Gene: NENF

29937
CIR2|SCIRP10|SPUF
neudesin neurotrophic factor
protein-coding
1q32.3
Ensembl:ENSG00000117691 MIM:611874 Vega:OTTHUMG00000036744 UniprotKB:Q9UMX5
NC_000001.11
SNP Mapped
3   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.733e-1 (AD)  1.003e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs483954chr1:212446872 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs4804chr1:212445997 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs583058chr1:212437413 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RPS90.914
FAU0.908
CHMP4A0.908
PFDN50.908
RPL110.907
RPL320.901
RPLP20.9
RPL190.9
RPS100.899
RPL350.899

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.686
OR4F5-0.641
HS6ST3-0.292
PRKG2-0.275
MED12L-0.268
PLEKHM3-0.267
PPM1E-0.264
CDKL5-0.26
DCC-0.258
GRM5-0.255

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of NENF mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of NENF mRNA"21346803
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NENF mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NENF mRNA"27188386
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of NENF mRNA24449571
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of NENF mRNA26001963
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of NENF mRNA"19150397
D004958EstradiolEstradiol results in decreased expression of NENF mRNA23019147
D004958EstradiolEstradiol results in increased expression of NENF mRNA15223131
C006780bisphenol Abisphenol A affects the expression of NENF mRNA21786754
C006780bisphenol Abisphenol A affects the expression of NENF mRNA25181051
C584509C646 compoundC646 compound results in increased expression of NENF mRNA26191083
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of NENF mRNA27339419
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of NENF mRNA23650126
C018021cobaltous chloridecobaltous chloride results in increased expression of NENF mRNA19376846
D019327Copper SulfateCopper Sulfate results in decreased expression of NENF mRNA19789285
D019327Copper SulfateCopper Sulfate results in increased expression of NENF mRNA19789285
D002945CisplatinCisplatin results in increased expression of NENF mRNA27594783
C082360fipronilfipronil results in increased expression of NENF mRNA23962444
D005839GentamicinsGentamicins results in decreased expression of NENF mRNA22061828
C492448ICG 001ICG 001 results in increased expression of NENF mRNA26191083
C016517indole-3-carbinolindole-3-carbinol affects the expression of NENF mRNA21396975
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of NENF mRNA25613284
D048628KetolidesKetolides analog results in increased expression of NENF mRNA24967691
D007854LeadLead affects the splicing of NENF mRNA28903495
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of NENF mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of NENF mRNA"25554681
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in decreased expression of NENF mRNA17616710
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of NENF mRNA]19482888
D010634PhenobarbitalPhenobarbital results in increased expression of NENF mRNA19482888
C006253pirinixic acidpirinixic acid results in increased expression of NENF mRNA18301758|2381119
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of NENF mRNA21296121
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of NENF mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to NENF promoter]19654925
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of NENF mRNA20959002
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] affects the expression of NENF mRNA25613284
D014241TrichloroethyleneTrichloroethylene results in decreased expression of NENF mRNA19448997
D014303TrinitrotolueneTrinitrotoluene affects the expression of NENF mRNA21346803
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NENF mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of NENF mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of NENF mRNA23179753|2438349
C025643vinclozolinvinclozolin results in decreased expression of NENF mRNA23034163
D014810Vitamin EVitamin E results in increased expression of NENF mRNA19244175
C111237vorinostatvorinostat results in increased expression of NENF mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0008083growth factor activity-IEA-  
GO:0020037heme binding-IBA21873635  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0032099negative regulation of appetite-ISS-  
GO:0043410positive regulation of MAPK cascade-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-IEA-  
GO:0005634nucleus-IDA-  
GO:0005654nucleoplasm-IDA-  
GO:0016020membrane-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal