Gene: NXPH1

30010
NPH1|Nbla00697
neurexophilin 1
protein-coding
7p21.3
Ensembl:ENSG00000122584 MIM:604639 Vega:OTTHUMG00000151941 UniprotKB:P58417
NC_000007.14
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.019e-1 (AD)  3.166e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7782816chr7:8700732 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GAD10.886
VWC20.879
GRIK10.868
LHX60.859
ZNF385D0.858
PLD50.85
GAD20.843
MYO5B0.838
BTBD110.836
MYO160.836

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ATOH8-0.542
PLIN2-0.523
TGIF1-0.508
BAG3-0.489
GPR4-0.489
WDR38-0.487
CDA-0.487
NFATC1-0.482
EVC2-0.481
A4GALT-0.481

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of NXPH1 mRNA19933214
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of NXPH1 gene27153756
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of NXPH1 mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of NXPH1 mRNA16483693
C015001arsenitearsenite results in increased methylation of NXPH1 promoter23974009
D001280AtrazineAtrazine results in decreased expression of NXPH1 mRNA25929836
C547126AZM551248AZM551248 results in decreased expression of NXPH1 mRNA22323515
C006780bisphenol Abisphenol A affects the expression of NXPH1 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of NXPH1 mRNA25181051
D002220CarbamazepineCarbamazepine affects the expression of NXPH1 mRNA25979313
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of NXPH1 mRNA24763279
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of NXPH1 gene20938992
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of NXPH1 mRNA]27941970
C540355fenamidonefenamidone results in decreased expression of NXPH1 mRNA27029645
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of NXPH1 gene20938992
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of NXPH1 mRNA24763279
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of NXPH1 mRNA26752646
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of NXPH1 gene20938992
C006253pirinixic acidpirinixic acid results in increased expression of NXPH1 mRNA18301758
D010936Plant ExtractsPlant Extracts results in decreased expression of NXPH1 mRNA23557933
C513428pyrachlostrobinpyrachlostrobin results in decreased expression of NXPH1 mRNA27029645
D012999SomanSoman results in decreased expression of NXPH1 mRNA19281266
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of NXPH1 mRNA19933214
D014212TretinoinTretinoin results in decreased expression of NXPH1 mRNA23724009
D014635Valproic AcidValproic Acid affects the expression of NXPH1 mRNA25979313
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of NXPH1 gene25560391
D015032ZincZinc results in decreased expression of NXPH1 mRNA20932299

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005102signaling receptor binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal