Gene: ICOS

29851
AILIM|CD278|CVID1
inducible T cell costimulator
protein-coding
2q33.2
Ensembl:ENSG00000163600 MIM:604558 Vega:OTTHUMG00000132880 UniprotKB:Q9Y6W8
NG_011586.1
PubMed
0   ANCO-SNPs
ND
6   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.098e-1 (AD)  2.446e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg18561976chr2:204801508ICOS2.420e-9Maternal smoking in pregnancy27040690

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CD480.617
ASB90.596
GZMA0.588
CD960.587
PARP150.583
SLC15A10.582
CD690.576
CPA30.571
SLPI0.568
BPI0.567

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ASPDH-0.369
CHRNA4-0.365
FEZF2-0.353
RAB26-0.35
OTUD7A-0.348
DBP-0.344
CYP46A1-0.339
FAM43B-0.339
MLYCD-0.333
GRM3-0.33

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of ICOS mRNA"18648102
D000082AcetaminophenAcetaminophen results in increased expression of ICOS mRNA26690555
D000171AcroleinAcrolein results in increased expression of ICOS mRNA18515264
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of ICOS gene27153756
C430898AGN 194204AGN 194204 results in decreased expression of ICOS mRNA16339527
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in increased expression of ICOS mRNA"23195993
C547126AZM551248AZM551248 results in increased expression of ICOS mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ICOS mRNA22316170
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ICOS mRNA21569818
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ICOS mRNA23735875
C002791bismuth tripotassium dicitratebismuth tripotassium dicitrate results in decreased expression of ICOS mRNA15912405
C006780bisphenol Abisphenol A results in decreased expression of ICOS mRNA25181051
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of ICOS mRNA20938992
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of ICOS mRNA17361019
D004041Dietary FatsDietary Fats results in increased expression of ICOS mRNA25016146
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of ICOS mRNA20938992
D005839GentamicinsGentamicins results in increased expression of ICOS mRNA22061828
C412815GW 4064GW 4064 results in decreased expression of ICOS mRNA26655953
C089796hexabromocyclododecanehexabromocyclododecane results in decreased expression of ICOS mRNA24680724
D017313FenretinideFenretinide results in decreased expression of ICOS mRNA28973697
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ICOS mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of ICOS mRNA26387944
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of ICOS mRNA20938992
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of ICOS mRNA"23845593|2555468
D009532NickelNickel results in increased expression of ICOS mRNA23195993|2558310
C028007nickel monoxidenickel monoxide results in increased expression of ICOS mRNA19167457
D052638Particulate MatterParticulate Matter results in increased expression of ICOS mRNA23638009
C006253pirinixic acidpirinixic acid results in decreased expression of ICOS mRNA17950772
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in decreased expression of ICOS mRNA]17950772
D018038Sodium SeleniteSodium Selenite results in increased expression of ICOS mRNA18175754
D053260SootSoot results in increased expression of ICOS mRNA22461453|2655175
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ICOS mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ICOS mRNA16102516|1868492
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ICOS mRNA25613284
C009495titanium dioxidetitanium dioxide affects the expression of ICOS mRNA23557971
C009495titanium dioxidetitanium dioxide results in increased expression of ICOS mRNA27760801
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of ICOS mRNA22363418
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of ICOS mRNA20133372
D014051Toluene 2,4-Diisocyanate"Toluene 2,4-Diisocyanate results in increased expression of ICOS protein"27103660
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of ICOS mRNA19042947
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of ICOS gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI11956294  16951355  27135603  
GO:0046934phosphatidylinositol-4,5-bisphosphate 3-kinase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0002517T cell tolerance induction-IEA-  
GO:0006955immune response-NAS9930702  
GO:0031295T cell costimulation-TAS-  
GO:0046854phosphatidylinositol phosphorylation-IEA-  
GO:0051897positive regulation of protein kinase B signaling-TAS-  
GO:0098609cell-cell adhesion-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-IEA-  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IEA-  
GO:0009897external side of plasma membrane-IEA-  
KEGG ID KEGG Term
hsa04514Cell adhesion molecules (CAMs)
hsa04660T cell receptor signaling pathway
hsa04672Intestinal immune network for IgA production
hsa05340Primary immunodeficiency
Reactome ID Reactome Term Evidence
R-HSA-1257604PIP3 activates AKT signalingTAS
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-162582Signal TransductionTAS
R-HSA-1643685DiseaseTAS
R-HSA-168256Immune SystemTAS
R-HSA-199418Negative regulation of the PI3K/AKT networkTAS
R-HSA-2219528PI3K/AKT Signaling in CancerTAS
R-HSA-2219530Constitutive Signaling by Aberrant PI3K in CancerTAS
R-HSA-388841Costimulation by the CD28 familyTAS
R-HSA-5663202Diseases of signal transductionTAS
R-HSA-6811558PI5P, PP2A and IER3 Regulate PI3K/AKT SignalingTAS
R-HSA-9006925Intracellular signaling by second messengersTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27777979The head and neck cancer immune landscape and its immunotherapeutic implications. (2016 Oct 20)Mandal RJCI Insight
27490795Six-SOMAmer Index Relating to Immune, Protease and Angiogenic Functions Predicts Progression in IPF. (2016)Ashley SLPLoS One
16512757No association between selected candidate gene polymorphisms and severe chronic periodontitis. (2006 Mar)Wohlfahrt JCJ Periodontol
21669243CTLA-4, CD28, and ICOS gene polymorphism associations with non-small-cell lung cancer. (2011 Oct)Karabon LHum Immunol
17076943Non-arteritic anterior ischemic optic neuropathy (NAION) and phosphodiesterase type-5 inhibitors. (2006 Oct)Bella AJCan J Urol
28179539Smoking reduces circulating CD26(hi)CD161(hi) MAIT cells in healthy individuals and patients with multiple sclerosis. (2017 May)Ammitzboll CJ Leukoc Biol