Gene: GYS1

2997
GSY|GYS
glycogen synthase 1
protein-coding
19q13.33
Ensembl:ENSG00000104812 MIM:138570 Vega:OTTHUMG00000150723 UniprotKB:P13807
NG_012923.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.244e-1 (AD)  2.635e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PLXNB20.872
SLC35A40.841
FADS30.839
ACADVL0.837
CRAT0.836
RAVER10.832
TUT10.827
SCAMP40.825
LRP10.822
LTBP30.82

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.654
OR4F29-0.597
OR6C74-0.273
CHP2-0.273
CETP-0.255
KLRC2-0.231
CASP12-0.212
HMHB1-0.208
CLEC6A-0.207
DYNAP-0.2

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in decreased expression of GYS1 mRNA28329830
C4175203-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione"3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [resveratrol results in increased phosphorylation of GYS1 protein]"23292070
C5529964-aminoethylamino-emodin[4-aminoethylamino-emodin co-treated with SB 216763] results in decreased expression of GYS1 protein modified form19228266
C5529964-aminoethylamino-emodin[4-aminoethylamino-emodin co-treated with WNT3A protein] results in decreased expression of GYS1 protein modified form19228266
C5529964-aminoethylamino-emodin4-aminoethylamino-emodin results in decreased expression of GYS1 protein modified form19228266
D000082Acetaminophen[Acetaminophen co-treated with PARK2 gene mutant form] results in decreased phosphorylation of GYS1 protein25752611
D020106AcrylamideAcrylamide affects the expression of GYS1 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of GYS1 gene27153756
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of GYS1 mRNA]22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of GYS1 mRNA22228805
D001622Betaine[Betaine co-treated with Choline co-treated with Folic Acid co-treated with bisphenol A] results in increased methylation of GYS1 promoter29065941
D001622Betaine[Betaine co-treated with Choline co-treated with Folic Acid] results in decreased expression of GYS1 mRNA29065941
D001622Betaine[Betaine co-treated with Choline co-treated with Folic Acid] results in increased methylation of GYS1 promoter29065941
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in decreased expression of GYS1 mRNA28946120
C006780bisphenol Abisphenol A affects the expression of GYS1 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of GYS1 protein26146954
C006780bisphenol Abisphenol A affects the expression of GYS1 mRNA25181051
C006780bisphenol A[Betaine co-treated with Choline co-treated with Folic Acid co-treated with bisphenol A] results in increased methylation of GYS1 promoter29065941
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of GYS1 mRNA15003993
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of GYS1 mRNA24763279
D002794Choline[Betaine co-treated with Choline co-treated with Folic Acid co-treated with bisphenol A] results in increased methylation of GYS1 promoter29065941
D002794Choline[Betaine co-treated with Choline co-treated with Folic Acid] results in decreased expression of GYS1 mRNA29065941
D002794Choline[Betaine co-treated with Choline co-treated with Folic Acid] results in increased methylation of GYS1 promoter29065941
C018021cobaltous chloridecobaltous chloride results in increased expression of GYS1 mRNA22202117
C018021cobaltous chloridezinc chloride inhibits the reaction [cobaltous chloride results in increased expression of GYS1 mRNA]22202117
C018021cobaltous chloridecobaltous chloride results in increased expression of GYS1 mRNA24386269
D003300Copper[Copper co-treated with Dietary Sucrose] results in increased expression of GYS1 mRNA26033743
D003300CopperCopper deficiency results in increased expression of GYS1 mRNA26033743
C038459curdlancurdlan results in decreased expression of GYS1 mRNA23543010
D016572CyclosporineCyclosporine results in decreased expression of GYS1 mRNA20106945|2556210
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of GYS1 mRNA]27941970
D003907DexamethasoneDexamethasone affects the phosphorylation of GYS1 protein18328801
C016366dibenzothiophenedibenzothiophene results in decreased expression of GYS1 mRNA23656968
D002945CisplatinCisplatin results in decreased expression of GYS1 mRNA27594783
C000944dicrotophosdicrotophos results in increased expression of GYS1 mRNA28302478
D019422Dietary Sucrose[Copper co-treated with Dietary Sucrose] results in increased expression of GYS1 mRNA26033743
D019422Dietary SucroseDietary Sucrose results in increased expression of GYS1 mRNA26033743
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in decreased expression of GYS1 mRNA28329830
C007738fluoranthenefluoranthene results in decreased expression of GYS1 mRNA28329830
D005492Folic Acid[Betaine co-treated with Choline co-treated with Folic Acid co-treated with bisphenol A] results in increased methylation of GYS1 promoter29065941
D005492Folic Acid[Betaine co-treated with Choline co-treated with Folic Acid] results in decreased expression of GYS1 mRNA29065941
D005492Folic Acid[Betaine co-treated with Choline co-treated with Folic Acid] results in increased methylation of GYS1 promoter29065941
C069837fullerene C60fullerene C60 results in decreased expression of GYS1 mRNA19167457
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of GYS1 mRNA24763279
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of GYS1 mRNA25613284
C008261lead acetatelead acetate results in increased expression of GYS1 mRNA25270620
C008261lead acetatelead acetate results in decreased expression of GYS1 mRNA28916327
C008261lead acetatelead acetate results in decreased expression of GYS1 protein28916327
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of GYS1 mRNA"24972896
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of GYS1 mRNA25613284
D008748MethylcholanthreneMethylcholanthrene results in increased expression of GYS1 mRNA18804290
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of GYS1 mRNA26011545
C500085muraglitazarmuraglitazar results in increased expression of GYS1 mRNA21515302
C022838nickel chloridenickel chloride affects the expression of GYS1 mRNA22110744
D010100OxygenOxygen deficiency results in increased expression of GYS1 mRNA20880076
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of GYS1 mRNA18804290
D010936Plant ExtractsPlant Extracts inhibits the reaction [Streptozocin results in decreased expression of GYS1 mRNA]27038876
D011794QuercetinQuercetin results in increased expression of GYS1 mRNA15309432
C059514resveratrol"3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [resveratrol results in increased phosphorylation of GYS1 protein]"23292070
C059514resveratrolTSC2 mutant form inhibits the reaction [resveratrol results in increased phosphorylation of GYS1 protein]23292070
C089730rosiglitazonerosiglitazone results in increased expression of GYS1 mRNA21515302
C417521SB 216763[4-aminoethylamino-emodin co-treated with SB 216763] results in decreased expression of GYS1 protein modified form19228266
C417521SB 216763SB 216763 results in decreased expression of GYS1 protein modified form19228266
D012969Sodium FluorideSodium Fluoride results in increased expression of GYS1 mRNA27862939
D013311StreptozocinPlant Extracts inhibits the reaction [Streptozocin results in decreased expression of GYS1 mRNA]27038876
D013311StreptozocinStreptozocin results in decreased expression of GYS1 mRNA27038876
C501413tesaglitazartesaglitazar results in increased expression of GYS1 mRNA21515302
D013739TestosteroneTestosterone results in increased expression of GYS1 mRNA21632903
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of GYS1 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in decreased expression of GYS1 mRNA25975270
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of GYS1 mRNA25613284
D014044TolbutamideTolbutamide results in increased expression of GYS1 mRNA16087376
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of GYS1 mRNA"26179874
D014635Valproic AcidValproic Acid results in decreased expression of GYS1 mRNA29154799
D014635Valproic AcidValproic Acid results in increased methylation of GYS1 gene29154799
D014635Valproic AcidValproic Acid affects the expression of GYS1 mRNA17963808
C016837zinc chloridezinc chloride inhibits the reaction [cobaltous chloride results in increased expression of GYS1 mRNA]22202117

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004373glycogen (starch) synthase activity-EXP19699667  
GO:0004373glycogen (starch) synthase activity-IBA21873635  
GO:0004373glycogen (starch) synthase activity-IDA16275910  
GO:0005515protein binding-IPI10481074  16189514  16282323  17055998  24165324  25416956  
27173435  28330616  
GO:0005536glucose binding-IBA21873635  
GO:0005536glucose binding-IEA-  
GO:0019901protein kinase binding-IBA21873635  
GO:0019901protein kinase binding-IPI16275910  
GO:0061547glycogen synthase activity, transferring glucose-1-phosphate-EXP21356517  
GO:0061547glycogen synthase activity, transferring glucose-1-phosphate-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005978glycogen biosynthetic process-IBA21873635  
GO:0005978glycogen biosynthetic process-IDA16275910  
GO:0005978glycogen biosynthetic process-IEA-  
GO:0005978glycogen biosynthetic process-TAS-  
GO:0007507heart development-IEA-  
GO:0009744response to sucrose-IBA21873635  
GO:0009749response to glucose-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0005829cytosol-TAS-  
GO:0016020membrane-HDA19946888  
GO:0016234inclusion body-IEA-  
KEGG ID KEGG Term
hsa00500Starch and sucrose metabolism
hsa04910Insulin signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1643685DiseaseTAS
R-HSA-3229121Glycogen storage diseasesTAS
R-HSA-3322077Glycogen synthesisTAS
R-HSA-3785653Myoclonic epilepsy of LaforaTAS
R-HSA-3814836Glycogen storage disease type XV (GYG1)TAS
R-HSA-3828062Glycogen storage disease type 0 (muscle GYS1)TAS
R-HSA-5663084Diseases of carbohydrate metabolismTAS
R-HSA-5668914Diseases of metabolismTAS
R-HSA-71387Metabolism of carbohydratesTAS
R-HSA-8982491Glycogen metabolismTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
17356695Variation in GYS1 interacts with exercise and gender to predict cardiovascular mortality. (2007 Mar 14)Fredriksson JPLoS One
17137217Association of sixty-one non-synonymous polymorphisms in forty-one hypertension candidate genes with blood pressure variation and hypertension. (2006 Aug)Kokubo YHypertens Res