Gene: GYPA

2993
CD235a|GPA|GPErik|GPSAT|HGpMiV|HGpMiXI|HGpSta(C)|MN|MNS|PAS-2
glycophorin A (MNS blood group)
protein-coding
4q31.21
Ensembl:ENSG00000170180 MIM:617922 Vega:OTTHUMG00000161403 UniprotKB:P02724
NG_007470.3
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.923e-1 (AD)  6.383e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GDF50.494
CD2470.489
FANCI0.489
ARID3A0.485
TNFSF13B0.483
TXK0.479
SLC2A30.471
KLK80.47
FILIP1L0.465
KLHDC7B0.465

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GPR17-0.319
ARSF-0.307
MMD2-0.298
HSD17B6-0.297
NEU4-0.289
OLIG1-0.287
PYGM-0.284
PLA2G5-0.282
C16orf74-0.282
NODAL-0.276

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C55310010-(4'-(N-diethylamino)butyl)-2-chlorophenoxazine10-(4'-(N-diethylamino)butyl)-2-chlorophenoxazine inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of GYPA protein]20523355
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of GYPA protein]20523355
C4778983-(4-(4-((1-(2-chlorophenyl)ethoxy)carbonyl amino)-3-methyl-5-isoxazolyl) benzylsulfanyl) propanoic acid3-(4-(4-((1-(2-chlorophenyl)ethoxy)carbonyl amino)-3-methyl-5-isoxazolyl) benzylsulfanyl) propanoic acid inhibits the reaction [[KITLG protein co-treated with EPO protein] results in increased expression of GYPA mRNA]21915944
C4778983-(4-(4-((1-(2-chlorophenyl)ethoxy)carbonyl amino)-3-methyl-5-isoxazolyl) benzylsulfanyl) propanoic acid3-(4-(4-((1-(2-chlorophenyl)ethoxy)carbonyl amino)-3-methyl-5-isoxazolyl) benzylsulfanyl) propanoic acid inhibits the reaction [[KITLG protein co-treated with EPO protein] results in increased expression of GYPA protein]21915944
C0106436-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid"6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of GYPA protein]"20523355
C072876A 771726A 771726 results in increased expression of GYPA protein12181422
C072876A 771726Cytidine inhibits the reaction [A 771726 results in increased expression of GYPA protein]12181422
C072876A 771726Uridine inhibits the reaction [A 771726 results in increased expression of GYPA protein]12181422
D000082AcetaminophenAcetaminophen results in decreased expression of GYPA mRNA17942131
C056165acetovanilloneacetovanillone inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of GYPA protein]20523355
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of GYPA protein]20523355
D020106AcrylamideAcrylamide affects the expression of GYPA mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of GYPA gene27153756
C095512alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of GYPA protein]"20523355
D047310ApigeninApigenin results in increased expression of GYPA protein25058688
C057792apigetrinapigetrin results in increased expression of GYPA protein25058688
D001151ArsenicArsenic results in increased mutagenesis of GYPA gene17029826
D001151ArsenicArsenic results in decreased expression of GYPA mRNA19654921
C006632arsenic trioxidearsenic trioxide results in decreased expression of GYPA protein16360329
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of GYPA mRNA17942131
C006780bisphenol Abisphenol A results in decreased expression of GYPA mRNA25181051
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in decreased expression of GYPA mRNA17942131
D020148Butyric AcidButyric Acid results in increased expression of GYPA protein14757314
D020148Butyric Acidtellimagrandin I inhibits the reaction [Butyric Acid results in increased expression of GYPA protein]14757314
D002211CapsaicinCapsaicin results in increased expression of GYPA mRNA17603282
C103481chebulinic acidchebulinic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of GYPA protein]14769215
C018021cobaltous chloridecobaltous chloride results in decreased expression of GYPA mRNA22941251
D016572CyclosporineCyclosporine results in decreased expression of GYPA mRNA17942131
D003562CytidineCytidine inhibits the reaction [A 771726 results in increased expression of GYPA protein]12181422
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of GYPA mRNA21266533
D019259Lamivudine[Zidovudine co-treated with Lamivudine] results in increased mutagenesis of GYPA gene17358027
C039060dihydroartemisinindihydroartemisinin affects the expression of GYPA protein20688127
C007517diphenyleneiodoniumdiphenyleneiodonium inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of GYPA protein]20523355
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GYPA mRNA17942748
D006160Guanosine TriphosphateGuanosine Triphosphate results in increased expression of GYPA protein17002868
C031927hydroquinonehydroquinone results in decreased expression of GYPA protein21414390
C013038hydroxyhydroquinonehydroxyhydroquinone results in decreased expression of GYPA protein21414390
C032881lysophosphatidic acidlysophosphatidic acid promotes the reaction [[KITLG protein co-treated with EPO protein] results in increased expression of GYPA mRNA]21915944
D008345ManganeseManganese results in increased expression of GYPA mRNA18284614
C059539midostaurinmidostaurin results in decreased expression of GYPA protein19573588
D011192Potassium DichromatePotassium Dichromate results in decreased expression of GYPA mRNA23608068
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of GYPA protein]20523355
D011794QuercetinQuercetin inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of GYPA protein]20523355
C059514resveratrolresveratrol results in increased expression of GYPA mRNA24526417
C059514resveratrolresveratrol results in increased expression of GYPA protein24526417
C087926tellimagrandin Itellimagrandin I inhibits the reaction [Butyric Acid results in increased expression of GYPA protein]14757314
C087926tellimagrandin Itellimagrandin I results in decreased expression of GYPA protein14757314
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GYPA mRNA17942748
D013755Tetradecanoylphorbol Acetate10-(4'-(N-diethylamino)butyl)-2-chlorophenoxazine inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of GYPA protein]20523355
D013755Tetradecanoylphorbol Acetate2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of GYPA protein]20523355
D013755Tetradecanoylphorbol Acetate"6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of GYPA protein]"20523355
D013755Tetradecanoylphorbol Acetateacetovanillone inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of GYPA protein]20523355
D013755Tetradecanoylphorbol AcetateAcetylcysteine inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of GYPA protein]20523355
D013755Tetradecanoylphorbol Acetate"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of GYPA protein]"20523355
D013755Tetradecanoylphorbol Acetatechebulinic acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of GYPA protein]14769215
D013755Tetradecanoylphorbol AcetateCYBA protein promotes the reaction [Tetradecanoylphorbol Acetate results in decreased expression of GYPA protein]20523355
D013755Tetradecanoylphorbol Acetatediphenyleneiodonium inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of GYPA protein]20523355
D013755Tetradecanoylphorbol Acetatepyrazolanthrone inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of GYPA protein]20523355
D013755Tetradecanoylphorbol AcetateQuercetin inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of GYPA protein]20523355
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in decreased expression of GYPA protein20523355
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased expression of GYPA protein14769215
D013755Tetradecanoylphorbol AcetateU 0126 inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of GYPA protein]20523355
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of GYPA mRNA20133372
C113580U 0126U 0126 inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of GYPA protein]20523355
D014529UridineUridine inhibits the reaction [A 771726 results in increased expression of GYPA protein]12181422
D015215Zidovudine[Zidovudine co-treated with Lamivudine] results in increased mutagenesis of GYPA gene17358027
D015032ZincZinc deficiency results in decreased expression of GYPA mRNA18356318

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0001618virus receptor activity-IEA-  
GO:0005515protein binding-IPI19438409  
GO:0042802identical protein binding-IPI14681217  15067009  23155421  
GO ID GO Term Qualifier Evidence PubMed
GO:0046718viral entry into host cell-IEA-  
GO:0050900leukocyte migration-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0016020membrane-TAS3456608  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
hsa04640Hematopoietic cell lineage
hsa05144Malaria
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-202733Cell surface interactions at the vascular wallTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21119205Chromosome 4q31 locus in COPD is also associated with lung cancer. (2010 Dec)Young RPEur Respir J