Gene: GUCY2C

2984
DIAR6|GC-C|GUC2C|MECIL|MUCIL|STAR
guanylate cyclase 2C
protein-coding
12p12.3
Ensembl:ENSG00000070019 MIM:601330 Vega:OTTHUMG00000168732 UniprotKB:P25092
NG_052021.1
PubMed
0   ANCO-SNPs
ND|AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.692e-1 (AD)  8.154e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ARHGEF390.584
PIGW0.548
NLRP30.542
OR11H70.531
CBWD30.527
C1orf1460.522
C3orf350.513
CYP1A20.51
OVGP10.501
NR2C10.497

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
USP12-AS2-0.284
WSCD1-0.28
SH2D7-0.279
CCDC102A-0.277
EPPIN-0.271
TSACC-0.264
GDF11-0.263
MIA-0.26
UBQLNL-0.258
C7orf61-0.255

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB08890LinaclotideSmall Molecule851199-59-2ApprovedTarget
ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of GUCY2C mRNA"19114083
C0142112,3,7,8-tetrachlorodibenzofuran"2,3,7,8-tetrachlorodibenzofuran results in decreased expression of GUCY2C mRNA"21724226
C0293704-toluidine4-toluidine results in increased expression of GUCY2C mRNA27638505
D000082AcetaminophenAcetaminophen affects the expression of GUCY2C mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of GUCY2C gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of GUCY2C mRNA23630614
D000643Ammonium ChlorideAmmonium Chloride affects the expression of GUCY2C mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of GUCY2C mRNA24449571
D001151ArsenicArsenic affects the methylation of GUCY2C gene25304211
D001280AtrazineAtrazine results in decreased expression of GUCY2C mRNA25929836
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of GUCY2C mRNA18164116
C006780bisphenol Abisphenol A results in decreased methylation of GUCY2C promoter27312807
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in increased expression of GUCY2C mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of GUCY2C mRNA25181051
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of GUCY2C mRNA12734012
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of GUCY2C mRNA]27941970
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of GUCY2C mRNA18164116
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in increased expression of GUCY2C mRNA27638505
D004768EnterotoxinsEnterotoxins binds to GUCY2C protein15049831
C074283estradiol 3-benzoateestradiol 3-benzoate results in increased methylation of GUCY2C promoter27415467
D005419FlavonoidsFlavonoids results in increased expression of GUCY2C mRNA18035473
C039281furanfuran results in increased expression of GUCY2C mRNA25539665|2738771
C000625835HFPO2 compoundHFPO2 compound results in increased expression of GUCY2C mRNA27553808
C000625836HFPO4 compoundHFPO4 compound results in increased expression of GUCY2C mRNA27553808
D008774MethylphenidateMethylphenidate results in decreased expression of GUCY2C mRNA22470460
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of GUCY2C mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of GUCY2C mRNA"25620056
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid affects the expression of GUCY2C mRNA19429403
C023036perfluorooctanoic acidperfluorooctanoic acid affects the expression of GUCY2C mRNA19429403
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of GUCY2C mRNA28511854
C501413tesaglitazartesaglitazar results in decreased expression of GUCY2C mRNA21515302
D013739Testosterone[bisphenol A co-treated with Testosterone] results in increased expression of GUCY2C mRNA26496021
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of GUCY2C mRNA21296121
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GUCY2C mRNA26377647
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of GUCY2C mRNA21724226
D013853ThioacetamideThioacetamide results in increased expression of GUCY2C mRNA23411599
C012589trichostatin Atrichostatin A results in increased expression of GUCY2C mRNA24935251
D014635Valproic AcidValproic Acid results in increased expression of GUCY2C mRNA24935251
D024483Vitamin K 3Vitamin K 3 affects the expression of GUCY2C mRNA20044591

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004016adenylate cyclase activity-IBA21873635  
GO:0004383guanylate cyclase activity-IBA21873635  
GO:0004672protein kinase activity-IEA-  
GO:0005515protein binding-IPI11950846  
GO:0005524ATP binding-IEA-  
GO:0005525GTP binding-IEA-  
GO:0015643toxic substance binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006182cGMP biosynthetic process-IBA21873635  
GO:0006468protein phosphorylation-IEA-  
GO:0007165signal transduction-IBA21873635  
GO:0007168receptor guanylyl cyclase signaling pathway-TAS1680854  
GO:0007586digestion-TAS-  
GO:0009190cyclic nucleotide biosynthetic process-IBA21873635  
GO:0009636response to toxic substance-IEA-  
GO:0035556intracellular signal transduction-IEA-  
GO:0042127regulation of cell proliferation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005789endoplasmic reticulum membrane-IEA-  
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-TAS-  
GO:0008074guanylate cyclase complex, soluble-IBA21873635  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
hsa00230Purine metabolism
Reactome ID Reactome Term Evidence
R-HSA-1643685DiseaseTAS
R-HSA-5339562Uptake and actions of bacterial toxinsTAS
R-HSA-5663205Infectious diseaseTAS
R-HSA-8935690DigestionTAS
R-HSA-8942233Intestinal infectious diseasesTAS
R-HSA-8963743Digestion and absorptionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal