Gene: HOOK2

29911
HK2
hook microtubule tethering protein 2
protein-coding
19p13.13
Ensembl:ENSG00000095066 MIM:607824 Vega:OTTHUMG00000180372 UniprotKB:Q96ED9
NC_000019.10
SNP Mapped
0   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.510e-1 (AD)  8.110e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SEMA6C0.928
IFT1720.925
ABCC100.925
CUL70.922
GGT70.92
CUL90.916
DPH10.915
PKD10.908
TMEM1450.903
STK11IP0.899

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.46
YES1-0.43
OR4F29-0.416
LRAT-0.411
REST-0.408
NXT2-0.401
RAI14-0.395
TFPI2-0.388
COPZ2-0.387
GNG12-0.383

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of HOOK2 mRNA"26377693
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of HOOK2 mRNA"28903501
C0094072,5,2',5'-tetrachlorobiphenyl"2,5,2',5'-tetrachlorobiphenyl results in increased expression of HOOK2 mRNA"23829299
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of HOOK2 mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of HOOK2 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of HOOK2 mRNA28628672
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of HOOK2 mRNA15336504
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of HOOK2 mRNA24763279
D002994ClofibrateClofibrate affects the expression of HOOK2 mRNA23811191
D019327Copper SulfateCopper Sulfate results in decreased expression of HOOK2 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of HOOK2 mRNA25562108|2798913
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of HOOK2 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of HOOK2 mRNA28628672
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of HOOK2 mRNA19850644
D004051Diethylhexyl PhthalatePPARA protein promotes the reaction [Diethylhexyl Phthalate results in increased expression of HOOK2 mRNA]19850644
C024565ethylene dichlorideethylene dichloride results in decreased expression of HOOK2 mRNA28189721
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of HOOK2 mRNA23649840
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of HOOK2 mRNA24763279
D017313FenretinideFenretinide results in increased expression of HOOK2 mRNA28973697
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of HOOK2 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of HOOK2 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of HOOK2 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of HOOK2 mRNA28628672
C544151jinfukangjinfukang results in increased expression of HOOK2 mRNA27392435
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of HOOK2 mRNA23103053
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of HOOK2 mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of HOOK2 mRNA"25620056
C410127PCB 180PCB 180 results in increased expression of HOOK2 mRNA23829299
D010634PhenobarbitalPhenobarbital results in increased expression of HOOK2 mRNA19270015
D011441PropylthiouracilPropylthiouracil results in increased expression of HOOK2 mRNA24780913
D011794QuercetinQuercetin results in increased expression of HOOK2 protein15221776
C045037testosterone-3-carboxymethyloxime-bovine serum albumin conjugatetestosterone-3-carboxymethyloxime-bovine serum albumin conjugate affects the expression of HOOK2 mRNA20189893
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of HOOK2 mRNA21570461
D013853ThioacetamideThioacetamide results in increased expression of HOOK2 mRNA23411599
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of HOOK2 mRNA28111298
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of HOOK2 mRNA"26743178
D014635Valproic AcidValproic Acid affects the expression of HOOK2 mRNA25979313
D001335Vehicle EmissionsVehicle Emissions affects the methylation of HOOK2 gene25560391
D000069470Venlafaxine HydrochlorideVenlafaxine Hydrochloride results in increased expression of HOOK2 mRNA25423262
C025643vinclozolinvinclozolin results in decreased expression of HOOK2 mRNA23034163

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI16189514  17140400  18799622  19273536  21516116  25416956  
GO:0008017microtubule binding-IBA21873635  
GO:0042802identical protein binding-IPI18799622  
GO:0051959dynein light intermediate chain binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006897endocytosis-TAS9927460  
GO:0007032endosome organization-IMP18799622  
GO:0007040lysosome organization-IMP18799622  
GO:0008333endosome to lysosome transport-IMP18799622  
GO:0015031protein transport-IEA-  
GO:0030705cytoskeleton-dependent intracellular transport-IBA21873635  
GO:0031122cytoplasmic microtubule organization-IBA21873635  
GO:0045022early endosome to late endosome transport-IMP18799622  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0005813centrosome-IBA21873635  
GO:0005813centrosome-IDA17140400  
GO:0005829cytosol-IDA-  
GO:0005874microtubule-IEA-  
GO:0030897HOPS complexcolocalizes_withIDA18799622  
GO:0043231intracellular membrane-bounded organelle-IDA-  
GO:0070695FHF complex-IDA18799622  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal