Gene: BAZ2B

29994
WALp4
bromodomain adjacent to zinc finger domain 2B
protein-coding
2q24.2
Ensembl:ENSG00000226266 MIM:605683 Vega:OTTHUMG00000132027 UniprotKB:Q9UIF8
NG_051314.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.190e-1 (AD)  2.803e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SGK30.88
ZBTB370.879
TJP10.852
MYO60.845
QKI0.841
AP3B10.838
IKZF20.837
ITGB80.832
ZNF240.83
BBX0.82

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PNOC-0.496
MCHR1-0.495
ADRA1D-0.483
RTP1-0.479
FBLN7-0.47
CRH-0.467
ABCC12-0.46
KCNK3-0.452
KLK5-0.448
PHOSPHO1-0.442

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5321622-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine"[PIK3CA gene mutant form results in increased susceptibility to 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine] which results in increased expression of BAZ2B mRNA"20453058
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of BAZ2B mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of BAZ2B mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of BAZ2B mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of BAZ2B mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of BAZ2B mRNA"25510870
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of BAZ2B mRNA"21346803
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of BAZ2B mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of BAZ2B mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of BAZ2B mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of BAZ2B mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of BAZ2B mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of BAZ2B gene27153756
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of BAZ2B mRNA21298039
C547126AZM551248AZM551248 results in decreased expression of BAZ2B mRNA22323515
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in decreased expression of BAZ2B mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of BAZ2B mRNA20106945|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of BAZ2B mRNA19770486
C006780bisphenol Abisphenol A results in increased methylation of BAZ2B gene28505145
C018475butyraldehydebutyraldehyde results in decreased expression of BAZ2B mRNA26079696
C584509C646 compoundC646 compound results in increased expression of BAZ2B mRNA26191083
D002737ChloropreneChloroprene results in increased expression of BAZ2B mRNA23125180
D003010ClorgylineClorgyline results in increased expression of BAZ2B mRNA19691856
C018021cobaltous chloridecobaltous chloride affects the expression of BAZ2B mRNA alternative form19320972
D003042CocaineCocaine results in increased expression of BAZ2B mRNA17898221
D019327Copper SulfateCopper Sulfate results in increased expression of BAZ2B mRNA19549813
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of BAZ2B mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of BAZ2B mRNA27392435
D002945CisplatinCisplatin results in decreased expression of BAZ2B mRNA27392435
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in increased expression of BAZ2B mRNA"23811387
C118739entinostatentinostat results in decreased expression of BAZ2B mRNA26272509|2718838
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of BAZ2B mRNA"27188386
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of BAZ2B mRNA22079256
D000431EthanolEthanol results in decreased expression of BAZ2B mRNA28986285
D005557FormaldehydeFormaldehyde results in decreased expression of BAZ2B mRNA23416264
D005839GentamicinsGentamicins results in decreased expression of BAZ2B mRNA22061828
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of BAZ2B mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of BAZ2B mRNA27392435
C544151jinfukangjinfukang results in decreased expression of BAZ2B mRNA27392435
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of BAZ2B mRNA"24972896
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of BAZ2B mRNA26378955
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of BAZ2B mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of BAZ2B mRNA"25554681
D009285NaphthoquinonesNaphthoquinones results in increased expression of BAZ2B mRNA23811387
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of BAZ2B mRNA25729387
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of BAZ2B mRNA"25510870
D010634PhenobarbitalPhenobarbital affects the expression of BAZ2B mRNA23091169
D010936Plant ExtractsPlant Extracts results in increased expression of BAZ2B mRNA23557933
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of BAZ2B mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of BAZ2B mRNA22079256|2271453
D011374ProgesteroneProgesterone results in increased expression of BAZ2B mRNA23012394
D011441PropylthiouracilPropylthiouracil results in increased expression of BAZ2B mRNA24780913
D011794QuercetinQuercetin results in decreased expression of BAZ2B mRNA21632981
D012715Sesame OilSesame Oil results in increased expression of BAZ2B mRNA29191790
D012834SilverSilver results in decreased expression of BAZ2B mRNA27131904
C017947sodium arsenitesodium arsenite affects the methylation of BAZ2B gene28589171
C017947sodium arsenitesodium arsenite results in decreased expression of BAZ2B mRNA28595984
C017947sodium arsenitesodium arsenite results in increased expression of BAZ2B mRNA17879257
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of BAZ2B mRNA26378955
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of BAZ2B mRNA21354282
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of BAZ2B mRNA25613284
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of BAZ2B mRNA25729387
D019772TopotecanTopotecan results in decreased expression of BAZ2B mRNA25729387
D014212TretinoinTretinoin results in increased expression of BAZ2B mRNA23724009
D014241TrichloroethyleneTrichloroethylene results in increased methylation of BAZ2B gene27618143
C057693troglitazonetroglitazone results in decreased expression of BAZ2B mRNA28973697
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of BAZ2B mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of BAZ2B mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of BAZ2B mRNA23179753|2438349
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of BAZ2B gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003677DNA binding-IEA-  
GO:0005515protein binding-IPI10662543  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006338chromatin remodeling-TAS28801535  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006357regulation of transcription by RNA polymerase II-NAS10662543  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27903268Long-term outdoor air pollution and DNA methylation in circulating monocytes: results from the Multi-Ethnic Study of Atherosclerosis (MESA). (2016 Dec 1)Chi GCEnviron Health