Gene info: ID 2966

Gene: GTF2H2

GENE ID: 2966

Synonyms: BTF2|BTF2P44|T-BTF2P44|TFIIH|p44

Description: general transcription factor IIH subunit 2

Gene type: protein-coding

Location: 5q13.2

dbXrefs: Ensembl:ENSG00000145736 MIM:601748 Vega:OTTHUMG00000164542 UniprotKB:Q13888

RefSeq: NC_000005.10

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 8.266e-1 (AD) NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
C1GALT1	0.46
TMEM106B	0.458
MAGOHB	0.449
MBIP	0.447
ZNF610	0.442
FPGT	0.438
ANAPC10	0.438
IFIT5	0.437
PHIP	0.428
G2E3	0.428

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
LRRC10	-0.253
KRT16	-0.215
KCNK16	-0.206
CSAG1	-0.206
CMA1	-0.2
OR7D2	-0.197
KRT77	-0.191
CYP11B2	-0.191
OR4D10	-0.189
KRTAP4-3	-0.189

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C016403	2,4-dinitrotoluene	"2,4-dinitrotoluene affects the expression of GTF2H2 mRNA"	21346803
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of GTF2H2 mRNA"	21346803
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased methylation of GTF2H2 gene	27153756
D001115	Arecoline	Arecoline results in decreased expression of GTF2H2 mRNA	17682004
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of GTF2H2 mRNA	20498004
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of GTF2H2 mRNA	22228805
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of GTF2H2 mRNA"	19150397
C006780	bisphenol A	bisphenol A affects the expression of GTF2H2 mRNA	21786754
C006780	bisphenol A	bisphenol A affects the methylation of GTF2H2 promoter	27334623
C016274	bromoacetate	bromoacetate results in decreased expression of GTF2H2 mRNA	19753638
D019256	Cadmium Chloride	Cadmium Chloride results in decreased expression of GTF2H2 mRNA	12160620
D002211	Capsaicin	Capsaicin results in decreased expression of GTF2H2 mRNA	16278290
C054133	casticin	casticin results in decreased expression of GTF2H2 mRNA	28444820
D005557	Formaldehyde	Formaldehyde results in decreased expression of GTF2H2 mRNA	23649840
C069837	fullerene C60	fullerene C60 results in decreased expression of GTF2H2 mRNA	19167457
D005839	Gentamicins	Gentamicins results in increased expression of GTF2H2 mRNA	22061828
D007213	Indomethacin	Indomethacin results in increased expression of GTF2H2 mRNA	28201806
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of GTF2H2 mRNA"	26251327
C005246	myristicin	myristicin results in decreased expression of GTF2H2 mRNA	24792648
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of GTF2H2 mRNA"	25554681
C028007	nickel monoxide	nickel monoxide results in decreased expression of GTF2H2 mRNA	19167457
C005290	oxybenzone	oxybenzone results in increased expression of GTF2H2 mRNA	22721600
D010634	Phenobarbital	Phenobarbital results in increased expression of GTF2H2 mRNA	19270015
C006253	pirinixic acid	pirinixic acid results in increased expression of GTF2H2 mRNA	23811191
D011374	Progesterone	Progesterone results in increased expression of GTF2H2 mRNA	23012394
D012643	Selenium	[Selenium co-treated with Vitamin E] results in increased expression of GTF2H2 mRNA	19244175
D012643	Selenium	Selenium results in decreased expression of GTF2H2 mRNA	19244175
C017947	sodium arsenite	sodium arsenite results in increased expression of GTF2H2 mRNA	12760830
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of GTF2H2 mRNA	21570461
D014212	Tretinoin	Tretinoin results in decreased expression of GTF2H2 mRNA	21934132
D014501	Uranium	Uranium affects the expression of GTF2H2 mRNA	15672453
C005460	uranyl acetate	uranyl acetate affects the expression of GTF2H2 mRNA	15672453
D014520	Urethane	Urethane results in decreased expression of GTF2H2 mRNA	28818685
C025643	vinclozolin	vinclozolin results in increased expression of GTF2H2 mRNA	20566332
C029297	vinylidene chloride	vinylidene chloride results in decreased expression of GTF2H2 mRNA	26682919
D014810	Vitamin E	[Selenium co-treated with Vitamin E] results in increased expression of GTF2H2 mRNA	19244175
D014810	Vitamin E	Vitamin E results in decreased expression of GTF2H2 mRNA	19244175

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0003676	nucleic acid binding	-	TAS	8194529
GO:0003700	DNA-binding transcription factor activity	-	NAS	8194529
GO:0004672	protein kinase activity	contributes_to	IDA	9852112
GO:0005515	protein binding	-	IPI	7664335 8652557 8692842 11445587 16669699 17438371 19172752 26496610
GO:0008094	DNA-dependent ATPase activity	contributes_to	IDA	9852112
GO:0008135	translation factor activity, RNA binding	-	TAS	8194529
GO:0008270	zinc ion binding	-	IEA	-
GO:0008353	RNA polymerase II carboxy-terminal domain kinase activity	contributes_to	IDA	9852112
GO:0047485	protein N-terminus binding	-	IPI	8652557

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0002031	G-protein coupled receptor internalization	-	IMP	15775968
GO:0006283	transcription-coupled nucleotide-excision repair	-	TAS	-
GO:0006289	nucleotide-excision repair	-	IBA	21873635
GO:0006293	nucleotide-excision repair, preincision complex stabilization	-	TAS	-
GO:0006294	nucleotide-excision repair, preincision complex assembly	-	TAS	-
GO:0006296	nucleotide-excision repair, DNA incision, 5'-to lesion	-	TAS	-
GO:0006357	regulation of transcription by RNA polymerase II	-	IBA	21873635
GO:0006361	transcription initiation from RNA polymerase I promoter	-	TAS	-
GO:0006363	termination of RNA polymerase I transcription	-	TAS	-
GO:0006366	transcription by RNA polymerase II	-	IDA	9852112 27193682
GO:0006366	transcription by RNA polymerase II	-	TAS	-
GO:0006367	transcription initiation from RNA polymerase II promoter	-	TAS	-
GO:0006368	transcription elongation from RNA polymerase II promoter	-	TAS	-
GO:0006370	7-methylguanosine mRNA capping	-	TAS	-
GO:0006412	translation	-	IEA	-
GO:0006468	protein phosphorylation	-	IEA	-
GO:0009411	response to UV	-	TAS	8194529
GO:0033683	nucleotide-excision repair, DNA incision	-	TAS	-
GO:0070911	global genome nucleotide-excision repair	-	TAS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000438	core TFIIH complex portion of holo TFIIH complex	-	IDA	27193682
GO:0005634	nucleus	-	IDA	27193682
GO:0005654	nucleoplasm	-	TAS	-
GO:0005669	transcription factor TFIID complex	-	IDA	27193682
GO:0005675	holo TFIIH complex	-	IBA	21873635
GO:0005675	holo TFIIH complex	-	IDA	9852112
GO:0016607	nuclear speck	-	IDA	-

KEGG ID	KEGG Term
hsa03022	Basal transcription factors
hsa03420	Nucleotide excision repair

Reactome ID	Reactome Term	Evidence
R-HSA-112382	Formation of RNA Pol II elongation complex	TAS
R-HSA-113418	Formation of the Early Elongation Complex	TAS
R-HSA-162587	HIV Life Cycle	IEA
R-HSA-162599	Late Phase of HIV Life Cycle	IEA
R-HSA-162906	HIV Infection	IEA
R-HSA-1643685	Disease	IEA
R-HSA-167152	Formation of HIV elongation complex in the absence of HIV Tat	IEA
R-HSA-167158	Formation of the HIV-1 Early Elongation Complex	IEA
R-HSA-167160	RNA Pol II CTD phosphorylation and interaction with CE during HIV infection	IEA
R-HSA-167161	HIV Transcription Initiation	IEA
R-HSA-167162	RNA Polymerase II HIV Promoter Escape	IEA
R-HSA-167169	HIV Transcription Elongation	IEA
R-HSA-167172	Transcription of the HIV genome	IEA
R-HSA-167200	Formation of HIV-1 elongation complex containing HIV-1 Tat	IEA
R-HSA-167246	Tat-mediated elongation of the HIV-1 transcript	IEA
R-HSA-212165	Epigenetic regulation of gene expression	IEA
R-HSA-212436	Generic Transcription Pathway	TAS
R-HSA-3700989	Transcriptional Regulation by TP53	TAS
R-HSA-427413	NoRC negatively regulates rRNA expression	IEA
R-HSA-5250941	Negative epigenetic regulation of rRNA expression	IEA
R-HSA-5663205	Infectious disease	IEA
R-HSA-5696395	Formation of Incision Complex in GG-NER	TAS
R-HSA-5696398	Nucleotide Excision Repair	TAS
R-HSA-5696399	Global Genome Nucleotide Excision Repair (GG-NER)	TAS
R-HSA-5696400	Dual Incision in GG-NER	TAS
R-HSA-674695	RNA Polymerase II Pre-transcription Events	TAS
R-HSA-6781823	Formation of TC-NER Pre-Incision Complex	TAS
R-HSA-6781827	Transcription-Coupled Nucleotide Excision Repair (TC-NER)	TAS
R-HSA-6782135	Dual incision in TC-NER	TAS
R-HSA-6782210	Gap-filling DNA repair synthesis and ligation in TC-NER	TAS
R-HSA-6796648	TP53 Regulates Transcription of DNA Repair Genes	TAS
R-HSA-72086	mRNA Capping	TAS
R-HSA-73762	RNA Polymerase I Transcription Initiation	TAS
R-HSA-73772	RNA Polymerase I Promoter Escape	TAS
R-HSA-73776	RNA Polymerase II Promoter Escape	TAS
R-HSA-73777	RNA Polymerase I Chain Elongation	TAS
R-HSA-73779	RNA Polymerase II Transcription Pre-Initiation And Promoter Opening	TAS
R-HSA-73854	RNA Polymerase I Promoter Clearance	TAS
R-HSA-73857	RNA Polymerase II Transcription	TAS
R-HSA-73863	RNA Polymerase I Transcription Termination	TAS
R-HSA-73864	RNA Polymerase I Transcription	TAS
R-HSA-73894	DNA Repair	TAS
R-HSA-74160	Gene expression (Transcription)	TAS
R-HSA-74160	Gene expression (Transcription)	IEA
R-HSA-75953	RNA Polymerase II Transcription Initiation	TAS
R-HSA-75955	RNA Polymerase II Transcription Elongation	TAS
R-HSA-76042	RNA Polymerase II Transcription Initiation And Promoter Clearance	TAS
R-HSA-77075	RNA Pol II CTD phosphorylation and interaction with CE	TAS
R-HSA-8953854	Metabolism of RNA	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
26203295	Altered placental DNA methylation patterns associated with maternal smoking: current perspectives. (2015 May 7)	Maccani JZ	Adv Genomics Genet