Gene: SLC40A1

30061
FPN1|HFE4|IREG1|MST079|MSTP079|MTP1|SLC11A3
solute carrier family 40 member 1
protein-coding
2q32.2
Ensembl:ENSG00000138449 MIM:604653 Vega:OTTHUMG00000132662 UniprotKB:Q9NP59
NG_009027.1
PubMed|SNP Mapped
ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.629e-2 (AD)  7.366e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs10188230chr2:189567887 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)
rs11539983chr2:189560748 (GRCh38.p7)T>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg04361126chr2:190446792SLC40A11.300e-13Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
EPS80.803
LEPROT0.752
SNTB10.749
GNG120.748
ANTXR10.747
PDLIM50.742
CD3020.738
PRKD30.734
CCDC500.731
MSRB30.73

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OVOL2-0.499
B3GNT4-0.493
EMX1-0.488
LRFN2-0.487
CPNE9-0.486
KCNB2-0.483
GALNT14-0.479
CACNA1F-0.477
GFRA2-0.468
SLC30A3-0.465

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of SLC40A1 mRNA"19162173
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of SLC40A1 mRNA"21354444
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of SLC40A1 mRNA19933214
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether analog results in decreased expression of SLC40A1 mRNA"19095052
C0140242,4,5,2',4',5'-hexachlorobiphenyl"2,4,5,2',4',5'-hexachlorobiphenyl results in increased expression of SLC40A1 protein"25686467
C0188552-tert-butylhydroquinone2-tert-butylhydroquinone results in increased expression of SLC40A1 mRNA16014739
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of SLC40A1 protein"25686467
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of SLC40A1 mRNA"23196670
C5202903,4-dihydroxybenzoate"3,4-dihydroxybenzoate inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of SLC40A1 protein]"19679656
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of SLC40A1 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC40A1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC40A1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC40A1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC40A1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC40A1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC40A1 mRNA"27188386
C1052604-tert-octylphenol4-tert-octylphenol results in increased expression of SLC40A1 mRNA17011747
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC40A1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC40A1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC40A1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC40A1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC40A1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC40A1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of SLC40A1 mRNA21420995|2906747
D000082AcetaminophenAcetaminophen results in increased expression of SLC40A1 mRNA22230336
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Cadmium results in increased expression of SLC40A1 mRNA]20090884
D020106AcrylamideAcrylamide results in increased expression of SLC40A1 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 affects the expression of SLC40A1 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of SLC40A1 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of SLC40A1 mRNA21632981
D000393Air PollutantsAir Pollutants analog results in decreased expression of SLC40A1 mRNA21757418
D000438AlcoholsAlcohols results in increased expression of SLC40A1 mRNA24025710
D000643Ammonium ChlorideAmmonium Chloride affects the expression of SLC40A1 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of SLC40A1 mRNA24449571
C006632arsenic trioxidearsenic trioxide results in increased expression of SLC40A1 mRNA19128835
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in decreased expression of SLC40A1 mRNA"18687144
D001379AzathioprineAzathioprine results in increased expression of SLC40A1 mRNA22623647
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SLC40A1 mRNA20106945|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of SLC40A1 mRNA20127859|2156981
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of SLC40A1 mRNA"26238291
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of SLC40A1 mRNA20660070
D004958EstradiolEstradiol results in increased expression of SLC40A1 mRNA16684588
D004958Estradiol[bisphenol A co-treated with Estradiol] results in increased expression of SLC40A1 mRNA26496021
C006780bisphenol Abisphenol A affects the expression of SLC40A1 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of SLC40A1 mRNA20170705
C006780bisphenol Abisphenol A results in increased expression of SLC40A1 mRNA29275510
C006780bisphenol Abisphenol A affects the expression of SLC40A1 mRNA25181051
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in increased expression of SLC40A1 mRNA26496021
D002104CadmiumAcetylcysteine inhibits the reaction [Cadmium results in increased expression of SLC40A1 mRNA]20090884
D002104CadmiumCadmium promotes the reaction [MTF1 protein binds to SLC40A1 promoter]20688958
D002104CadmiumCadmium results in increased expression of SLC40A1 mRNA20090884|2068895
D002104CadmiumCadmium results in increased expression of SLC40A1 protein20090884
D002104CadmiumDactinomycin inhibits the reaction [Cadmium results in increased expression of SLC40A1 mRNA]20090884
D002104CadmiumMTF1 protein affects the reaction [Cadmium results in increased expression of SLC40A1 mRNA]20688958
D019256Cadmium ChlorideCadmium Chloride results in increased expression of SLC40A1 mRNA27671773
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of SLC40A1 protein21540277
D019256Cadmium ChlorideCadmium Chloride results in increased expression of SLC40A117483498
D002185CannabidiolCannabidiol results in increased expression of SLC40A1 mRNA21542829
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of SLC40A1 protein17544377
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of SLC40A1 mRNA24763279
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of SLC40A1 mRNA18178546
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC40A1 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in increased expression of SLC40A1 mRNA26272509
D002737ChloropreneChloroprene results in increased expression of SLC40A1 mRNA23125180
D004390ChlorpyrifosChlorpyrifos results in increased expression of SLC40A1 mRNA25176568
C074702chromium hexavalent ionchromium hexavalent ion results in decreased expression of SLC40A1 mRNA24418189
C074702chromium hexavalent ionchromium hexavalent ion results in decreased expression of SLC40A1 mRNA24418189
D002922CiguatoxinsCiguatoxins affects the expression of SLC40A1 mRNA18353800
D003035CobaltCobalt inhibits the reaction [SLC40A1 protein results in increased export of Manganese]22178646
D003035CobaltCobalt results in increased expression of SLC40A1 protein20016736
C018021cobaltous chloridecobaltous chloride results in increased expression of SLC40A1 mRNA23814049|2438626
C018021cobaltous chloridePlicamycin inhibits the reaction [cobaltous chloride results in increased expression of SLC40A1 mRNA]23814049
D003300CopperCopper deficiency results in decreased expression of SLC40A1 mRNA18505688
D003300CopperCopper results in increased expression of SLC40A1 mRNA12220667
D003300CopperCopper results in increased expression of SLC40A1 protein12220667
D003300CopperCopper affects the expression of SLC40A1 mRNA16614410
D003300CopperCopper affects the expression of SLC40A1 protein16614410
D003300CopperCopper deficiency results in increased expression of SLC40A1 mRNA23555700
D003300CopperCopper deficiency results in increased expression of SLC40A1 protein23555700
D003300CopperCopper results in increased expression of SLC40A1 mRNA20016736
D003300CopperCopper results in increased expression of SLC40A1 protein20016736
D003300CopperEPAS1 gene mutant form inhibits the reaction [Copper deficiency results in increased expression of SLC40A1 mRNA]23555700
D003300CopperCopper deficiency results in decreased expression of SLC40A1 protein18505688
D003300CopperCopper deficiency results in increased expression of SLC40A1 mRNA20164366
D003300CopperCopper deficiency results in increased expression of SLC40A1 protein20164366|2135501
D019327Copper Sulfate"[Copper Sulfate co-treated with Iron, Dietary] results in increased expression of SLC40A1 mRNA"18987288
D019327Copper SulfateCopper Sulfate results in increased expression of SLC40A1 mRNA18987288
D019327Copper SulfateCopper Sulfate results in increased expression of SLC40A1 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of SLC40A1 mRNA20106945|2490755
D016572CyclosporineCyclosporine results in decreased expression of SLC40A1 mRNA19770486
D003561CytarabineCytarabine results in decreased expression of SLC40A1 mRNA21198554
D003609DactinomycinDactinomycin inhibits the reaction [Cadmium results in increased expression of SLC40A1 mRNA]20090884
D000069439DasatinibDasatinib results in increased expression of SLC40A1 mRNA20579391
D013759DronabinolDronabinol results in increased expression of SLC40A1 mRNA21542829
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of SLC40A1 mRNA]27941970
D003907DexamethasoneDexamethasone results in increased expression of SLC40A1 mRNA25047013
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of SLC40A1 mRNA28628672
D003907DexamethasoneDexamethasone results in decreased expression of SLC40A1 mRNA22733784
D003976DiazinonDiazinon results in increased methylation of SLC40A1 gene22964155
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of SLC40A1 mRNA17361019|2126653
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of SLC40A1 mRNA27392435
D002945Cisplatin[Cisplatin co-treated with panobinostat] affects the expression of SLC40A1 mRNA21791302
C000944dicrotophosdicrotophos results in decreased expression of SLC40A1 mRNA28302478
D019259Lamivudine[Zidovudine co-treated with Lamivudine] results in increased expression of SLC40A1 mRNA18313992
D004040Dietary CarbohydratesDietary Carbohydrates results in increased expression of SLC40A1 mRNA17490981
D004041Dietary Fats[Dietary Fats co-treated with resveratrol] results in increased expression of SLC40A1 mRNA21852083
C014476diethyl maleatediethyl maleate inhibits the reaction [Lipopolysaccharides results in decreased expression of SLC40A1 mRNA]21303654
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of SLC40A1 mRNA19061943
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of SLC40A1 protein19061943
D004052DiethylnitrosamineIron inhibits the reaction [Diethylnitrosamine results in decreased expression of SLC40A1 mRNA]19061943
D004052DiethylnitrosamineIron inhibits the reaction [Diethylnitrosamine results in decreased expression of SLC40A1 protein]19061943
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of SLC40A1 mRNA19638242
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of SLC40A1 mRNA17011747
D004178DiquatDiquat results in decreased expression of SLC40A1 mRNA21698372
D004317DoxorubicinDoxorubicin results in increased expression of SLC40A1 mRNA25896364
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of SLC40A1 mRNA22079256
D000431EthanolEthanol results in increased expression of SLC40A1 protein16737972
D000431EthanolHAMP protein inhibits the reaction [Ethanol results in increased expression of SLC40A1 protein]16737972
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of SLC40A1 mRNA20170705
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of SLC40A1 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of SLC40A1 mRNA27690074
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of SLC40A1 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of SLC40A1 mRNA17108234
C020326ferric nitrilotriacetateferric nitrilotriacetate results in decreased expression of SLC40A1 mRNA11925462
D0150732-Acetylaminofluorene2-Acetylaminofluorene results in increased expression of SLC40A1 mRNA21785164
D005485FlutamideFlutamide results in decreased expression of SLC40A1 mRNA24793618
D005492Folic AcidFolic Acid affects the expression of SLC40A1 mRNA17868486
C038958gadolinium chloridegadolinium chloride results in decreased expression of SLC40A119721414
C027235gallium nitrategallium nitrate results in decreased expression of SLC40A1 mRNA18586083
C004312glycidolglycidol results in decreased expression of SLC40A1 mRNA24915197
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of SLC40A1 mRNA24763279
D017313FenretinideFenretinide results in increased expression of SLC40A1 mRNA28973697
D006997Hypochlorous AcidHypochlorous Acid results in increased expression of SLC40A1 mRNA19376150
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of SLC40A1 mRNA28628672
D007213IndomethacinIndomethacin results in increased expression of SLC40A1 mRNA28201806
D007501Iron[CP protein results in increased oxidation of Iron] which results in increased stability of SLC40A1 protein20655381
D007501IronIron affects the reaction [HAMP protein results in increased uptake of SLC40A1 protein]20655381
D007501IronIron inhibits the reaction [SLC40A1 protein results in increased export of Manganese]22178646
D007501Iron[HBB-B1 gene mutant form results in increased abundance of Iron] which results in increased expression of SLC40A1 mRNA17018382
D007501Iron[HBB-B2 gene mutant form results in increased abundance of Iron] which results in increased expression of SLC40A1 mRNA17018382
D007501IronIron deficiency results in increased expression of SLC40A1 mRNA18648087|2377659
D007501IronIron inhibits the reaction [Diethylnitrosamine results in decreased expression of SLC40A1 mRNA]19061943
D007501IronIron inhibits the reaction [Diethylnitrosamine results in decreased expression of SLC40A1 protein]19061943
D007501IronIron results in decreased expression of SLC40A1 protein22659129
D007501IronIron results in increased expression of SLC40A1 mRNA16565419|1664823
D007501IronNFE2L2 protein promotes the reaction [SLC40A1 protein results in increased export of Iron]21303654
D007501IronSLC40A1 protein affects the metabolism of Iron17194590
D007501IronSLC40A1 protein mutant form results in decreased export of Iron16457665
D007501IronSLC40A1 protein mutant form results in increased export of Iron16457665
D007501IronSLC40A1 protein results in increased export of Iron16457665|2130365
D007501IronIron deficiency results in increased expression of SLC40A1 mRNA19821111|2154027
D007501IronIron results in decreased expression of SLC40A1 protein22659129
D007501IronSLC40A1 protein results in increased export of Iron20164366
D019266Iron, Dietary"Iron, Dietary promotes the reaction [[HAMP protein binds to and results in increased degradation of SLC40A1 protein] which results in decreased uptake of Iron, Dietary]"20105537
D019266Iron, Dietary"Iron, Dietary results in decreased expression of SLC40A1 protein"20105537
D019266Iron, Dietary"[Copper Sulfate co-treated with Iron, Dietary] results in increased expression of SLC40A1 mRNA"18987288
D019266Iron, Dietary"Iron, Dietary results in increased expression of SLC40A1 mRNA"18987288
D019266Iron, Dietary"Iron, Dietary affects the expression of SLC40A1 mRNA"15637178
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of SLC40A1 mRNA28628672
D007545IsoproterenolIsoproterenol results in increased expression of SLC40A1 mRNA20003209
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of SLC40A1 mRNA27392435
C008261lead acetatelead acetate results in decreased expression of SLC40A1 mRNA22613225
C008261lead acetatelead acetate results in decreased expression of SLC40A1 mRNA23219683
C008261lead acetatelead acetate results in decreased expression of SLC40A1 protein23219683
D008070Lipopolysaccharidesdiethyl maleate inhibits the reaction [Lipopolysaccharides results in decreased expression of SLC40A1 mRNA]21303654
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of SLC40A1 mRNA21303654
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of SLC40A1 mRNA16565419|1664823
D008070Lipopolysaccharidessulforafan inhibits the reaction [Lipopolysaccharides results in decreased expression of SLC40A1 mRNA]21303654
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in increased expression of SLC40A1 mRNA21641980|2308674
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of SLC40A1 mRNA26378955
D008345ManganeseCobalt inhibits the reaction [SLC40A1 protein results in increased export of Manganese]22178646
D008345ManganeseIron inhibits the reaction [SLC40A1 protein results in increased export of Manganese]22178646
D008345ManganeseNickel inhibits the reaction [SLC40A1 protein results in increased export of Manganese]22178646
D008345ManganeseSLC40A1 protein results in increased export of Manganese22178646
C042720mercuric bromidemercuric bromide results in increased expression of SLC40A1 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC40A1 mRNA"27188386
D008627Mercuric ChlorideMercuric Chloride results in increased expression of SLC40A1 mRNA16507785
D008694Methamphetamine[Methamphetamine co-treated with SCH 23390] results in decreased expression of SLC40A1 mRNA19564919
D008694MethamphetamineMethamphetamine results in decreased expression of SLC40A1 mRNA19564919
D008701MethapyrileneMethapyrilene results in increased expression of SLC40A1 mRNA28935588
D008713MethimazoleMethimazole results in increased expression of SLC40A1 mRNA20144635
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of SLC40A1 mRNA23179753
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of SLC40A1 mRNA"26251327
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of SLC40A1 protein"19679656
D0156321-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine"3,4-dihydroxybenzoate inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of SLC40A1 protein]"19679656
C523799MRK 003SLC40A1 results in increased susceptibility to MRK 00319903844
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of SLC40A1 mRNA"25554681
C031721naphthalenenaphthalene analog results in increased expression of SLC40A1 mRNA24976557
C051752nefazodonenefazodone results in increased expression of SLC40A1 mRNA24136188
C026385n-hexanen-hexane results in decreased expression of SLC40A1 mRNA23353815
D009532NickelNickel inhibits the reaction [SLC40A1 protein results in increased export of Manganese]22178646
D009532NickelNickel results in decreased expression of SLC40A1 mRNA24768652|2558310
C022838nickel chloridenickel chloride affects the expression of SLC40A1 mRNA22110744
C029938nickel sulfatenickel sulfate results in increased expression of SLC40A1 mRNA22714537
C496932panobinostat[Cisplatin co-treated with panobinostat] affects the expression of SLC40A1 mRNA21791302
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC40A1 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of SLC40A1 mRNA26272509
C016030pantogabpantogab results in decreased expression of SLC40A1 mRNA17379144
D052638Particulate MatterParticulate Matter results in decreased expression of SLC40A1 mRNA25858758
C086401pentabromodiphenyl etherpentabromodiphenyl ether analog results in decreased expression of SLC40A1 mRNA19095052
D010416PentachlorophenolPentachlorophenol results in increased expression of SLC40A1 mRNA23892564
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of SLC40A1 mRNA23427857
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of SLC40A1 mRNA17560707
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of SLC40A1 mRNA19162173
D026023PermethrinPermethrin results in decreased expression of SLC40A1 mRNA19017407
D010615PhenacetinPhenacetin results in increased expression of SLC40A1 mRNA17082564
D010634PhenobarbitalPhenobarbital results in increased expression of SLC40A1 mRNA25270620
C030299phenylhydrazinephenylhydrazine results in increased expression of SLC40A1 mRNA17082564
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC40A1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of SLC40A1 mRNA26272509
C018637phoronephorone affects the expression of SLC40A1 mRNA18198479
C006253pirinixic acidpirinixic acid results in decreased expression of SLC40A1 mRNA18445702
D008926PlicamycinPlicamycin inhibits the reaction [cobaltous chloride results in increased expression of SLC40A1 mRNA]23814049
D008926PlicamycinPlicamycin results in decreased expression of SLC40A1 mRNA23814049
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of SLC40A1 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of SLC40A1 mRNA22079256
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of SLC40A1 mRNA20660070
D011794QuercetinQuercetin results in decreased expression of SLC40A1 mRNA21632981|2505815
D011794QuercetinQuercetin results in decreased expression of SLC40A1 protein25058155
D011794QuercetinQuercetin results in decreased expression of SLC40A1 mRNA25058155
C059514resveratrol[Dietary Fats co-treated with resveratrol] results in increased expression of SLC40A1 mRNA21852083
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in decreased expression of SLC40A1 mRNA21427059
C534628SCH 23390[Methamphetamine co-treated with SCH 23390] results in decreased expression of SLC40A1 mRNA19564919
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of SLC40A1 mRNA25895662
D012822Silicon DioxideSilicon Dioxide results in decreased expression of SLC40A1 mRNA23221170
D012822Silicon DioxideSilicon Dioxide results in increased expression of SLC40A1 mRNA19073995
D012834SilverSilver results in increased expression of SLC40A1 mRNA26014281
C009277sodium arsenatesodium arsenate results in increased expression of SLC40A1 mRNA23922661
C017947sodium arsenitesodium arsenite results in increased expression of SLC40A1 mRNA22714537
C017947sodium arsenitesodium arsenite results in increased expression of SLC40A1 mRNA25270620
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in increased expression of SLC40A1 mRNA21641980|2308674
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in increased expression of SLC40A1 mRNA26378955
C016766sulforafansulforafan inhibits the reaction [Lipopolysaccharides results in decreased expression of SLC40A1 mRNA]21303654
D013629TamoxifenTamoxifen affects the expression of SLC40A1 mRNA17555576
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of SLC40A1 mRNA25172293
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SLC40A1 mRNA22574217
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SLC40A1 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin binds to AHR protein] which results in decreased expression of SLC40A1 mRNA16214954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SLC40A1 mRNA19770486|2821309
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SLC40A1 mRNA19933214
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of SLC40A1 protein28213091
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SLC40A1 mRNA20959002|2121527
D013853ThioacetamideThioacetamide results in increased expression of SLC40A1 mRNA23411599
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of SLC40A1 mRNA27404394|2786577
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of SLC40A1 mRNA20133372
D014050TolueneToluene results in increased expression of SLC40A1 mRNA22967744
D014212TretinoinTretinoin results in increased expression of SLC40A1 mRNA21934132|2372400
D014212TretinoinTretinoin results in decreased expression of SLC40A1 mRNA20488242
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC40A1 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of SLC40A1 mRNA24935251|2627250
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of SLC40A1 mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of SLC40A1 mRNA"26743178
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of SLC40A1 mRNA"24407104
D014415TunicamycinTunicamycin results in decreased expression of SLC40A1 mRNA17127020
D014425TurpentineTurpentine results in decreased expression of SLC40A1 mRNA23353815
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SLC40A1 mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of SLC40A1 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in decreased expression of SLC40A1 mRNA21427059
D014635Valproic AcidValproic Acid results in increased expression of SLC40A1 mRNA24896083
D014638VanadatesVanadates results in decreased expression of SLC40A1 mRNA22714537
D015215ZidovudineZidovudine results in increased expression of SLC40A1 mRNA24292225
D015215Zidovudine[Zidovudine co-treated with Lamivudine] results in increased expression of SLC40A1 mRNA18313992
D015032ZincMTF1 mutant form inhibits the reaction [Zinc results in increased expression of SLC40A1 mRNA]20688958
D015032ZincZinc results in increased expression of SLC40A1 mRNA20688958
D015032ZincZinc results in decreased expression of SLC40A1 protein16614402
D015032ZincZinc results in increased expression of SLC40A1 protein16614402
C088658zoledronic acidzoledronic acid results in increased expression of SLC40A1 mRNA24714768
D015054ZymosanZymosan results in decreased expression of SLC40A119721414

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005381iron ion transmembrane transporter activity-IMP12091367  
GO:0005515protein binding-IPI20817278  24867889  
GO:0015093ferrous iron transmembrane transporter activity-ISS-  
GO:0017046peptide hormone binding-IPI22682227  
GO:0042802identical protein binding-IEA-  
GO:0097689iron channel activity-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0002260lymphocyte homeostasis-IEA-  
GO:0003158endothelium development-IEA-  
GO:0006879cellular iron ion homeostasis-IMP12091367  
GO:0006879cellular iron ion homeostasis-TAS-  
GO:0034395regulation of transcription from RNA polymerase II promoter in response to iron-IEA-  
GO:0034755iron ion transmembrane transport-IMP12091367  
GO:0043066negative regulation of apoptotic process-IEA-  
GO:0045944positive regulation of transcription by RNA polymerase II-IEA-  
GO:0060345spleen trabecula formation-IEA-  
GO:0060586multicellular organismal iron ion homeostasis-ISS-  
GO:1903988ferrous iron export across plasma membrane-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005622intracellular-IDA20019163  
GO:0005654nucleoplasm-IDA-  
GO:0005737cytoplasm-TAS10747949  
GO:0005829cytosol-IDA-  
GO:0005886plasma membrane-IDA20019163  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IC12091367  
GO:0008021synaptic vesicle-IEA-  
GO:0016021integral component of membrane-TAS10747949  
GO:0016323basolateral plasma membrane-IDA20019163  
GO:0016323basolateral plasma membrane-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1643685DiseaseTAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-425366Transport of bile salts and organic acids, metal ions and amine compoundsTAS
R-HSA-425407SLC-mediated transmembrane transportTAS
R-HSA-425410Metal ion SLC transportersTAS
R-HSA-5619049Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages)TAS
R-HSA-5619102SLC transporter disordersTAS
R-HSA-5619115Disorders of transmembrane transportersTAS
R-HSA-5655799Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum)TAS
R-HSA-917937Iron uptake and transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26474245The role of genetic factors in patients with hepatocellular carcinoma and iron overload - a prospective series of 234 patients. (2016 May)Funakoshi NLiver Int
27170390Pathogenesis, Diagnosis and Treatment of Hemochromatosis. (2016)Zoller HDig Dis