Gene: EFEMP2

30008
ARCL1B|FBLN4|MBP1|UPH1
EGF containing fibulin extracellular matrix protein 2
protein-coding
11q13.1
Ensembl:ENSG00000172638 MIM:604633 Vega:OTTHUMG00000166664 UniprotKB:O95967
NG_012304.2
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.022e-1 (AD)  6.139e-2 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg20051715chr11:65639798EFEMP27.100e-12Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DDAH20.89
TRIP60.885
SZRD10.879
PLTP0.878
FXYD10.875
ACAA20.874
PON20.872
ALDH20.87
ACSF20.868
RAB340.867

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.523
OR4F29-0.519
GABRG3-0.499
IL12RB2-0.489
TYRP1-0.479
OSBPL10-0.478
KCNH1-0.475
MUM1L1-0.471
EPHA5-0.469
KCNH5-0.464

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane affects the expression of EFEMP2 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EFEMP2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EFEMP2 mRNA"27188386
D000082AcetaminophenAcetaminophen results in increased expression of EFEMP2 mRNA22230336
D000082AcetaminophenAcetaminophen affects the expression of EFEMP2 mRNA17562736
D020106AcrylamideAcrylamide results in decreased expression of EFEMP2 mRNA28959563
C059765amphotericin B, deoxycholate drug combination"amphotericin B, deoxycholate drug combination results in increased expression of EFEMP2 mRNA"22863853
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of EFEMP2 mRNA24449571
C547126AZM551248AZM551248 results in increased expression of EFEMP2 mRNA22323515
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of EFEMP2 mRNA26377693
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of EFEMP2 mRNA18164116
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of EFEMP2 mRNA26001963
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of EFEMP2 mRNA22228805
C006780bisphenol Abisphenol A affects the expression of EFEMP2 mRNA25181051
C005961bis(tri-n-butyltin)oxidebis(tri-n-butyltin)oxide results in increased expression of EFEMP2 mRNA18958704
C584509C646 compoundC646 compound results in increased expression of EFEMP2 mRNA26191083
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of EFEMP2 mRNA20938992
C000541cyclopaminecyclopamine results in decreased expression of EFEMP2 mRNA22265815
D003561CytarabineCytarabine results in decreased expression of EFEMP2 mRNA21198554
C014347decitabinedecitabine affects the expression of EFEMP2 mRNA23300844
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of EFEMP2 mRNA17361019|2126653
D002945CisplatinCisplatin affects the expression of EFEMP2 mRNA23300844
D002945CisplatinCisplatin results in decreased expression of EFEMP2 mRNA22023808
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of EFEMP2 mRNA18164116
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of EFEMP2 mRNA19371625
D002117CalcitriolCalcitriol results in decreased expression of EFEMP2 mRNA26485663
D004237DiuronDiuron results in decreased expression of EFEMP2 mRNA25152437
D004237DiuronDiuron results in increased expression of EFEMP2 mRNA21551480
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of EFEMP2 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of EFEMP2 mRNA23300682
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of EFEMP2 mRNA20938992
C039281furanfuran results in increased expression of EFEMP2 mRNA27387713
D005839GentamicinsGentamicins results in increased expression of EFEMP2 mRNA22061828
D005947Glucose[INS protein co-treated with Glucose] results in increased expression of EFEMP2 mRNA22634610
C492448ICG 001ICG 001 results in increased expression of EFEMP2 mRNA26191083
D007854LeadLead affects the expression of EFEMP2 mRNA28903495
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of EFEMP2 mRNA20938992
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of EFEMP2 mRNA28001369
C008493methylselenic acidmethylselenic acid results in increased expression of EFEMP2 mRNA18548127
C517284monomethyl phthalatemonomethyl phthalate affects the expression of EFEMP2 mRNA26924002
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of EFEMP2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of EFEMP2 mRNA"25554681
C022838nickel chloridenickel chloride results in increased expression of EFEMP2 mRNA21455298
C029938nickel sulfatenickel sulfate results in decreased expression of EFEMP2 mRNA22714537
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of EFEMP2 mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of EFEMP2 mRNA25729387
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of EFEMP2 mRNA22714537
D011374ProgesteroneProgesterone results in decreased expression of EFEMP2 mRNA23012394
C513428pyrachlostrobinpyrachlostrobin results in increased expression of EFEMP2 mRNA27029645
D015474IsotretinoinIsotretinoin results in increased expression of EFEMP2 mRNA20436886
D012643SeleniumSelenium results in increased expression of EFEMP2 mRNA19244175
D012999SomanSoman results in increased expression of EFEMP2 mRNA19281266
D013629TamoxifenTamoxifen affects the expression of EFEMP2 mRNA17555576
C004648testosterone enanthatetestosterone enanthate affects the expression of EFEMP2 mRNA17440010
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of EFEMP2 mRNA21570461
D013893ThiramThiram results in decreased expression of EFEMP2 mRNA20530235
C009495titanium dioxidetitanium dioxide results in increased expression of EFEMP2 mRNA23557971
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of EFEMP2 mRNA25729387
D019772TopotecanTopotecan results in increased expression of EFEMP2 mRNA25729387
D014212TretinoinTretinoin results in decreased expression of EFEMP2 mRNA20530235
D014212TretinoinTretinoin results in increased expression of EFEMP2 mRNA21934132|2372400
C012589trichostatin Atrichostatin A results in decreased expression of EFEMP2 mRNA24935251
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EFEMP2 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of EFEMP2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of EFEMP2 mRNA23179753|2627250
D014635Valproic AcidValproic Acid results in increased methylation of EFEMP2 gene29154799
D014640VancomycinVancomycin results in decreased expression of EFEMP2 mRNA18930951
D014810Vitamin EVitamin E results in increased expression of EFEMP2 mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005201extracellular matrix structural constituent-TAS10601734  
GO:0005509calcium ion binding-IEA-  
GO:0005515protein binding-IPI16189514  16713569  19570982  19855011  23088713  25416956  
25910212  26871637  27107014  
GO ID GO Term Qualifier Evidence PubMed
GO:0048251elastic fiber assembly-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005604basement membrane-TAS10601734  
GO:0070062extracellular exosome-HDA19199708  23533145  
GO:1903561extracellular vesicle-HDA24769233  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1474244Extracellular matrix organizationTAS
R-HSA-1474244Extracellular matrix organizationIEA
R-HSA-1566948Elastic fibre formationTAS
R-HSA-1566948Elastic fibre formationIEA
R-HSA-2129379Molecules associated with elastic fibresTAS
R-HSA-2129379Molecules associated with elastic fibresIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21563328EFEMP2-Related Cutis Laxa (1993)Loeys B-