Gene: EEF2K

29904
HSU93850|eEF-2K
eukaryotic elongation factor 2 kinase
protein-coding
16p12.2
Ensembl:ENSG00000103319 MIM:606968 Vega:OTTHUMG00000094771 UniprotKB:O00418
NC_000016.10
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.470e-2 (AD)  6.759e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs4783448chr16:22230112 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
JARID20.769
FBXO210.741
MTMR10.741
SYNE10.74
SNRNP2000.74
TMEM1920.739
ANKFY10.732
USP40.732
ARID1A0.725
ABHD20.722

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.465
OR4F29-0.417
KLRC2-0.338
TNFRSF13B-0.322
ANXA13-0.32
CTNNA3-0.309
TMEM139-0.306
KLRC3-0.286
SGMS2-0.277
RASGRP3-0.268

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of EEF2K mRNA19933214
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of EEF2K mRNA"25510870
C0297902,2',3',4,4',5-hexachlorobiphenyl"2,2',3',4,4',5-hexachlorobiphenyl results in decreased expression of EEF2K mRNA"23829299
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of EEF2K mRNA"21394737|2729130
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of EEF2K mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of EEF2K mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of EEF2K mRNA"25510870
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of EEF2K mRNA"21346803
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of EEF2K mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"2,5,2',5'-tetrachlorobiphenyl results in increased expression of EEF2K mRNA"23829299
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of EEF2K mRNA"21346803
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EEF2K mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EEF2K mRNA"27188386
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of EEF2K mRNA"21346803
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EEF2K mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EEF2K mRNA"27188386
C496492abrineabrine results in decreased expression of EEF2K mRNA22595364
D000082AcetaminophenAcetaminophen results in decreased expression of EEF2K mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of EEF2K mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of EEF2K mRNA27153756
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of EEF2K mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of EEF2K mRNA16483693
D001151ArsenicArsenic affects the methylation of EEF2K gene25304211
D001507BeclomethasoneBeclomethasone results in increased expression of EEF2K mRNA23656298
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of EEF2K mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of EEF2K mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of EEF2K mRNA22228805
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of EEF2K mRNA20660070
D004958EstradiolEstradiol results in increased expression of EEF2K mRNA23019147
D001622BetaineBetaine results in increased expression of EEF2K mRNA26391144
C006780bisphenol Abisphenol A affects the expression of EEF2K mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of EEF2K mRNA25181051
D002220CarbamazepineCarbamazepine affects the expression of EEF2K mRNA25979313
D002737ChloropreneChloroprene results in increased expression of EEF2K mRNA23125180
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of EEF2K gene20938992
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of EEF2K mRNA20971185
D003345CorticosteroneCorticosterone results in increased expression of EEF2K mRNA15755911
D003471CuprizoneCuprizone results in increased expression of EEF2K mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of EEF2K mRNA20106945|2556210
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of EEF2K mRNA23640034
D003976DiazinonDiazinon results in increased methylation of EEF2K gene22964155
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of EEF2K mRNA27392435
C000944dicrotophosdicrotophos results in increased expression of EEF2K mRNA28302478
C014476diethyl maleatediethyl maleate results in decreased expression of EEF2K mRNA21161181
D004147DioxinsDioxins affects the expression of EEF2K mRNA20463971
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of EEF2K mRNA22079256
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of EEF2K mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of EEF2K mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of EEF2K mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of EEF2K mRNA17351261
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of EEF2K mRNA17557909
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of EEF2K mRNA23649840
D005419FlavonoidsFlavonoids results in increased expression of EEF2K mRNA18035473
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of EEF2K gene20938992
D005557FormaldehydeFormaldehyde results in decreased expression of EEF2K mRNA23649840
C069837fullerene C60fullerene C60 results in increased expression of EEF2K mRNA19167457
D005947GlucoseGlucose results in increased phosphorylation of EEF2K protein19765649
D005947Glucoseresveratrol inhibits the reaction [Glucose results in increased phosphorylation of EEF2K protein]19765649
D017313FenretinideFenretinide results in decreased expression of EEF2K mRNA28973697
D007213IndomethacinIndomethacin results in decreased expression of EEF2K mRNA28201806
D007213IndomethacinIndomethacin results in increased expression of EEF2K mRNA28201806
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of EEF2K mRNA25613284
D007501IronIron deficiency results in increased expression of EEF2K mRNA16629162
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of EEF2K mRNA27392435
C544151jinfukangjinfukang results in increased expression of EEF2K mRNA27392435
C098607JP8 aviation fuelJP8 aviation fuel results in decreased expression of EEF2K protein17337753
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of EEF2K mRNA25982114
D007649KetamineKetamine results in decreased expression of EEF2K mRNA20080153
D007854LeadLead results in decreased expression of EEF2K mRNA19921347
C045463leflunomideleflunomide results in decreased expression of EEF2K mRNA28988120
D008694MethamphetamineMethamphetamine results in decreased methylation of EEF2K promoter26307267
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of EEF2K gene20938992
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of EEF2K mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of EEF2K mRNA"20188158
C406082monomethylarsonous acidmonomethylarsonous acid results in decreased expression of EEF2K mRNA20886546
D009151Mustard GasMustard Gas results in increased phosphorylation of EEF2K protein19845377
D009151Mustard GasMustard Gas results in decreased expression of EEF2K mRNA18955075
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in decreased expression of EEF2K mRNA17616710
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of EEF2K mRNA20971185
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of EEF2K mRNA"25510870
C058305phenethyl isothiocyanatephenethyl isothiocyanate results in decreased expression of EEF2K mRNA17616710
C006253pirinixic acidpirinixic acid results in decreased expression of EEF2K mRNA23811191
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of EEF2K mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of EEF2K mRNA22079256
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of EEF2K mRNA28903501
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of EEF2K mRNA20660070
D011441PropylthiouracilPropylthiouracil results in increased expression of EEF2K mRNA24780913
C010313pseudocumenepseudocumene results in decreased expression of EEF2K protein17337753
C059514resveratrolresveratrol inhibits the reaction [Glucose results in increased phosphorylation of EEF2K protein]19765649
C059514resveratrolresveratrol results in increased expression of EEF2K mRNA25905778
D012715Sesame OilSesame Oil results in increased expression of EEF2K mRNA29191790
C009277sodium arsenatesodium arsenate results in decreased expression of EEF2K mRNA23922661
D012969Sodium FluorideSodium Fluoride results in increased phosphorylation of EEF2K protein24954634
D012999SomanSoman results in decreased expression of EEF2K mRNA19281266
D053260SootSoot results in increased expression of EEF2K mRNA26551751
D013629TamoxifenTamoxifen affects the expression of EEF2K mRNA17555576
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of EEF2K mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of EEF2K mRNA19933214
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of EEF2K mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of EEF2K mRNA21215274
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of EEF2K mRNA25613284
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of EEF2K mRNA28065790
C011559tributyltintributyltin results in increased expression of EEF2K mRNA21683754
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EEF2K mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of EEF2K mRNA24935251|2627250
C022884undecaneundecane results in decreased expression of EEF2K protein17337753
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of EEF2K mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of EEF2K mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of EEF2K mRNA28001369|2915479
D014635Valproic AcidValproic Acid results in increased expression of EEF2K mRNA23179753|2493525
D014635Valproic AcidValproic Acid affects the expression of EEF2K mRNA17292431
C025643vinclozolinvinclozolin results in increased expression of EEF2K mRNA23555832
D015032ZincZinc results in increased expression of EEF2K mRNA17074742
D019287Zinc SulfateZinc Sulfate results in increased expression of EEF2K mRNA17074742

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004672protein kinase activity-TAS9144159  
GO:0004686elongation factor-2 kinase activity-IDA9144159  
GO:0005509calcium ion binding-IEA-  
GO:0005516calmodulin binding-IDA9144159  
GO:0005524ATP binding-IEA-  
GO:0008135translation factor activity, RNA binding-TAS9144159  
GO ID GO Term Qualifier Evidence PubMed
GO:0002931response to ischemia-IEA-  
GO:0006414translational elongation-TAS9144159  
GO:0031952regulation of protein autophosphorylation-IEA-  
GO:0032869cellular response to insulin stimulus-IEA-  
GO:0043066negative regulation of apoptotic process-IEA-  
GO:0045807positive regulation of endocytosis-IEA-  
GO:0046777protein autophosphorylation-IDA9144159  23184662  
GO:0051965positive regulation of synapse assembly-IEA-  
GO:0061003positive regulation of dendritic spine morphogenesis-IEA-  
GO:0071277cellular response to calcium ion-IEA-  
GO:0071320cellular response to cAMP-IEA-  
GO:0071454cellular response to anoxia-IEA-  
GO:1990416cellular response to brain-derived neurotrophic factor stimulus-IEA-  
GO:1990637response to prolactin-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-TAS9144159  
GO:0005829cytosol-TAS-  
GO:0014069postsynaptic density-IEA-  
GO:0043197dendritic spine-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-165159mTOR signallingTAS
R-HSA-166208mTORC1-mediated signallingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal