Gene: TBX21

30009
T-PET|T-bet|TBET|TBLYM
T-box 21
protein-coding
17q21.32
Ensembl:ENSG00000073861 MIM:604895 Vega:OTTHUMG00000178287 UniprotKB:Q9UL17
NG_012166.1
PubMed
0   ANCO-SNPs
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.847e-1 (AD)  8.438e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
IL2RB0.9
KLRB10.883
SLAMF70.868
LY90.868
FCRL30.863
CD20.858
CD3G0.853
PRF10.842
GZMA0.839
PYHIN10.828

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LGI1-0.507
CYP46A1-0.499
CDS1-0.498
BDH1-0.492
CNNM1-0.488
OMG-0.484
KHDC1-0.482
KIAA0319-0.482
EFNA5-0.482
L1CAM-0.48

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C559381((1-ethylpyrrolidin-2-yl) methyl)-4-hydroxy-7-methoxy-quinoline-3-carboxamide((1-ethylpyrrolidin-2-yl) methyl)-4-hydroxy-7-methoxy-quinoline-3-carboxamide results in increased expression of TBX21 mRNA21195814
C0188552-tert-butylhydroquinone[2-tert-butylhydroquinone results in increased activity of NFE2L2 protein] which results in decreased activity of TBX21 protein22250088
C0261373-hydroxyacetanilide3-hydroxyacetanilide results in decreased expression of TBX21 mRNA18544908
C496492abrineabrine results in increased expression of TBX21 mRNA22595364
D000082AcetaminophenAcetaminophen results in decreased expression of TBX21 mRNA22230336
D000082AcetaminophenAcetaminophen results in decreased expression of TBX21 mRNA18544908
C430898AGN 194204AGN 194204 results in decreased expression of TBX21 mRNA11970994
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of TBX21 mRNA24449571
D001241AspirinTBX21 SNP affects the susceptibility to Aspirin15806396
D001379AzathioprineAzathioprine results in increased expression of TBX21 mRNA24184165
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of TBX21 mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of TBX21 mRNA27858113
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of TBX21 mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TBX21 mRNA21569818
D004958EstradiolTBX21 protein inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to GREB1 enhancer]]20068169
D004958EstradiolTBX21 protein inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to XBP1 enhancer]]20068169
D004958EstradiolTBX21 protein inhibits the reaction [Estradiol results in increased expression of GREB1 mRNA]20068169
D004958EstradiolTBX21 protein inhibits the reaction [Estradiol results in increased expression of XBP1 mRNA]20068169
C006780bisphenol Abisphenol A results in decreased expression of TBX21 protein20553123|2774367
C006780bisphenol APhytochemicals inhibits the reaction [bisphenol A results in decreased expression of TBX21 protein]20553123
C006780bisphenol Abisphenol A affects the expression of TBX21 mRNA25181051
D001761BleomycinBleomycin results in increased expression of TBX21 mRNA29033951
D019328Buthionine Sulfoximine[Phenytoin co-treated with Buthionine Sulfoximine] results in decreased expression of TBX21 mRNA23986454
C018475butyraldehydebutyraldehyde results in increased expression of TBX21 mRNA26079696
D002220CarbamazepineCarbamazepine results in decreased expression of TBX21 mRNA22790970
C515179caryophyllene oxidecaryophyllene oxide inhibits the reaction [Ovalbumin results in increased expression of TBX21 mRNA]28344896
D002737ChloropreneChloroprene results in decreased expression of TBX21 mRNA23125180
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of TBX21 mRNA28472532
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of TBX21 mRNA27858113
C004712cytisinecytisine analog results in decreased expression of TBX21 mRNA17630191
C556733dechlorane 602dechlorane 602 results in decreased expression of TBX21 mRNA27081854
D003907DexamethasoneDexamethasone results in decreased expression of TBX21 mRNA25900201
D004008DiclofenacDiclofenac results in decreased expression of TBX21 mRNA22285467
C031818enterotoxin B, staphylococcal"enterotoxin B, staphylococcal results in increased expression of TBX21 mRNA"25556216
D005557FormaldehydeFormaldehyde results in decreased expression of TBX21 mRNA18849615
C039281furanfuran results in increased methylation of TBX21 gene22079235
D007052IbuprofenIbuprofen analog results in decreased expression of TBX21 mRNA17630191
D007052IbuprofenIbuprofen results in decreased expression of TBX21 mRNA17630191
D015759Ionomycinlactacystin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TBX21 mRNA]22398747
D015759Ionomycin[PSMB8 protein co-treated with PSMB10 protein] affects the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TBX21 mRNA]22398747
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TBX21 mRNA22398747
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TBX21 mRNA25613284
C067713lactacystinlactacystin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TBX21 mRNA]22398747
D007840LatexLatex analog results in increased expression of TBX21 mRNA24768652
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of TBX21 mRNA18657572
D008713MethimazoleMethimazole results in decreased expression of TBX21 mRNA22407903
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of TBX21 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of TBX21 mRNA"25554681
D037742Nanotubes, Carbon"TBX21 gene mutant form results in increased susceptibility to Nanotubes, Carbon"24499286
D037742Nanotubes, Carbon"[TBX21 gene mutant form results in increased susceptibility to Nanotubes, Carbon] which results in increased expression of CCL2 protein"24499286
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in decreased expression of TBX21 mRNA20594950
D009532NickelNickel results in increased expression of TBX21 mRNA24768652
D009532NickelCCL2 protein affects the reaction [TBX21 gene mutant form results in increased susceptibility to Nickel analog]24499286
D009532NickelCCL2 protein affects the reaction [[TBX21 gene mutant form results in increased susceptibility to Nickel analog] which results in increased expression of MUC5AC mRNA]24499286
D009532NickelTBX21 gene mutant form results in increased susceptibility to Nickel analog24499286
D009532Nickel[TBX21 gene mutant form results in increased susceptibility to Nickel analog] which results in increased expression of CCL2 protein24499286
D009532Nickel[TBX21 gene mutant form results in increased susceptibility to Nickel analog] which results in increased expression of IL13 protein24499286
D009532Nickel[TBX21 gene mutant form results in increased susceptibility to Nickel analog] which results in increased expression of MUC5AC mRNA24499286
D009532Nickel[TBX21 gene mutant form results in increased susceptibility to Nickel analog] which results in increased expression of MUC5B mRNA24499286
D010047Ovalbumincaryophyllene oxide inhibits the reaction [Ovalbumin results in increased expression of TBX21 mRNA]28344896
D010047OvalbuminOvalbumin results in increased expression of TBX21 mRNA28344896
D052638Particulate MatterCCL2 protein affects the reaction [TBX21 gene mutant form results in increased susceptibility to Particulate Matter]24499286
D052638Particulate MatterCCL2 protein affects the reaction [[TBX21 gene mutant form results in increased susceptibility to Particulate Matter] which results in increased expression of MUC5AC mRNA]24499286
D052638Particulate MatterParticulate Matter results in decreased expression of TBX21 mRNA23416701|2363800
D052638Particulate MatterTBX21 gene mutant form results in increased susceptibility to Particulate Matter24499286
D052638Particulate Matter[TBX21 gene mutant form results in increased susceptibility to Particulate Matter] which results in increased expression of CCL2 protein24499286
D052638Particulate Matter[TBX21 gene mutant form results in increased susceptibility to Particulate Matter] which results in increased expression of IL13 protein24499286
D052638Particulate Matter[TBX21 gene mutant form results in increased susceptibility to Particulate Matter] which results in increased expression of MUC5AC mRNA24499286
D052638Particulate Matter[TBX21 gene mutant form results in increased susceptibility to Particulate Matter] which results in increased expression of MUC5B mRNA24499286
D052638Particulate MatterParticulate Matter results in decreased expression of TBX21 mRNA22134058
C046012pentanalpentanal results in increased expression of TBX21 mRNA26079696
D010476PerfumePerfume results in increased expression of TBX21 mRNA24768652
D015232DinoprostoneDinoprostone results in decreased expression of TBX21 mRNA19273625
D010672Phenytoin[Phenytoin co-treated with Buthionine Sulfoximine] results in decreased expression of TBX21 mRNA23986454
D010672PhenytoinPhenytoin results in decreased expression of TBX21 mRNA23986454
D064209PhytochemicalsPhytochemicals inhibits the reaction [bisphenol A results in decreased expression of TBX21 protein]20553123
D010936Plant ExtractsPlant Extracts results in increased expression of TBX21 mRNA20580249
C059514resveratrolresveratrol results in decreased expression of TBX21 mRNA22962611
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of TBX21 mRNA25895662
C017947sodium arsenitesodium arsenite results in decreased expression of TBX21 mRNA28843991
D053260SootSoot results in decreased expression of TBX21 mRNA26551751
D013629TamoxifenTBX21 protein results in decreased susceptibility to Tamoxifen20068169
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TBX21 mRNA24058054
D013755Tetradecanoylphorbol Acetatelactacystin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TBX21 mRNA]22398747
D013755Tetradecanoylphorbol Acetate[PSMB8 protein co-treated with PSMB10 protein] affects the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TBX21 mRNA]22398747
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TBX21 mRNA22398747
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of TBX21 mRNA25613284
C009495titanium dioxidetitanium dioxide results in decreased expression of TBX21 mRNA27760801
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of TBX21 mRNA20133372
D014050TolueneToluene results in decreased expression of TBX21 mRNA19571489|2205703
D014212TretinoinTretinoin results in decreased expression of TBX21 mRNA17118196
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of TBX21 mRNA19042947
D014520UrethaneUrethane results in decreased expression of TBX21 mRNA28818685
D001335Vehicle EmissionsVehicle Emissions results in decreased expression of TBX21 mRNA18849615

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISM19274049  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001227transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding-IC-  
GO:0003700DNA-binding transcription factor activity-TAS10761931  
GO:0005515protein binding-IPI15662016  17075044  24845384  
GO:0043565sequence-specific DNA binding-IDA23332764  
GO:0044212transcription regulatory region DNA binding-IDA19805038  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IDA18504404  
GO:0006351transcription, DNA-templated-IEA-  
GO:0006355regulation of transcription, DNA-templated-TAS10761931  
GO:0007275multicellular organism development-TAS10761931  
GO:0009615response to virus-IEP20583921  
GO:0030217T cell differentiation-IEA-  
GO:0032703negative regulation of interleukin-2 production-ISS-  
GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process-ISS-  
GO:0045580regulation of T cell differentiation-ISS-  
GO:0045892negative regulation of transcription, DNA-templated-ISS-  
GO:0045893positive regulation of transcription, DNA-templated-IDA19805038  
GO:0048304positive regulation of isotype switching to IgG isotypes-IEA-  
GO:0071310cellular response to organic substance-IEA-  
GO:0072676lymphocyte migration-IDA19805038  
GO:2000320negative regulation of T-helper 17 cell differentiation-ISS-  
GO:2000329negative regulation of T-helper 17 cell lineage commitment-ISS-  
GO:2000552negative regulation of T-helper 2 cell cytokine production-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-ISS-  
GO:0043025neuronal cell body-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28658564A clustering approach to identify and characterize the asthma and chronic obstructive pulmonary disease overlap phenotype. (2017 Nov)Hirai KClin Exp Allergy
29615105TBX21 predicts prognosis of patients and drives cancer stem cell maintenance via the TBX21-IL-4 pathway in lung adenocarcinoma. (2018 Apr 3)Zhao SStem Cell Res Ther
23036591Dendritic cells provide a potential link between smoking and inflammation in rheumatoid arthritis. (2012 Oct 4)Kazantseva MGArthritis Res Ther