Gene info: ID 2977

SNP ID	Position	Alleles	Trait	Variation Type
rs10890597	chr11:106804584 (GRCh38.p7)	A>G	alcohol dependence	SNV(Single Nucleotide Variation)

Gene Symbol	Pearson Correlation Coefficient
FAM126B	0.939
CACNB4	0.939
CHM	0.935
GABRA4	0.934
CSRNP3	0.933
SLC2A13	0.933
SACS	0.931
FRRS1L	0.93
PTPN4	0.928
CHIC1	0.923

Gene Symbol	Pearson Correlation Coefficient
CSAG1	-0.52
FLT3LG	-0.484
HEY2	-0.475
MYL3	-0.473
COPZ2	-0.47
RAB13	-0.468
ROM1	-0.455
AGTRAP	-0.452
EMP3	-0.447
RHOD	-0.44

DrugBank
CTD

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00435	Nitric Oxide	Small Molecule	10102-43-9	Approved	Target
DB01020	Isosorbide Mononitrate	Small Molecule	16051-77-7	Approved	Target
DB08931	Riociguat	Small Molecule	625115-55-1	Approved	Target
DB09241	Methylene blue	Small Molecule	61-73-4	Approved\|Investigational	Target
DB09282	Molsidomine	Small Molecule	25717-80-0	Approved\|Investigational	Target
DB13170	Plecanatide	Small Molecule	467426-54-6	Approved\|Investigational	Target
DB09282	Molsidomine	Small Molecule	25717-80-0	Approved\|Investigational	Enzyme

ID	Drug Name	Action	PubMed
C026486	1,2,5,6-dibenzanthracene	"1,2,5,6-dibenzanthracene results in increased expression of GUCY1A2 mRNA"	26377693
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GUCY1A2 mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GUCY1A2 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GUCY1A2 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GUCY1A2 mRNA"	27188386
D000638	Amiodarone	Amiodarone results in increased expression of GUCY1A2 mRNA	19774075
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of GUCY1A2 mRNA	16483693
D001104	Arbutin	Arbutin results in decreased expression of GUCY1A2 mRNA	17103032
C547126	AZM551248	AZM551248 results in decreased expression of GUCY1A2 mRNA	22323515
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of GUCY1A2 mRNA	17879257
C006780	bisphenol A	bisphenol A results in decreased expression of GUCY1A2 mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased expression of GUCY1A2 mRNA	29097150
C018475	butyraldehyde	butyraldehyde results in decreased expression of GUCY1A2 mRNA	26079696
D019256	Cadmium Chloride	Cadmium Chloride results in decreased methylation of GUCY1A2 promoter	22457795
D020245	p-Chloromercuribenzoic Acid	"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of GUCY1A2 mRNA"	27188386
D020245	p-Chloromercuribenzoic Acid	p-Chloromercuribenzoic Acid results in decreased expression of GUCY1A2 mRNA	26272509
D003471	Cuprizone	Cuprizone results in decreased expression of GUCY1A2 mRNA	26577399
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in decreased expression of GUCY1A2 mRNA	23640034
C118739	entinostat	entinostat results in decreased expression of GUCY1A2 mRNA	27188386
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in increased expression of GUCY1A2 mRNA	29097150
D005419	Flavonoids	Flavonoids results in increased expression of GUCY1A2 mRNA	18035473
D004397	Fonofos	Fonofos results in increased methylation of GUCY1A2 promoter	22847954
D006152	Cyclic GMP	[[GUCY1A2 protein binds to GUCY1B1 protein] which results in increased metabolism of Guanosine Triphosphate] which results in increased chemical synthesis of Cyclic GMP	19895661
D006160	Guanosine Triphosphate	[GUCY1A2 protein binds to GUCY1B1 protein] which results in increased metabolism of Guanosine Triphosphate	19895661
D006160	Guanosine Triphosphate	[[GUCY1A2 protein binds to GUCY1B1 protein] which results in increased metabolism of Guanosine Triphosphate] which results in increased chemical synthesis of Cyclic GMP	19895661
C011890	kojic acid	kojic acid results in decreased expression of GUCY1A2 mRNA	16595896
D007854	Lead	Lead affects the expression of GUCY1A2 mRNA	28903495
C004925	methylmercuric chloride	methylmercuric chloride affects the expression of GUCY1A2 protein	27012723
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of GUCY1A2 mRNA"	25554681\|2562005
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of GUCY1A2 mRNA"	25554681
D009532	Nickel	Nickel results in decreased expression of GUCY1A2 mRNA	24768652\|2558310
D009569	Nitric Oxide	Nitric Oxide binds to and results in increased activity of [GUCY1A2 protein binds to GUCY1B1 protein]	19895661
D010278	Parathion	Parathion results in increased methylation of GUCY1A2 promoter	22847954
C101814	perfluoro-n-undecanoic acid	perfluoro-n-undecanoic acid results in increased expression of GUCY1A2 mRNA	23602845
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of GUCY1A2 mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in increased expression of GUCY1A2 mRNA	26272509
D010936	Plant Extracts	Plant Extracts results in decreased expression of GUCY1A2 mRNA	23557933
D011441	Propylthiouracil	Propylthiouracil results in decreased expression of GUCY1A2 mRNA	24780913
D012822	Silicon Dioxide	Silicon Dioxide analog results in increased expression of GUCY1A2 mRNA	23806026
D053260	Soot	Soot results in decreased expression of GUCY1A2 mRNA	26551751
C012568	terbufos	terbufos results in increased methylation of GUCY1A2 promoter	22847954
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of GUCY1A2 mRNA	21570461
D014241	Trichloroethylene	Trichloroethylene results in decreased methylation of GUCY1A2 gene	27618143
C012589	trichostatin A	trichostatin A results in decreased expression of GUCY1A2 mRNA	28542535
D014635	Valproic Acid	Valproic Acid results in decreased expression of GUCY1A2 mRNA	27188386
D014635	Valproic Acid	Valproic Acid results in increased expression of GUCY1A2 mRNA	28001369

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005515	protein binding	-	IPI	24550280
GO:0005525	GTP binding	-	IEA	-
GO:0020037	heme binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0007165	signal transduction	-	TAS	1683630
GO:0035556	intracellular signal transduction	-	IEA	-

KEGG ID	KEGG Term
hsa00230	Purine metabolism
hsa04270	Vascular smooth muscle contraction
hsa04540	Gap junction
hsa04730	Long-term depression
hsa04970	Salivary secretion

Reactome ID	Reactome Term	Evidence
R-HSA-109582	Hemostasis	IEA
R-HSA-392154	Nitric oxide stimulates guanylate cyclase	IEA
R-HSA-418346	Platelet homeostasis	IEA

Gene: GUCY1A2

ANCO-SNPs

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Top 10 negatively co-expressed genes

Drugs/Compounds

GO/Pathway

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)