Gene: GTF2H2

2966
BTF2|BTF2P44|T-BTF2P44|TFIIH|p44
general transcription factor IIH subunit 2
protein-coding
5q13.2
Ensembl:ENSG00000145736 MIM:601748 Vega:OTTHUMG00000164542 UniprotKB:Q13888
NC_000005.10
PubMed
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.266e-1 (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
C1GALT10.46
TMEM106B0.458
MAGOHB0.449
MBIP0.447
ZNF6100.442
FPGT0.438
ANAPC100.438
IFIT50.437
PHIP0.428
G2E30.428

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LRRC10-0.253
KRT16-0.215
KCNK16-0.206
CSAG1-0.206
CMA1-0.2
OR7D2-0.197
KRT77-0.191
CYP11B2-0.191
OR4D10-0.189
KRTAP4-3-0.189

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of GTF2H2 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of GTF2H2 mRNA"21346803
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of GTF2H2 gene27153756
D001115ArecolineArecoline results in decreased expression of GTF2H2 mRNA17682004
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of GTF2H2 mRNA20498004
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of GTF2H2 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of GTF2H2 mRNA"19150397
C006780bisphenol Abisphenol A affects the expression of GTF2H2 mRNA21786754
C006780bisphenol Abisphenol A affects the methylation of GTF2H2 promoter27334623
C016274bromoacetatebromoacetate results in decreased expression of GTF2H2 mRNA19753638
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of GTF2H2 mRNA12160620
D002211CapsaicinCapsaicin results in decreased expression of GTF2H2 mRNA16278290
C054133casticincasticin results in decreased expression of GTF2H2 mRNA28444820
D005557FormaldehydeFormaldehyde results in decreased expression of GTF2H2 mRNA23649840
C069837fullerene C60fullerene C60 results in decreased expression of GTF2H2 mRNA19167457
D005839GentamicinsGentamicins results in increased expression of GTF2H2 mRNA22061828
D007213IndomethacinIndomethacin results in increased expression of GTF2H2 mRNA28201806
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of GTF2H2 mRNA"26251327
C005246myristicinmyristicin results in decreased expression of GTF2H2 mRNA24792648
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of GTF2H2 mRNA"25554681
C028007nickel monoxidenickel monoxide results in decreased expression of GTF2H2 mRNA19167457
C005290oxybenzoneoxybenzone results in increased expression of GTF2H2 mRNA22721600
D010634PhenobarbitalPhenobarbital results in increased expression of GTF2H2 mRNA19270015
C006253pirinixic acidpirinixic acid results in increased expression of GTF2H2 mRNA23811191
D011374ProgesteroneProgesterone results in increased expression of GTF2H2 mRNA23012394
D012643Selenium[Selenium co-treated with Vitamin E] results in increased expression of GTF2H2 mRNA19244175
D012643SeleniumSelenium results in decreased expression of GTF2H2 mRNA19244175
C017947sodium arsenitesodium arsenite results in increased expression of GTF2H2 mRNA12760830
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GTF2H2 mRNA21570461
D014212TretinoinTretinoin results in decreased expression of GTF2H2 mRNA21934132
D014501UraniumUranium affects the expression of GTF2H2 mRNA15672453
C005460uranyl acetateuranyl acetate affects the expression of GTF2H2 mRNA15672453
D014520UrethaneUrethane results in decreased expression of GTF2H2 mRNA28818685
C025643vinclozolinvinclozolin results in increased expression of GTF2H2 mRNA20566332
C029297vinylidene chloridevinylidene chloride results in decreased expression of GTF2H2 mRNA26682919
D014810Vitamin E[Selenium co-treated with Vitamin E] results in increased expression of GTF2H2 mRNA19244175
D014810Vitamin EVitamin E results in decreased expression of GTF2H2 mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003676nucleic acid binding-TAS8194529  
GO:0003700DNA-binding transcription factor activity-NAS8194529  
GO:0004672protein kinase activitycontributes_toIDA9852112  
GO:0005515protein binding-IPI7664335  8652557  8692842  11445587  16669699  17438371  
19172752  26496610  
GO:0008094DNA-dependent ATPase activitycontributes_toIDA9852112  
GO:0008135translation factor activity, RNA binding-TAS8194529  
GO:0008270zinc ion binding-IEA-  
GO:0008353RNA polymerase II carboxy-terminal domain kinase activitycontributes_toIDA9852112  
GO:0047485protein N-terminus binding-IPI8652557  
GO ID GO Term Qualifier Evidence PubMed
GO:0002031G-protein coupled receptor internalization-IMP15775968  
GO:0006283transcription-coupled nucleotide-excision repair-TAS-  
GO:0006289nucleotide-excision repair-IBA21873635  
GO:0006293nucleotide-excision repair, preincision complex stabilization-TAS-  
GO:0006294nucleotide-excision repair, preincision complex assembly-TAS-  
GO:0006296nucleotide-excision repair, DNA incision, 5'-to lesion-TAS-  
GO:0006357regulation of transcription by RNA polymerase II-IBA21873635  
GO:0006361transcription initiation from RNA polymerase I promoter-TAS-  
GO:0006363termination of RNA polymerase I transcription-TAS-  
GO:0006366transcription by RNA polymerase II-IDA9852112  27193682  
GO:0006366transcription by RNA polymerase II-TAS-  
GO:0006367transcription initiation from RNA polymerase II promoter-TAS-  
GO:0006368transcription elongation from RNA polymerase II promoter-TAS-  
GO:00063707-methylguanosine mRNA capping-TAS-  
GO:0006412translation-IEA-  
GO:0006468protein phosphorylation-IEA-  
GO:0009411response to UV-TAS8194529  
GO:0033683nucleotide-excision repair, DNA incision-TAS-  
GO:0070911global genome nucleotide-excision repair-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000438core TFIIH complex portion of holo TFIIH complex-IDA27193682  
GO:0005634nucleus-IDA27193682  
GO:0005654nucleoplasm-TAS-  
GO:0005669transcription factor TFIID complex-IDA27193682  
GO:0005675holo TFIIH complex-IBA21873635  
GO:0005675holo TFIIH complex-IDA9852112  
GO:0016607nuclear speck-IDA-  
KEGG ID KEGG Term
hsa03022Basal transcription factors
hsa03420Nucleotide excision repair
Reactome ID Reactome Term Evidence
R-HSA-112382Formation of RNA Pol II elongation complex TAS
R-HSA-113418Formation of the Early Elongation ComplexTAS
R-HSA-162587HIV Life CycleIEA
R-HSA-162599Late Phase of HIV Life CycleIEA
R-HSA-162906HIV InfectionIEA
R-HSA-1643685DiseaseIEA
R-HSA-167152Formation of HIV elongation complex in the absence of HIV TatIEA
R-HSA-167158Formation of the HIV-1 Early Elongation ComplexIEA
R-HSA-167160RNA Pol II CTD phosphorylation and interaction with CE during HIV infectionIEA
R-HSA-167161HIV Transcription InitiationIEA
R-HSA-167162RNA Polymerase II HIV Promoter EscapeIEA
R-HSA-167169HIV Transcription ElongationIEA
R-HSA-167172Transcription of the HIV genomeIEA
R-HSA-167200Formation of HIV-1 elongation complex containing HIV-1 TatIEA
R-HSA-167246Tat-mediated elongation of the HIV-1 transcriptIEA
R-HSA-212165Epigenetic regulation of gene expressionIEA
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-3700989Transcriptional Regulation by TP53TAS
R-HSA-427413NoRC negatively regulates rRNA expressionIEA
R-HSA-5250941Negative epigenetic regulation of rRNA expressionIEA
R-HSA-5663205Infectious diseaseIEA
R-HSA-5696395Formation of Incision Complex in GG-NERTAS
R-HSA-5696398Nucleotide Excision RepairTAS
R-HSA-5696399Global Genome Nucleotide Excision Repair (GG-NER)TAS
R-HSA-5696400Dual Incision in GG-NERTAS
R-HSA-674695RNA Polymerase II Pre-transcription EventsTAS
R-HSA-6781823Formation of TC-NER Pre-Incision ComplexTAS
R-HSA-6781827Transcription-Coupled Nucleotide Excision Repair (TC-NER)TAS
R-HSA-6782135Dual incision in TC-NERTAS
R-HSA-6782210Gap-filling DNA repair synthesis and ligation in TC-NERTAS
R-HSA-6796648TP53 Regulates Transcription of DNA Repair GenesTAS
R-HSA-72086mRNA CappingTAS
R-HSA-73762RNA Polymerase I Transcription InitiationTAS
R-HSA-73772RNA Polymerase I Promoter EscapeTAS
R-HSA-73776RNA Polymerase II Promoter EscapeTAS
R-HSA-73777RNA Polymerase I Chain ElongationTAS
R-HSA-73779RNA Polymerase II Transcription Pre-Initiation And Promoter OpeningTAS
R-HSA-73854RNA Polymerase I Promoter ClearanceTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-73863RNA Polymerase I Transcription TerminationTAS
R-HSA-73864RNA Polymerase I TranscriptionTAS
R-HSA-73894DNA RepairTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-74160Gene expression (Transcription)IEA
R-HSA-75953RNA Polymerase II Transcription InitiationTAS
R-HSA-75955RNA Polymerase II Transcription ElongationTAS
R-HSA-76042RNA Polymerase II Transcription Initiation And Promoter ClearanceTAS
R-HSA-77075RNA Pol II CTD phosphorylation and interaction with CETAS
R-HSA-8953854Metabolism of RNATAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26203295Altered placental DNA methylation patterns associated with maternal smoking: current perspectives. (2015 May 7)Maccani JZAdv Genomics Genet