Gene: CYP2S1

29785
CYPIIS1
cytochrome P450 family 2 subfamily S member 1
protein-coding
19q13.2
Ensembl:ENSG00000167600 MIM:611529 Vega:OTTHUMG00000182721 UniprotKB:Q96SQ9
NG_007933.3
PubMed
0   ANCO-SNPs
ND|AD
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.718e-1 (AD)  7.365e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OLFML2B0.645
ARHGAP250.624
NABP10.62
RAC20.618
VAV10.617
ARID3A0.616
KCNK60.594
JAK30.591
PIM10.591
KCNJ80.585

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EDN3-0.343
HES5-0.328
TMSB4Y-0.322
RPS4Y1-0.307
RELN-0.298
NPBWR1-0.296
POU3F4-0.294
EIF1AY-0.289
RXRG-0.288
HPDL-0.287

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in decreased expression of CYP2S1 mRNA"26377693
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of CYP2S1 mRNA19933214
C4257842-(4-amino-3-methylphenyl)-5-fluorobenzothiazoleCYP2S1 protein results in increased reduction of 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole metabolite23682735
C4257842-(4-amino-3-methylphenyl)-5-fluorobenzothiazole[CYP2S1 protein results in increased reduction of Hydroxylamine] which results in increased chemical synthesis of 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole22734839
C4257842-(4-amino-3-methylphenyl)-5-fluorobenzothiazoleOxygen affects the reaction [CYP2S1 protein results in increased reduction of 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole metabolite]23682735
C0121772-aminofluoreneCYP2S1 protein results in increased reduction of 2-aminofluorene analog23682735
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP2S1 mRNA"23994337
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CYP2S1 mRNA"27188386
C0067574-biphenylamineCYP2S1 protein results in increased reduction of 4-biphenylamine analog23682735
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CYP2S1 mRNA"27188386
C0233899,10-dihydrobenzo(a)pyrene"[CYP2S1 protein co-treated with cumene hydroperoxide] results in increased oxidation of 9,10-dihydrobenzo(a)pyrene"19713358
D000082AcetaminophenAcetaminophen results in decreased expression of CYP2S1 mRNA17585979
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of CYP2S1 mRNA22100608
D016604Aflatoxin B1[CYP2S1 protein co-treated with cumene hydroperoxide] results in increased oxidation of Aflatoxin B119713358
D016604Aflatoxin B1[CYP2S1 protein co-treated with Hydrogen Peroxide] results in increased oxidation of Aflatoxin B119713358
D0150812-NaphthylamineCYP2S1 protein results in increased reduction of 2-Naphthylamine analog23682735
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of CYP2S1 mRNA24449571
C094428AQ4N[CYP2S1 protein co-treated with Oxygen deficiency] results in increased reduction of AQ4N23682735
D001379AzathioprineAzathioprine results in increased expression of CYP2S1 mRNA22623647
D001507BeclomethasoneBeclomethasone results in decreased expression of CYP2S1 mRNA22155357
C030233benzo(a)pyrene-1,6-quinone"[[CYP2S1 protein co-treated with cumene hydroperoxide] results in increased oxidation of Benzo(a)pyrene] which results in increased abundance of benzo(a)pyrene-1,6-quinone"19713358
C030233benzo(a)pyrene-1,6-quinone"[[CYP2S1 protein co-treated with Hydrogen Peroxide] results in increased oxidation of Benzo(a)pyrene] which results in increased abundance of benzo(a)pyrene-1,6-quinone"19713358
C018003benzo(a)pyrene-3,6-quinone"[[CYP2S1 protein co-treated with cumene hydroperoxide] results in increased oxidation of Benzo(a)pyrene] which results in increased abundance of benzo(a)pyrene-3,6-quinone"19713358
C018003benzo(a)pyrene-3,6-quinone"[[CYP2S1 protein co-treated with Hydrogen Peroxide] results in increased oxidation of Benzo(a)pyrene] which results in increased abundance of benzo(a)pyrene-3,6-quinone"19713358
C014357benzo(a)pyrene-6,12-quinone"[[CYP2S1 protein co-treated with cumene hydroperoxide] results in increased oxidation of Benzo(a)pyrene] which results in increased abundance of benzo(a)pyrene-6,12-quinone"19713358
C014357benzo(a)pyrene-6,12-quinone"[[CYP2S1 protein co-treated with Hydrogen Peroxide] results in increased oxidation of Benzo(a)pyrene] which results in increased abundance of benzo(a)pyrene-6,12-quinone"19713358
C074998benzo(a)pyrene-7,8,9,10-tetrol"[[CYP2S1 protein co-treated with cumene hydroperoxide] results in increased oxidation of benzo(a)pyrene 7,8-dihydrodiol] which results in increased abundance of benzo(a)pyrene-7,8,9,10-tetrol"19713358
C074998benzo(a)pyrene-7,8,9,10-tetrol"[[CYP2S1 protein co-treated with Hydrogen Peroxide] results in increased oxidation of benzo(a)pyrene 7,8-dihydrodiol] which results in increased abundance of benzo(a)pyrene-7,8,9,10-tetrol"19713358
C017228benzo(a)pyrene 7,8-dihydrodiol"[CYP2S1 protein co-treated with cumene hydroperoxide] results in increased oxidation of benzo(a)pyrene 7,8-dihydrodiol"19713358
C017228benzo(a)pyrene 7,8-dihydrodiol"[[CYP2S1 protein co-treated with cumene hydroperoxide] results in increased oxidation of benzo(a)pyrene 7,8-dihydrodiol] which results in increased abundance of benzo(a)pyrene-7,8,9,10-tetrol"19713358
C017228benzo(a)pyrene 7,8-dihydrodiol"[[CYP2S1 protein co-treated with Hydrogen Peroxide] results in increased oxidation of benzo(a)pyrene 7,8-dihydrodiol] which results in increased abundance of benzo(a)pyrene-7,8,9,10-tetrol"19713358
D019324beta-Naphthoflavonebeta-Naphthoflavone results in increased expression of CYP2S1 mRNA23994337
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CYP2S1 mRNA21632981|2231617
D001564Benzo(a)pyrene[CYP2S1 protein co-treated with cumene hydroperoxide] results in increased oxidation of Benzo(a)pyrene19713358
D001564Benzo(a)pyrene"[[CYP2S1 protein co-treated with cumene hydroperoxide] results in increased oxidation of Benzo(a)pyrene] which results in increased abundance of benzo(a)pyrene-1,6-quinone"19713358
D001564Benzo(a)pyrene"[[CYP2S1 protein co-treated with cumene hydroperoxide] results in increased oxidation of Benzo(a)pyrene] which results in increased abundance of benzo(a)pyrene-3,6-quinone"19713358
D001564Benzo(a)pyrene"[[CYP2S1 protein co-treated with cumene hydroperoxide] results in increased oxidation of Benzo(a)pyrene] which results in increased abundance of benzo(a)pyrene-6,12-quinone"19713358
D001564Benzo(a)pyrene[CYP2S1 protein co-treated with Hydrogen Peroxide] results in increased oxidation of Benzo(a)pyrene19713358
D001564Benzo(a)pyrene"[[CYP2S1 protein co-treated with Hydrogen Peroxide] results in increased oxidation of Benzo(a)pyrene] which results in increased abundance of benzo(a)pyrene-1,6-quinone"19713358
D001564Benzo(a)pyrene"[[CYP2S1 protein co-treated with Hydrogen Peroxide] results in increased oxidation of Benzo(a)pyrene] which results in increased abundance of benzo(a)pyrene-3,6-quinone"19713358
D001564Benzo(a)pyrene"[[CYP2S1 protein co-treated with Hydrogen Peroxide] results in increased oxidation of Benzo(a)pyrene] which results in increased abundance of benzo(a)pyrene-6,12-quinone"19713358
D001564Benzo(a)pyreneAHR affects the reaction [Benzo(a)pyrene results in increased expression of CYP2S1 mRNA]21995607
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of CYP2S1 mRNA]22228805
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to CYP2S1 promoter]21995607
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CYP2S1 mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of CYP2S1 mRNA21995607
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of CYP2S1 mRNA"20382639
D004958EstradiolEstradiol results in increased expression of CYP2S1 mRNA21632981
C006780bisphenol Abisphenol A results in decreased expression of CYP2S1 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of CYP2S1 mRNA26079696
D003033Coal TarCoal Tar results in increased expression of CYP2S1 mRNA12711469|1605418
C007164cumene hydroperoxide"[CYP2S1 protein co-treated with cumene hydroperoxide] results in increased oxidation of 9,10-dihydrobenzo(a)pyrene"19713358
C007164cumene hydroperoxide"[CYP2S1 protein co-treated with cumene hydroperoxide] results in increased oxidation of 9,10-Dimethyl-1,2-benzanthracene"19713358
C007164cumene hydroperoxide[CYP2S1 protein co-treated with cumene hydroperoxide] results in increased oxidation of Aflatoxin B119713358
C007164cumene hydroperoxide[CYP2S1 protein co-treated with cumene hydroperoxide] results in increased oxidation of Benzo(a)pyrene19713358
C007164cumene hydroperoxide"[CYP2S1 protein co-treated with cumene hydroperoxide] results in increased oxidation of benzo(a)pyrene 7,8-dihydrodiol"19713358
C007164cumene hydroperoxide"[[CYP2S1 protein co-treated with cumene hydroperoxide] results in increased oxidation of benzo(a)pyrene 7,8-dihydrodiol] which results in increased abundance of benzo(a)pyrene-7,8,9,10-tetrol"19713358
C007164cumene hydroperoxide"[[CYP2S1 protein co-treated with cumene hydroperoxide] results in increased oxidation of Benzo(a)pyrene] which results in increased abundance of benzo(a)pyrene-1,6-quinone"19713358
C007164cumene hydroperoxide"[[CYP2S1 protein co-treated with cumene hydroperoxide] results in increased oxidation of Benzo(a)pyrene] which results in increased abundance of benzo(a)pyrene-3,6-quinone"19713358
C007164cumene hydroperoxide"[[CYP2S1 protein co-treated with cumene hydroperoxide] results in increased oxidation of Benzo(a)pyrene] which results in increased abundance of benzo(a)pyrene-6,12-quinone"19713358
C007164cumene hydroperoxide[CYP2S1 protein co-treated with cumene hydroperoxide] results in increased oxidation of Tretinoin19713358
D003471CuprizoneCuprizone results in decreased expression of CYP2S1 mRNA26577399
D016572CyclosporineCyclosporine results in increased expression of CYP2S1 mRNA25562108
D016572CyclosporineCyclosporine results in decreased expression of CYP2S1 mRNA19770486
D003609DactinomycinDactinomycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP2S1 mRNA]17277313
D003907DexamethasoneDexamethasone results in decreased expression of CYP2S1 mRNA22155357
D003907DexamethasoneDexamethasone results in decreased expression of CYP2S1 protein22155357
D003907DexamethasoneNR3C1 protein promotes the reaction [Dexamethasone results in decreased expression of CYP2S1 mRNA]22155357
D003907DexamethasoneNR3C1 protein promotes the reaction [Dexamethasone results in decreased expression of CYP2S1 protein]22155357
D003907Dexamethasonetrichostatin A inhibits the reaction [Dexamethasone results in decreased expression of CYP2S1 mRNA]22155357
D003976DiazinonDiazinon results in increased methylation of CYP2S1 gene22964155
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of CYP2S1 mRNA27392435
D002945CisplatinCisplatin results in increased expression of CYP2S1 mRNA27392435
D004041Dietary FatsDietary Fats results in decreased expression of CYP2S1 mRNA25016146
D002117CalcitriolCalcitriol results in decreased expression of CYP2S1 mRNA16002434
D002117CalcitriolCalcitriol results in increased expression of CYP2S1 mRNA21592394|2710755
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of CYP2S1 mRNA21592394
D0151279,10-Dimethyl-1,2-benzanthracene"[CYP2S1 protein co-treated with cumene hydroperoxide] results in increased oxidation of 9,10-Dimethyl-1,2-benzanthracene"19713358
D004147DioxinsDioxins results in increased expression of CYP2S115608128
D004147DioxinsDioxins results in increased expression of CYP2S1 mRNA16054184
C118739entinostatentinostat results in increased expression of CYP2S1 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CYP2S1 mRNA"27188386
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of CYP2S1 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of CYP2S1 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CYP2S1 mRNA17942748
D005047EtoposideEtoposide results in decreased expression of CYP2S1 mRNA25270620
C007734flunisolideflunisolide results in decreased expression of CYP2S1 mRNA22155357
D005472FluorouracilFluorouracil affects the expression of CYP2S1 mRNA20421339
D017313FenretinideFenretinide results in decreased expression of CYP2S1 mRNA28973697
D006854HydrocortisoneHydrocortisone results in decreased expression of CYP2S1 mRNA22155357
D006861Hydrogen Peroxide[CYP2S1 protein co-treated with Hydrogen Peroxide] results in increased oxidation of Aflatoxin B119713358
D006861Hydrogen Peroxide[CYP2S1 protein co-treated with Hydrogen Peroxide] results in increased oxidation of Benzo(a)pyrene19713358
D006861Hydrogen Peroxide"[[CYP2S1 protein co-treated with Hydrogen Peroxide] results in increased oxidation of benzo(a)pyrene 7,8-dihydrodiol] which results in increased abundance of benzo(a)pyrene-7,8,9,10-tetrol"19713358
D006861Hydrogen Peroxide"[[CYP2S1 protein co-treated with Hydrogen Peroxide] results in increased oxidation of Benzo(a)pyrene] which results in increased abundance of benzo(a)pyrene-1,6-quinone"19713358
D006861Hydrogen Peroxide"[[CYP2S1 protein co-treated with Hydrogen Peroxide] results in increased oxidation of Benzo(a)pyrene] which results in increased abundance of benzo(a)pyrene-3,6-quinone"19713358
D006861Hydrogen Peroxide"[[CYP2S1 protein co-treated with Hydrogen Peroxide] results in increased oxidation of Benzo(a)pyrene] which results in increased abundance of benzo(a)pyrene-6,12-quinone"19713358
D006861Hydrogen Peroxide[CYP2S1 protein co-treated with Hydrogen Peroxide] results in increased oxidation of Tretinoin19713358
D019811HydroxylamineCYP2S1 protein results in increased reduction of Hydroxylamine22734839
D019811Hydroxylamine[CYP2S1 protein results in increased reduction of Hydroxylamine] which results in increased chemical synthesis of 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole22734839
C075954indolo(3,2-b)carbazole"indolo(3,2-b)carbazole results in increased expression of CYP2S1 mRNA"23994337
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of CYP2S1 mRNA27392435
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of CYP2S1 mRNA26378955
C013598methoxyacetic acidmethoxyacetic acid affects the expression of CYP2S1 mRNA20421339
D008748MethylcholanthreneMethylcholanthrene results in increased expression of CYP2S1 mRNA19883719
C028577monobutyl phthalatemonobutyl phthalate affects the expression of CYP2S1 mRNA20421339
D009151Mustard GasMustard Gas results in increased expression of CYP2S1 mRNA25102026
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of CYP2S1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of CYP2S1 mRNA"25554681
C031721naphthaleneCYP2S1 protein affects the metabolism of naphthalene16054184
C464660obeticholic acidobeticholic acid results in decreased expression of CYP2S1 mRNA27939613
D010100OxygenOxygen affects the reaction [CYP2S1 protein results in increased reduction of 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole metabolite]23682735
D010100Oxygen[CYP2S1 protein co-treated with Oxygen deficiency] results in increased reduction of AQ4N23682735
D010126OzoneOzone results in decreased expression of CYP2S1 mRNA12763052
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of CYP2S1 protein26879310
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of CYP2S1 mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of CYP2S1 mRNA17426115
D011239PrednisolonePrednisolone results in decreased expression of CYP2S1 mRNA22155357
D011794QuercetinQuercetin results in increased expression of CYP2S1 mRNA21632981
D012293Rifampin[Rifampin co-treated with NR1I2 protein] results in increased expression of CYP2S1 mRNA21127053
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of CYP2S1 mRNA21427059
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of CYP2S1 mRNA25895662
D012834SilverSilver results in increased expression of CYP2S1 mRNA27131904
D018038Sodium SeleniteSodium Selenite results in decreased expression of CYP2S1 mRNA18175754
D053260SootSoot results in decreased expression of CYP2S1 mRNA26551751
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of CYP2S1 mRNA26378955
D013629TamoxifenTamoxifen affects the expression of CYP2S1 mRNA17555576
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of CYP2S1 mRNA21592394
D013739TestosteroneTestosterone results in increased expression of CYP2S1 mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CYP2S1 mRNA22344700
D013749TetrachlorodibenzodioxinAHR affects the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP2S1 mRNA]21995607
D013749TetrachlorodibenzodioxinDactinomycin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP2S1 mRNA]17277313
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CYP2S1 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CYP2S1 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [[AHR protein binds to ARNT protein] which binds to CYP2S1 promoter]17277313
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP2S1 gene]28213091
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CYP2S1 mRNA19770486
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CYP2S1 mRNA17277313|1794274
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CYP2S1 mRNA19883719
C009495titanium dioxidetitanium dioxide affects the expression of CYP2S1 mRNA23557971
D014028Tobacco Smoke Pollution[APOE gene mutant form affects the susceptibility to Tobacco Smoke Pollution] which results in decreased expression of CYP2S1 mRNA24096154
D014212TretinoinCYP2S1 protein affects the metabolism of Tretinoin16054184
D014212Tretinoin[CYP2S1 protein co-treated with cumene hydroperoxide] results in increased oxidation of Tretinoin19713358
D014212Tretinoin[CYP2S1 protein co-treated with Hydrogen Peroxide] results in increased oxidation of Tretinoin19713358
D014212TretinoinCYP2S1 protein results in increased metabolism of Tretinoin12711469
D014212TretinoinTretinoin results in increased expression of CYP2S1 mRNA12711469|1698516
D014212TretinoinTretinoin affects the expression of CYP2S1 mRNA20421339
D014222Triamcinolone AcetonideTriamcinolone Acetonide results in decreased expression of CYP2S1 mRNA22155357
C012589trichostatin Atrichostatin A inhibits the reaction [Dexamethasone results in decreased expression of CYP2S1 mRNA]22155357
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate affects the expression of CYP2S1 mRNA"26179874
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of CYP2S1 mRNA29024780
D014635Valproic AcidValproic Acid results in increased expression of CYP2S1 mRNA23527032
D014635Valproic AcidValproic Acid affects the expression of CYP2S1 mRNA20421339
D014635Valproic AcidValproic Acid results in increased expression of CYP2S1 mRNA21427059

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005506iron ion binding-IEA-  
GO:0005515protein binding-IPI25416956  
GO:0008392arachidonic acid epoxygenase activity-IBA21873635  
GO:0008395steroid hydroxylase activity-IBA21873635  
GO:0008401retinoic acid 4-hydroxylase activity-TAS-  
GO:0016712oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen-IBA21873635  
GO:0020037heme binding-IBA21873635  
GO:0020037heme binding-IEA-  
GO:0070330aromatase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006082organic acid metabolic process-IBA21873635  
GO:0006805xenobiotic metabolic process-IBA21873635  
GO:0042738exogenous drug catabolic process-IBA21873635  
GO:0055114oxidation-reduction process-IBA21873635  
GO:0055114oxidation-reduction process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0005783endoplasmic reticulum-IDA-  
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0031090organelle membrane-IEA-  
GO:0043231intracellular membrane-bounded organelle-IBA21873635  
KEGG ID KEGG Term
hsa00980Metabolism of xenobiotics by cytochrome P450
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-211859Biological oxidationsTAS
R-HSA-211897Cytochrome P450 - arranged by substrate typeTAS
R-HSA-211945Phase I - Functionalization of compoundsTAS
R-HSA-211958Miscellaneous substratesTAS
R-HSA-211981XenobioticsTAS
R-HSA-211999CYP2E1 reactionsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25872594Expression of CYP2E1 and CYP2U1 proteins in amygdala and prefrontal cortex: influence of alcoholism and smoking. (2015 May)Toselli FAlcohol Clin Exp Res
16815959CYP2A13 in human respiratory tissues and lung cancers: an immunohistochemical study with a new peptide-specific antibody. (2006 Oct)Zhu LRDrug Metab Dispos
22232929[Polymorphic markers of the CYP1B1 (4326C > G), CYP2F1 (c.14_15insC), CYP2J2 (-76G > T), and CYP2S1 (13106C > T and 13255A > G) genes and genetic predisposition to chronic respiratory diseases induced by smoking and occupational factors]. (2011 Oct)Akhmadishina LAGenetika
26095139Gene expression profiling of cytochromes P450, ABC transporters and their principal transcription factors in the amygdala and prefrontal cortex of alcoholics, smokers and drug-free controls by qRT-PCR. (2015)Toselli FXenobiotica