Gene: PDZRN4

29951
LNX4|SAMCAP3L
PDZ domain containing ring finger 4
protein-coding
12q12
Ensembl:ENSG00000165966 MIM:609730 Vega:OTTHUMG00000169364 UniprotKB:Q6ZMN7
NC_000012.12
SNP Mapped
1   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.590e-2 (AD)  3.002e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs10785246chr12:41353626 (GRCh38.p7)C>Tnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HS3ST40.808
FOXP20.806
GRIK30.776
RXFP10.772
SLC35F10.772
KCNK20.772
THEMIS0.768
B3GALT20.763
CLSTN20.76
TSHZ20.756

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ASB4-0.373
MSX2-0.358
CYP11A1-0.357
IMPA2-0.354
AQP5-0.353
RAB13-0.338
RGS20-0.337
P2RY2-0.334
OR4F5-0.333
S100A14-0.331

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of PDZRN4 gene27153756
C006632arsenic trioxidearsenic trioxide results in decreased expression of PDZRN4 mRNA26705709
C006780bisphenol Abisphenol A results in decreased expression of PDZRN4 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of PDZRN4 gene28505145
D003471CuprizoneCuprizone results in increased expression of PDZRN4 mRNA27523638
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of PDZRN4 mRNA]27941970
D004041Dietary FatsDietary Fats results in increased expression of PDZRN4 mRNA25016146
C069837fullerene C60fullerene C60 results in decreased expression of PDZRN4 mRNA19167457
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of PDZRN4 mRNA23103053
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of PDZRN4 mRNA23179753
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in decreased expression of PDZRN4 mRNA22401849
D009532NickelNickel results in decreased expression of PDZRN4 mRNA25583101
C028007nickel monoxidenickel monoxide results in decreased expression of PDZRN4 mRNA19167457
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of PDZRN4 mRNA26705709
D011441PropylthiouracilPropylthiouracil results in increased expression of PDZRN4 mRNA24780913
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of PDZRN4 mRNA25895662
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of PDZRN4 mRNA28111298
D014212TretinoinTretinoin results in increased expression of PDZRN4 mRNA21934132
D014635Valproic AcidValproic Acid results in increased expression of PDZRN4 mRNA28001369

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0046872metal ion binding-IEA-  
GO:0061630ubiquitin protein ligase activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0016567protein ubiquitination-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal