Gene: STRN4

29888
PPP2R6C|ZIN|zinedin
striatin 4
protein-coding
19q13.32
Ensembl:ENSG00000090372 MIM:614767 Vega:OTTHUMG00000183432 UniprotKB:Q9NRL3
NC_000019.10
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.438e-1 (AD)  8.497e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs3786704chr19:46721333 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SH3GL10.934
BCL7B0.922
TESK10.921
SRF0.921
MLF20.913
SCAF10.913
EPN10.909
ARF10.909
CTBP10.907
CHMP1A0.906

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.781
OR4F29-0.748
PHEX-0.301
VNN2-0.283
FCGR3B-0.272
C1orf87-0.252
HBD-0.251
CXCR2-0.25
MBNL3-0.249
ASB4-0.244

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of STRN4 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of STRN4 mRNA"21346803
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of STRN4 mRNA"15215175
D000082AcetaminophenAcetaminophen affects the expression of STRN4 mRNA17562736
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of STRN4 mRNA21298039
D001151ArsenicArsenic affects the methylation of STRN4 gene25304211
D001241AspirinAspirin results in increased expression of STRN4 mRNA11906190
D001280AtrazineAtrazine results in decreased expression of STRN4 mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of STRN4 mRNA26001963
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of STRN4 mRNA20106945
C044887beta-methylcholinebeta-methylcholine affects the expression of STRN4 mRNA21179406
C006780bisphenol Abisphenol A results in increased expression of STRN4 mRNA25181051
D003024ClozapineClozapine results in increased expression of STRN4 mRNA14647396
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of STRN4 mRNA23640034|2391405
D004041Dietary FatsDietary Fats results in decreased expression of STRN4 mRNA19030233
D004041Dietary Fatsrimonabant inhibits the reaction [Dietary Fats results in decreased expression of STRN4 mRNA]19030233
C069837fullerene C60fullerene C60 results in increased expression of STRN4 mRNA19167457
D006220HaloperidolHaloperidol results in increased expression of STRN4 mRNA14647396
C028007nickel monoxidenickel monoxide results in increased expression of STRN4 mRNA19167457
C006253pirinixic acidpirinixic acid results in increased expression of STRN4 mRNA12832660
D011748PyrogallolPyrogallol results in increased expression of STRN4 mRNA20362636
D011794QuercetinQuercetin affects the expression of STRN4 mRNA18178720
C089032rimonabantrimonabant inhibits the reaction [Dietary Fats results in decreased expression of STRN4 mRNA]19030233
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of STRN4 mRNA21570461
D014635Valproic AcidValproic Acid affects the expression of STRN4 mRNA25979313
D014635Valproic AcidValproic Acid affects the expression of STRN4 mRNA17963808
D014635Valproic AcidValproic Acid results in decreased expression of STRN4 mRNA21427059
D014635Valproic AcidValproic Acid results in increased expression of STRN4 mRNA21427059

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI17353931  18782753  20195357  23455922  
GO:0005516calmodulin binding-IBA21873635  
GO:0005516calmodulin binding-NAS10748158  
GO:0044877protein-containing complex binding-IDA18782753  
GO:0051721protein phosphatase 2A binding-IBA21873635  
GO:0051721protein phosphatase 2A binding-IDA18782753  
GO:0070016armadillo repeat domain binding-IBA21873635  
GO:0070016armadillo repeat domain binding-IPI18502210  
GO ID GO Term Qualifier Evidence PubMed
GO:0008150biological_process-ND-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000159protein phosphatase type 2A complexCOLOCALIZES_WITHIBA21873635  
GO:0000159protein phosphatase type 2A complexcolocalizes_withIDA18782753  
GO:0005737cytoplasm-IEA-  
GO:0016020membrane-IEA-  
GO:0030425dendrite-IBA21873635  
GO:0043197dendritic spine-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal