Gene info: ID 2956

Gene: MSH6

GENE ID: 2956

Synonyms: GTBP|GTMBP|HNPCC5|HSAP|p160

Description: mutS homolog 6

Gene type: protein-coding

Location: 2p16.3

dbXrefs: Ensembl:ENSG00000116062 MIM:600678 Vega:OTTHUMG00000129129 UniprotKB:P52701

RefSeq: NG_007111.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 4

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 6.104e-1 (AD) 2.627e-1 (ND)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg09898070	chr2:48009866	MSH6	Promoter	4.369e-5	Alcohol use disorders	26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
CNOT2	0.904
MPP5	0.894
ITCH	0.894
TIAL1	0.892
SPTLC2	0.889
DHX15	0.884
BIRC2	0.879
SETX	0.867
ELF2	0.867
PRPF4B	0.867

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.513
OR4F29	-0.499
HES5	-0.342
PLA2G5	-0.331
PTGDR2	-0.262
DIO2	-0.255
OR4F16	-0.248
WNT7B	-0.245
TNNT1	-0.245
REN	-0.24

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C028474	1,4-bis(2-(3,5-dichloropyridyloxy))benzene	"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of MSH6 mRNA"	28903501
C532162	2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine	"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in decreased expression of MSH6 mRNA"	20453058
C029790	2,2',3',4,4',5-hexachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of MSH6 mRNA"	25510870
C029497	2,3-bis(3'-hydroxybenzyl)butyrolactone	"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of MSH6 mRNA"	19167446
C081766	2,4,4'-trichlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of MSH6 mRNA"	25510870
C014024	2,4,5,2',4',5'-hexachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of MSH6 mRNA"	25510870
C009828	2,4,5,2',5'-pentachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of MSH6 mRNA"	25510870
C009407	2,5,2',5'-tetrachlorobiphenyl	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of MSH6 mRNA"	25510870
C049584	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine	"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of MSH6 protein"	26091049
C049584	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine	"MSH6 protein affects the susceptibility to 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"	11425520
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MSH6 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MSH6 mRNA"	27188386
D000082	Acetaminophen	Acetaminophen results in increased expression of MSH6 mRNA	22230336
D000082	Acetaminophen	Acetaminophen results in decreased expression of MSH6 mRNA	17585979
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Cadmium results in decreased expression of MSH6 mRNA]	23143036
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of MSH6 mRNA	21641981
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of MSH6 mRNA	19770486
D006710	Homocysteine	Homocysteine results in decreased expression of MSH6 mRNA	17326132
D001280	Atrazine	Atrazine results in increased expression of MSH6 mRNA	25929836
D001379	Azathioprine	Azathioprine results in decreased expression of MSH6 mRNA	22623647
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of MSH6 mRNA	21632981
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of MSH6 protein	23313663
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of MSH6 mRNA	19770486\|2590861
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of MSH6 mRNA"	26238291
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of MSH6 mRNA"	20382639
D004958	Estradiol	Estradiol results in decreased expression of MSH6 mRNA	22082530\|2380431
D004958	Estradiol	[sodium arsenite co-treated with Estradiol] results in decreased expression of MSH6 mRNA	23804311
C006780	bisphenol A	bisphenol A affects the expression of MSH6 mRNA	21786754
D000069286	Bortezomib	Bortezomib results in decreased expression of MSH6 mRNA	17659339
D002084	Butylated Hydroxytoluene	Butylated Hydroxytoluene inhibits the reaction [Cadmium results in decreased expression of MSH6 mRNA]	23143036
D020122	tert-Butylhydroperoxide	tert-Butylhydroperoxide results in decreased expression of MSH6 mRNA	15336504
D002104	Cadmium	Acetylcysteine inhibits the reaction [Cadmium results in decreased expression of MSH6 mRNA]	23143036
D002104	Cadmium	Butylated Hydroxytoluene inhibits the reaction [Cadmium results in decreased expression of MSH6 mRNA]	23143036
D002104	Cadmium	Cadmium results in decreased expression of MSH6	26130599
D002104	Cadmium	Cadmium results in decreased expression of MSH6 mRNA	23143036
D002104	Cadmium	Mannitol inhibits the reaction [Cadmium results in decreased expression of MSH6 mRNA]	23143036
D019256	Cadmium Chloride	Cadmium Chloride results in decreased activity of MSH6 protein	26130599
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of MSH6 mRNA	23644582
C074702	chromium hexavalent ion	MSH6 protein results in increased susceptibility to chromium hexavalent ion	15831465
D003078	Colchicine	Colchicine results in decreased expression of MSH6 mRNA	24211769
D003300	Copper	[NSC 689534 binds to Copper] which results in decreased expression of MSH6 mRNA	20971185
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of MSH6 mRNA	19549813
D003375	Coumestrol	"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of MSH6 mRNA"	19167446
D003375	Coumestrol	[Coumestrol co-treated with resveratrol] results in increased expression of MSH6 mRNA	19167446
D003375	Coumestrol	Coumestrol results in increased expression of MSH6 mRNA	19167446
C408982	CPG-oligonucleotide	CPG-oligonucleotide results in decreased expression of MSH6 mRNA	21878529
D016572	Cyclosporine	Cyclosporine results in decreased expression of MSH6 mRNA	25562108
C093628	cyproconazole	cyproconazole affects the expression of MSH6 mRNA	21621602
C014347	decitabine	decitabine results in increased expression of MSH6 mRNA	22082530
D003703	Demecolcine	Demecolcine results in decreased expression of MSH6 mRNA	23649840
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in decreased expression of MSH6 mRNA	21266533
D002945	Cisplatin	Cisplatin results in decreased expression of MSH6 mRNA	24211769
C036042	dicyclohexyl phthalate	dicyclohexyl phthalate affects the expression of MSH6 mRNA	26924002
D004026	Dieldrin	Dieldrin results in increased expression of MSH6 mRNA	23041725
D004147	Dioxins	Dioxins affects the expression of MSH6 mRNA	20463971
D004317	Doxorubicin	Doxorubicin results in decreased expression of MSH6 mRNA	16404146
D004791	Enzyme Inhibitors	[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of MSH6 protein	23301498
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of MSH6 mRNA	17942748
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MSH6 mRNA	17942748
C034096	ethoxyacetic acid	ethoxyacetic acid affects the expression of MSH6 mRNA	21621602
D005020	Ethyl Methanesulfonate	Ethyl Methanesulfonate results in decreased expression of MSH6 mRNA	24211769
D005038	Ethylnitrosourea	MSH6 gene mutant form results in decreased susceptibility to Ethylnitrosourea	18522974
D005038	Ethylnitrosourea	Ethylnitrosourea results in increased mutagenesis of MSH6 gene	16495775\|1841748
D005047	Etoposide	Etoposide results in decreased expression of MSH6 mRNA	24211769
C061365	flusilazole	flusilazole affects the expression of MSH6 mRNA	21621602
D005557	Formaldehyde	Formaldehyde results in decreased expression of MSH6 mRNA	23649840
C106014	gedunin	gedunin results in decreased expression of MSH6 mRNA	17010675
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in decreased expression of MSH6 mRNA	23143036
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the expression of MSH6 mRNA	20044591
D006918	Hydroxyurea	Hydroxyurea results in decreased expression of MSH6 mRNA	24211769
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in increased expression of MSH6 mRNA	25961927
C410337	K 7174	K 7174 results in decreased expression of MSH6 mRNA	24086573
C045463	leflunomide	leflunomide results in decreased expression of MSH6 mRNA	28988120
C015329	lycopene	lycopene results in increased expression of MSH6 mRNA	16886892
D008345	Manganese	Manganese results in decreased expression of MSH6 mRNA	17175027
C025340	manganese chloride	manganese chloride results in decreased expression of MSH6 mRNA	17175027
D008353	Mannitol	Mannitol inhibits the reaction [Cadmium results in decreased expression of MSH6 mRNA]	23143036
D008627	Mercuric Chloride	Mercuric Chloride results in decreased activity of MSH6 protein	26130599
D008628	Mercury	Mercury results in increased expression of MSH6 mRNA	19937285
C013598	methoxyacetic acid	methoxyacetic acid affects the expression of MSH6 mRNA	21621602
D008767	Methylmercury Compounds	Methylmercury Compounds results in decreased expression of MSH6 mRNA	24694518
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of MSH6 mRNA	24211769
D008770	Methylnitrosourea	MSH6 gene mutant form results in decreased susceptibility to Methylnitrosourea	18522974
D008770	Methylnitrosourea	Methylnitrosourea promotes the reaction [MSH2 protein binds to PCNA protein binds to MSH6 protein]	16204460
D008777	Methyltestosterone	Methyltestosterone results in decreased expression of MSH6 mRNA	29191790
D016685	Mitomycin	Mitomycin results in decreased expression of MSH6 mRNA	24211769
C517284	monomethyl phthalate	monomethyl phthalate affects the expression of MSH6 mRNA	26924002
D009151	Mustard Gas	Mustard Gas results in decreased expression of MSH6 mRNA	25102026
C558013	NSC 689534	[NSC 689534 binds to Copper] which results in decreased expression of MSH6 mRNA	20971185
D010269	Paraquat	Paraquat results in decreased expression of MSH6 mRNA	23143036
C410127	PCB 180	"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of MSH6 mRNA"	25510870
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in increased expression of MSH6 protein	26178269
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of MSH6 protein	26879310
D010634	Phenobarbital	Phenobarbital affects the expression of MSH6 mRNA	19159669
D010634	Phenobarbital	Phenobarbital results in increased expression of MSH6 mRNA	19270015
C415326	phenoxyacetic acid	phenoxyacetic acid affects the expression of MSH6 mRNA	21621602
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MSH6 mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in decreased expression of MSH6 mRNA	26272509
C006253	pirinixic acid	pirinixic acid results in decreased expression of MSH6 mRNA	18445702
D010894	Piroxicam	Piroxicam results in decreased expression of MSH6 mRNA	21858171
D010936	Plant Extracts	Plant Extracts results in increased expression of MSH6 mRNA	23557933
D011192	Potassium Dichromate	Potassium Dichromate results in increased expression of MSH6 mRNA	23628323
D011794	Quercetin	Quercetin results in decreased expression of MSH6 mRNA	21632981
D017382	Reactive Oxygen Species	Reactive Oxygen Species affects the expression of MSH6 mRNA	25800948
C059514	resveratrol	[Coumestrol co-treated with resveratrol] results in increased expression of MSH6 mRNA	19167446
C059514	resveratrol	resveratrol results in decreased expression of MSH6 mRNA	18089832
C059514	resveratrol	resveratrol results in decreased expression of MSH6 protein	18089832
C547185	riccardin D	riccardin D results in decreased expression of MSH6 mRNA	24069304
C064116	S-(1,1,2,2-tetrafluoroethyl)cysteine	"S-(1,1,2,2-tetrafluoroethyl)cysteine results in decreased expression of MSH6 mRNA"	16678137
D012715	Sesame Oil	Sesame Oil results in increased expression of MSH6 mRNA	29191790
D012834	Silver	Silver results in decreased expression of MSH6 mRNA	26014281
D012834	Silver	Silver results in increased expression of MSH6 mRNA	27131904
D012906	Smoke	Smoke affects the expression of MSH6 mRNA	23693141
C017947	sodium arsenite	[sodium arsenite co-treated with Estradiol] results in decreased expression of MSH6 mRNA	23804311
C017947	sodium arsenite	sodium arsenite results in decreased expression of MSH6 mRNA	23804311
C017947	sodium arsenite	sodium arsenite results in decreased expression of MSH6 mRNA	16014739\|2578715
C017947	sodium arsenite	sodium arsenite results in increased expression of MSH6 protein	19072884
C016104	sodium bichromate	sodium bichromate results in increased expression of MSH6 mRNA	22155349
C061133	tamibarotene	tamibarotene results in decreased expression of MSH6 mRNA	15498508
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of MSH6 mRNA	21570461
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of MSH6 mRNA	17942748
C009495	titanium dioxide	[Vitallium analog binds to titanium dioxide] which results in decreased expression of MSH6 mRNA	23825117
C496197	trans-10,cis-12-conjugated linoleic acid	"trans-10,cis-12-conjugated linoleic acid results in decreased expression of MSH6 mRNA"	17951470
D014212	Tretinoin	Tretinoin results in decreased expression of MSH6 mRNA	15498508\|2193413
C050414	tripterine	tripterine results in decreased expression of MSH6 mRNA	17010675
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of MSH6 mRNA"	26179874
D014520	Urethane	Urethane results in decreased expression of MSH6 mRNA	28818685
D014635	Valproic Acid	Valproic Acid affects the expression of MSH6 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased expression of MSH6 mRNA	23179753\|2800136
D014635	Valproic Acid	Valproic Acid results in increased expression of MSH6 mRNA	29154799
D014635	Valproic Acid	Valproic Acid results in increased methylation of MSH6 gene	29154799
C025643	vinclozolin	vinclozolin results in decreased expression of MSH6 mRNA	23034163
D014800	Vitallium	[Vitallium analog binds to titanium dioxide] which results in decreased expression of MSH6 mRNA	23825117
D014800	Vitallium	Vitallium analog results in decreased expression of MSH6 mRNA	23825117
D000225	Adenine	Adenine results in decreased expression of MSH6 mRNA	24211769
D024483	Vitamin K 3	Vitamin K 3 affects the expression of MSH6 mRNA	20044591

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000287	magnesium ion binding	contributes_to	IDA	16403449
GO:0000400	four-way junction DNA binding	-	IBA	21873635
GO:0000400	four-way junction DNA binding	contributes_to	IDA	12034830
GO:0003682	chromatin binding	-	IEA	-
GO:0003684	damaged DNA binding	-	IBA	21873635
GO:0003690	double-stranded DNA binding	contributes_to	IDA	11809883
GO:0005515	protein binding	-	IPI	8942985 9774676 10856833 11005803 11801590 14657349 16403449 17314511 17353931 19377479 25241761 26496610
GO:0005515	protein binding	contributes_to	IPI	16403449
GO:0005524	ATP binding	CONTRIBUTES_TO	IBA	21873635
GO:0005524	ATP binding	contributes_to	IDA	15105434
GO:0008094	DNA-dependent ATPase activity	-	IBA	21873635
GO:0016887	ATPase activity	contributes_to	IDA	16403449
GO:0030983	mismatched DNA binding	-	IBA	21873635
GO:0030983	mismatched DNA binding	-	IDA	23622243
GO:0030983	mismatched DNA binding	contributes_to	IDA	8942985 11756455 11801590
GO:0032137	guanine/thymine mispair binding	-	IBA	21873635
GO:0032137	guanine/thymine mispair binding	contributes_to	IDA	8942985 11809883
GO:0032138	single base insertion or deletion binding	-	IBA	21873635
GO:0032142	single guanine insertion binding	contributes_to	IDA	8942985
GO:0032143	single thymine insertion binding	CONTRIBUTES_TO	IBA	21873635
GO:0032143	single thymine insertion binding	contributes_to	IDA	8942985
GO:0032357	oxidized purine DNA binding	contributes_to	IDA	11756455 11801590
GO:0032405	MutLalpha complex binding	CONTRIBUTES_TO	IBA	21873635
GO:0032405	MutLalpha complex binding	contributes_to	IDA	16403449
GO:0035064	methylated histone binding	-	IBA	21873635
GO:0035064	methylated histone binding	-	IDA	23622243
GO:0042803	protein homodimerization activity	NOT	IPI	8942985
GO:0043531	ADP binding	CONTRIBUTES_TO	IBA	21873635
GO:0043531	ADP binding	contributes_to	IDA	15105434

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000710	meiotic mismatch repair	-	IBA	21873635
GO:0000710	meiotic mismatch repair	-	ISS	-
GO:0006281	DNA repair	-	IDA	8942985
GO:0006290	pyrimidine dimer repair	-	IBA	21873635
GO:0006298	mismatch repair	-	IBA	21873635
GO:0006298	mismatch repair	-	IDA	10871409 23622243
GO:0006298	mismatch repair	-	IGI	23603115
GO:0006298	mismatch repair	-	IMP	8782829
GO:0006298	mismatch repair	-	TAS	-
GO:0007095	mitotic G2 DNA damage checkpoint	-	IBA	21873635
GO:0008340	determination of adult lifespan	-	IBA	21873635
GO:0008340	determination of adult lifespan	-	ISS	-
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	-	IBA	21873635
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	-	ISS	-
GO:0009411	response to UV	-	IBA	21873635
GO:0009411	response to UV	-	ISS	-
GO:0016032	viral process	-	IEA	-
GO:0016446	somatic hypermutation of immunoglobulin genes	-	IBA	21873635
GO:0016446	somatic hypermutation of immunoglobulin genes	-	ISS	-
GO:0016447	somatic recombination of immunoglobulin gene segments	-	ISS	-
GO:0030890	positive regulation of B cell proliferation	-	IBA	21873635
GO:0032876	negative regulation of DNA endoreduplication	-	IBA	21873635
GO:0036297	interstrand cross-link repair	-	IBA	21873635
GO:0043111	replication fork arrest	-	IBA	21873635
GO:0043570	maintenance of DNA repeat elements	-	IBA	21873635
GO:0043570	maintenance of DNA repeat elements	NOT	IMP	16388310
GO:0045190	isotype switching	-	IBA	21873635
GO:0045190	isotype switching	-	ISS	-
GO:0045830	positive regulation of isotype switching	-	IBA	21873635
GO:0045830	positive regulation of isotype switching	-	IEA	-
GO:0045910	negative regulation of DNA recombination	-	IBA	21873635
GO:0045910	negative regulation of DNA recombination	-	IDA	17715146
GO:0051096	positive regulation of helicase activity	-	IBA	21873635
GO:0051096	positive regulation of helicase activity	-	IDA	17715146
GO:0097193	intrinsic apoptotic signaling pathway	-	ISS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000790	nuclear chromatin	-	IEA	-
GO:0005654	nucleoplasm	-	IDA	-
GO:0005654	nucleoplasm	-	TAS	-
GO:0005794	Golgi apparatus	-	IDA	-
GO:0005829	cytosol	-	IDA	-
GO:0032300	mismatch repair complex	-	IBA	21873635
GO:0032301	MutSalpha complex	-	IBA	21873635
GO:0032301	MutSalpha complex	-	IDA	8942985 23622243
GO:0043231	intracellular membrane-bounded organelle	-	IDA	-

KEGG ID	KEGG Term
hsa03430	Mismatch repair
hsa05200	Pathways in cancer
hsa05210	Colorectal cancer

Reactome ID	Reactome Term	Evidence
R-HSA-1643685	Disease	TAS
R-HSA-5358508	Mismatch Repair	TAS
R-HSA-5358565	Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)	TAS
R-HSA-5423599	Diseases of Mismatch Repair (MMR)	TAS
R-HSA-5632928	Defective Mismatch Repair Associated With MSH2	TAS
R-HSA-5632968	Defective Mismatch Repair Associated With MSH6	TAS
R-HSA-73894	DNA Repair	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
20301390	Lynch Syndrome (1993)	Kohlmann W	-
21559014	Body mass index in early adulthood and colorectal cancer risk for carriers and non-carriers of germline mutations in DNA mismatch repair genes. (2011 Jun 28)	Win AK	Br J Cancer
21938565	[Bladder cancer at an early age in father and son]. (2011 Dec)	Ovsiannikov D	Urologe A
18523027	Mismatch repair polymorphisms and risk of colon cancer, tumour microsatellite instability and interactions with lifestyle factors. (2009 May)	Campbell PT	Gut