Gene: RHOD

29984
ARHD|RHOHP1|RHOM|Rho
ras homolog family member D
protein-coding
11q13.2
Ensembl:ENSG00000173156 MIM:605781 Vega:OTTHUMG00000167102 UniprotKB:O00212
NC_000011.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.781e-2 (AD)  7.160e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FCGRT0.76
DOK10.754
TMCO40.749
ITGB50.742
AGTRAP0.732
TRIOBP0.731
TRIP60.727
CHST140.725
NFATC10.725
DDAH20.723

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CHRM2-0.599
SPHKAP-0.589
PPEF1-0.588
EPHA5-0.587
PCSK1-0.586
TYRP1-0.581
ADTRP-0.58
SLC8A3-0.577
XKR4-0.57
GABRG3-0.57

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C49562614-deoxy-11,12-didehydroandrographolide"14-deoxy-11,12-didehydroandrographolide results in decreased expression of RHOD mRNA"22101062
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of RHOD mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of RHOD mRNA"21346803
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl affects the expression of RHOD mRNA"20638727
D000082AcetaminophenAcetaminophen affects the expression of RHOD mRNA17562736
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of RHOD mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of RHOD mRNA]17585979
D020106AcrylamideAcrylamide results in increased expression of RHOD mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of RHOD mRNA21641981|2715375
C006632arsenic trioxideRHOD protein results in decreased susceptibility to arsenic trioxide20707922
D001280AtrazineAtrazine results in increased expression of RHOD mRNA18585445
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of RHOD mRNA22228805
C006780bisphenol Abisphenol A results in increased expression of RHOD mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of RHOD gene28505145
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of RHOD mRNA15336504
D002220CarbamazepineCarbamazepine affects the expression of RHOD mRNA25979313
C100187chloropicrinchloropicrin results in decreased expression of RHOD mRNA26352163
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of RHOD mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of RHOD mRNA]17585979
D002945CisplatinCisplatin results in increased expression of RHOD mRNA27392435
D004041Dietary FatsDietary Fats affects the expression of RHOD mRNA19680557
C472511dimethylarsinous aciddimethylarsinous acid results in increased expression of RHOD mRNA20886546
C479799(E)-4-((2-N-(4-methoxybenzenesulfonyl)amino)stilbazole)1-oxide(E)-4-((2-N-(4-methoxybenzenesulfonyl)amino)stilbazole)1-oxide results in decreased expression of RHOD mRNA15528975
C045651epigallocatechin gallateepigallocatechin gallate results in decreased expression of RHOD mRNA18851785
C540355fenamidonefenamidone results in increased expression of RHOD mRNA27029645
D005485FlutamideFlutamide results in increased expression of RHOD mRNA24136188
D017313FenretinideFenretinide results in increased expression of RHOD mRNA28973697
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of RHOD mRNA26752646
D008694Methamphetamine[Methamphetamine co-treated with SCH 23390] affects the expression of RHOD mRNA19564919
D008694MethamphetamineMethamphetamine results in increased expression of RHOD mRNA19564919
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of RHOD mRNA"26251327
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in decreased expression of RHOD mRNA22401849
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of RHOD mRNA"25554681
D000073878Palm OilPalm Oil affects the expression of RHOD mRNA19680557
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of RHOD mRNA27153767
C006253pirinixic acidpirinixic acid results in increased expression of RHOD mRNA23811191
D010936Plant ExtractsPlant Extracts results in decreased expression of RHOD mRNA23557933
D011192Potassium DichromatePotassium Dichromate results in decreased expression of RHOD mRNA23608068
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of RHOD mRNA28903501
D011441PropylthiouracilPropylthiouracil results in decreased expression of RHOD mRNA24780913
C513428pyrachlostrobinpyrachlostrobin results in increased expression of RHOD mRNA27029645
C534628SCH 23390[Methamphetamine co-treated with SCH 23390] affects the expression of RHOD mRNA19564919
D012906SmokeSmoke results in decreased expression of RHOD mRNA21095227
C013698tallowtallow affects the expression of RHOD mRNA19680557
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of RHOD mRNA21570461
D019284ThapsigarginThapsigargin results in decreased expression of RHOD protein24648495
D014520UrethaneUrethane results in increased expression of RHOD mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of RHOD mRNA25979313
D014635Valproic AcidValproic Acid affects the expression of RHOD mRNA17292431|1796380

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003924GTPase activity-IBA21873635  
GO:0003924GTPase activity-IEA-  
GO:0005525GTP binding-IBA21873635  
GO:0005525GTP binding-IEA-  
GO:0019901protein kinase binding-IBA21873635  
GO:0019901protein kinase binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006605protein targeting-IEA-  
GO:0007015actin filament organization-IBA21873635  
GO:0007163establishment or maintenance of cell polarity-IBA21873635  
GO:0007266Rho protein signal transduction-IBA21873635  
GO:0007266Rho protein signal transduction-TAS9116026  
GO:0008360regulation of cell shape-IBA21873635  
GO:0016477cell migration-IBA21873635  
GO:0030032lamellipodium assembly-IMP23087206  
GO:0030334regulation of cell migration-IBA21873635  
GO:0030335positive regulation of cell migration-IMP23087206  
GO:0030950establishment or maintenance of actin cytoskeleton polarity-IBA21873635  
GO:0032956regulation of actin cytoskeleton organization-IBA21873635  
GO:0045785positive regulation of cell adhesion-IMP23087206  
GO:0048041focal adhesion assembly-IMP23087206  
GO:0051017actin filament bundle assembly-IBA21873635  
GO:0051017actin filament bundle assembly-IMP23087206  
GO:0051056regulation of small GTPase mediated signal transduction-TAS-  
GO:0051893regulation of focal adhesion assembly-IEA-  
GO:2000249regulation of actin cytoskeleton reorganization-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0005769early endosome-IEA-  
GO:0005829cytosol-TAS-  
GO:0005886plasma membraneCOLOCALIZES_WITHIBA21873635  
GO:0005886plasma membrane-TAS-  
GO:0005938cell cortex-IBA21873635  
GO:0010008endosome membrane-TAS-  
GO:0031410cytoplasmic vesicle-IBA21873635  
GO:0032153cell division site-IBA21873635  
GO:0043231intracellular membrane-bounded organelle-IBA21873635  
KEGG ID KEGG Term
hsa04360Axon guidance
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-194315Signaling by Rho GTPasesTAS
R-HSA-194840Rho GTPase cycleTAS
R-HSA-195258RHO GTPase EffectorsTAS
R-HSA-5663220RHO GTPases Activate ForminsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19371621Direct toxic effects of aqueous extract of cigarette smoke on cardiac myocytes at clinically relevant concentrations. (2009 Apr 1)Yamada SToxicol Appl Pharmacol