide9854036
C007164cumene hydroperoxideGSTT1 protein affects the metabolism of cumene hydroperoxide1848757
D003471CuprizoneCuprizone results in increased expression of GSTT1 mRNA26577399
C057862cyanoginosin LRGSTT1 protein results in increased glutathionylation of and affects the susceptibility to cyanoginosin LR21504230
D016572CyclosporineCyclosporine results in decreased expression of GSTT1 mRNA20106945|2383089
D016572CyclosporineCyclosporine results in decreased expression of GSTT1 mRNA19770486|2330838
C093628cyproconazolecyproconazole results in increased expression of GSTT1 mRNA22334560
C017180decamethrin[decamethrin results in decreased susceptibility to decamethrin] which results in decreased expression of GSTT126588704
D003687DehydroepiandrosteroneDehydroepiandrosterone results in increased expression of GSTT1 mRNA17823450
D064791Desoxycorticosterone Acetate"[Desoxycorticosterone Acetate co-treated with Sodium Chloride, Dietary co-treated with Potassium Chloride] results in decreased expression of GSTT1 mRNA"22228705
D003907Dexamethasone[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of GSTT1 mRNA16054899
D003907DexamethasoneDexamethasone results in decreased expression of GSTT1 mRNA12971794
D003976DiazinonDiazinon results in increased expression of GSTT1 mRNA17452286
D015946Ethylene DibromideGSTT1 gene SNP inhibits the reaction [GSTT1 protein results in increased glutathionylation of Ethylene Dibromide]21781954|2178195
D015946Ethylene DibromideGSTT1 protein affects the metabolism of and results in increased activity of Ethylene Dibromide8565128
D015946Ethylene DibromideGSTT1 protein results in increased activity of Ethylene Dibromide19664997
D015946Ethylene DibromideGSTT1 protein results in increased glutathionylation of Ethylene Dibromide21781954
D015946Ethylene DibromideGSTT1 protein affects the susceptibility to Ethylene Dibromide12902151
D015946Ethylene DibromideGSTT1 protein results in increased activity of Ethylene Dibromide12505322
D015946Ethylene DibromideGSTT1 protein results in increased metabolism of and results in increased activity of Ethylene Dibromide10413528
D002945CisplatinGSTT1 gene polymorphism affects the susceptibility to [Paclitaxel co-treated with Cisplatin]12851839
D004008DiclofenacDiclofenac affects the activity of GSTT1 protein27183920
D004008DiclofenacDiclofenac affects the expression of GSTT1 mRNA24752500
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of GSTT1 mRNA26924002
C014476diethyl maleatediethyl maleate results in increased expression of GSTT1 protein9794803
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in increased expression of GSTT1 mRNA27638505
C024629dimethyl phthalatedimethyl phthalate results in decreased expression of GSTT1 mRNA26924002
D004137DinitrochlorobenzeneGSTT1 protein affects the metabolism of [Dinitrochlorobenzene co-treated with Glutathione]15950511
D004137DinitrochlorobenzeneGSTT1 protein results in increased metabolism of Dinitrochlorobenzene23505503
D004137DinitrochlorobenzeneDinitrochlorobenzene results in decreased expression of GSTT1 mRNA28219650
D004610Ellagic AcidEllagic Acid affects the expression of GSTT1 protein9855024
D004785Environmental PollutantsEnvironmental Pollutants results in increased expression of GSTT1 mRNA24534155
C109476epoxiconazoleepoxiconazole results in increased expression of GSTT1 mRNA22334560
C007366erythritol anhydrideGSTT1 gene polymorphism affects the susceptibility to erythritol anhydride12694746|1503612
C007366erythritol anhydrideGSTT1 gene polymorphism results in increased susceptibility to erythritol anhydride17078101
C007366erythritol anhydrideGSTT1 protein affects the metabolism of and results in increased activity of erythritol anhydride8565128
C007366erythritol anhydrideGSTT1 protein results in decreased activity of erythritol anhydride12694746
C007366erythritol anhydrideGSTT1 protein affects the metabolism of and results in increased activity of erythritol anhydride7578934
D002393Estrogens, Catechol"GSTT1 protein affects the metabolism of Estrogens, Catechol metabolite"15455371
D004976Ethacrynic AcidEthacrynic Acid results in decreased activity of GSTT1 protein23505503
D000431EthanolGSTT1 gene polymorphism affects the susceptibility to Ethanol15932176
D005001EthionineEthionine affects the expression of GSTT1 mRNA19483382
D005015EthoxyquinEthoxyquin results in increased expression of GSTT1 mRNA18723825
D005015EthoxyquinEthoxyquin results in increased expression of GSTT1 mRNA9794803
D005015EthoxyquinEthoxyquin results in increased expression of GSTT1 protein9794803
C002994ethylene dimethanesulfonateethylene dimethanesulfonate results in decreased expression of GSTT1 mRNA22711419
D005027Ethylene OxideGSTT1 protein affects the abundance of Ethylene Oxide metabolite17416773
D005038EthylnitrosoureaGSTT1 gene polymorphism affects the susceptibility to Ethylnitrosourea17158087
D005472FluorouracilFluorouracil results in increased expression of GSTT1 protein15585135|1680352
D005557Formaldehyde[GSTT1 protein affects the metabolism of Methylene Chloride] which results in increased abundance of Formaldehyde16765633
C039281furanfuran results in increased methylation of GSTT1 gene22079235
D005938GlucocorticoidsGSTT1 gene polymorphism affects the susceptibility to Glucocorticoids15457183
D005944GlucosamineGlucosamine results in increased expression of GSTT1 mRNA17178593
D005978GlutathioneGSTT1 protein affects the metabolism of [Dinitrochlorobenzene co-treated with Glutathione]15950511
D005978GlutathioneGSTT1 protein affects the metabolism of Glutathione14727918
D005978GlutathioneGSTT1 protein polymorphism affects the metabolism of [Benzene co-treated with Glutathione]15533900
D005978GlutathioneGSTT1 protein affects the metabolism of [bromodichloromethane co-treated with Glutathione]14998683
D005978GlutathioneGSTT1 protein affects the metabolism of Glutathione14727918
C071834glycidamide[CYP2E1 gene polymorphism co-treated with EPHX1 gene polymorphism co-treated with GSTT1 gene polymorphism] affects the abundance of glycidamide19131562
C071834glycidamide[CYP2E1 gene polymorphism co-treated with EPHX1 gene polymorphism co-treated with GSTT1 gene polymorphism] affects the metabolism of glycidamide19131562
C071834glycidamide[CYP2E1 gene polymorphism co-treated with GSTM1 gene polymorphism co-treated with GSTT1 gene polymorphism] affects the abundance of glycidamide19131562
C071834glycidamideGSTT1 gene polymorphism affects the abundance of glycidamide19131562
D006016GlycolatesGlycolates analog binds to and results in decreased activity of GSTT1 protein6686184
D006540HerbicidesHerbicides binds to and results in decreased activity of GSTT1 protein6686184
D017313FenretinideFenretinide results in decreased expression of GSTT1 mRNA16467112
D006843Hydrocarbons, Chlorinated"GSTT1 gene polymorphism affects the susceptibility to Hydrocarbons, Chlorinated"26479327
D006846Hydrocarbons, Halogenated"GSTT1 protein affects the metabolism of and results in increased activity of Hydrocarbons, Halogenated"11511186
D006846Hydrocarbons, Halogenated"GSTT1 protein affects the metabolism of and results in increased activity of Hydrocarbons, Halogenated"11511186
D006846Hydrocarbons, Halogenated"GSTT1 protein affects the metabolism of Hydrocarbons, Halogenated"8625454
D006861Hydrogen Peroxide[HP gene polymorphism co-treated with GSTT1 gene polymorphism] affects the susceptibility to Hydrogen Peroxide20444272
D007052IbuprofenIbuprofen results in increased expression of GSTT1 protein9729437
C016517indole-3-carbinolindole-3-carbinol affects the expression of GSTT1 mRNA21396975
C016517indole-3-carbinolindole-3-carbinol results in increased expression of GSTT1 mRNA10413528|9794803
C016517indole-3-carbinolindole-3-carbinol results in increased expression of GSTT1 protein10413528|9794803
D007213IndomethacinIndomethacin results in increased expression of GSTT1 protein9729437
D007306InsecticidesGSTT1 gene polymorphism affects the susceptibility to Insecticides12930676
D007306InsecticidesGSTT1 protein affects the metabolism of and results in decreased alkylation of Insecticides15103050
D0150561-Methyl-3-isobutylxanthine[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of GSTT1 mRNA16054899
D007538IsoniazidGSTT1 gene polymorphism affects the susceptibility to [Isoniazid co-treated with Rifampin]20485159
D007538IsoniazidGSTT1 gene polymorphism results in increased susceptibility to [Isoniazid co-treated with Rifampin co-treated with Pyrazinamide]18397238
D017879IsothiocyanatesGSTT1 gene polymorphism affects the susceptibility to Isothiocyanates14693750
C098607JP8 aviation fuelGSTT1 gene affects the susceptibility to JP8 aviation fuel21961652
C098607JP8 aviation fuelJP8 aviation fuel results in decreased expression of GSTT1 mRNA12832151
C410337K 7174K 7174 results in decreased expression of GSTT1 mRNA24086573
D007854Lead[GSTM1 gene mutant form co-treated with GSTT1 gene mutant form] promotes the reaction [Lead results in increased expression of CRP protein]23484121
D007854Lead[GSTM1 gene mutant form co-treated with GSTT1 gene mutant form] results in increased susceptibility to Lead23484121
D007854LeadGSTT1 gene mutant form promotes the reaction [Lead results in increased expression of CRP protein]23484121
D007854LeadGSTT1 gene mutant form results in increased susceptibility to Lead23484121
D007854LeadGSTT1 gene polymorphism affects the abundance of Lead25728017
D007854LeadLead results in decreased expression of GSTT1 mRNA19921347
C017461lead nitratelead nitrate affects the reaction [GSTT1 affects the expression of MT1 mRNA]11891201
C017461lead nitratelead nitrate affects the reaction [GSTT1 affects the expression of MT2 mRNA]11891201
D008054Lipid PeroxidesGSTT1 protein affects the metabolism of and results in decreased susceptibility to Lipid Peroxides9576856
C482199lipopolysaccharide, E coli O55-B5"[lipopolysaccharide, E coli O55-B5 co-treated with Benzo(a)pyrene] affects the expression of GSTT1 mRNA"28987381
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of GSTT1 mRNA24001438
D008070LipopolysaccharidesPlant Extracts inhibits the reaction [Lipopolysaccharides results in increased expression of GSTT1 mRNA]24001438
D008315MalondialdehydeGSTT1 gene polymorphism affects the abundance of Malondialdehyde25728017
C033266Menhaden oilMenhaden oil promotes the reaction [Polycyclic Aromatic Hydrocarbons results in increased expression of GSTT1 mRNA]22066002
C033266Menhaden oilMenhaden oil results in increased expression of GSTT1 mRNA22066002
D008627Mercuric ChlorideMercuric Chloride affects the expression of GSTT1 mRNA20353558
D008628Mercury[GSTM1 gene polymorphism co-treated with GSTT1 gene polymorphism] affects the susceptibility to Mercury24319713
D008628MercuryGSTT1 gene polymorphism affects the abundance of Mercury21967774
D008628MercuryGSTT1 gene polymorphism affects the susceptibility to Mercury20194072
D008628MercuryGSTT1 gene polymorphism promotes the reaction [GSTP1 gene polymorphism affects the abundance of Mercury]19515364
D008628MercuryGSTT1 polymorphism affects the susceptibility to Mercury17716707
D008694MethamphetamineGSTT1 gene polymorphism affects the susceptibility to Methamphetamine18186040
D008694MethamphetamineGSTT1 protein affects the susceptibility to Methamphetamine19254865
D008713MethimazoleMethimazole results in increased expression of GSTT1 mRNA22504374
C013598methoxyacetic acidmethoxyacetic acid affects the expression of GSTT1 mRNA20864626
C005218methyl bromideGSTT1 protein results in increased metabolism of methyl bromide11305778
D008737Methyl ChlorideGSTT1 protein polymorphism affects the metabolism of and affects the susceptibility to Methyl Chloride11218045
D008737Methyl ChlorideGSTT1 protein results in increased metabolism of Methyl Chloride11305778
C027947methylene bromideGSTT1 protein affects the metabolism of and results in increased activity of methylene bromide8565128
C027947methylene bromideGSTT1 protein affects the metabolism of methylene bromide14727918
C027947methylene bromideGSTT1 protein affects the metabolism of and results in increased activity of methylene bromide11511186
C027947methylene bromideGSTT1 protein affects the metabolism of methylene bromide14727918
D008752Methylene ChlorideGSTT1 gene polymorphism affects the metabolism of Methylene Chloride7979958
D008752Methylene ChlorideGSTT1 protein affects the metabolism of Methylene Chloride14727918|1568336
D008752Methylene ChlorideGSTT1 protein alternative form affects the susceptibility to Methylene Chloride20837120
D008752Methylene ChlorideGSTT1 protein results in increased metabolism of Methylene Chloride11446825|1205476
D008752Methylene ChlorideGSTT1 protein affects the metabolism of and results in increased activity of Methylene Chloride15683365|8761485
D008752Methylene ChlorideGSTT1 protein affects the metabolism of Methylene Chloride17827337|8670055
D008752Methylene Chloride[GSTT1 protein affects the metabolism of Methylene Chloride] which results in increased abundance of Formaldehyde16765633
D008752Methylene ChlorideGSTT1 protein affects the metabolism of Methylene Chloride1848757|8670055
D008752Methylene ChlorideGSTT1 protein affects the metabolism of Methylene Chloride14727918
D008752Methylene ChlorideGSTT1 protein results in increased metabolism of and results in increased activity of Methylene Chloride10413528
D008752Methylene ChlorideGSTT1 protein results in increased metabolism of Methylene Chloride11453994
D008752Methylene ChlorideGSTT1 protein results in increased metabolism of Methylene Chloride20837120
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of GSTT1 mRNA23103053
D008743Methyl ParathionGSTT1 protein affects the metabolism of and results in decreased alkylation of Methyl Parathion15103050
C043243methyl tert-butyl ethermethyl tert-butyl ether affects the expression of GSTT1 mRNA24128854
C063855microcystin RRGSTT1 protein results in increased glutathionylation of microcystin RR23538035
D052998MicrocystinsMicrocystins affects the expression of GSTT1 mRNA19790251
D052998MicrocystinsMicrocystins results in increased expression of GSTT1 mRNA19790251
C020300monomethylarsonic acidGSTT1 protein affects the methylation of monomethylarsonic acid17431481
C517284monomethyl phthalatemonomethyl phthalate affects the expression of GSTT1 mRNA26924002
C005939muconic acidGSTT1 affects the abundance of muconic acid10780264
C058346N-(4-methoxyphenyl)retinamideN-(4-methoxyphenyl)retinamide results in decreased expression of GSTT1 mRNA16467112
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of GSTT1 mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of GSTT1 mRNA"25554681
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of GSTT1 mRNA12883083
C017096n-butoxyethanoln-butoxyethanol results in increased expression of GSTT1 mRNA19812364
D009532NickelNickel results in decreased expression of GSTT1 mRNA24768652
C022838nickel chloridenickel chloride results in decreased expression of GSTT1 mRNA12729255|1464567
C017557nickel subsulfidenickel subsulfide results in decreased expression of GSTT1 mRNA12729255
D009585Nitrogen DioxideGSTT1 gene polymorphism affects the susceptibility to Nitrogen Dioxide22732554
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of GSTT1 mRNA27935865
C464660obeticholic acidobeticholic acid results in increased expression of GSTT1 mRNA27939613
C025589ochratoxin Aochratoxin A results in decreased expression of GSTT1 mRNA23358140
C026209oltiprazoltipraz affects the localization of GSTT1 protein10413528|9794803
C026209oltiprazoltipraz results in increased expression of GSTT1 protein9794803|9855024
D009853OmeprazoleOmeprazole affects the expression of GSTT1 mRNA19483382
C016340o,p'-DDT"o,p'-DDT affects the expression of GSTT1 mRNA"17984292
D010755OrganophosphatesGSTT1 gene polymorphism affects the susceptibility to Organophosphates26318115
D010126OzoneGSTT1 gene polymorphism affects the susceptibility to Ozone22732554
D017239PaclitaxelGSTT1 gene polymorphism affects the susceptibility to [Paclitaxel co-treated with Cisplatin]12851839
D010269ParaquatGSTT1 protein affects the susceptibility to Paraquat23045187
D052638Particulate Matter2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Particulate Matter results in decreased expression of GSTT1 mRNA]28655636
D052638Particulate MatterGSTT1 gene polymorphism affects the susceptibility to Particulate Matter22732554
D052638Particulate MatterParticulate Matter results in decreased expression of GSTT1 mRNA28655636
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of GSTT1 mRNA19162173
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid affects the expression of GSTT1 mRNA19429403
C023036perfluorooctanoic acidperfluorooctanoic acid affects the expression of GSTT1 mRNA19429403
D010575PesticidesGSTT1 affects the susceptibility to Pesticides26656529
D010575PesticidesGSTT1 gene polymorphism affects the susceptibility to Pesticides14504370|1592252
D010575PesticidesGSTT1 protein results in increased susceptibility to Pesticides18550589
C058305phenethyl isothiocyanatephenethyl isothiocyanate results in increased expression of GSTT1 protein9855024
D010634PhenobarbitalPhenobarbital results in decreased expression of GSTT1 mRNA19952500
D010634PhenobarbitalPhenobarbital affects the expression of GSTT1 mRNA23091169
D010634PhenobarbitalPhenobarbital results in increased expression of GSTT1 mRNA18723825|9854036
D010634PhenobarbitalPhenobarbital affects the expression of GSTT1 mRNA19162173
D010634PhenobarbitalPhenobarbital results in increased expression of GSTT1 mRNA10413528
D010634PhenobarbitalPhenobarbital results in increased expression of GSTT1 protein10413528|9794803
D010695PhlorhizinPhlorhizin results in decreased expression of GSTT1 mRNA22538082
D010695PhlorhizinPhlorhizin results in increased expression of GSTT1 mRNA22538082
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of GSTT1 mRNA27935865
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of GSTT1 mRNA19710929
C006253pirinixic acidpirinixic acid affects the expression of GSTT1 mRNA19483382
D010894PiroxicamPiroxicam results in increased expression of GSTT1 protein9729437
D010936Plant ExtractsPlant Extracts inhibits the reaction [Lipopolysaccharides results in increased expression of GSTT1 mRNA]24001438
D028321Plant PreparationsGSTT1 gene polymorphism affects the susceptibility to Plant Preparations17602170
D017671Platinum CompoundsGSTT1 affects the susceptibility to Platinum Compounds21844884
D011084Polycyclic Aromatic HydrocarbonsGSTT1 gene polymorphism affects the susceptibility to Polycyclic Aromatic Hydrocarbons12807751
D011084Polycyclic Aromatic HydrocarbonsGSTT1 protein affects the metabolism of and results in decreased activity of Polycyclic Aromatic Hydrocarbons15122594
D011084Polycyclic Aromatic HydrocarbonsGSTT1 protein results in decreased activity of Polycyclic Aromatic Hydrocarbons15122594
D011084Polycyclic Aromatic HydrocarbonsMenhaden oil promotes the reaction [Polycyclic Aromatic Hydrocarbons results in increased expression of GSTT1 mRNA]22066002
D011084Polycyclic Aromatic HydrocarbonsPolycyclic Aromatic Hydrocarbons results in increased expression of GSTT1 mRNA22066002
D011189Potassium Chloride"[Desoxycorticosterone Acetate co-treated with Sodium Chloride, Dietary co-treated with Potassium Chloride] results in decreased expression of GSTT1 mRNA"22228705
D011192Potassium DichromatePotassium Dichromate results in increased expression of GSTT1 mRNA18332044
D011374ProgesteroneProgesterone results in decreased expression of GSTT1 mRNA23018184
D011374Progesterone[Progesterone co-treated with Estradiol] results in decreased expression of GSTT1 mRNA17404688
C045950propiconazolepropiconazole results in increased expression of GSTT1 mRNA22334560
D011441PropylthiouracilPropylthiouracil affects the expression of GSTT1 mRNA19483382
D011441PropylthiouracilPropylthiouracil results in increased expression of GSTT1 mRNA22504374|2478091
D011718PyrazinamideGSTT1 gene polymorphism results in increased susceptibility to [Isoniazid co-treated with Rifampin co-treated with Pyrazinamide]18397238
C031280pyrazolepyrazole results in decreased expression of GSTT1 mRNA17945193
D011794QuercetinQuercetin results in decreased expression of GSTT1 protein22830632
D011794QuercetinQuercetin results in decreased expression of GSTT1 mRNA16455785
D012293RifampinGSTT1 gene polymorphism affects the susceptibility to [Isoniazid co-treated with Rifampin]20485159
D012293RifampinGSTT1 gene polymorphism results in increased susceptibility to [Isoniazid co-treated with Rifampin co-treated with Pyrazinamide]18397238
C089730rosiglitazone[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of GSTT1 mRNA16054899
C089730rosiglitazonerosiglitazone affects the expression of GSTT1 mRNA17245590
C541923sandostatinLARsandostatinLAR results in decreased expression of GSTT1 mRNA17210224
D012643SeleniumSelenium deficiency results in increased expression of GSTT19331086
C009237senecioninesenecionine results in decreased expression of GSTT1 mRNA26100227
C058186S-hexylglutathione-sepharoseS-hexylglutathione-sepharose binds to GSTT1 protein2337594
D012834SilverSilver results in increased expression of GSTT1 mRNA21276481
D020123SirolimusGSTT1 gene mutant form results in increased susceptibility to Sirolimus12916871
C017947sodium arsenitesodium arsenite affects the expression of GSTT1 mRNA16507464
C017947sodium arsenite[sodium arsenite co-treated with Tetradecanoylphorbol Acetate] results in increased expression of GSTT1 mRNA16368122
C017947sodium arsenitesodium arsenite results in decreased expression of GSTT1 mRNA29108910
C017947sodium arsenitesodium arsenite results in increased expression of GSTT1 mRNA17451858
C016104sodium bichromatesodium bichromate results in increased expression of GSTT1 mRNA12325037
D017673Sodium Chloride, Dietary"[Desoxycorticosterone Acetate co-treated with Sodium Chloride, Dietary co-treated with Potassium Chloride] results in decreased expression of GSTT1 mRNA"22228705
D012982Sodium, Dietary"GSTT1 gene polymorphism affects the susceptibility to Sodium, Dietary"14696128
D018038Sodium SeleniteSodium Selenite results in increased expression of GSTT1 mRNA16705456|2438354
D012997SolventsGSTT1 polymorphism affects the susceptibility to Solvents24914957
D053260SootSoot results in decreased expression of GSTT1 mRNA23065132
C053003S-phenyl-N-acetylcysteineGSTT1 gene polymorphism affects the abundance of S-phenyl-N-acetylcysteine20100551
C053003S-phenyl-N-acetylcysteineGSTT1 gene polymorphism affects the reaction [GSTM1 gene polymorphism affects the abundance of S-phenyl-N-acetylcysteine]20100551
C053003S-phenyl-N-acetylcysteineGSTT1 polymorphism affects the abundance of S-phenyl-N-acetylcysteine21300142
C053003S-phenyl-N-acetylcysteineGSTT1 protein polymorphism affects the chemical synthesis of S-phenyl-N-acetylcysteine15533900|1593580
D013241SterigmatocystinGSTT1 protein affects the metabolism of and results in decreased activity of Sterigmatocystin metabolite8951341
C025906stilbene oxidestilbene oxide results in increased expression of GSTT1 protein9794803
D020058StyreneGSTM1 gene polymorphism promotes the reaction [GSTT1 gene polymorphism results in increased susceptibility to Styrene]12016165
D020058StyreneGSTT1 gene polymorphism affects the susceptibility to Styrene12717779|1475167
D020058StyreneGSTT1 gene polymorphism results in increased susceptibility to Styrene12016165|1642482
C013690styrene oxideGSTT1 gene polymorphism results in increased susceptibility to styrene oxide12016165
C013690styrene oxideGSTT1 protein affects the susceptibility to styrene oxide15468052
C016766sulforafansulforafan results in decreased expression of GSTT1 mRNA20442190
C016766sulforafansulforafan analog results in increased expression of GSTT1 protein9855024
D013457Sulfur CompoundsGSTT1 gene polymorphism affects the susceptibility to Sulfur Compounds15033463
D013467SulindacSulindac results in increased expression of GSTT1 protein9729437
C446685systhanesysthane results in increased expression of GSTT1 mRNA16730040
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of GSTT1 mRNA25172293
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of GSTT1 mRNA11272835
D013749TetrachlorodibenzodioxinAHR protein affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of GSTT1 mRNA]22496397
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of GSTT1 mRNA22496397
D013755Tetradecanoylphorbol Acetate[sodium arsenite co-treated with Tetradecanoylphorbol Acetate] results in increased expression of GSTT1 mRNA16368122
D013827ThiabendazoleThiabendazole results in increased expression of GSTT1 mRNA15110098
D013849ThimerosalGSTT1 affects the susceptibility to Thimerosal11007341
D013849ThimerosalThimerosal results in decreased expression of GSTT1 mRNA27188386
D013853ThioacetamideThioacetamide affects the expression of GSTT1 mRNA19483382
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased susceptibility to GSTT1 protein polymorphism23643483
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of GSTT1 mRNA20133372
C032910triadimefontriadimefon results in increased expression of GSTT1 mRNA16730040
D014241TrichloroethyleneTrichloroethylene results in decreased expression of GSTT1 mRNA19448997
D022882TrihalomethanesGSTT1 affects the susceptibility to Trihalomethanes20675267
D014303TrinitrotolueneTrinitrotoluene affects the expression of GSTT1 mRNA21346803
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of GSTT1 mRNA"26179874
D014315TriterpenesTriterpenes results in increased expression of GSTT1 mRNA18544911
C057693troglitazoneGSTT1 gene polymorphism affects the susceptibility to troglitazone12732844
D014415TunicamycinTunicamycin results in decreased expression of GSTT1 mRNA17127020
D014527Uric AcidGSTT1 protein polymorphism affects the abundance of Uric Acid23747713
D014635Valproic AcidValproic Acid affects the expression of GSTT1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of GSTT1 mRNA23179753|2915479
D001335Vehicle Emissions2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Vehicle Emissions results in decreased expression of GSTT1 mRNA]28655636
D001335Vehicle EmissionsVehicle Emissions results in decreased expression of GSTT1 mRNA28655636
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of GSTT1 gene25560391
D001335Vehicle EmissionsVehicle Emissions analog results in increased expression of GSTT1 mRNA15541757
C025643vinclozolinvinclozolin results in decreased expression of GSTT1 mRNA23034163
C025643vinclozolinvinclozolin results in increased expression of GSTT1 mRNA22570695
D014752Vinyl Chloride[GSTM1 gene polymorphism co-treated with GSTT1 gene polymorphism] results in increased susceptibility to Vinyl Chloride16977343
D014752Vinyl ChlorideGSTT1 gene polymorphism affects the reaction [XRCC1 gene polymorphism affects the reaction [Vinyl Chloride affects the mutagenesis of TP53 gene]]16097394
D014752Vinyl ChlorideGSTT1 gene polymorphism results in increased susceptibility to Vinyl Chloride16270392
C104536xanthohumolxanthohumol results in increased expression of GSTT1 mRNA23085367
C104536xanthohumolxanthohumol results in increased expression of GSTT1 protein23085367
C016837zinc chloridezinc chloride results in increased expression of GSTT1 mRNA19683351

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004364glutathione transferase activity-IBA21873635  
GO:0004364glutathione transferase activity-IDA9307035  9434735  20097269  
GO:0004364glutathione transferase activity-TAS-  
GO:0004602glutathione peroxidase activity-IDA9307035  9434735  
GO:0005515protein binding-IPI25910212  
GO ID GO Term Qualifier Evidence PubMed
GO:0006749glutathione metabolic process-IBA21873635  
GO:0006749glutathione metabolic process-IDA9307035  9434735  20097269  
GO:0098869cellular oxidant detoxification-IEA-  
GO:1901687glutathione derivative biosynthetic process-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0005829cytosol-IDA8799324  
GO:0005829cytosol-TAS-  
GO:0070062extracellular exosome-HDA23533145  
KEGG ID KEGG Term
hsa00480Glutathione metabolism
hsa00980Metabolism of xenobiotics by cytochrome P450
hsa00982Drug metabolism - cytochrome P450
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-156580Phase II - Conjugation of compoundsTAS
R-HSA-156590Glutathione conjugationTAS
R-HSA-211859Biological oxidationsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

There is no Interaction data for this gene.

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
11257276Interaction of the glutathione S-transferase genes and cigarette smoking on risk of lower extremity arterial disease: the Atherosclerosis Risk in Communities (ARIC) study. (2001 Feb 15)Li RAtherosclerosis
18690546CYP1A2, CYP2D6, GSTM1, GSTP1, and GSTT1 gene polymorphisms in patients with bladder cancer in a Turkish population. (2009)Altayli EInt Urol Nephrol
23840148CYP1A1, GSTM1, GSTT1 and NQO1 polymorphisms and colorectal adenomas in Japanese men. (2013 Jul 7)Hamachi TWorld J Gastroenterol
12811412Interactive effect of the glutathione S-transferase genes and cigarette smoking on occurrence and severity of coronary artery risk. (2003 Aug)Masetti SJ Mol Med (Berl)
15829318Polymorphisms in genes involved in xenobiotic metabolism and lung cancer risk under the age of 60 years. A pooled study of lung cancer patients in Denmark and Norway. (2005 May)Skuladottir HLung Cancer
26600754Prostate cancer and glutathione S-transferase deletions. (2015)Malik SSEXCLI J
15840612Cigarette smoking and colorectal cancer: APC mutations, hMLH1 expression, and GSTM1 and GSTT1 polymorphisms. (2005 May 1)Luchtenborg MAm J Epidemiol
10511265Variations in urinary 1-hydroxypyrene glucuronide in relation to smoking and the modification effects of GSTM1 and GSTT1. (1999 Sep 5)Hong YCToxicol Lett
20847076Genetic susceptibility to asbestos-related fibrotic pleuropulmonary changes. (2011 Sep)Kukkonen MKEur Respir J
15646021Genetic polymorphism of the CYP1A1, CYP2E1, GSTM1 and GSTT1 genes and lung cancer susceptibility in a north indian population. (2004 Nov)Sobti RCMol Cell Biochem
27275760Metabolites of the Polycyclic Aromatic Hydrocarbon Phenanthrene in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer. (2016)Patel YMPLoS One
19960570Glutathione-S-transferase (GSTM1, GSTT1) and the risk of gastrointestinal cancer in a Korean population. (2009 Dec 7)Piao JMWorld J Gastroenterol
11097350Influence of glutathione S-transferase M1 and T1 genotypes on larynx cancer risk among Korean smokers. (2000 Sep)Hong YJClin Chem Lab Med
10334644Genetic polymorphism of glutathione S-transferase P1 gene and lung cancer risk. (1999 Feb)To-Figueras JCancer Causes Control
12468438CYP1A1*2B (Val) allele is overrepresented in a subgroup of acute myeloid leukemia patients with poor-risk karyotype associated with NRAS mutation, but not associated with FLT3 internal tandem duplication. (2003 Apr 1)Bowen DTBlood
24670356GSTP1, GSTM1 and GSTT1 genetic polymorphisms and total serum GST concentration in stable male COPD. (2014 Mar)Zuntar IActa Pharm
12037246Organic solvent exposure, genes, and risk of neuropsychological impairment. (2002 Jun)Dick FQJM
28696897Polymorphisms of xenobiotic metabolizing enzymes in bladder cancer patients of the Semmelweis University Budapest, Hungary. (2017)Ebbinghaus DJ Toxicol Environ Health A
21189176[Relationship between genetic polymorphism of GSTT1 gene and inherent susceptibility to lung cancer in Han population in Sichuan, China]. (2005 Apr 20)Yuan TZhongguo Fei Ai Za Zhi
23661016Association between GSTP1, GSTM1 and GSTT1 polymorphisms involved in xenobiotic metabolism and head and neck cancer development. (2013 Jul)Russo AMol Biol Rep
11401922Feasibility of collecting buccal cell DNA by mail in a cohort study. (2001 Jun)Le Marchand LCancer Epidemiol Biomarkers Prev
8988674Glutathione S-transferase and cytochrome-P-450 polymorphism as risk factors for squamous cell carcinoma of the larynx. (1996 Dec)Jahnke VAm J Surg
29111615Glutathione S-transferase genes and the risk of type 2 diabetes mellitus: Role of sexual dimorphism, gene-gene and gene-smoking interactions in disease susceptibility. (2018 May)Azarova IJ Diabetes
24075358GSTA1, GSTM1, GSTP1, and GSTT1 polymorphisms and susceptibility to smoking-related bladder cancer: a case-control study. (2013 Oct)Matic MUrol Oncol
10840461Polymorphisms of N-acetyltransferase 2, glutathione S-transferase mu and theta genes as risk factors of bladder cancer in relation to asthma and tuberculosis. (2000 Jul)Kim WJJ Urol
15093278Cytogenetic biomarkers and genetic polymorphisms. (2004 Apr 1)Norppa HToxicol Lett
27686690Glutathione S-Transferase T1 (GSTT1) Null Polymorphism, Smoking, and Their Interaction in Coronary Heart Disease: A Comprehensive Meta-Analysis. (2017 Apr)Song YHeart Lung Circ
22502660An updated pooled analysis of glutathione S-transferase genotype polymorphisms and risk of adult gliomas. (2012)Yao LAsian Pac J Cancer Prev
14618622Effect of SULT1A1 and NAT2 genetic polymorphism on the association between cigarette smoking and colorectal adenomas. (2004 Jan 1)Tiemersma EWInt J Cancer
15223862Glutathione S transferase deficiency and passive smoking increase childhood asthma. (2004 Jul)Kabesch MThorax
16535824[Relationship between GSTM1 and GSTT1 gene polymorphisms and noise induced hearing loss in Chinese workers]. (2005 Nov)Yang MWei Sheng Yan Jiu
18463401CYP1A1, GSTM1, and GSTT1 polymorphisms, smoking, and lung cancer risk in a pooled analysis among Asian populations. (2008 May)Lee KMCancer Epidemiol Biomarkers Prev
11854392A population-based, case-control study of polymorphisms in carcinogen-metabolizing genes, smoking, and pancreatic adenocarcinoma risk. (2002 Feb 20)Duell EJJ Natl Cancer Inst
22234881Copy number variations of GSTT1 and GSTM1, colorectal cancer risk and possible effect modification of cigarette smoking and menopausal hormone therapy. (2012 Sep 1)Rudolph AInt J Cancer
10371337Glutathione-S-transferase polymorphisms and risk of squamous-cell carcinoma of the head and neck. (1999 Jun 21)Cheng LInt J Cancer
9804932Chromosomal aberrations, sister-chromatid exchanges, cells with high frequency of SCE, micronuclei and comet assay parameters in 1, 3-butadiene-exposed workers. (1998 Nov 9)Sram RJMutat Res
12296511Cigarette smoking, glutathione-s-transferase M1 and t1 genetic polymorphisms, and breast cancer risk (United States). (2002 Sep)Zheng TCancer Causes Control
9748537Comparison of DNA adduct levels associated with oxidative stress in human pancreas. (1998 Sep 20)Kadlubar FFMutat Res
24535881Association of the GSTT1 polymorphism in upper aerodigestive tract cancer with tobacco smoking. (2014 Jan 21)Silva TMGenet Mol Res
24266295Polymorphisms of genes involved in polycyclic aromatic hydrocarbons' biotransformation and atherosclerosis. (2013)Marinkovic NBiochem Med (Zagreb)
12712736[Glutathione S-transferase GSTM1 and GSTT1 genotypes and susceptibility to lung cancer]. (1999 Jan 30)Lan QWei Sheng Yan Jiu
23845145Risk factors for serious adverse effects of thiopurines in patients with Crohn's disease. (2013 Jul)Mazor YCurr Drug Saf
17160896Orofacial cleft risk is increased with maternal smoking and specific detoxification-gene variants. (2007 Jan)Shi MAm J Hum Genet
22330623Association of manganese superoxide dismutase and glutathione S-transferases genotypes with carotid atherosclerosis in patients with diabetes mellitus type 2. (2012 Feb)Santl Letonja MInt Angiol
25348056Joint effect of glutathione S-transferase genotypes and cigarette smoking on idiopathic male infertility. (2015 Nov)Yarosh SLAndrologia
15258326GSTT1 gene deletion is associated with lung cancer in Mexican patients. (2003-2004)Gallegos-Arreola MPDis Markers
20534171Cigarette smoking, genetic polymorphisms and colorectal cancer risk: the Fukuoka Colorectal Cancer Study. (2010 Jun 10)Nisa HBMC Cancer
19917083Examination of polymorphic glutathione S-transferase (GST) genes, tobacco smoking and prostate cancer risk among men of African descent: a case-control study. (2009 Nov 16)Lavender NABMC Cancer
21436184Glutathione S-transferase M1 (GSTM1) and glutathione S-transferase T1 (GSTT1) null polymorphisms, smoking, and their interaction in oral cancer: a HuGE review and meta-analysis. (2011 Apr 15)Zhang ZJAm J Epidemiol
16206220A multi-biomarker analysis of DNA damage in automobile painters. (2005 Oct)Testa AEnviron Mol Mutagen
19701675Genetic susceptibility in solvent induced neurobehavioral effects. (2010 Apr)Godderis LNeurotox Res
28192769Disorganization at the stage of schizophrenia clinical outcome: Clinical-biological study. (2017 May)Nestsiarovich AEur Psychiatry
16977512The association between polymorphic genotypes of glutathione S-transferases and COPD in the Turkish population. (2006 Oct)Calikoglu MBiochem Genet
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