Gene: GTF2H4

2968
P52|TFB2|TFIIH
general transcription factor IIH subunit 4
protein-coding
6p21.33
Ensembl:ENSG00000213780 MIM:601760 Vega:OTTHUMG00000031043 UniprotKB:Q92759
NC_000006.12
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MAP3K120.91
SKIV2L0.909
SUGP20.909
DPH10.908
CMTR10.905
TBCD0.904
FAM160A20.901
C16orf580.901
HMGXB30.9
QRICH10.9

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.55
OR4F29-0.502
MTRNR2L6-0.396
MTRNR2L9-0.39
MTRNR2L10-0.369
PPBP-0.315
TTLL10-0.305
HEY2-0.292
MTRNR2L8-0.29
FCGR3B-0.287

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane affects the expression of GTF2H4 mRNA"18648102
D001280AtrazineAtrazine results in decreased expression of GTF2H4 mRNA22378314
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of GTF2H4 mRNA"19150397
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of GTF2H4 mRNA"20018196
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of GTF2H4 mRNA28628672
C006780bisphenol Abisphenol A affects the methylation of GTF2H4 promoter27334623
C006780bisphenol Abisphenol A affects the expression of GTF2H4 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of GTF2H4 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in increased expression of GTF2H4 mRNA23741332
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of GTF2H4 promoter22457795
D002220CarbamazepineCarbamazepine affects the expression of GTF2H4 mRNA24752500
D003300Copper[ATP7A gene mutant form results in increased abundance of Copper] which results in decreased expression of GTF2H4 mRNA15467011
D019327Copper SulfateCopper Sulfate results in decreased expression of GTF2H4 mRNA19549813
D003375CoumestrolCoumestrol results in increased expression of GTF2H4 mRNA19167446
C408982CPG-oligonucleotideCPG-oligonucleotide results in decreased expression of GTF2H4 mRNA21878529
D016572CyclosporineCyclosporine results in increased expression of GTF2H4 mRNA20106945|2556210
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of GTF2H4 mRNA28628672
D004008DiclofenacDiclofenac affects the expression of GTF2H4 mRNA24752500
D004147DioxinsDioxins affects the expression of GTF2H4 mRNA20463971
D004610Ellagic AcidEllagic Acid results in increased expression of GTF2H4 mRNA12002526
C056493imiquimodimiquimod results in decreased expression of GTF2H4 mRNA21878529
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of GTF2H4 mRNA28628672
D007213IndomethacinIndomethacin results in increased expression of GTF2H4 mRNA28201806
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of GTF2H4 mRNA28628672
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of GTF2H4 mRNA26254443
D048628KetolidesKetolides analog results in decreased expression of GTF2H4 mRNA24967691
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of GTF2H4 mRNA"24972896
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of GTF2H4 mRNA23458150
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of GTF2H4 mRNA"20188158
C406082monomethylarsonous acidmonomethylarsonous acid results in increased expression of GTF2H4 protein24625837
C568376MT19c compoundMT19c compound results in decreased expression of GTF2H4 mRNA21781307
C028007nickel monoxidenickel monoxide results in increased expression of GTF2H4 mRNA19167457
D010416PentachlorophenolPentachlorophenol results in increased expression of GTF2H4 mRNA23892564
C006253pirinixic acidpirinixic acid results in decreased expression of GTF2H4 mRNA18445702
D011374ProgesteroneProgesterone results in increased expression of GTF2H4 mRNA19690047
D011794QuercetinQuercetin results in increased expression of GTF2H4 mRNA21632981
C059514resveratrolresveratrol results in increased expression of GTF2H4 mRNA12002526
C009277sodium arsenatesodium arsenate results in increased expression of GTF2H4 mRNA23922661
C017947sodium arsenitesodium arsenite results in increased expression of GTF2H4 mRNA16014739
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GTF2H4 mRNA21570461
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased expression of GTF2H4 mRNA19031421

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003690double-stranded DNA binding-IBA21873635  
GO:0003700DNA-binding transcription factor activity-TAS9118947  
GO:0004003ATP-dependent DNA helicase activity-IEA-  
GO:0004672protein kinase activitycontributes_toIDA9852112  
GO:0005515protein binding-IPI17466626  19172752  26496610  
GO:0008094DNA-dependent ATPase activitycontributes_toIDA9852112  
GO:0008353RNA polymerase II carboxy-terminal domain kinase activityCONTRIBUTES_TOIBA21873635  
GO:0008353RNA polymerase II carboxy-terminal domain kinase activitycontributes_toIDA9852112  
GO ID GO Term Qualifier Evidence PubMed
GO:0006281DNA repair-TAS9118947  
GO:0006283transcription-coupled nucleotide-excision repair-TAS-  
GO:0006289nucleotide-excision repair-IBA21873635  
GO:0006293nucleotide-excision repair, preincision complex stabilization-TAS-  
GO:0006294nucleotide-excision repair, preincision complex assembly-TAS-  
GO:0006296nucleotide-excision repair, DNA incision, 5'-to lesion-TAS-  
GO:0006361transcription initiation from RNA polymerase I promoter-TAS-  
GO:0006363termination of RNA polymerase I transcription-TAS-  
GO:0006366transcription by RNA polymerase II-IDA9852112  27193682  
GO:0006366transcription by RNA polymerase II-TAS-  
GO:0006367transcription initiation from RNA polymerase II promoter-TAS-  
GO:0006368transcription elongation from RNA polymerase II promoter-TAS-  
GO:00063707-methylguanosine mRNA capping-TAS-  
GO:0032508DNA duplex unwinding-IEA-  
GO:0033683nucleotide-excision repair, DNA incision-TAS-  
GO:0070816phosphorylation of RNA polymerase II C-terminal domain-IBA21873635  
GO:0070911global genome nucleotide-excision repair-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000438core TFIIH complex portion of holo TFIIH complex-IDA27193682  
GO:0000439core TFIIH complex-IBA21873635  
GO:0005634nucleus-IDA27193682  
GO:0005654nucleoplasm-TAS-  
GO:0005669transcription factor TFIID complex-IDA27193682  
GO:0005675holo TFIIH complex-IBA21873635  
GO:0005675holo TFIIH complex-IDA9852112  
GO:0016607nuclear speck-IDA-  
KEGG ID KEGG Term
hsa03022Basal transcription factors
hsa03420Nucleotide excision repair
Reactome ID Reactome Term Evidence
R-HSA-112382Formation of RNA Pol II elongation complex TAS
R-HSA-113418Formation of the Early Elongation ComplexTAS
R-HSA-162587HIV Life CycleIEA
R-HSA-162599Late Phase of HIV Life CycleIEA
R-HSA-162906HIV InfectionIEA
R-HSA-1643685DiseaseIEA
R-HSA-167152Formation of HIV elongation complex in the absence of HIV TatIEA
R-HSA-167158Formation of the HIV-1 Early Elongation ComplexIEA
R-HSA-167160RNA Pol II CTD phosphorylation and interaction with CE during HIV infectionIEA
R-HSA-167161HIV Transcription InitiationIEA
R-HSA-167162RNA Polymerase II HIV Promoter EscapeIEA
R-HSA-167169HIV Transcription ElongationIEA
R-HSA-167172Transcription of the HIV genomeIEA
R-HSA-167200Formation of HIV-1 elongation complex containing HIV-1 TatIEA
R-HSA-167246Tat-mediated elongation of the HIV-1 transcriptIEA
R-HSA-212165Epigenetic regulation of gene expressionIEA
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-3700989Transcriptional Regulation by TP53TAS
R-HSA-427413NoRC negatively regulates rRNA expressionIEA
R-HSA-5250941Negative epigenetic regulation of rRNA expressionIEA
R-HSA-5663205Infectious diseaseIEA
R-HSA-5696395Formation of Incision Complex in GG-NERTAS
R-HSA-5696398Nucleotide Excision RepairTAS
R-HSA-5696399Global Genome Nucleotide Excision Repair (GG-NER)TAS
R-HSA-5696400Dual Incision in GG-NERTAS
R-HSA-674695RNA Polymerase II Pre-transcription EventsTAS
R-HSA-6781823Formation of TC-NER Pre-Incision ComplexTAS
R-HSA-6781827Transcription-Coupled Nucleotide Excision Repair (TC-NER)TAS
R-HSA-6782135Dual incision in TC-NERTAS
R-HSA-6782210Gap-filling DNA repair synthesis and ligation in TC-NERTAS
R-HSA-6796648TP53 Regulates Transcription of DNA Repair GenesTAS
R-HSA-72086mRNA CappingTAS
R-HSA-73762RNA Polymerase I Transcription InitiationTAS
R-HSA-73772RNA Polymerase I Promoter EscapeTAS
R-HSA-73776RNA Polymerase II Promoter EscapeTAS
R-HSA-73777RNA Polymerase I Chain ElongationTAS
R-HSA-73779RNA Polymerase II Transcription Pre-Initiation And Promoter OpeningTAS
R-HSA-73854RNA Polymerase I Promoter ClearanceTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-73863RNA Polymerase I Transcription TerminationTAS
R-HSA-73864RNA Polymerase I TranscriptionTAS
R-HSA-73894DNA RepairTAS
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-74160Gene expression (Transcription)IEA
R-HSA-75953RNA Polymerase II Transcription InitiationTAS
R-HSA-75955RNA Polymerase II Transcription ElongationTAS
R-HSA-76042RNA Polymerase II Transcription Initiation And Promoter ClearanceTAS
R-HSA-77075RNA Pol II CTD phosphorylation and interaction with CETAS
R-HSA-8953854Metabolism of RNATAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22524621Lack of association between GTF2H4 genetic variants and AERD development and FEV1 decline by aspirin provocation. (2012 Dec)Kim JYInt J Immunogenet
21976407Genetic variability in DNA repair and cell cycle control pathway genes and risk of smoking-related lung cancer. (2012 Oct)Buch SCMol Carcinog