Gene: MYLPF

29895
HUMMLC2B|MLC2B|MRLC2|MYL11
myosin light chain, phosphorylatable, fast skeletal muscle
protein-coding
16p11.2
Ensembl:ENSG00000180209 MIM:617378 Vega:OTTHUMG00000132399 UniprotKB:Q96A32
NG_050592.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.507e-2 (AD)  6.284e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MYL10.884
MYH20.863
TNNI20.834
MYH10.798
CKM0.792
ACTA10.777
TNNI10.771
XIRP20.751
MB0.741
TNNT30.713

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ZFHX2-0.332
DNASE1L2-0.313
AMH-0.297
HIC2-0.297
RFX1-0.292
PLK1-0.292
ATXN7L2-0.291
OSBPL7-0.29
ABCA7-0.285
SLC22A14-0.285

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of MYLPF mRNA"19114083
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of MYLPF mRNA"18648102
D020106AcrylamideAcrylamide results in decreased expression of MYLPF mRNA22197712|2860676
D000643Ammonium ChlorideAmmonium Chloride affects the expression of MYLPF mRNA16483693
D001151ArsenicArsenic affects the methylation of MYLPF gene25304211
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MYLPF mRNA22228805
D004958EstradiolEstradiol results in decreased expression of MYLPF mRNA19484750
C006780bisphenol Abisphenol A results in decreased methylation of MYLPF promoter27312807
C006780bisphenol Abisphenol A results in decreased expression of MYLPF mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of MYLPF gene28505145
C007020chlorophyllin"[chlorophyllin co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in decreased expression of MYLPF mRNA"22485181
D002922CiguatoxinsCiguatoxins affects the expression of MYLPF mRNA18353800
D002994ClofibrateClofibrate results in decreased expression of MYLPF mRNA22300585
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of MYLPF mRNA21266533
D003999Dichloroacetic AcidDichloroacetic Acid results in decreased expression of MYLPF mRNA28962523
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of MYLPF mRNA28085963
D0151279,10-Dimethyl-1,2-benzanthracene"[chlorophyllin co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in decreased expression of MYLPF mRNA"22485181
D004237DiuronDiuron results in decreased expression of MYLPF mRNA25152437
D000431EthanolEthanol results in decreased expression of MYLPF mRNA15513904
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of MYLPF mRNA23550701
D006108GraphiteGraphite results in increased expression of MYLPF mRNA27440207
C412815GW 4064GW 4064 results in decreased expression of MYLPF mRNA26655953
D000432MethanolMethanol results in increased expression of MYLPF protein22257634
C406082monomethylarsonous acidmonomethylarsonous acid results in increased expression of MYLPF protein24625837
C031721naphthalenenaphthalene analog results in decreased expression of MYLPF mRNA24976557
C017096n-butoxyethanoln-butoxyethanol results in increased expression of MYLPF mRNA19812364
C017557nickel subsulfidenickel subsulfide results in increased expression of MYLPF mRNA21086188
C029938nickel sulfatenickel sulfate results in increased expression of MYLPF mRNA16166746
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of MYLPF mRNA27935865
D010416PentachlorophenolPentachlorophenol results in increased expression of MYLPF mRNA23892564
D010634PhenobarbitalPhenobarbital affects the expression of MYLPF mRNA23091169
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of MYLPF mRNA27935865
D010936Plant ExtractsPlant Extracts results in decreased expression of MYLPF mRNA23557933
C059514resveratrolresveratrol results in increased expression of MYLPF mRNA25905778
D012838SilymarinSilymarin results in decreased expression of MYLPF mRNA22386810
C017947sodium arsenitesodium arsenite affects the expression of MYLPF mRNA29319823
D053260SootSoot results in increased expression of MYLPF mRNA26551751
D013096SpermineSpermine results in increased expression of MYLPF mRNA18673383
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MYLPF mRNA21570461
D014118Toxins, Biological"Toxins, Biological affects the expression of MYLPF mRNA"19682533
D014635Valproic AcidValproic Acid results in increased methylation of MYLPF gene29154799
D001335Vehicle EmissionsVehicle Emissions affects the methylation of MYLPF gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005509calcium ion binding-IEA-  
GO:0008307structural constituent of muscle-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006936muscle contraction-TAS-  
GO:0006955immune response-IEA-  
GO:0007519skeletal muscle tissue development-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005765lysosomal membrane-HDA17897319  
GO:0005829cytosol-TAS-  
GO:0005859muscle myosin complex-TAS6179945  
KEGG ID KEGG Term
hsa04510Focal adhesion
hsa04530Tight junction
hsa04670Leukocyte transendothelial migration
hsa04810Regulation of actin cytoskeleton
Reactome ID Reactome Term Evidence
R-HSA-397014Muscle contractionTAS
R-HSA-445355Smooth Muscle ContractionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22197712Neurobehavioral and transcriptional effects of acrylamide in juvenile rats. (2012 Mar)Seale SMPharmacol Biochem Behav