Gene: PACSIN1

29993
SDPI
protein kinase C and casein kinase substrate in neurons 1
protein-coding
6p21.31
Ensembl:ENSG00000124507 MIM:606512 Vega:OTTHUMG00000014547 UniprotKB:Q9BY11
NC_000006.12
SNP Mapped
2   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.148e-1 (AD)  7.974e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs4713806chr6:34506852 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)
rs4713797chr6:34490756 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KCNAB20.983
DMTN0.978
JPH40.974
SEPT50.971
ATXN7L30.97
DLG40.969
CBX70.968
SCAMP50.967
FBXO410.966
CAMK2A0.965

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.642
OR4F29-0.587
TFPI2-0.519
SGMS2-0.462
CNN2-0.459
WWTR1-0.454
RAI14-0.45
CLEC2B-0.447
KCNJ15-0.446
SNHG18-0.445

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of PACSIN1 mRNA"21394737
C5724913-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol results in increased expression of PACSIN1 protein26194647
D000082AcetaminophenAcetaminophen results in decreased expression of PACSIN1 mRNA22230336
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of PACSIN1 gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PACSIN1 mRNA16483693
D001151ArsenicArsenic affects the methylation of PACSIN1 gene25304211
D004958EstradiolEGF protein promotes the reaction [Estradiol results in decreased expression of PACSIN1 mRNA]24758408
D004958EstradiolEstradiol results in decreased expression of PACSIN1 mRNA24758408
C006780bisphenol Abisphenol A affects the methylation of PACSIN1 promoter27415467
C006780bisphenol Abisphenol A results in increased expression of PACSIN1 mRNA27257137
D000069286BortezomibBortezomib results in increased expression of PACSIN1 mRNA20977926
C018475butyraldehydebutyraldehyde results in decreased expression of PACSIN1 mRNA26079696
D004041Dietary FatsDietary Fats results in decreased expression of PACSIN1 mRNA25016146
D002117CalcitriolCalcitriol results in increased expression of PACSIN1 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in increased expression of PACSIN1 mRNA21592394
C118739entinostatentinostat results in increased expression of PACSIN1 mRNA27188386
D019833GenisteinGenistein results in increased expression of PACSIN1 protein24552547
C010974glyphosate[Surface-Active Agents co-treated with glyphosate] results in increased expression of PACSIN1 mRNA22467014
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of PACSIN1 mRNA20044591
C503753Indolinone AIndolinone A results in increased phosphorylation of PACSIN1 protein15712243
D015122MercaptopurineMercaptopurine results in decreased expression of PACSIN1 mRNA23358152
D008694MethamphetamineMethamphetamine results in decreased expression of PACSIN1 protein19826936
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of PACSIN1 mRNA"26251327
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of PACSIN1 mRNA28511854
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of PACSIN1 mRNA19710929
C005556propionaldehydepropionaldehyde results in decreased expression of PACSIN1 mRNA26079696
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of PACSIN1 mRNA25895662
D013501Surface-Active Agents[Surface-Active Agents co-treated with glyphosate] results in increased expression of PACSIN1 mRNA22467014
D013739Testosterone[Testosterone co-treated with Calcitriol] results in increased expression of PACSIN1 mRNA21592394
D013739TestosteroneTestosterone results in increased expression of PACSIN1 mRNA21592394
D0156472,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine"2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in decreased expression of PACSIN1 protein"25852303
D013849ThimerosalThimerosal results in decreased expression of PACSIN1 mRNA27188386
D014212TretinoinTretinoin results in decreased expression of PACSIN1 mRNA23724009
C012589trichostatin Atrichostatin A affects the expression of PACSIN1 mRNA28542535
C012589trichostatin Atrichostatin A results in increased expression of PACSIN1 mRNA24935251
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of PACSIN1 mRNA"26179874
D014635Valproic AcidValproic Acid results in increased expression of PACSIN1 mRNA24935251|2800136
D014635Valproic AcidValproic Acid results in increased methylation of PACSIN1 gene29154799
C025643vinclozolinvinclozolin affects the expression of PACSIN1 mRNA19015723
C070417Win 55212-2Win 55212-2 results in decreased expression of PACSIN1 mRNA12237329

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI16189514  16318909  17161366  17500595  20936779  21044950  
25416956  
GO:0005543phospholipid binding-IBA21873635  
GO:0005543phospholipid binding-IDA19549836  
GO:0008092cytoskeletal protein binding-IBA21873635  
GO:0008092cytoskeletal protein binding-IEA-  
GO:0042802identical protein binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007010cytoskeleton organization-IBA21873635  
GO:0007015actin filament organization-IEA-  
GO:0030100regulation of endocytosis-IBA21873635  
GO:0030182neuron differentiation-IBA21873635  
GO:0045806negative regulation of endocytosis-IEA-  
GO:0048488synaptic vesicle endocytosis-ISS-  
GO:0048812neuron projection morphogenesis-IBA21873635  
GO:0048812neuron projection morphogenesis-ISS-  
GO:0072657protein localization to membrane-ISS-  
GO:0072659protein localization to plasma membrane-ISS-  
GO:0097320plasma membrane tubulation-IBA21873635  
GO:0097320plasma membrane tubulation-IDA19549836  
GO:1900006positive regulation of dendrite development-IBA21873635  
GO:1900006positive regulation of dendrite development-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IDA-  
GO:0005768endosome-IBA21873635  
GO:0005829cytosol-IEA-  
GO:0005856cytoskeleton-IBA21873635  
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-ISS-  
GO:0030054cell junction-IEA-  
GO:0030137COPI-coated vesicle-IEA-  
GO:0030659cytoplasmic vesicle membrane-IEA-  
GO:0032587ruffle membrane-ISS-  
GO:0043209myelin sheath-IEA-  
GO:0043679axon terminus-ISS-  
GO:0045202synapse-ISS-  
GO:0048471perinuclear region of cytoplasm-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-199991Membrane TraffickingTAS
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-8856828Clathrin-mediated endocytosisTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal