Gene: GSTZ1

2954
GSTZ1-1|MAAI|MAAID|MAI
glutathione S-transferase zeta 1
protein-coding
14q24.3
Ensembl:ENSG00000100577 MIM:603758 Vega:OTTHUMG00000171551 UniprotKB:O43708
NC_000014.9
PubMed
0   ANCO-SNPs
ND
3   
1.555e-1 (AD)  7.555e-1 (ND)   (Frontal_Cortex)
1.498e-1 (AD)  5.885e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CIRBP0.823
COMMD40.806
CDPF10.803
FAHD2B0.786
NMRAL10.786
TRAPPC6A0.769
HINT20.762
DHRS120.761
MMAB0.755
CYB5D20.754

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.486
OR4F29-0.477
EPPIN-0.385
SIX4-0.366
CCDC36-0.355
MTRNR2L6-0.352
MTRNR2L9-0.348
RAX2-0.348
CELSR1-0.342
DNAH11-0.335

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00143GlutathioneSmall Molecule70-18-8Approved|Investigational|NutraceuticalTarget
DB044471,4-DithiothreitolSmall Molecule3483-12-3ExperimentalTarget
DB08809Dichloroacetic AcidSmall Molecule79-43-6Approved|InvestigationalTarget
ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of GSTZ1 mRNA"23962555
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of GSTZ1 mRNA"27291303
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of GSTZ1 mRNA"27291303
C0668412,3,7,8-tetrabromodibenzo-4-dioxin"2,3,7,8-tetrabromodibenzo-4-dioxin results in increased expression of GSTZ1 protein"27604104
C0352082-amino-4,6-dinitrotoluene"2-amino-4,6-dinitrotoluene results in increased expression of GSTZ1 mRNA"26251320
C0502243,5,5-trimethylhexanoylferrocene"3,5,5-trimethylhexanoylferrocene results in decreased expression of GSTZ1 protein"22649188
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of GSTZ1 mRNA"18648102
C0326424-aminophenylarsenoxide4-aminophenylarsenoxide binds to GSTZ1 protein26598702
C0326424-aminophenylarsenoxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to GSTZ1 protein]26598702
D000082AcetaminophenAcetaminophen results in increased expression of GSTZ1 mRNA25704631
D000082AcetaminophenAcetaminophen affects the expression of GSTZ1 mRNA17562736
D000082Acetaminophen[CTH gene mutant form results in increased susceptibility to Acetaminophen] which results in decreased expression of GSTZ1 protein25499718
D000082AcetaminophenGSTZ1 protein affects the susceptibility to Acetaminophen16278372
D016604Aflatoxin B1Aflatoxin B1 affects the expression of GSTZ1 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of GSTZ1 mRNA22100608
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of GSTZ1 mRNA19770486
D000638AmiodaroneAmiodarone results in increased expression of GSTZ1 mRNA19774075
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of GSTZ1 mRNA24449571
C004984apocarotenalapocarotenal results in decreased expression of GSTZ1 mRNA17034753
C006632arsenic trioxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to GSTZ1 protein]26598702
C006632arsenic trioxidearsenic trioxide results in increased expression of GSTZ1 mRNA15761015
C039726artesunateGSTZ1 mRNA affects the susceptibility to artesunate15796179
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of GSTZ1 mRNA20106945
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of GSTZ1 mRNA19770486
D019207beta Carotenebeta Carotene results in decreased expression of GSTZ1 mRNA17034753
D001647Bile Acids and SaltsBile Acids and Salts results in decreased activity of GSTZ1 protein1846734
C006780bisphenol Abisphenol A results in decreased expression of GSTZ1 mRNA25181051
D001965BromidesBromides inhibits the reaction [Dichloroacetic Acid results in decreased activity of GSTZ1 protein]24632415
D020122tert-ButylhydroperoxideGSTZ1 protein affects the metabolism of tert-Butylhydroperoxide9396740
D002104CadmiumCadmium affects the expression of GSTZ1 mRNA21276481
D002104CadmiumCadmium results in increased expression of GSTZ1 mRNA19744577
D019256Cadmium ChlorideCadmium Chloride results in increased expression of GSTZ1 protein24527689
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of GSTZ1 mRNA20061341
C034939cadmium sulfidecadmium sulfide results in increased expression of GSTZ1 mRNA27866839
D002220CarbamazepineCarbamazepine affects the expression of GSTZ1 mRNA25979313
D002220CarbamazepineCarbamazepine results in increased expression of GSTZ1 mRNA17112801
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of GSTZ1 mRNA27339419
C026690cerous chloride[cerous chloride co-treated with lanthanum chloride] results in increased expression of GSTZ1 mRNA28954213
D002712ChloridesChlorides inhibits the reaction [Dichloroacetic Acid results in decreased activity of GSTZ1 protein]24632415
C120963chlorofluoroacetic acidGSTZ1 protein affects the metabolism of chlorofluoroacetic acid12119007
C120963chlorofluoroacetic acidGSTZ1 protein polymorphism affects the metabolism of chlorofluoroacetic acid12119007
C120963chlorofluoroacetic acidGSTZ1 protein affects the metabolism of chlorofluoroacetic acid12441371
D002994ClofibrateClofibrate results in increased expression of GSTZ1 mRNA18723825
C018021cobaltous chloridecobaltous chloride results in decreased expression of GSTZ1 mRNA19376846
C007164cumene hydroperoxideGSTZ1 protein affects the metabolism of cumene hydroperoxide9396740
C029892cupric chloridecupric chloride results in increased expression of GSTZ1 mRNA23707386
D016572CyclosporineCyclosporine results in decreased expression of GSTZ1 mRNA20106945
C010902decabromobiphenyl etherdecabromobiphenyl ether affects the expression of GSTZ1 mRNA24834073
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of GSTZ1 mRNA23640034
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of GSTZ1 mRNA23640034
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of GSTZ1 mRNA]27941970
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of GSTZ1 mRNA17361019|2126653
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of GSTZ1 mRNA21266533
D003999Dichloroacetic AcidBromides inhibits the reaction [Dichloroacetic Acid results in decreased activity of GSTZ1 protein]24632415
D003999Dichloroacetic AcidChlorides inhibits the reaction [Dichloroacetic Acid results in decreased activity of GSTZ1 protein]24632415
D003999Dichloroacetic AcidDichloroacetic Acid results in decreased activity of GSTZ1 protein12119007|1243732
D003999Dichloroacetic AcidDichloroacetic Acid results in decreased activity of GSTZ1 protein polymorphism12119007
D003999Dichloroacetic AcidGSTZ1 protein binds to and affects the metabolism of Dichloroacetic Acid12437329
D003999Dichloroacetic AcidGSTZ1 protein SNP results in increased metabolism of Dichloroacetic Acid10739172
D003999Dichloroacetic AcidIodides inhibits the reaction [Dichloroacetic Acid results in decreased activity of GSTZ1 protein]24632415
D003999Dichloroacetic AcidSulfites inhibits the reaction [Dichloroacetic Acid results in decreased activity of GSTZ1 protein]24632415
D003999Dichloroacetic AcidDichloroacetic Acid results in decreased activity of GSTZ1 protein11960676
D003999Dichloroacetic AcidGSTZ1 protein affects the metabolism of Dichloroacetic Acid15277241
D003999Dichloroacetic AcidGSTZ1 protein results in increased metabolism of Dichloroacetic Acid20045428
D003999Dichloroacetic AcidDichloroacetic Acid results in decreased activity of GSTZ1 protein10471397|1244137
D003999Dichloroacetic AcidDichloroacetic Acid results in decreased expression of and results in decreased activity of GSTZ1 protein12019185
D003999Dichloroacetic AcidDichloroacetic Acid results in decreased expression of GSTZ1 protein14599561
D003999Dichloroacetic AcidGSTZ1 protein affects the metabolism of and results in increased activity of Dichloroacetic Acid15144222
D003999Dichloroacetic AcidGSTZ1 protein affects the metabolism of Dichloroacetic Acid12019185|1244137
D003999Dichloroacetic AcidGSTZ1 protein results in increased metabolism of Dichloroacetic Acid24632415
D003999Dichloroacetic Acid[GSTZ1 protein results in increased metabolism of Dichloroacetic Acid] which results in increased chemical synthesis of glyoxylic acid24632415
D002945CisplatinCisplatin results in increased expression of GSTZ1 protein22023808
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of GSTZ1 mRNA26924002
D004041Dietary FatsDietary Fats results in decreased expression of GSTZ1 mRNA18042831
C024629dimethyl phthalatedimethyl phthalate results in decreased expression of GSTZ1 mRNA26924002
D004137DinitrochlorobenzeneGSTZ1 protein affects the metabolism of Dinitrochlorobenzene1846734
C051904dinophysistoxin 1dinophysistoxin 1 results in decreased expression of GSTZ1 mRNA28939011
D004178DiquatDiquat affects the expression of GSTZ1 mRNA22814884
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of GSTZ1 protein23301498
D004976Ethacrynic AcidGSTZ1 protein affects the metabolism of Ethacrynic Acid9396740
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GSTZ1 mRNA17942748
C574336excavatolide Bexcavatolide B results in increased expression of GSTZ1 protein26790859
D005485FlutamideFlutamide results in decreased expression of GSTZ1 mRNA24136188
C460373fumarylacetonefumarylacetone results in increased alkylation of and results in decreased activity of GSTZ1 protein12018993
C460373fumarylacetoneGSTZ1 protein affects the metabolism of fumarylacetone12018993
C056933fumonisin B1fumonisin B1 results in decreased expression of GSTZ1 mRNA16221962
D005897GlafenineGlafenine results in decreased expression of GSTZ1 mRNA24136188
D005978GlutathioneGlutathione binds to GSTZ1 protein11327815|1517317
D005978GlutathioneGSTZ1 protein affects the metabolism of Glutathione1846734
D005978GlutathioneGSTZ1 protein binds to and affects the metabolism of Glutathione12852784
C031150glyoxylic acid[GSTZ1 protein results in increased metabolism of Dichloroacetic Acid] which results in increased chemical synthesis of glyoxylic acid24632415
D006427HeminHemin results in decreased activity of GSTZ1 protein1846734
D006861Hydrogen PeroxideGSTZ1 protein affects the metabolism of Hydrogen Peroxide1846734
D007454IodidesIodides inhibits the reaction [Dichloroacetic Acid results in decreased activity of GSTZ1 protein]24632415
D007529IsoflavonesIsoflavones affects the expression of GSTZ1 mRNA16365062
C028521lanthanum chloride[cerous chloride co-treated with lanthanum chloride] results in increased expression of GSTZ1 mRNA28954213
C043073leukotriene A methyl esterGSTZ1 protein affects the metabolism of leukotriene A methyl ester1846734
C460372maleylacetoneGSTZ1 protein affects the metabolism of maleylacetone12018993|1211900
C460372maleylacetoneGSTZ1 protein polymorphism affects the metabolism of maleylacetone12119007
C460372maleylacetonemaleylacetone results in decreased activity of GSTZ1 protein10471397
C460372maleylacetonemaleylacetone results in increased alkylation of and results in decreased activity of GSTZ1 protein12018993
C460372maleylacetoneGSTZ1 protein affects the metabolism of maleylacetone12019185
C460372maleylacetonemaleylacetone results in decreased activity of GSTZ1 protein10471397|1459956
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of GSTZ1 mRNA23103053
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of GSTZ1 mRNA28001369
D052998MicrocystinsMicrocystins affects the expression of GSTZ1 mRNA19790251
D052998MicrocystinsMicrocystins results in decreased expression of GSTZ1 mRNA19790251
C406082monomethylarsonous acidmonomethylarsonous acid results in increased expression of GSTZ1 mRNA22108045
C517284monomethyl phthalatemonomethyl phthalate affects the expression of GSTZ1 mRNA26924002
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of GSTZ1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of GSTZ1 mRNA"25554681
C005273naringeninnaringenin results in increased expression of GSTZ1 mRNA24561720
C005273naringeninParaquat inhibits the reaction [naringenin results in increased expression of GSTZ1 mRNA]24561720
D009532NickelNickel results in decreased expression of GSTZ1 mRNA24084258
C012655nimesulidenimesulide results in decreased expression of GSTZ1 mRNA24136188
C002741N-nitrosomorpholineN-nitrosomorpholine results in increased expression of GSTZ1 protein19716841
D000073878Palm OilPalm Oil results in decreased expression of GSTZ1 mRNA18042831
D010269Paraquat[Paraquat co-treated with Quercetin] results in increased expression of GSTZ1 mRNA22996356
D010269ParaquatParaquat inhibits the reaction [naringenin results in increased expression of GSTZ1 mRNA]24561720
D010269ParaquatParaquat results in increased expression of GSTZ1 mRNA22996356
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of GSTZ1 mRNA23427857
D010634PhenobarbitalPhenobarbital affects the expression of GSTZ1 mRNA19159669
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of GSTZ1 mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of GSTZ1 mRNA17426115
D011374ProgesteroneProgesterone results in decreased expression of GSTZ1 mRNA23018184
D011794Quercetin[Paraquat co-treated with Quercetin] results in increased expression of GSTZ1 mRNA22996356
D011794QuercetinQuercetin results in increased expression of GSTZ1 mRNA22996356
C059514resveratrolresveratrol results in increased expression of GSTZ1 mRNA22610192
D015474IsotretinoinIsotretinoin results in decreased expression of GSTZ1 mRNA20436886
C089730rosiglitazonerosiglitazone affects the expression of GSTZ1 mRNA17245590
D012524SarinSarin results in decreased expression of GSTZ1 mRNA19522546
D012834SilverSilver analog affects the expression of GSTZ1 mRNA21276481
C016104sodium bichromatesodium bichromate affects the expression of GSTZ1 mRNA22110744
C016104sodium bichromatesodium bichromate results in decreased expression of GSTZ1 mRNA25993096
D012969Sodium FluorideSodium Fluoride results in increased expression of GSTZ1 protein28918527
C025906stilbene oxideGSTZ1 protein affects the metabolism of stilbene oxide1846734
D013447SulfitesSulfites inhibits the reaction [Dichloroacetic Acid results in decreased activity of GSTZ1 protein]24632415
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GSTZ1 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GSTZ1 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to GSTZ1 promoter]19654925
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of GSTZ1 mRNA18163543
D013853ThioacetamideThioacetamide results in decreased expression of GSTZ1 mRNA23411599
C009495titanium dioxidetitanium dioxide results in decreased expression of GSTZ1 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of GSTZ1 protein22609517
D022882TrihalomethanesGSTZ1 polymorphism affects the susceptibility to Trihalomethanes20675267
D014635Valproic AcidValproic Acid affects the expression of GSTZ1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of GSTZ1 mRNA23179753|2800136
D014640VancomycinVancomycin results in increased expression of GSTZ1 mRNA18930951
C029297vinylidene chloridevinylidene chloride results in decreased expression of GSTZ1 mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004364glutathione transferase activity-IBA21873635  
GO:0004364glutathione transferase activity-IDA10739172  
GO:0004364glutathione transferase activity-TAS-  
GO:0004602glutathione peroxidase activity-TAS9396740  
GO:0005515protein binding-IPI17474147  
GO:0016034maleylacetoacetate isomerase activity-EXP11327815  
GO:0016034maleylacetoacetate isomerase activity-IBA21873635  
GO:0016034maleylacetoacetate isomerase activity-IDA10739172  
GO:0019120hydrolase activity, acting on acid halide bonds, in C-halide compounds-TAS-  
GO:0042802identical protein binding-IPI16189514  25416956  
GO:0042803protein homodimerization activity-IPI10739172  
GO ID GO Term Qualifier Evidence PubMed
GO:0006559L-phenylalanine catabolic process-IBA21873635  
GO:0006559L-phenylalanine catabolic process-IEA-  
GO:0006559L-phenylalanine catabolic process-TAS-  
GO:0006572tyrosine catabolic process-IEA-  
GO:0006749glutathione metabolic process-IBA21873635  
GO:0006749glutathione metabolic process-IDA10739172  
GO:0010510regulation of acetyl-CoA biosynthetic process from pyruvate-TAS-  
GO:0098869cellular oxidant detoxification-IEA-  
GO:1901687glutathione derivative biosynthetic process-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-IBA21873635  
GO:0005739mitochondrion-ISS-  
GO:0005759mitochondrial matrix-TAS-  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa00350Tyrosine metabolism
hsa00480Glutathione metabolism
hsa00980Metabolism of xenobiotics by cytochrome P450
hsa00982Drug metabolism - cytochrome P450
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1428517The citric acid (TCA) cycle and respiratory electron transportTAS
R-HSA-1430728MetabolismTAS
R-HSA-156580Phase II - Conjugation of compoundsTAS
R-HSA-156590Glutathione conjugationTAS
R-HSA-204174Regulation of pyruvate dehydrogenase (PDH) complexTAS
R-HSA-211859Biological oxidationsTAS
R-HSA-6788656Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolismTAS
R-HSA-70268Pyruvate metabolismTAS
R-HSA-71182Phenylalanine and tyrosine catabolismTAS
R-HSA-71291Metabolism of amino acids and derivativesTAS
R-HSA-71406Pyruvate metabolism and Citric Acid (TCA) cycleTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25505599Gene expression analysis of membrane transporters and drug-metabolizing enzymes in the lung of healthy and COPD subjects. (2014 Aug)Berg TPharmacol Res Perspect
11548073Significance of genetic polymorphisms in glutathione S-transferase multigene family and lung cancer risk. (2001)Reszka EInt J Occup Med Environ Health
19859803No evidence for glutathione S-transferases GSTA2, GSTM2, GSTO1, GSTO2, and GSTZ1 in breast cancer risk. (2010 Jun)Andonova IEBreast Cancer Res Treat