Gene: GUCY2D

3000
CACD1|CORD5|CORD6|CYGD|GUC1A4|GUC2D|LCA|LCA1|RCD2|RETGC-1|ROS-GC1|ROSGC|retGC
guanylate cyclase 2D, retinal
protein-coding
17p13.1
Ensembl:ENSG00000132518 MIM:600179 Vega:OTTHUMG00000108169 UniprotKB:Q02846
NG_009092.1
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.368e-2 (AD)  7.900e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7503918chr17:8018707 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CCR100.561
CITED40.56
PPM1J0.559
MAN1C10.558
MESP10.557
PALM30.556
MIF0.553
UNC1190.549
YPEL40.544
AGPAT20.543

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CDCA7L-0.372
KLRB1-0.371
EVA1A-0.341
RAI14-0.321
NEK7-0.311
KLRF1-0.31
ZNF501-0.309
KLRK1-0.309
DNASE1L3-0.309
CTNNA3-0.309

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C02017516 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3,20-dione"16 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3,20-dione results in increased expression of GUCY2D mRNA"20519331
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of GUCY2D mRNA"23962555
D000082AcetaminophenAcetaminophen results in decreased expression of GUCY2D mRNA26690555
D000643Ammonium ChlorideAmmonium Chloride affects the expression of GUCY2D mRNA16483693
D001280AtrazineAtrazine results in increased expression of GUCY2D mRNA25929836
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of GUCY2D mRNA26001963
C006780bisphenol Abisphenol A results in decreased expression of GUCY2D mRNA25181051
D002713Chlorine[Ozone co-treated with Chlorine] affects the expression of GUCY2D mRNA18636392
D003300CopperCopper results in decreased expression of GUCY2D mRNA26293553
D003471CuprizoneCuprizone results in increased expression of GUCY2D mRNA27523638
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal results in increased expression of GUCY2D mRNA"23811387
D005419FlavonoidsFlavonoids results in decreased expression of GUCY2D mRNA18035473
D004397FonofosFonofos results in increased methylation of GUCY2D promoter22847954
C419708gefitinibgefitinib results in decreased expression of GUCY2D mRNA16685379
C059539midostaurinmidostaurin results in decreased expression of GUCY2D mRNA20980353
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of GUCY2D mRNA"25620056
D009285NaphthoquinonesNaphthoquinones results in increased expression of GUCY2D mRNA23811387
D010126Ozone[Ozone co-treated with Chlorine] affects the expression of GUCY2D mRNA18636392
D010278ParathionParathion results in increased methylation of GUCY2D promoter22847954
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of GUCY2D mRNA19710929
C012568terbufosterbufos results in increased methylation of GUCY2D promoter22847954

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004016adenylate cyclase activity-IBA21873635  
GO:0004383guanylate cyclase activity-IBA21873635  
GO:0004383guanylate cyclase activity-TAS-  
GO:0004672protein kinase activity-IEA-  
GO:0005515protein binding-IPI21124868  
GO:0005524ATP binding-IEA-  
GO:0005525GTP binding-IEA-  
GO:0038023signaling receptor activity-TAS1356371  
GO ID GO Term Qualifier Evidence PubMed
GO:0006182cGMP biosynthetic process-IBA21873635  
GO:0006468protein phosphorylation-IEA-  
GO:0007165signal transduction-IBA21873635  
GO:0007168receptor guanylyl cyclase signaling pathway-TAS1356371  
GO:0007601visual perception-IEA-  
GO:0009190cyclic nucleotide biosynthetic process-IBA21873635  
GO:0022400regulation of rhodopsin mediated signaling pathway-TAS-  
GO:0035556intracellular signal transduction-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005640nuclear outer membrane-TAS7777544  
GO:0005886plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-TAS1356371  
GO:0008074guanylate cyclase complex, soluble-IBA21873635  
GO:0097381photoreceptor disc membrane-TAS-  
KEGG ID KEGG Term
hsa00230Purine metabolism
hsa04740Olfactory transduction
hsa04744Phototransduction
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-2187338Visual phototransductionTAS
R-HSA-2514856The phototransduction cascadeTAS
R-HSA-2514859Inactivation, recovery and regulation of the phototransduction cascadeTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-418594G alpha (i) signalling eventsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal