Gene: NPC1L1

29881
LDLCQ7|NPC11L1|SLC65A2
NPC1 like intracellular cholesterol transporter 1
protein-coding
7p13
Ensembl:ENSG00000015520 MIM:608010 Vega:OTTHUMG00000023691 UniprotKB:Q9UHC9
NG_013088.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.492e-1 (AD)  4.802e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TLR90.829
PPEF20.766
CELSR10.763
TDRG10.754
ADCY100.751
NANOS20.734
C9orf1520.733
FGFR40.728
DCAF4L10.721
ESPNL0.709

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ZSCAN1-0.432
SNX22-0.426
TMEM86A-0.409
TTC30A-0.402
SAPCD2-0.401
AGL-0.399
CCT6B-0.395
SLC35G1-0.387
HAPLN1-0.385
CIRBP-0.38

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00973EzetimibeSmall Molecule163222-33-1ApprovedTarget
ID Drug Name Action PubMed
C11912918alpha-glycyrrhetinic acid18alpha-glycyrrhetinic acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of NPC1L1 mRNA]28549656
C0030017-ketocholesterol7-ketocholesterol results in decreased expression of NPC1L123454145
D000082AcetaminophenAcetaminophen affects the expression of NPC1L1 mRNA25064622
D000082AcetaminophenAcetaminophen results in decreased expression of NPC1L1 mRNA21420995
D000082AcetaminophenAcetaminophen results in increased expression of NPC1L1 mRNA22230336
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of NPC1L1 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of NPC1L1 mRNA22100608
D000638AmiodaroneAmiodarone affects the expression of NPC1L1 mRNA25064622
D001398AztreonamAztreonam results in decreased expression of NPC1L1 mRNA24657338
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of NPC1L1 gene25435355
C006780bisphenol Abisphenol A results in increased expression of NPC1L1 mRNA28057006
C006780bisphenol Abisphenol A results in increased expression of NPC1L1 protein28057006
C006780bisphenol ASREBF2 promotes the reaction [bisphenol A results in increased expression of NPC1L1 mRNA]28057006
C018475butyraldehydebutyraldehyde results in increased expression of NPC1L1 mRNA26079696
D002512Cephalothin[Cephalothin co-treated with Neomycin] results in increased expression of NPC1L1 mRNA24657338
D002746ChlorpromazineChlorpromazine affects the expression of NPC1L1 mRNA25064622
D002784Cholesterol[Cholesterol deficiency co-treated with Dietary Fats] results in decreased expression of NPC1L1 mRNA18356535
D016572CyclosporineCyclosporine affects the expression of NPC1L1 mRNA25064622
D016572CyclosporineCyclosporine affects the expression of NPC1L1 mRNA25562108
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of NPC1L1 mRNA]27941970
C000944dicrotophosdicrotophos results in increased expression of NPC1L1 mRNA28302478
D004041Dietary Fats[Cholesterol deficiency co-treated with Dietary Fats] results in decreased expression of NPC1L1 mRNA18356535
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of NPC1L1 mRNA24535843
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of NPC1L1 mRNA24535843
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of NPC1L1 mRNA25064622
D000069438EzetimibeEzetimibe results in decreased activity of NPC1L1 protein28057006
D000069438EzetimibeEzetimibe results in decreased expression of NPC1L1 mRNA16177187
D000069438EzetimibeNPC1L1 exon SNP results in decreased susceptibility to Ezetimibe15679830
D000069438EzetimibeEzetimibe results in increased expression of NPC1L1 mRNA17130282
D000069438EzetimibeSimvastatin promotes the reaction [Ezetimibe results in increased expression of NPC1L1 mRNA]17130282
D000069438EzetimibeEzetimibe results in decreased activity of NPC1L1 protein17130282
D005228Fatty Acids, Essential"Fatty Acids, Essential deficiency results in increased expression of NPC1L1 mRNA"23333450
D005228Fatty Acids, Essential"NR1H2 gene mutant form promotes the reaction [Fatty Acids, Essential deficiency results in increased expression of NPC1L1 mRNA]"23333450
D005228Fatty Acids, Essential"NR1H3 gene mutant form promotes the reaction [Fatty Acids, Essential deficiency results in increased expression of NPC1L1 mRNA]"23333450
D005231Fatty Acids, Unsaturated"Fatty Acids, Unsaturated results in decreased expression of NPC1L1 mRNA"18356535
D015378Imipenem[Vancomycin co-treated with Imipenem] results in decreased expression of NPC1L1 mRNA24657338
C039281furanfuran results in increased expression of NPC1L1 mRNA27387713
D019695Glycyrrhizic AcidGlycyrrhizic Acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of NPC1L1 mRNA]28549656
C473027GW 3965GW 3965 results in decreased expression of NPC1L1 mRNA15633131
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of NPC1L1 mRNA"24972896
D008727MethotrexateMethotrexate results in increased expression of NPC1L1 mRNA24449571
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of NPC1L1 mRNA"20188158
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in increased expression of NPC1L1 mRNA22401849
C500085muraglitazarmuraglitazar results in increased expression of NPC1L1 mRNA21515302
D0150581-Naphthylisothiocyanate18alpha-glycyrrhetinic acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of NPC1L1 mRNA]28549656
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of NPC1L1 mRNA28549656
D0150581-NaphthylisothiocyanateGlycyrrhizic Acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of NPC1L1 mRNA]28549656
D009355Neomycin[Cephalothin co-treated with Neomycin] results in increased expression of NPC1L1 mRNA24657338
C028007nickel monoxidenickel monoxide results in increased expression of NPC1L1 mRNA19167457
C025589ochratoxin Aochratoxin A results in decreased methylation of NPC1L1 gene26431795
D010269ParaquatParaquat affects the expression of NPC1L1 mRNA25064622
C058305phenethyl isothiocyanatephenethyl isothiocyanate results in increased expression of NPC1L1 mRNA17616710
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of NPC1L1 mRNA24535843
C089730rosiglitazonerosiglitazone results in increased expression of NPC1L1 mRNA21515302
D012402Rotenone[Stigmasterol co-treated with Rotenone] results in increased expression of NPC1L1 mRNA23454145
D019821SimvastatinSimvastatin results in decreased expression of NPC1L1 mRNA17980884
D019821SimvastatinSimvastatin promotes the reaction [Ezetimibe results in increased expression of NPC1L1 mRNA]17130282
D013261SterolsNPC1L1 protein affects the import of Sterols15737409
D013265Stigmasterol[Stigmasterol co-treated with KNG1 protein modified form] results in increased expression of NPC1L1 mRNA23454145
D013265Stigmasterol[Stigmasterol co-treated with Rotenone] results in increased expression of NPC1L1 mRNA23454145
D013662TeaTea results in increased expression of NPC1L1 mRNA19193814
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NPC1L1 mRNA26377647
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of NPC1L1 mRNA28213091|2823826
D013752TetracyclineTetracycline affects the expression of NPC1L1 mRNA25064622
D013853ThioacetamideThioacetamide affects the expression of NPC1L1 mRNA25064622
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of NPC1L1 mRNA28065790
D014241TrichloroethyleneTrichloroethylene results in decreased expression of NPC1L1 mRNA26745549
C009564trilinoleintrilinolein results in decreased expression of NPC1L1 mRNA18356535
C101314trilinolenintrilinolenin results in decreased expression of NPC1L1 mRNA18356535
D014304TrioleinTriolein results in decreased expression of NPC1L1 mRNA18356535
C057693troglitazonetroglitazone results in increased expression of NPC1L1 mRNA21515302
D014635Valproic AcidValproic Acid affects the expression of NPC1L1 mRNA25064622
D014640Vancomycin[Vancomycin co-treated with Imipenem] results in decreased expression of NPC1L1 mRNA24657338
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of NPC1L1 gene25560391
C088658zoledronic acidzoledronic acid results in increased expression of NPC1L1 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI19542231  22095670  
GO:0008144drug binding-IEA-  
GO:0017137Rab GTPase binding-IPI19542231  
GO:0031489myosin V binding-IPI19542231  
GO ID GO Term Qualifier Evidence PubMed
GO:0006695cholesterol biosynthetic process-IMP17140581  
GO:0030299intestinal cholesterol absorption-IMP17140581  
GO:0030301cholesterol transport-IMP17140581  
GO:0042157lipoprotein metabolic process-IMP17140581  
GO:0042493response to drug-IEA-  
GO:0071501cellular response to sterol depletion-IDA19325169  
GO:0098856intestinal lipid absorption-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0016324apical plasma membrane-IEA-  
GO:0030659cytoplasmic vesicle membrane-IEA-  
GO:0031526brush border membrane-IEA-  
GO:0044214spanning component of plasma membrane-IDA19325169  
KEGG ID KEGG Term
hsa04975Fat digestion and absorption
Reactome ID Reactome Term Evidence
R-HSA-8963676Intestinal absorptionTAS
R-HSA-8963676Intestinal absorptionIEA
R-HSA-8963678Intestinal lipid absorptionTAS
R-HSA-8963678Intestinal lipid absorptionIEA
R-HSA-8963743Digestion and absorptionTAS
R-HSA-8963743Digestion and absorptionIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28101967Host-related factors explaining interindividual variability of carotenoid bioavailability and tissue concentrations in humans. (2017 Jun)Bohn TMol Nutr Food Res
22646906Association of rs2072183 SNP and serum lipid levels in the Mulao and Han populations. (2012 May 30)Miao LLipids Health Dis