Gene: TRPM5

29850
LTRPC5|MTR1
transient receptor potential cation channel subfamily M member 5
protein-coding
11p15.5
Ensembl:ENSG00000070985 MIM:604600 Vega:OTTHUMG00000009896 UniprotKB:Q9NZQ8
NC_000011.10
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.027e-1 (AD)  6.727e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs886277chr11:2418537 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg26917665chr11:2444485TRPM5Promoter6.675e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
BCL2L150.387
PNPLA30.383
ATP1A40.363
TGM70.352
MYL70.341
BMP100.339
DYNAP0.336
NPIPB30.333
SBK20.329
ODF40.323

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
APOC3-0.234
YIPF7-0.229
TMSB15A-0.223
AZGP1-0.213
HP-0.211
IFNA2-0.208
S100A7-0.207
AADAC-0.202
ORM1-0.202
KLRG1-0.2

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of TRPM5 mRNA"18648102
D000082AcetaminophenAcetaminophen results in decreased expression of TRPM5 mRNA22230336
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TRPM5 mRNA20713471
C006780bisphenol Abisphenol A results in increased methylation of TRPM5 promoter27312807
C006780bisphenol Abisphenol A results in decreased expression of TRPM5 mRNA25181051
D003300CopperTRPM5 protein affects the susceptibility to Copper19244541
D019327Copper SulfateTRPM5 protein affects the susceptibility to Copper Sulfate19244541
D003976DiazinonDiazinon results in increased methylation of TRPM5 gene22964155
C112943dioctanoyl-phosphatidylinositol 4,5-bisphosphate"dioctanoyl-phosphatidylinositol 4,5-bisphosphate affects the activity of TRPM5 protein"17599963
C020748ferrous sulfateTRPM5 protein affects the susceptibility to ferrous sulfate19244541
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of TRPM5 mRNA26752646
D008278Magnesium SulfateTRPM5 protein affects the susceptibility to Magnesium Sulfate19244541
D008727MethotrexateMethotrexate affects the expression of TRPM5 mRNA18502557
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of TRPM5 mRNA"20188158
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of TRPM5 mRNA28511854
D012492SaltsTRPM5 protein affects the susceptibility to Salts19244541
D018038Sodium SeleniteSodium Selenite results in decreased expression of TRPM5 mRNA18175754
C063888triphenylphosphine oxidetriphenylphosphine oxide results in decreased activity of TRPM5 protein25787141
D014635Valproic AcidValproic Acid results in increased methylation of TRPM5 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of TRPM5 gene25560391
D019287Zinc SulfateTRPM5 protein affects the susceptibility to Zinc Sulfate19244541

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005216ion channel activity-TAS10607831  
GO:0005227calcium activated cation channel activity-IEA-  
GO:0005244voltage-gated ion channel activity-IEA-  
GO:0005267potassium channel activity-IEA-  
GO:0005272sodium channel activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0034765regulation of ion transmembrane transport-IEA-  
GO:0035725sodium ion transmembrane transport-IEA-  
GO:0050909sensory perception of taste-IEA-  
GO:0070588calcium ion transmembrane transport-TAS-  
GO:0071805potassium ion transmembrane transport-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0016021integral component of membrane-IEA-  
GO:0030425dendrite-IEA-  
GO:0043025neuronal cell body-IEA-  
KEGG ID KEGG Term
hsa04742Taste transduction
Reactome ID Reactome Term Evidence
R-HSA-2672351Stimuli-sensing channelsTAS
R-HSA-3295583TRP channelsTAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-983712Ion channel transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal