Gene: DSE

29940
DS-epi1|DSEP|DSEPI|EDSMC2|SART-2|SART2
dermatan sulfate epimerase
protein-coding
6q22.1
Ensembl:ENSG00000111817 MIM:605942 Vega:OTTHUMG00000015434 UniprotKB:Q9UL01
NG_033266.3
PubMed|SNP Mapped
1   ANCO-SNPs
ND|AD
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.770e-1 (AD)  6.167e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2252790chr6:116342160 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CASP40.871
PPP1R3B0.858
ANO60.857
ZNF2170.857
LHFPL20.842
CMTM60.841
LCP10.836
TEP10.834
RP20.833
IL1R10.833

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MARCH4-0.504
ABCC12-0.494
CRH-0.494
SLC7A4-0.489
ZSCAN1-0.486
KCNIP3-0.482
TMEM179-0.478
PPEF1-0.474
DLK2-0.47
CORT-0.47

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0319031-UFT protocolDSE protein results in decreased susceptibility to 1-UFT protocol16734730
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of DSE mRNA"18648102
D000082AcetaminophenAcetaminophen results in increased expression of DSE mRNA22230336|2906747
D016604Aflatoxin B1Aflatoxin B1 affects the expression of DSE protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of DSE gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of DSE mRNA22100608
D018501Antirheumatic AgentsAntirheumatic Agents affects the expression of DSE mRNA24449571
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of DSE mRNA20106945
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of DSE mRNA21632981|2187194
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of DSE mRNA"19150397
D004958EstradiolEstradiol affects the expression of DSE mRNA22574217
C044887beta-methylcholinebeta-methylcholine affects the expression of DSE mRNA21179406
C006780bisphenol Abisphenol A results in decreased expression of DSE mRNA25181051
D000069287CapecitabineDSE protein results in decreased susceptibility to Capecitabine16734730
D002220CarbamazepineCarbamazepine affects the expression of DSE mRNA25979313
D003300Copper[Disulfiram binds to Copper] which results in increased expression of DSE mRNA24690739
D016572CyclosporineCyclosporine results in increased expression of DSE mRNA20106945
D002945CisplatinCisplatin results in increased expression of DSE mRNA27392435|2759478
D004041Dietary FatsDietary Fats results in decreased expression of DSE mRNA18042831
D004041Dietary FatsDietary Fats results in increased expression of DSE mRNA25016146
D004041Dietary FatsDietary Fats results in increased expression of DSE mRNA21852083
D004137DinitrochlorobenzeneDinitrochlorobenzene results in decreased expression of DSE mRNA17374397
D004221Disulfiram[Disulfiram binds to Copper] which results in increased expression of DSE mRNA24690739
C025034doxifluridineDSE protein results in decreased susceptibility to doxifluridine16734730
D052244Endocrine DisruptorsEndocrine Disruptors results in increased expression of DSE mRNA25198161
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of DSE mRNA22079256
C082360fipronilfipronil results in increased expression of DSE mRNA23962444
D005557FormaldehydeFormaldehyde results in increased expression of DSE mRNA23649840
D017313FenretinideFenretinide results in decreased expression of DSE mRNA28973697
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of DSE mRNA25613284
D016685MitomycinDSE protein affects the susceptibility to Mitomycin16217747
C523799MRK 003DSE results in increased susceptibility to MRK 00319903844
C029938nickel sulfatenickel sulfate results in decreased expression of DSE mRNA17374397
D010081OxazoloneOxazolone results in decreased expression of DSE mRNA17374397
D000073878Palm OilPalm Oil results in decreased expression of DSE mRNA18042831
D010634PhenobarbitalPhenobarbital affects the expression of DSE mRNA23091169
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of DSE mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of DSE mRNA22079256
D011794QuercetinQuercetin results in increased expression of DSE mRNA21632981
D015125OxyquinolineOxyquinoline results in increased expression of DSE mRNA21632981
C079198S 1 (combination)DSE protein results in decreased susceptibility to S 1 (combination)16734730
D012643SeleniumSelenium results in decreased expression of DSE mRNA19244175
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of DSE mRNA25613284
D019284ThapsigarginThapsigargin results in decreased expression of DSE protein24648495
D019772TopotecanDSE protein affects the susceptibility to Topotecan16217747
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of DSE mRNA29024780
D014635Valproic AcidValproic Acid affects the expression of DSE mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of DSE mRNA29154799
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of DSE gene25560391
C029297vinylidene chloridevinylidene chloride results in increased expression of DSE mRNA26682919
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in increased expression of DSE mRNA"25198161
C088658zoledronic acidzoledronic acid results in increased expression of DSE mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0047757chondroitin-glucuronate 5-epimerase activity-IDA16505484  
GO:0047757chondroitin-glucuronate 5-epimerase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0015012heparan sulfate proteoglycan biosynthetic process-IEA-  
GO:0030206chondroitin sulfate biosynthetic process-IEA-  
GO:0030208dermatan sulfate biosynthetic process-IDA16505484  
GO:0030208dermatan sulfate biosynthetic process-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-TAS-  
GO:0005654nucleoplasm-IDA-  
GO:0005783endoplasmic reticulum-IDA10679095  
GO:0005794Golgi apparatus-IDA10679095  
GO:0005829cytosol-IDA-  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
hsa00532Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1630316Glycosaminoglycan metabolismTAS
R-HSA-1793185Chondroitin sulfate/dermatan sulfate metabolismTAS
R-HSA-2022923Dermatan sulfate biosynthesisTAS
R-HSA-71387Metabolism of carbohydratesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
12501642[Studies on inhibition of human lung carcinogenesis in early stage by oltipraz and its effects on some gene expression and regulation]. (1998 Jul)Bai HSheng Li Ke Xue Jin Zhan
16169362Clinical and prognostic implications of angina pectoris developing during dobutamine stress echocardiography in the absence of inducible wall motion abnormalities. (2005 Sep 15)Elhendy AAm J Cardiol
16282570Long-term prediction of mortality in elderly persons by dobutamine stress echocardiography. (2005 Oct)Biagini EJ Gerontol A Biol Sci Med Sci
20682679A 1-year lifestyle intervention for weight loss in individuals with type 2 diabetes reduces high C-reactive protein levels and identifies metabolic predictors of change: from the Look AHEAD (Action for Health in Diabetes) study. (2010 Nov)Belalcazar LMDiabetes Care