Gene: TRHDE

29953
PAP-II|PGPEP2|TRH-DE
thyrotropin releasing hormone degrading enzyme
protein-coding
12q21.1
Ensembl:ENSG00000072657 MIM:606950 Vega:OTTHUMG00000169642 UniprotKB:Q9UKU6
NG_046971.1
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.547e-1 (AD)  3.422e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs11179306chr12:72653857 (GRCh38.p7)C>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FLRT30.95
OXR10.949
FAM102B0.948
PRKCE0.947
NEGR10.947
HCN10.946
CDK140.945
ATRNL10.945
HECW10.945
SLC4A100.945

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RNF135-0.59
RAB13-0.588
CHST14-0.571
HEY2-0.566
CSAG1-0.561
CMTM3-0.558
STON2-0.55
YES1-0.549
ROM1-0.544
MYL3-0.543

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TRHDE mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TRHDE mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TRHDE mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TRHDE mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 affects the expression of TRHDE protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of TRHDE gene27153756
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of TRHDE mRNA21298039
D001151ArsenicArsenic affects the methylation of TRHDE gene25304211
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TRHDE mRNA20106945
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TRHDE mRNA21839799
D004958EstradiolEstradiol results in decreased expression of TRHDE mRNA20106945
C006780bisphenol Abisphenol A results in decreased expression of TRHDE mRNA25181051
D002220CarbamazepineCarbamazepine affects the expression of TRHDE mRNA25979313
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of TRHDE gene20938992
D003471CuprizoneCuprizone results in decreased expression of TRHDE mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of TRHDE mRNA20106945|2798913
D002945CisplatinCisplatin inhibits the reaction [Piroxicam results in decreased expression of TRHDE mRNA]21858171
D004041Dietary FatsDietary Fats results in decreased expression of TRHDE mRNA25016146
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of TRHDE gene20938992
D004397FonofosFonofos results in increased methylation of TRHDE promoter22847954
C039281furanfuran results in decreased expression of TRHDE mRNA25539665
C004312glycidolglycidol results in decreased expression of TRHDE mRNA24915197
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of TRHDE mRNA24796395
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of TRHDE gene20938992
D010278ParathionParathion results in increased methylation of TRHDE promoter22847954
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TRHDE mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of TRHDE mRNA26272509
D010894PiroxicamCisplatin inhibits the reaction [Piroxicam results in decreased expression of TRHDE mRNA]21858171
D010894PiroxicamPiroxicam results in decreased expression of TRHDE mRNA21858171
D011441PropylthiouracilPropylthiouracil results in decreased expression of TRHDE mRNA24780913
C016104sodium bichromatesodium bichromate results in decreased expression of TRHDE mRNA25993096
C012568terbufosterbufos results in increased methylation of TRHDE promoter22847954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of TRHDE mRNA20106945
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TRHDE mRNA22298810
D013755Tetradecanoylphorbol Acetate[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of TRHDE mRNA16979875
D013853ThioacetamideThioacetamide results in decreased activity of TRHDE protein11856362
D013853ThioacetamideThioacetamide results in decreased expression of TRHDE mRNA23411599
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of TRHDE mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of TRHDE mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of TRHDE gene29154799
D014635Valproic AcidValproic Acid results in increased expression of TRHDE mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in decreased expression of TRHDE mRNA24896083
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of TRHDE gene25560391
C111237vorinostatvorinostat results in increased expression of TRHDE mRNA27188386
D015032Zinc[Zinc co-treated with Tetradecanoylphorbol Acetate] affects the expression of TRHDE mRNA16979875

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004177aminopeptidase activity-TAS10491199  
GO:0008270zinc ion binding-IBA21873635  
GO:0042277peptide binding-IBA21873635  
GO:0070006metalloaminopeptidase activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006508proteolysis-IBA21873635  
GO:0006508proteolysis-IEA-  
GO:0007165signal transduction-IBA21873635  
GO:0007165signal transduction-TAS10491199  
GO:0007267cell-cell signaling-TAS10491199  
GO:0008217regulation of blood pressure-IBA21873635  
GO:0043171peptide catabolic process-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0005886plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-TAS10491199  
GO:0070062extracellular exosome-HDA23533145  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal