Gene: H2AFX

3014
H2A.X|H2A/X|H2AX
H2A histone family member X
protein-coding
11q23.3
Ensembl:ENSG00000188486 MIM:601772 Vega:OTTHUMG00000166196 UniprotKB:P16104
NC_000011.10
PubMed
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.382e-1 (AD)  6.895e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TMUB10.9
UBE2J20.892
TPRA10.881
RBM420.88
SGTA0.88
AKT1S10.879
ZNF7870.865
C19orf250.863
HSF10.861
RFNG0.86

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.69
OR4F29-0.648
HMCN1-0.33
FER1L6-0.327
MXRA5-0.327
PZP-0.323
CETP-0.322
CYSLTR1-0.307
CASQ2-0.302
GADL1-0.302

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0252051,10-phenanthroline"[Copper binds to phthalic acid binds to 1,10-phenanthroline] which results in increased expression of H2AFX protein modified form"22659117
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of H2AFX mRNA"28903501
C0330201-aminobenzotriazole1-aminobenzotriazole inhibits the reaction [propylene dichloride results in increased phosphorylation of H2AFX protein]28300663
C1087311'-(hydroxymethyl)eugenol1'-(hydroxymethyl)eugenol results in increased expression of H2AFX protein26542539
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in decreased expression of H2AFX mRNA28329830
C0787652,3,5-(triglutathion-S-yl)hydroquinone"2,3,5-(triglutathion-S-yl)hydroquinone results in increased phosphorylation of H2AFX protein"21135414
C0787652,3,5-(triglutathion-S-yl)hydroquinone"Acetylcysteine inhibits the reaction [2,3,5-(triglutathion-S-yl)hydroquinone results in increased phosphorylation of H2AFX protein]"21135414
C0294972,3-bis(3'-hydroxybenzyl)butyrolactone"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of H2AFX mRNA"19167446
C0630022,3-dimethoxy-1,4-naphthoquinone"2,3-dimethoxy-1,4-naphthoquinone results in increased expression of H2AFX mRNA"19031421
C0109142,4-diaminotoluene"2,4-diaminotoluene results in decreased expression of H2AFX mRNA"20713471
C1177762,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone"2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone analog results in increased expression of H2AFX protein modified form"26630137
C0158022,6-dichloro-4-nitrophenol"2,6-dichloro-4-nitrophenol results in decreased expression of H2AFX mRNA"11227219
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of H2AFX protein modified form"28160022
C0369892-amino-3,4-dimethylimidazo(4,5-f)quinoline"2-amino-3,4-dimethylimidazo(4,5-f)quinoline results in increased expression of H2AFX protein modified form"28160022
C0369902-amino-3,8-dimethylimidazo(4,5-f)quinoxaline"2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of H2AFX protein modified form"28160022
C0178212-amino-3-methyl-9H-pyrido(2,3-b)indole"2-amino-3-methyl-9H-pyrido(2,3-b)indole results in increased expression of H2AFX protein modified form"28160022
C0292162-amino-3-methylimidazo(4,5-f)quinoline"2-amino-3-methylimidazo(4,5-f)quinoline results in increased expression of H2AFX protein modified form"28160022
C4325232-amino-3-methylimidazo(4,5-f)quinoxaline"2-amino-3-methylimidazo(4,5-f)quinoxaline results in increased expression of H2AFX protein modified form"28160022
C0237852-amino-6-methyldipyrido(1,2-a-3',2'-d)imidazole"2-amino-6-methyldipyrido(1,2-a-3',2'-d)imidazole results in increased expression of H2AFX protein modified form"28160022
C0178222-amino-9H-pyrido(2,3-b)indole"2-amino-9H-pyrido(2,3-b)indole results in increased expression of H2AFX protein modified form"28160022
C0312782-chloroethyl ethyl sulfide2-chloroethyl ethyl sulfide results in increased expression of H2AFX protein modified form20840853
C0312782-chloroethyl ethyl sulfide2-chloroethyl ethyl sulfide results in increased phosphorylation of H2AFX protein21722719
C0312782-chloroethyl ethyl sulfideGlutathione inhibits the reaction [2-chloroethyl ethyl sulfide results in increased phosphorylation of H2AFX protein]21722719
C0228302-methoxyestradiol2-methoxyestradiol results in increased expression of H2AFX protein modified form23967052
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide results in decreased expression of H2AFX protein modified form26651356
C4958182-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of H2AFX protein]26231820
C4958182-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [propylene dichloride results in increased phosphorylation of H2AFX protein]28300663
C4958182-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [T-2 Toxin results in increased activity of H2AFX protein]20150440
C4958182-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one promotes the reaction [Flavanones results in increased phosphorylation of H2AFX protein]21616090
C4958182-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one results in decreased phosphorylation of H2AFX protein23227178
C4958182-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one2-(morpholin-4-yl)benzo(h)chromen-4-one promotes the reaction [2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one results in decreased phosphorylation of H2AFX protein]23227178
C4958182-morpholin-4-yl-6-thianthren-1-yl-pyran-4-onebisphenol A promotes the reaction [2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one results in decreased phosphorylation of H2AFX protein]23227178
C4958182-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [arsenic trioxide results in increased expression of H2AFX protein]23337567
C4792352-(morpholin-4-yl)benzo(h)chromen-4-one2-(morpholin-4-yl)benzo(h)chromen-4-one promotes the reaction [2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one results in decreased phosphorylation of H2AFX protein]23227178
C0053282-nitroanisole2-nitroanisole results in increased expression of H2AFX protein26338220
C0194992-nitrofluorene2-nitrofluorene results in increased expression of H2AFX mRNA15890375
C0188552-tert-butylhydroquinone2-tert-butylhydroquinone inhibits the reaction [ferrous sulfate results in increased expression of H2AFX protein]28583816
C0454213,4,8-trimethylimidazo(4,5-f)quinoxalin-2-amine"3,4,8-trimethylimidazo(4,5-f)quinoxalin-2-amine results in increased expression of H2AFX protein modified form"28160022
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid analog results in increased phosphorylation of H2AFX protein17512204
C0191323-amino-1,4-dimethyl-5H-pyrido(4,3-b)indole"3-amino-1,4-dimethyl-5H-pyrido(4,3-b)indole results in increased expression of H2AFX protein modified form"28160022
C0191333-amino-1-methyl-5H-pyrido(4,3-b)indole"3-amino-1-methyl-5H-pyrido(4,3-b)indole results in increased expression of H2AFX protein modified form"28160022
C5605803-amino-6-(4-(methylsulfonyl)phenyl)-N-phenylpyrazine-2-carboxamide3-amino-6-(4-(methylsulfonyl)phenyl)-N-phenylpyrazine-2-carboxamide inhibits the reaction [Camptothecin results in increased expression of H2AFX protein modified form]25269479
C5605803-amino-6-(4-(methylsulfonyl)phenyl)-N-phenylpyrazine-2-carboxamide3-amino-6-(4-(methylsulfonyl)phenyl)-N-phenylpyrazine-2-carboxamide inhibits the reaction [NSC 724998 results in increased expression of H2AFX protein modified form]25269479
C0781573-aminopyridine-2-carboxaldehyde thiosemicarbazone3-aminopyridine-2-carboxaldehyde thiosemicarbazone results in increased expression of H2AFX protein25130544
C0179063-dinitrobenzene3-dinitrobenzene results in decreased expression of H2AFX mRNA21983209
C0006147253'-oxomethylisoeugenol3'-oxomethylisoeugenol results in increased expression of H2AFX protein26542539
C0708994,4'-(1,2-dimethyl-1,2-ethanediyl)bis-2,6-piperazinedione"4,4'-(1,2-dimethyl-1,2-ethanediyl)bis-2,6-piperazinedione inhibits the reaction [Doxorubicin results in increased expression of H2AFX protein]"17875725
C0708994,4'-(1,2-dimethyl-1,2-ethanediyl)bis-2,6-piperazinedione"4,4'-(1,2-dimethyl-1,2-ethanediyl)bis-2,6-piperazinedione inhibits the reaction [Etoposide results in increased expression of H2AFX protein]"17875725
C0909424-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [resveratrol results in increased phosphorylation of H2AFX protein]25619392
C0909424-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Etoposide results in increased expression of H2AFX protein]20643100
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in increased phosphorylation of H2AFX protein22331492
C0275764-hydroxy-2-nonenalPOLH protein affects the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of H2AFX protein]22331492
C0275764-hydroxy-2-nonenalPOLK protein affects the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of H2AFX protein]22331492
C0275764-hydroxy-2-nonenalPOLL protein affects the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of H2AFX protein]22331492
C0275764-hydroxy-2-nonenalREV1 protein affects the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of H2AFX protein]22331492
C0275764-hydroxy-2-nonenalREV3L protein affects the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of H2AFX protein]22331492
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of H2AFX protein]26231820
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in increased phosphorylation of H2AFX protein21882252
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of H2AFX protein26231820
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanoneCaffeine inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of H2AFX protein]26231820
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanoneCatechin inhibits the reaction [[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in increased phosphorylation of H2AFX protein]21882252
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanoneCYP2A13 protein promotes the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of H2AFX protein]26231820
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of H2AFX mRNA15890375
C5582885-methylselenylmethyl-2'-deoxyuridine5-methylselenylmethyl-2'-deoxyuridine results in increased phosphorylation of H2AFX protein22002103
C5582895-phenylselenylmethyl-2'-deoxyuridine5-phenylselenylmethyl-2'-deoxyuridine results in increased phosphorylation of H2AFX protein22002103
C5715326-(3-cyclopentyl-2-(4-(trifluoromethyl)-1H-imidazol-1-yl)propanamido)nicotinic acid6-(3-cyclopentyl-2-(4-(trifluoromethyl)-1H-imidazol-1-yl)propanamido)nicotinic acid results in increased expression of H2AFX protein25316768
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine results in increased phosphorylation of H2AFX protein"23274516
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"Acetylcysteine inhibits the reaction [(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine results in increased phosphorylation of H2AFX protein]"23274516
C093792680C91680C91 results in decreased expression of H2AFX protein modified form26651356
C4210109-(4'-aminophenyl)-9H-pyrido(3,4-b)indole"9-(4'-aminophenyl)-9H-pyrido(3,4-b)indole results in increased expression of H2AFX protein modified form"28160022
D000082AcetaminophenAcetaminophen affects the expression of H2AFX mRNA25458485
D000082AcetaminophenAcetaminophen results in increased expression of H2AFX mRNA21420995|2223033
D000082AcetaminophenAcetaminophen affects the expression of H2AFX mRNA17562736
D000082AcetaminophenAcetaminophen results in decreased expression of H2AFX protein26011634
C487680acetylbritannilatoneacetylbritannilatone analog results in increased expression of H2AFX protein27262408
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Sulindac promotes the reaction [Bortezomib results in increased phosphorylation of H2AFX protein]]16033843
D000111Acetylcysteine"Acetylcysteine inhibits the reaction [2,3,5-(triglutathion-S-yl)hydroquinone results in increased phosphorylation of H2AFX protein]"21135414
D000111Acetylcysteine"Acetylcysteine inhibits the reaction [(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine results in increased phosphorylation of H2AFX protein]"23274516
D000111AcetylcysteineAcetylcysteine inhibits the reaction [alpha-terthienylmethanol results in increased phosphorylation of H2AFX protein]28506552
D000111AcetylcysteineAcetylcysteine inhibits the reaction [[Bortezomib co-treated with romidepsin] results in increased phosphorylation of H2AFX protein]15173094
D000111AcetylcysteineAcetylcysteine inhibits the reaction [cobaltous chloride promotes the reaction [nickel chloride results in increased phosphorylation of H2AFX protein]]22172632
D000111AcetylcysteineAcetylcysteine inhibits the reaction [cobaltous chloride results in increased phosphorylation of H2AFX protein]22172632
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Doxorubicin results in increased phosphorylation of H2AFX protein]15489221
D000111AcetylcysteineAcetylcysteine inhibits the reaction [[fludarabine co-treated with LAQ824] results in increased expression of H2AFX protein]18852132
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of H2AFX protein]28300663
D000111AcetylcysteineAcetylcysteine inhibits the reaction [LAQ824 results in increased expression of H2AFX protein]18852132
D000111AcetylcysteineAcetylcysteine inhibits the reaction [manumycin results in increased phosphorylation of H2AFX protein]19409983
D000111AcetylcysteineAcetylcysteine inhibits the reaction [nickel chloride promotes the reaction [cobaltous chloride results in increased phosphorylation of H2AFX protein]]22172632
D000111AcetylcysteineAcetylcysteine inhibits the reaction [nickel chloride results in increased phosphorylation of H2AFX protein]22172632
D000111AcetylcysteineAcetylcysteine inhibits the reaction [PCB 180 metabolite results in increased phosphorylation of H2AFX protein]26148434
D000111AcetylcysteineAcetylcysteine inhibits the reaction [propylene dichloride results in increased phosphorylation of H2AFX protein]28300663
D000111AcetylcysteineAcetylcysteine inhibits the reaction [erythritol anhydride results in increased expression of H2AFX protein modified form]25633853
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Zinc Oxide analog results in increased activity of H2AFX protein]24614525
D000111AcetylcysteineAcetylcysteine inhibits the reaction [tributyltin results in increased expression of H2AFX protein modified form]26079211
D016604Aflatoxin B1Aflatoxin B1 results in increased phosphorylation of H2AFX protein28882572
D016604Aflatoxin B1AHR protein affects the reaction [Aflatoxin B1 results in increased phosphorylation of H2AFX protein]28882572
D016604Aflatoxin B1ARNT protein affects the reaction [Aflatoxin B1 results in increased phosphorylation of H2AFX protein]28882572
D016604Aflatoxin B1TP53 protein affects the reaction [Aflatoxin B1 results in increased phosphorylation of H2AFX protein]28882572
D016604Aflatoxin B1Aflatoxin B1 results in increased phosphorylation of H2AFX protein19770486
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of H2AFX mRNA15890375
C027955aflatoxin G1aflatoxin G1 results in increased expression of H2AFX protein modified form23907605
C027955aflatoxin G1Methoxsalen inhibits the reaction [aflatoxin G1 results in increased expression of H2AFX protein modified form]23907605
C027955aflatoxin G1Nicotine inhibits the reaction [aflatoxin G1 results in increased expression of H2AFX protein modified form]23907605
D000393Air PollutantsAir Pollutants results in increased phosphorylation of H2AFX protein23159502
C000607033alpha-terthienylmethanolAcetylcysteine inhibits the reaction [alpha-terthienylmethanol results in increased phosphorylation of H2AFX protein]28506552
C000607033alpha-terthienylmethanolalpha-terthienylmethanol results in increased phosphorylation of H2AFX protein28506552
D024502alpha-Tocopherolalpha-Tocopherol inhibits the reaction [Sulindac promotes the reaction [Bortezomib results in increased phosphorylation of H2AFX protein]]16033843
C005197alternariolalternariol results in increased expression of H2AFX protein modified form26341179
C077990alvocidibalvocidib affects the expression of H2AFX protein15078984
D000585AminacrineAminacrine results in decreased phosphorylation of H2AFX protein26928355
D000585Aminacrine[Aminacrine results in decreased phosphorylation of H2AFX protein] inhibits the reaction [Camptothecin results in increased activity of and affects the localization of MDC1 protein]26928355
C413760aminoflavoneaminoflavone results in increased expression of H2AFX protein24885022
D000872AnthocyaninsAnthocyanins results in increased phosphorylation of H2AFX protein27444805
D018906Antineoplastic Agents, Alkylating"Antineoplastic Agents, Alkylating results in increased expression of H2AFX protein"21500194
D016590AphidicolinAphidicolin inhibits the reaction [docetaxel results in increased expression of H2AFX protein]20878124
C006632arsenic trioxide[arsenic trioxide co-treated with Sulindac] results in increased phosphorylation of H2AFX protein18636201
C006632arsenic trioxidearsenic trioxide inhibits the reaction [SHH protein inhibits the reaction [Cisplatin results in increased phosphorylation of H2AFX protein]]23861973
C006632arsenic trioxidearsenic trioxide results in increased expression of H2AFX protein modified form28265077|2831838
C006632arsenic trioxidearsenic trioxide results in increased phosphorylation of H2AFX protein16891316|2386197
C006632arsenic trioxideMUS81 protein mutant form inhibits the reaction [arsenic trioxide results in increased expression of H2AFX protein modified form]28318385
C006632arsenic trioxidearsenic trioxide results in increased expression of H2AFX protein modified form28265077
C006632arsenic trioxide2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [arsenic trioxide results in increased expression of H2AFX protein]23337567
C006632arsenic trioxidearsenic trioxide results in increased expression of H2AFX protein23337567
D001205Ascorbic Acid[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone] results in decreased expression of H2AFX mRNA26424790
D001205Ascorbic Acid[Ascorbic Acid results in increased reduction of Vitamin K 3] which results in increased phosphorylation of H2AFX protein19482829
D001241AspirinAspirin results in decreased expression of H2AFX protein23363784
D001280AtrazineAtrazine affects the expression of H2AFX protein modified form26518232
D001374AzacitidineAzacitidine results in increased expression of H2AFX protein17991895
D001374AzacitidineAzacitidine inhibits the reaction [potassium bromate results in increased phosphorylation of H2AFX protein]25015661
D001379AzathioprineAzathioprine results in decreased expression of H2AFX mRNA22623647
D001554BenzeneBenzene results in increased expression of H2AFX mRNA15120971|1512265
C043931benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide-DNA"benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide-DNA results in increased phosphorylation of H2AFX protein"18848825
C072019benzo(a)pyrene diolepoxide Ibenzo(a)pyrene diolepoxide I results in increased expression of H2AFX protein modified form27694624
D001564Benzo(a)pyrene[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in increased phosphorylation of H2AFX protein21882252
D001564Benzo(a)pyreneARNT protein affects the reaction [Benzo(a)pyrene results in increased phosphorylation of H2AFX protein]28882572
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of H2AFX protein21873372
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of H2AFX protein modified form26657896
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased phosphorylation of H2AFX protein20888899|2238920
D001564Benzo(a)pyreneCaffeine promotes the reaction [Benzo(a)pyrene results in increased phosphorylation of H2AFX protein]20888899
D001564Benzo(a)pyreneCatechin inhibits the reaction [[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in increased phosphorylation of H2AFX protein]21882252
D001564Benzo(a)pyrenePCB 180 metabolite promotes the reaction [Benzo(a)pyrene results in increased phosphorylation of H2AFX protein]26148434
D001564Benzo(a)pyreneTP53 protein affects the reaction [Benzo(a)pyrene results in increased phosphorylation of H2AFX protein]28882572
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased phosphorylation of H2AFX protein19770486
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased phosphorylation of H2AFX protein"24743697
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the phosphorylation of H2AFX protein"18848825
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of H2AFX mRNA"20382639
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of H2AFX mRNA"19150397
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"[Hydrogen Peroxide co-treated with 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide] results in increased phosphorylation of H2AFX protein"18848825
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased phosphorylation of H2AFX protein"22331492
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"POLH protein affects the reaction [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased phosphorylation of H2AFX protein]"22331492
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"REV1 protein affects the reaction [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased phosphorylation of H2AFX protein]"22331492
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"REV3L protein affects the reaction [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased phosphorylation of H2AFX protein]"22331492
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [veliparib promotes the reaction [Camptothecin results in increased expression of H2AFX protein]]21227924
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Doxorubicin results in increased expression of H2AFX protein]17875725
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Etoposide results in increased expression of H2AFX protein]17875725
C517629benzyloxycarbonyl-valyl-alanyl-aspartic acidbenzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [[Fluorouracil co-treated with olaparib] results in increased phosphorylation of H2AFX protein]26544897
C517629benzyloxycarbonyl-valyl-alanyl-aspartic acidbenzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [[TNF protein co-treated with trovafloxacin] results in increased expression of H2AFX protein modified form]25748550
C517629benzyloxycarbonyl-valyl-alanyl-aspartic acidbenzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [trovafloxacin results in increased expression of H2AFX protein modified form]25748550
C517629benzyloxycarbonyl-valyl-alanyl-aspartic acidTP53 gene mutant form affects the reaction [benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [[Fluorouracil co-treated with olaparib] results in increased phosphorylation of H2AFX protein]]26544897
D001599BerberineBerberine results in decreased expression of H2AFX mRNA27311644
D001599BerberineBerberine results in decreased expression of H2AFX protein23363784
D001599BerberineBerberine results in increased expression of H2AFX protein modified form23747414
D001599BerberineTOP2A protein affects the reaction [Berberine results in increased expression of H2AFX protein modified form]23747414
D004958EstradiolEstradiol promotes the reaction [PCB 180 metabolite results in increased phosphorylation of H2AFX protein]26148434
D004958EstradiolEstradiol results in increased expression of H2AFX mRNA16474171|1916744
D004958EstradiolEstradiol results in increased expression of H2AFX protein16462019
D004958EstradiolEstradiol results in increased expression of H2AFX protein modified form25933419
D004958EstradiolEstradiol results in increased expression of H2AFX protein23788033
D004958Estradiolfulvestrant inhibits the reaction [Estradiol results in increased expression of H2AFX protein]23788033
C031463beta-glycerophosphoric acid[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone] results in decreased expression of H2AFX mRNA26424790
D0150822,2'-Dipyridyl"[Copper binds to phthalic acid binds to 2,2'-Dipyridyl] which results in increased expression of H2AFX protein modified form"22659117
C006780bisphenol Abisphenol A promotes the reaction [2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one results in decreased phosphorylation of H2AFX protein]23227178
C006780bisphenol Abisphenol A results in decreased expression of H2AFX mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of H2AFX mRNA16474171
C006780bisphenol Abisphenol A results in increased expression of H2AFX protein16462019|2927551
C006780bisphenol Abisphenol A results in increased expression of H2AFX protein modified form25933419
C006780bisphenol AMYC protein promotes the reaction [bisphenol A results in increased expression of H2AFX protein modified form]25933419
C006780bisphenol Abisphenol A inhibits the reaction [[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] which results in increased expression of H2AFX protein]25693136
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in increased expression of H2AFX mRNA26496021
C006780bisphenol Abisphenol A results in increased expression of H2AFX protein23788033
C006780bisphenol Afulvestrant inhibits the reaction [bisphenol A results in increased expression of H2AFX protein]23788033
C000611646bisphenol Fbisphenol F results in increased expression of H2AFX protein29102535
D001761BleomycinBleomycin results in increased expression of H2AFX protein25130544
C000591165BO-1012BO-1012 results in increased expression of H2AFX protein24823293
C557045BO-1051BO-1051 results in increased expression of H2AFX protein modified form21184746
D000069286BortezomibAcetylcysteine inhibits the reaction [Sulindac promotes the reaction [Bortezomib results in increased phosphorylation of H2AFX protein]]16033843
D000069286Bortezomibalpha-Tocopherol inhibits the reaction [Sulindac promotes the reaction [Bortezomib results in increased phosphorylation of H2AFX protein]]16033843
D000069286BortezomibSulindac promotes the reaction [Bortezomib results in increased phosphorylation of H2AFX protein]16033843
D000069286BortezomibAcetylcysteine inhibits the reaction [[Bortezomib co-treated with romidepsin] results in increased phosphorylation of H2AFX protein]15173094
D000069286Bortezomib[Bortezomib co-treated with romidepsin] results in increased phosphorylation of H2AFX protein15173094
D000069286BortezomibBortezomib results in increased expression of H2AFX protein modified form16778179|1879076
D000069286Bortezomibleptomycin B promotes the reaction [Bortezomib results in increased expression of H2AFX protein modified form]16778179
D000069286BortezomibBortezomib inhibits the reaction [Doxorubicin results in increased expression of H2AFX protein]17875725
D000069286BortezomibBortezomib inhibits the reaction [Etoposide results in increased expression of H2AFX protein]17875725
D000069286BortezomibBortezomib results in increased expression of H2AFX protein20028860
D001959BromatesBromates results in increased phosphorylation of H2AFX protein21864635
D001959Bromateschlorite promotes the reaction [Bromates results in increased phosphorylation of H2AFX protein]21864635
D002066BusulfanBusulfan results in increased phosphorylation of H2AFX protein18339423
D002066Busulfan[clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased expression of H2AFX protein20933509
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased phosphorylation of H2AFX protein24743697
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of H2AFX mRNA15336504
D002085ButylhydroxybutylnitrosamineButylhydroxybutylnitrosamine results in increased expression of H2AFX protein26338220
D020148Butyric AcidButyric Acid results in decreased expression of H2AFX mRNA12800193
D020148Butyric AcidButyric Acid results in increased expression of H2AFX protein25070040
C584509C646 compoundC646 compound results in decreased expression of H2AFX mRNA26191083
C584509C646 compoundC646 compound results in decreased phosphorylation of H2AFX protein23698071
D002104CadmiumCadmium results in increased expression of H2AFX protein27658547
D019256Cadmium ChlorideCadmium Chloride affects the expression of H2AFX mRNA18974090
D019256Cadmium ChlorideCadmium Chloride results in increased phosphorylation of H2AFX protein20435356
D019256Cadmium ChlorideCadmium Chloride results in increased expression of H2AFX protein22457795
D002110CaffeineCaffeine inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of H2AFX protein]26231820
D002110CaffeineCaffeine inhibits the reaction [resveratrol results in increased phosphorylation of H2AFX protein]15975956
D002110CaffeineCaffeine inhibits the reaction [riccardin D results in increased phosphorylation of H2AFX protein]24069304
D002110CaffeineCaffeine inhibits the reaction [silybin results in increased phosphorylation of H2AFX protein]16777994
D002110CaffeineCaffeine promotes the reaction [Benzo(a)pyrene results in increased phosphorylation of H2AFX protein]20888899
D002110Caffeine[Caffeine co-treated with Ephedrine] results in increased phosphorylation of H2AFX protein15537744
D002166Camptothecin3-amino-6-(4-(methylsulfonyl)phenyl)-N-phenylpyrazine-2-carboxamide inhibits the reaction [Camptothecin results in increased expression of H2AFX protein modified form]25269479
D002166Camptothecin[Aminacrine results in decreased phosphorylation of H2AFX protein] inhibits the reaction [Camptothecin results in increased activity of and affects the localization of MDC1 protein]26928355
D002166Camptothecinbenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [veliparib promotes the reaction [Camptothecin results in increased expression of H2AFX protein]]21227924
D002166CamptothecinCamptothecin results in increased expression of H2AFX protein21227924|2230203
D002166CamptothecinCamptothecin results in increased expression of H2AFX protein modified form25269479|2577243
D002166CamptothecinCamptothecin results in increased phosphorylation of H2AFX protein21646468
D002166CamptothecinERCC1 protein promotes the reaction [veliparib promotes the reaction [Camptothecin results in increased expression of H2AFX protein]]21227924
D002166CamptothecinERCC4 protein promotes the reaction [veliparib promotes the reaction [Camptothecin results in increased expression of H2AFX protein]]21227924
D002166CamptothecinH2AFX gene mutant form inhibits the reaction [MIR138-1 results in increased susceptibility to Camptothecin]21693595
D002166Camptothecin[MIR138-1 results in decreased expression of H2AFX] which results in increased susceptibility to Camptothecin21693595
D002166Camptothecinpalbociclib inhibits the reaction [Camptothecin results in increased expression of H2AFX protein]22302033
D002166CamptothecinPPP2R2A protein inhibits the reaction [Camptothecin results in increased expression of H2AFX protein modified form]25772433
D002166CamptothecinPPP2R5C protein promotes the reaction [Camptothecin results in increased expression of H2AFX protein modified form]25772433
D002166CamptothecinPPP2R5E protein inhibits the reaction [Camptothecin results in increased expression of H2AFX protein modified form]25772433
D002166Camptothecin[Propyl Gallate results in decreased phosphorylation of H2AFX protein] inhibits the reaction [Camptothecin results in increased activity of and affects the localization of MDC1 protein]26928355
D002166CamptothecinTDP1 protein inhibits the reaction [Camptothecin results in increased expression of H2AFX protein]21227924
D002166CamptothecinTDP1 protein inhibits the reaction [veliparib promotes the reaction [Camptothecin results in increased expression of H2AFX protein]]21227924
D002166Camptothecinveliparib promotes the reaction [Camptothecin results in increased expression of H2AFX protein]21227924
D002166CamptothecinCamptothecin results in increased expression of H2AFX protein17875725
D002166CamptothecinCamptothecin results in increased expression of H2AFX protein17875725
D002211CapsaicinCapsaicin results in increased localization of H2AFX protein22226932
D002219CarbamatesCarbamates analog results in increased phosphorylation of and results in increased activity of H2AFX protein19376255
D002219CarbamatesCarbamates analog results in increased phosphorylation of H2AFX protein19111005
C524865carfilzomib[carfilzomib co-treated with vorinostat] results in increased expression of H2AFX protein20233973
D002330CarmustineCarmustine affects the localization of H2AFX protein20472715
D002330CarmustineCarmustine results in decreased expression of H2AFX mRNA15980968
D002330CarmustineCarmustine results in increased phosphorylation of H2AFX protein20472715
D002330CarmustineMDM4 protein promotes the reaction [Carmustine affects the localization of H2AFX protein]20472715
D002330CarmustineMDM4 protein promotes the reaction [Carmustine results in increased phosphorylation of H2AFX protein]20472715
D002392CatechinCatechin inhibits the reaction [[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone co-treated with Benzo(a)pyrene] results in increased phosphorylation of H2AFX protein]21882252
D000068579CelecoxibCelecoxib inhibits the reaction [Etoposide results in increased phosphorylation of H2AFX protein]21745461
D002699ChlorambucilChlorambucil analog results in increased phosphorylation of H2AFX protein16861886
C001599chloritechlorite promotes the reaction [Bromates results in increased phosphorylation of H2AFX protein]21864635
D002737ChloropreneChloroprene results in increased expression of H2AFX mRNA23125180
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased phosphorylation of H2AFX protein20548288
C074702chromium hexavalent ionATR protein affects the reaction [chromium hexavalent ion results in increased phosphorylation of H2AFX protein]25288669
C074702chromium hexavalent ionATR protein affects the reaction [chromium hexavalent ion results in increased ubiquitination of H2AFX protein]25288669
C074702chromium hexavalent ionchromium hexavalent ion results in increased phosphorylation of H2AFX protein25288669
C074702chromium hexavalent ionchromium hexavalent ion results in increased ubiquitination of H2AFX protein25288669
C074702chromium hexavalent ionATR protein affects the reaction [chromium hexavalent ion results in increased phosphorylation of H2AFX protein]25288669
C074702chromium hexavalent ionATR protein affects the reaction [chromium hexavalent ion results in increased ubiquitination of H2AFX protein]25288669
C074702chromium hexavalent ionchromium hexavalent ion results in increased expression of H2AFX protein25352572
C074702chromium hexavalent ionchromium hexavalent ion results in increased phosphorylation of H2AFX protein25288669
C074702chromium hexavalent ionchromium hexavalent ion results in increased ubiquitination of H2AFX protein25288669
C530333cis-diammine(pyridine)chloroplatinum(II)cis-diammine(pyridine)chloroplatinum(II) results in increased phosphorylation of and results in increased ubiquitination of H2AFX protein21750216
D007464ClioquinolClioquinol results in increased phosphorylation of H2AFX protein22627294
C068329clofarabine[clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased expression of H2AFX protein20933509
C034456CMF regimenH2AFX mRNA affects the susceptibility to CMF regimen18925433
C018021cobaltous chlorideAcetylcysteine inhibits the reaction [cobaltous chloride promotes the reaction [nickel chloride results in increased phosphorylation of H2AFX protein]]22172632
C018021cobaltous chlorideAcetylcysteine inhibits the reaction [cobaltous chloride results in increased phosphorylation of H2AFX protein]22172632
C018021cobaltous chlorideAcetylcysteine inhibits the reaction [nickel chloride promotes the reaction [cobaltous chloride results in increased phosphorylation of H2AFX protein]]22172632
C018021cobaltous chloridecobaltous chloride promotes the reaction [nickel chloride results in increased phosphorylation of H2AFX protein]22172632
C018021cobaltous chloridecobaltous chloride results in decreased expression of H2AFX mRNA19376846
C018021cobaltous chloridecobaltous chloride results in increased phosphorylation of H2AFX protein22172632
C018021cobaltous chloridenickel chloride promotes the reaction [cobaltous chloride results in increased phosphorylation of H2AFX protein]22172632
C018021cobaltous chloridecobaltous chloride results in decreased expression of H2AFX mRNA24386269
D003300Copper"[Copper binds to phthalic acid binds to 1,10-phenanthroline] which results in increased expression of H2AFX protein modified form"22659117
D003300Copper"[Copper binds to phthalic acid binds to 2,2'-Dipyridyl] which results in increased expression of H2AFX protein modified form"22659117
C464760copper-1,10-phenanthroline"copper-1,10-phenanthroline results in increased expression of H2AFX protein modified form"24638265
D019327Copper SulfateCopper Sulfate results in decreased expression of H2AFX mRNA19549813
D003375Coumestrol"[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of H2AFX mRNA"19167446
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of H2AFX mRNA19167446
D003375CoumestrolCoumestrol results in increased expression of H2AFX mRNA19167446
D003375CoumestrolCoumestrol results in increased expression of H2AFX protein modified form28986287
C408982CPG-oligonucleotideCPG-oligonucleotide results in decreased expression of H2AFX mRNA21878529
C408982CPG-oligonucleotideCPG-oligonucleotide results in decreased expression of H2AFX mRNA21878529
C408982CPG-oligonucleotideCPG-oligonucleotide results in increased expression of H2AFX mRNA21878529
C029892cupric chloridecupric chloride results in increased phosphorylation of H2AFX protein20435356
C030973cupric oxidecupric oxide analog results in increased expression of H2AFX protein27270449
C030973cupric oxidecupric oxide results in decreased expression of H2AFX mRNA22077320
D003474Curcumin[Curcumin co-treated with Metribolone] results in increased phosphorylation of H2AFX protein21134073
D003474CurcuminCurcumin results in increased phosphorylation of H2AFX protein19401701|2113407
D003474Curcumin[Isoflavones co-treated with Curcumin] results in increased phosphorylation of H2AFX protein21134073
D016572CyclosporineCyclosporine results in decreased expression of H2AFX mRNA20106945|2163298
C037304cyhalothrin[fludioxonil co-treated with cyprodinil co-treated with procymidone co-treated with iprodione co-treated with cyhalothrin] results in increased phosphorylation of H2AFX protein22389207
C108338cyprodinilcyprodinil results in increased phosphorylation of H2AFX protein22389207
C108338cyprodinil[fludioxonil co-treated with cyprodinil co-treated with procymidone co-treated with iprodione co-treated with cyhalothrin] results in increased phosphorylation of H2AFX protein22389207
D003561CytarabineCytarabine results in increased phosphorylation of H2AFX protein19628630
C515055darinaparsindarinaparsin results in increased phosphorylation of H2AFX protein22535156
D003630DaunorubicinDaunorubicin affects the expression of H2AFX mRNA27780733
C014347decitabineATM protein affects the reaction [decitabine results in increased expression of H2AFX protein]17991895
C014347decitabinedecitabine affects the localization of H2AFX protein17991895
C014347decitabinedecitabine results in increased expression of H2AFX protein17991895|1822369
C014347decitabinedecitabine results in increased phosphorylation of H2AFX protein19215824|1973295
C014347decitabineDNMT1 protein affects the reaction [decitabine results in increased expression of H2AFX protein]17991895
C014347decitabinepifithrin inhibits the reaction [decitabine results in increased phosphorylation of H2AFX protein]19732952
C014347decitabinewortmannin inhibits the reaction [decitabine results in increased expression of H2AFX protein]17991895
D003847DeoxyglucoseDeoxyglucose results in decreased expression of H2AFX protein23363784
D003907Dexamethasone[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone] results in decreased expression of H2AFX mRNA26424790
C539263di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone"di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone affects the expression of H2AFX protein"25130544
D016190CarboplatinCarboplatin results in increased expression of H2AFX protein22302033
D016190Carboplatinpalbociclib inhibits the reaction [Carboplatin results in increased expression of H2AFX protein]22302033
C121930dibenzo(a,l)pyrene diol epoxide"dibenzo(a,l)pyrene diol epoxide affects the phosphorylation of H2AFX protein"18848825
C121930dibenzo(a,l)pyrene diol epoxide"[Hydrogen Peroxide co-treated with dibenzo(a,l)pyrene diol epoxide] results in increased phosphorylation of H2AFX protein"18848825
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of H2AFX mRNA17361019|2126653
D002945CisplatinCisplatin results in increased phosphorylation of H2AFX protein24743697
D002945Cisplatinarsenic trioxide inhibits the reaction [SHH protein inhibits the reaction [Cisplatin results in increased phosphorylation of H2AFX protein]]23861973
D002945CisplatinBMI1 inhibits the reaction [Cisplatin results in increased phosphorylation of H2AFX protein]21445297
D002945CisplatinBRCA1 mutant form promotes the reaction [RRM2 mutant form promotes the reaction [TP53 mutant form promotes the reaction [Cisplatin results in increased phosphorylation of H2AFX protein]]]21875941
D002945CisplatinCisplatin results in increased expression of H2AFX mRNA27594783
D002945CisplatinCisplatin results in increased expression of H2AFX protein21500194|2238352
D002945CisplatinCisplatin results in increased expression of H2AFX protein modified form22659117|2499962
D002945CisplatinCisplatin results in increased phosphorylation of and results in increased ubiquitination of H2AFX protein21750216
D002945CisplatinCisplatin results in increased phosphorylation of H2AFX protein20145152|2128535
D002945CisplatinERCC1 mutant form inhibits the reaction [RRM2 mutant form promotes the reaction [TP53 mutant form promotes the reaction [Cisplatin results in increased phosphorylation of H2AFX protein]]]21875941
D002945CisplatinERCC1 mutant form inhibits the reaction [TP53 mutant form promotes the reaction [Cisplatin results in increased phosphorylation of H2AFX protein]]21875941
D002945CisplatinERCC5 mutant form inhibits the reaction [RRM2 mutant form promotes the reaction [TP53 mutant form promotes the reaction [Cisplatin results in increased phosphorylation of H2AFX protein]]]21875941
D002945CisplatinERCC6 protein inhibits the reaction [Cisplatin results in increased phosphorylation of H2AFX protein]21324906
D002945CisplatinH2AFX gene mutant form inhibits the reaction [MIR138-1 results in increased susceptibility to Cisplatin]21693595
D002945CisplatinLovastatin inhibits the reaction [Cisplatin results in increased phosphorylation of H2AFX protein]21356574
D002945Cisplatin[MIR138-1 results in decreased expression of H2AFX] which results in increased susceptibility to Cisplatin21693595
D002945CisplatinMIR630 mRNA inhibits the reaction [Cisplatin results in increased phosphorylation of H2AFX protein]20145152
D002945Cisplatin[Proadifen co-treated with Cisplatin] results in increased phosphorylation of H2AFX protein26721606
D002945CisplatinQuercetin inhibits the reaction [Cisplatin results in increased expression of H2AFX protein modified form]24999622
D002945CisplatinRRM2 mutant form promotes the reaction [TP53 mutant form promotes the reaction [Cisplatin results in increased phosphorylation of H2AFX protein]]21875941
D002945CisplatinS100A11 mutant form promotes the reaction [Cisplatin results in increased expression of H2AFX protein]25940438
D002945CisplatinSHH protein inhibits the reaction [Cisplatin results in increased phosphorylation of H2AFX protein]23861973
D002945CisplatinTP53 mutant form promotes the reaction [Cisplatin results in increased phosphorylation of H2AFX protein]21875941
D002945CisplatinTriiodothyronine analog promotes the reaction [Cisplatin results in increased expression of H2AFX protein]22383522
D002945CisplatinXPA mutant form inhibits the reaction [RRM2 mutant form promotes the reaction [TP53 mutant form promotes the reaction [Cisplatin results in increased phosphorylation of H2AFX protein]]]21875941
D002945CisplatinCisplatin results in increased expression of H2AFX protein26723870
D002945CisplatinCisplatin results in increased expression of H2AFX protein modified form26739623
D002945CisplatinCisplatin results in increased phosphorylation of H2AFX protein21285353|2159348
D002945Cisplatinerdosteine inhibits the reaction [Cisplatin results in increased phosphorylation of H2AFX protein]26193055
D002945CisplatinLovastatin inhibits the reaction [Cisplatin results in increased expression of H2AFX protein modified form]26739623
D002945CisplatinPRKDC protein mutant form promotes the reaction [Cisplatin results in increased phosphorylation of H2AFX protein]21324906
D002945CisplatinCisplatin results in increased expression of H2AFX protein modified form26739623
D002945CisplatinLovastatin inhibits the reaction [Cisplatin results in increased expression of H2AFX protein modified form]26739623
D004041Dietary FatsDietary Fats results in decreased expression of H2AFX mRNA25016146
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of H2AFX protein modified form27746196
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of H2AFX protein26589970
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of H2AFX mRNA15890375
D002117CalcitriolCalcitriol results in decreased expression of H2AFX mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of H2AFX mRNA21592394
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of H2AFX protein"25448685
D0151279,10-Dimethyl-1,2-benzanthracene"A gene mutant form affects the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of H2AFX protein]"25448685
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of H2AFX protein"23969067
D004126DimethylformamideDimethylformamide results in increased expression of H2AFX protein26387567
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of H2AFX mRNA15890375
C024629dimethyl phthalatedimethyl phthalate affects the expression of H2AFX mRNA26924002
D004139DinitrofluorobenzeneDinitrofluorobenzene results in increased expression of H2AFX mRNA23999411
D004221DisulfiramDisulfiram inhibits the reaction [propylene dichloride results in increased phosphorylation of H2AFX protein]28300663
C067311docetaxelAphidicolin inhibits the reaction [docetaxel results in increased expression of H2AFX protein]20878124
C067311docetaxeldocetaxel results in increased expression of H2AFX protein20878124
C067311docetaxelwortmannin promotes the reaction [docetaxel results in increased expression of H2AFX protein]20878124
D004317DoxorubicinAcetylcysteine inhibits the reaction [Doxorubicin results in increased phosphorylation of H2AFX protein]15489221
D004317DoxorubicinDoxorubicin affects the expression of H2AFX mRNA27780733
D004317DoxorubicinDoxorubicin inhibits the reaction [palbociclib results in decreased phosphorylation of H2AFX protein]22751436
D004317DoxorubicinDoxorubicin promotes the reaction [[CD40LG protein co-treated with IL4 protein] results in increased expression of H2AFX protein modified form]27634759
D004317DoxorubicinDoxorubicin results in increased expression of H2AFX protein22302033
D004317DoxorubicinDoxorubicin results in increased phosphorylation of H2AFX protein15489221|1643217
D004317Doxorubicinpalbociclib inhibits the reaction [Doxorubicin results in increased expression of H2AFX protein]22302033
D004317Doxorubicinshogaol analog inhibits the reaction [Doxorubicin results in increased phosphorylation of H2AFX protein]23899529
D004317DoxorubicinDoxorubicin results in increased expression of H2AFX protein17875725
D004317DoxorubicinDoxorubicin results in increased expression of H2AFX protein modified form28710503
D004317DoxorubicinDoxorubicin results in increased phosphorylation of H2AFX protein22712078
D004317DoxorubicinLovastatin inhibits the reaction [Doxorubicin results in increased expression of H2AFX protein modified form]28710503
D004317DoxorubicinLovastatin inhibits the reaction [Doxorubicin results in increased phosphorylation of H2AFX protein]22712078
D004317DoxorubicinNSC 23766 inhibits the reaction [Doxorubicin results in increased expression of H2AFX protein modified form]28710503
D004317DoxorubicinTOP2B protein affects the reaction [Doxorubicin results in increased expression of H2AFX protein]17875725
D004317Doxorubicin"4,4'-(1,2-dimethyl-1,2-ethanediyl)bis-2,6-piperazinedione inhibits the reaction [Doxorubicin results in increased expression of H2AFX protein]"17875725
D004317Doxorubicinbenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Doxorubicin results in increased expression of H2AFX protein]17875725
D004317DoxorubicinBortezomib inhibits the reaction [Doxorubicin results in increased expression of H2AFX protein]17875725
D004317DoxorubicinDoxorubicin results in increased expression of H2AFX protein17875725
D004317DoxorubicinDoxorubicin results in increased expression of H2AFX protein modified form24902966
D004317DoxorubicinQuercetin inhibits the reaction [Doxorubicin results in increased expression of H2AFX protein modified form]24902966
D004317DoxorubicinRazoxane inhibits the reaction [Doxorubicin results in increased expression of H2AFX protein]17875725
C561944EMD 534085EMD 534085 results in increased expression of H2AFX protein modified form18451153
D004642EmodinEmodin results in increased expression of H2AFX protein modified form20855424
D004642EmodinTOP2A affects the reaction [Emodin results in increased expression of H2AFX protein modified form]20855424
D004809Ephedrine[Caffeine co-treated with Ephedrine] results in increased phosphorylation of H2AFX protein15537744
C045651epigallocatechin gallateepigallocatechin gallate inhibits the reaction [epigallocatechin gallate results in increased phosphorylation of H2AFX protein]25528115
C045651epigallocatechin gallateepigallocatechin gallate results in increased expression of H2AFX protein25585349|2917557
C045651epigallocatechin gallateepigallocatechin gallate results in increased phosphorylation of H2AFX protein25528115
C093787epothilone A[epothilone A co-treated with Metformin] results in increased expression of H2AFX mRNA29117515
C093787epothilone Aepothilone A results in increased expression of H2AFX mRNA29117515
C048498erdosteineerdosteine inhibits the reaction [Cisplatin results in increased phosphorylation of H2AFX protein]26193055
D000069347Erlotinib HydrochlorideErlotinib Hydrochloride promotes the reaction [resveratrol results in increased expression of H2AFX protein modified form]25895606
D000069347Erlotinib HydrochlorideErlotinib Hydrochloride results in increased expression of H2AFX protein modified form25895606
D000069347Erlotinib Hydrochlorideresveratrol promotes the reaction [Erlotinib Hydrochloride results in increased expression of H2AFX protein modified form]25895606
C007366erythritol anhydrideAcetylcysteine inhibits the reaction [erythritol anhydride results in increased expression of H2AFX protein modified form]25633853
C007366erythritol anhydrideerythritol anhydride results in increased expression of H2AFX protein modified form25633853
C007633estragoleestragole results in increased expression of H2AFX protein modified form29054680
D000431EthanolEthanol results in decreased expression of H2AFX mRNA24355176
D000431EthanolEthanol results in increased phosphorylation of H2AFX protein24374569
D000431EthanolBRCA1 gene mutant form promotes the reaction [Ethanol results in increased phosphorylation of H2AFX protein]26629949
D000431Ethanol[BRCA1 gene mutant form results in increased susceptibility to Ethanol] which results in increased phosphorylation of H2AFX protein26629949
D000431EthanolEthanol results in increased phosphorylation of H2AFX protein26629949
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of H2AFX mRNA12072388
D005047EtoposideEtoposide results in increased phosphorylation of H2AFX protein24743697
D005047EtoposideCelecoxib inhibits the reaction [Etoposide results in increased phosphorylation of H2AFX protein]21745461
D005047EtoposideEtoposide results in increased expression of H2AFX protein22302033|2625960
D005047EtoposideEtoposide results in increased phosphorylation of H2AFX protein20978201|2174546
D005047EtoposideN-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [Etoposide results in increased phosphorylation of H2AFX protein]21745461
D005047Etoposidenimesulide inhibits the reaction [Etoposide results in increased phosphorylation of H2AFX protein]21745461
D005047Etoposidepalbociclib inhibits the reaction [Etoposide results in increased expression of H2AFX protein]22302033
D005047Etoposidepifithrin promotes the reaction [Etoposide results in increased expression of H2AFX protein]26259609
D005047Etoposide4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [Etoposide results in increased expression of H2AFX protein]20643100
D005047EtoposideEtoposide results in increased expression of H2AFX protein17875725|2064310
D005047EtoposideH2AFX protein results in decreased susceptibility to Etoposide21555580
D005047EtoposideTOP2B protein affects the reaction [Etoposide results in increased expression of H2AFX protein]17875725
D005047Etoposide"4,4'-(1,2-dimethyl-1,2-ethanediyl)bis-2,6-piperazinedione inhibits the reaction [Etoposide results in increased expression of H2AFX protein]"17875725
D005047Etoposidebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Etoposide results in increased expression of H2AFX protein]17875725
D005047EtoposideBortezomib inhibits the reaction [Etoposide results in increased expression of H2AFX protein]17875725
D005047EtoposideEtoposide results in increased expression of H2AFX protein17875725
D005047EtoposideRazoxane inhibits the reaction [Etoposide results in increased expression of H2AFX protein]17875725
D015025ZearalenoneZearalenone results in increased expression of H2AFX protein modified form28089945|2855277
C000499ferric oxideferric oxide analog results in increased expression of H2AFX protein27270449
C000499ferric oxideOxygen deficiency inhibits the reaction [ferric oxide analog results in increased expression of H2AFX protein]27270449
C020748ferrous sulfate2-tert-butylhydroquinone inhibits the reaction [ferrous sulfate results in increased expression of H2AFX protein]28583816
C020748ferrous sulfateferrous sulfate results in increased expression of H2AFX protein28583816
D044950Flavanones2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one promotes the reaction [Flavanones results in increased phosphorylation of H2AFX protein]21616090
D044950FlavanonesCDKN1A gene mutant form promotes the reaction [Flavanones results in increased phosphorylation of H2AFX protein]21616090
D044950FlavanonesFlavanones results in increased phosphorylation of H2AFX protein21616090
D044950FlavanonesPI103 promotes the reaction [Flavanones results in increased phosphorylation of H2AFX protein]21616090
D044950FlavanonesTP53 gene mutant form promotes the reaction [Flavanones results in increased phosphorylation of H2AFX protein]21616090
D044950FlavanonesU 0126 promotes the reaction [Flavanones results in increased phosphorylation of H2AFX protein]21616090
C024352fludarabineAcetylcysteine inhibits the reaction [[fludarabine co-treated with LAQ824] results in increased expression of H2AFX protein]18852132
C024352fludarabine[clofarabine co-treated with fludarabine co-treated with Busulfan] results in increased expression of H2AFX protein20933509
C024352fludarabine[fludarabine co-treated with LAQ824] results in increased expression of H2AFX protein18852132
C024352fludarabinefludarabine results in increased expression of H2AFX protein18852132
C024352fludarabinemanganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [[fludarabine co-treated with LAQ824] results in increased expression of H2AFX protein]18852132
C108339fludioxonil[fludioxonil co-treated with cyprodinil co-treated with procymidone co-treated with iprodione co-treated with cyhalothrin] results in increased phosphorylation of H2AFX protein22389207
C108339fludioxonilfludioxonil results in increased phosphorylation of H2AFX protein22389207
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in decreased expression of H2AFX mRNA28329830
D0150732-Acetylaminofluorene2-Acetylaminofluorene results in increased expression of H2AFX protein26338220
D005472Fluorouracilbenzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [[Fluorouracil co-treated with olaparib] results in increased phosphorylation of H2AFX protein]26544897
D005472FluorouracilFluorouracil affects the expression of H2AFX mRNA16584549
D005472Fluorouracil[Fluorouracil co-treated with olaparib] results in increased phosphorylation of H2AFX protein26544897
D005472FluorouracilFluorouracil results in increased phosphorylation of H2AFX protein26544897
D005472Fluorouracil[S100A11 mutant form results in increased susceptibility to Fluorouracil] which results in increased expression of H2AFX protein25940438
D005472FluorouracilTP53 gene mutant form affects the reaction [benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [[Fluorouracil co-treated with olaparib] results in increased phosphorylation of H2AFX protein]]26544897
D005472FluorouracilTP53 protein affects the reaction [Fluorouracil results in decreased expression of H2AFX mRNA]15016801
D005485FlutamideFlutamide results in increased expression of H2AFX mRNA24793618
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased phosphorylation of H2AFX protein20548288
C010238fomepizolefomepizole inhibits the reaction [propylene dichloride results in increased phosphorylation of H2AFX protein]28300663
C054368fotemustinefotemustine results in increased expression of H2AFX protein modified form25125662
C070081fulvestrantfulvestrant inhibits the reaction [bisphenol A results in increased expression of H2AFX protein]23788033
C070081fulvestrantfulvestrant inhibits the reaction [Estradiol results in increased expression of H2AFX protein]23788033
C056933fumonisin B1fumonisin B1 results in decreased expression of H2AFX protein25800559
C039281furanfuran results in increased methylation of H2AFX gene22079235
D019833GenisteinATM protein affects the reaction [Genistein results in increased phosphorylation of H2AFX protein]15177039
D019833GenisteinGenistein results in increased expression of H2AFX mRNA16474171
D019833GenisteinGenistein results in increased phosphorylation of H2AFX protein15177039
C023847Glu-P-2Glu-P-2 results in increased expression of H2AFX protein modified form28160022
D005978GlutathioneGlutathione inhibits the reaction [2-chloroethyl ethyl sulfide results in increased phosphorylation of H2AFX protein]21722719
D006575Heterocyclic Compounds, 3-Ring"Heterocyclic Compounds, 3-Ring results in increased expression of H2AFX protein"21500194
D006861Hydrogen PeroxideHydrogen Peroxide results in increased phosphorylation of H2AFX protein18793623|2474369
D006861Hydrogen Peroxidemorin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of H2AFX protein]18793623
D006861Hydrogen PeroxideAcetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of H2AFX protein]28300663
D006861Hydrogen Peroxide[ERCC6 protein affects the susceptibility to Hydrogen Peroxide] which affects the expression of H2AFX protein25136123
D006861Hydrogen Peroxide"[Hydrogen Peroxide co-treated with 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide] results in increased phosphorylation of H2AFX protein"18848825
D006861Hydrogen Peroxide"[Hydrogen Peroxide co-treated with dibenzo(a,l)pyrene diol epoxide] results in increased phosphorylation of H2AFX protein"18848825
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of H2AFX protein modified form27655674
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of H2AFX mRNA25972194
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of H2AFX protein25972194
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of H2AFX protein modified form29074359
D006861Hydrogen PeroxideHydrogen Peroxide results in increased phosphorylation of H2AFX protein28300663
D006861Hydrogen PeroxideMIRLET7G mRNA inhibits the reaction [Hydrogen Peroxide results in increased expression of H2AFX protein]25972194
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of H2AFX protein17875725
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of H2AFX protein17875725
C031927hydroquinonehydroquinone affects the localization of H2AFX protein modified form20036648
C031927hydroquinonehydroquinone results in increased expression of H2AFX protein alternative form21267443
C031927hydroquinonehydroquinone results in increased phosphorylation of H2AFX protein18835433
C031927hydroquinone[POLH mutant form results in increased susceptibility to hydroquinone] which results in increased expression of H2AFX protein22981619
C031927hydroquinoneWRN gene mutant form promotes the reaction [hydroquinone results in increased expression of H2AFX protein alternative form]21267443
C031927hydroquinoneWRN protein affects the reaction [hydroquinone results in increased expression of H2AFX protein]17875398
D006918HydroxyureaHydroxyurea results in increased expression of H2AFX protein25130544
D006918HydroxyureaHydroxyurea results in increased expression of H2AFX protein modified form25125662
D006918HydroxyureaHydroxyurea results in increased phosphorylation of H2AFX protein29228353
D006918HydroxyureaTRP53 gene mutant form inhibits the reaction [Hydroxyurea results in increased phosphorylation of H2AFX protein]29228353
C492448ICG 001ICG 001 results in decreased expression of H2AFX mRNA26191083
D000068877Imatinib MesylateImatinib Mesylate promotes the reaction [ON 01910 results in increased phosphorylation of H2AFX protein]26008977
D000068877Imatinib MesylateImatinib Mesylate results in increased expression of H2AFX protein20028860
D000068877Imatinib MesylateImatinib Mesylate results in increased phosphorylation of H2AFX protein26008977
D000068877Imatinib MesylateON 01910 promotes the reaction [Imatinib Mesylate results in increased phosphorylation of H2AFX protein]26008977
C056493imiquimodimiquimod results in decreased expression of H2AFX mRNA21878529
C578795indimitecanindimitecan results in increased phosphorylation of H2AFX protein21710981
C033148iprodione[fludioxonil co-treated with cyprodinil co-treated with procymidone co-treated with iprodione co-treated with cyhalothrin] results in increased phosphorylation of H2AFX protein22389207
C051890irinotecanirinotecan metabolite results in increased expression of H2AFX mRNA15956246
C051890irinotecanirinotecan results in increased expression of H2AFX mRNA15956246
D017953IsocyanatesIsocyanates analog results in increased phosphorylation of H2AFX protein19111005
D017953IsocyanatesIsocyanates results in increased expression of H2AFX protein19283680
D017953Isocyanates[Isocyanates results in increased phosphorylation of ATM protein] which results in increased phosphorylation of H2AFX protein19197993
D007529Isoflavones[Isoflavones co-treated with Curcumin] results in increased phosphorylation of H2AFX protein21134073
D007545IsoproterenolIsoproterenol results in increased expression of H2AFX mRNA21335049
C006552kaempferolkaempferol results in increased phosphorylation of H2AFX protein19028473
C006552kaempferolkaempferol results in increased expression of H2AFX protein24595819
C477361LAQ824Acetylcysteine inhibits the reaction [[fludarabine co-treated with LAQ824] results in increased expression of H2AFX protein]18852132
C477361LAQ824Acetylcysteine inhibits the reaction [LAQ824 results in increased expression of H2AFX protein]18852132
C477361LAQ824[fludarabine co-treated with LAQ824] results in increased expression of H2AFX protein18852132
C477361LAQ824LAQ824 results in increased expression of H2AFX protein18852132
C477361LAQ824manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [[fludarabine co-treated with LAQ824] results in increased expression of H2AFX protein]18852132
C477361LAQ824manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [LAQ824 results in increased expression of H2AFX protein]18852132
D007840LatexLatex analog results in increased expression of H2AFX mRNA24768652
C045463leflunomideleflunomide results in decreased expression of H2AFX mRNA28988120
C038753leptomycin Bleptomycin B promotes the reaction [Bortezomib results in increased expression of H2AFX protein modified form]16778179
C506643liposomal doxorubicinliposomal doxorubicin results in increased phosphorylation of H2AFX protein27923599
D008130LomustineLomustine results in increased phosphorylation of H2AFX protein24743697
C581034longikaurin Alongikaurin A results in increased expression of H2AFX protein modified form28801140
D008148LovastatinLovastatin inhibits the reaction [Cisplatin results in increased phosphorylation of H2AFX protein]21356574
D008148LovastatinLovastatin inhibits the reaction [Cisplatin results in increased expression of H2AFX protein modified form]26739623
D008148LovastatinLovastatin inhibits the reaction [Doxorubicin results in increased expression of H2AFX protein modified form]28710503
D008148LovastatinLovastatin inhibits the reaction [Doxorubicin results in increased phosphorylation of H2AFX protein]22712078
D008148LovastatinLovastatin inhibits the reaction [Cisplatin results in increased expression of H2AFX protein modified form]26739623
C048341mafosfamidemafosfamide results in increased phosphorylation of H2AFX protein24743697
C097284manganese(III)-tetrakis(4-benzoic acid)porphyrinmanganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [[fludarabine co-treated with LAQ824] results in increased expression of H2AFX protein]18852132
C097284manganese(III)-tetrakis(4-benzoic acid)porphyrinmanganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [LAQ824 results in increased expression of H2AFX protein]18852132
C097284manganese(III)-tetrakis(4-benzoic acid)porphyrinmanganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [resveratrol promotes the reaction [panobinostat results in increased expression of H2AFX protein]]22923501
C054474manumycinAcetylcysteine inhibits the reaction [manumycin results in increased phosphorylation of H2AFX protein]19409983
C054474manumycinmanumycin results in increased phosphorylation of H2AFX protein19409983
D008466MechlorethamineMechlorethamine results in increased expression of H2AFX protein modified form25891025
D008627Mercuric ChlorideMercuric Chloride affects the expression of H2AFX mRNA20353558
D008687Metformin[epothilone A co-treated with Metformin] results in increased expression of H2AFX mRNA29117515
D008687MetforminMetformin results in decreased expression of H2AFX protein23363784
D008687MetforminMetformin results in increased expression of H2AFX mRNA29117515
D008701MethapyrileneMethapyrilene results in increased expression of H2AFX mRNA15890375
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased phosphorylation of H2AFX protein20548288
D008727MethotrexateH2AFX protein affects the susceptibility to Methotrexate16217747
D008727MethotrexateMethotrexate results in increased phosphorylation of H2AFX protein21114963
D008730MethoxsalenMethoxsalen inhibits the reaction [aflatoxin G1 results in increased expression of H2AFX protein modified form]23907605
C005223methyleugenolmethyleugenol results in increased expression of H2AFX protein26011634
C000614724methyleugenol-2',3'-epoxide"methyleugenol-2',3'-epoxide results in increased expression of H2AFX protein"26542539
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased phosphorylation of H2AFX protein24743697
D008769MethylnitronitrosoguanidineMethylnitronitrosoguanidine results in increased phosphorylation of H2AFX protein24743697
D0156551-Methyl-4-phenylpyridinium1-Methyl-4-phenylpyridinium results in decreased expression of H2AFX mRNA24810058
D015741MetriboloneATM mutant form inhibits the reaction [Metribolone results in increased expression of H2AFX protein]23272087
D015741Metribolone[ATM mutant form inhibits the reaction [Metribolone results in increased expression of H2AFX protein]] which results in increased expression of ERG mRNA23272087
D015741MetriboloneATR mutant form inhibits the reaction [Metribolone results in increased expression of H2AFX protein]23272087
D015741Metribolone[Curcumin co-treated with Metribolone] results in increased phosphorylation of H2AFX protein21134073
D015741MetriboloneMetribolone results in increased expression of H2AFX protein23272087
D016685MitomycinMitomycin results in increased phosphorylation of H2AFX protein24743697
D016685MitomycinMitomycin results in increased phosphorylation of H2AFX protein21386838
D008942MitoxantroneMitoxantrone results in increased expression of H2AFX protein24994473
C517284monomethyl phthalatemonomethyl phthalate affects the expression of H2AFX mRNA26924002
C008548morinmorin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of H2AFX protein]18793623
C568376MT19c compoundMT19c compound results in decreased expression of H2AFX mRNA21781307
D009151Mustard GasMustard Gas results in increased expression of H2AFX protein modified form25102026
D009151Mustard GasMustard Gas results in increased phosphorylation of H2AFX protein20435105|2544827
D009151Mustard Gaspifithrin promotes the reaction [Mustard Gas results in increased phosphorylation of H2AFX protein]25448276
C080955N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamideN-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [Etoposide results in increased phosphorylation of H2AFX protein]21745461
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of H2AFX mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of H2AFX mRNA"25554681
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate affects the expression of H2AFX protein26011634
D009532NickelNickel results in increased expression of H2AFX mRNA25583101
C119536nickel acetateNFE2L2 protein inhibits the reaction [nickel acetate results in increased expression of H2AFX mRNA]23023193
C119536nickel acetatenickel acetate results in decreased expression of H2AFX mRNA23023193
C022838nickel chlorideAcetylcysteine inhibits the reaction [cobaltous chloride promotes the reaction [nickel chloride results in increased phosphorylation of H2AFX protein]]22172632
C022838nickel chlorideAcetylcysteine inhibits the reaction [nickel chloride promotes the reaction [cobaltous chloride results in increased phosphorylation of H2AFX protein]]22172632
C022838nickel chlorideAcetylcysteine inhibits the reaction [nickel chloride results in increased phosphorylation of H2AFX protein]22172632
C022838nickel chloridecobaltous chloride promotes the reaction [nickel chloride results in increased phosphorylation of H2AFX protein]22172632
C022838nickel chloridenickel chloride promotes the reaction [cobaltous chloride results in increased phosphorylation of H2AFX protein]22172632
C022838nickel chloridenickel chloride results in decreased expression of H2AFX mRNA17312168
C022838nickel chloridenickel chloride results in increased expression of H2AFX protein modified form28552779
C022838nickel chloridenickel chloride results in increased phosphorylation of H2AFX protein22172632
C028007nickel monoxidenickel monoxide analog results in increased expression of H2AFX protein27270449
C028007nickel monoxideOxygen deficiency inhibits the reaction [nickel monoxide analog results in increased expression of H2AFX protein]27270449
D009538NicotineNicotine inhibits the reaction [aflatoxin G1 results in increased expression of H2AFX protein modified form]23907605
C012655nimesulidenimesulide inhibits the reaction [Etoposide results in increased phosphorylation of H2AFX protein]21745461
D015376NimustineNimustine results in increased phosphorylation of H2AFX protein26418950
D009588Nitrogen Mustard CompoundsMGMT protein affects the reaction [Nitrogen Mustard Compounds results in increased expression of H2AFX protein]27342729
D009588Nitrogen Mustard CompoundsNitrogen Mustard Compounds results in decreased expression of and results in increased phosphorylation of H2AFX protein27342729
D009588Nitrogen Mustard CompoundsNitrogen Mustard Compounds results in increased expression of H2AFX mRNA27342729
D009588Nitrogen Mustard CompoundsNitrogen Mustard Compounds results in increased expression of H2AFX protein27342729
D0151124-Nitroquinoline-1-oxide4-Nitroquinoline-1-oxide results in increased phosphorylation of H2AFX protein24743697
D015739NocodazoleNocodazole results in increased expression of H2AFX protein modified form26914363
D009640NorethindroneNorethindrone results in increased phosphorylation of H2AFX protein15905198
C487513NSC 23766NSC 23766 inhibits the reaction [Doxorubicin results in increased expression of H2AFX protein modified form]28710503
C553898NSC 7249983-amino-6-(4-(methylsulfonyl)phenyl)-N-phenylpyrazine-2-carboxamide inhibits the reaction [NSC 724998 results in increased expression of H2AFX protein modified form]25269479
C553898NSC 724998NSC 724998 results in increased expression of H2AFX protein modified form25269479
C553898NSC 724998NSC 724998 results in increased phosphorylation of H2AFX protein21710981
C025589ochratoxin Aochratoxin A results in decreased expression of H2AFX mRNA19287073
C025589ochratoxin Aochratoxin A results in increased expression of H2AFX protein28286205
C025589ochratoxin Aochratoxin A results in increased expression of H2AFX mRNA23358140
C025589ochratoxin Aochratoxin A results in increased expression of H2AFX protein modified form24243707
C531550olaparibbenzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [[Fluorouracil co-treated with olaparib] results in increased phosphorylation of H2AFX protein]26544897
C531550olaparib[Fluorouracil co-treated with olaparib] results in increased phosphorylation of H2AFX protein26544897
C531550olaparibTP53 gene mutant form affects the reaction [benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [[Fluorouracil co-treated with olaparib] results in increased phosphorylation of H2AFX protein]]26544897
C507134ON 01910Imatinib Mesylate promotes the reaction [ON 01910 results in increased phosphorylation of H2AFX protein]26008977
C507134ON 01910ON 01910 promotes the reaction [Imatinib Mesylate results in increased phosphorylation of H2AFX protein]26008977
C507134ON 01910ON 01910 results in increased expression of H2AFX protein25316768
C507134ON 01910ON 01910 results in increased phosphorylation of H2AFX protein21646468|2558085
C030110oxaliplatinoxaliplatin results in increased phosphorylation of H2AFX protein24743697
C030110oxaliplatinMSH3 protein promotes the reaction [oxaliplatin results in increased phosphorylation of and affects the localization of H2AFX protein]21285347
C030110oxaliplatinoxaliplatin affects the localization of H2AFX protein modified form19735649
C030110oxaliplatinoxaliplatin results in increased expression of H2AFX protein modified form19735649
C030110oxaliplatinoxaliplatin results in increased phosphorylation of and affects the localization of H2AFX protein21285347
C030110oxaliplatinoxaliplatin results in increased phosphorylation of and results in increased ubiquitination of H2AFX protein21750216
C030110oxaliplatin[pifithrin results in decreased phosphorylation of TP53 protein] inhibits the reaction [oxaliplatin results in increased expression of H2AFX protein modified form]19735649
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of H2AFX mRNA25729387
C552952oxazolinodaunorubicinoxazolinodaunorubicin affects the expression of H2AFX mRNA27780733
D010100OxygenOxygen deficiency inhibits the reaction [ferric oxide analog results in increased expression of H2AFX protein]27270449
D010100OxygenOxygen deficiency inhibits the reaction [nickel monoxide analog results in increased expression of H2AFX protein]27270449
D010100OxygenOxygen deficiency results in decreased expression of H2AFX mRNA26516004
D017239PaclitaxelPaclitaxel results in increased expression of H2AFX protein22302033
D017239PaclitaxelPaclitaxel results in increased expression of H2AFX protein modified form18451153
D017239Paclitaxelpalbociclib inhibits the reaction [Paclitaxel results in increased expression of H2AFX protein]22302033
C500026palbociclibDoxorubicin inhibits the reaction [palbociclib results in decreased phosphorylation of H2AFX protein]22751436
C500026palbociclibpalbociclib inhibits the reaction [Camptothecin results in increased expression of H2AFX protein]22302033
C500026palbociclibpalbociclib inhibits the reaction [Carboplatin results in increased expression of H2AFX protein]22302033
C500026palbociclibpalbociclib inhibits the reaction [Doxorubicin results in increased expression of H2AFX protein]22302033
C500026palbociclibpalbociclib inhibits the reaction [Etoposide results in increased expression of H2AFX protein]22302033
C500026palbociclibpalbociclib inhibits the reaction [Paclitaxel results in increased expression of H2AFX protein]22302033
C500026palbociclibpalbociclib results in decreased phosphorylation of H2AFX protein22751436
C500026palbociclibRB1 protein affects the reaction [palbociclib results in decreased phosphorylation of H2AFX protein]22751436
C005413palmatinepalmatine results in increased expression of H2AFX protein modified form23747414
C496932panobinostatmanganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [resveratrol promotes the reaction [panobinostat results in increased expression of H2AFX protein]]22923501
C496932panobinostatpanobinostat promotes the reaction [SRT2183 results in increased expression of H2AFX protein modified form]23681230
C496932panobinostatpanobinostat results in increased expression of H2AFX protein22923501
C496932panobinostatresveratrol promotes the reaction [panobinostat results in increased expression of H2AFX protein]22923501
D052638Particulate MatterParticulate Matter results in increased expression of H2AFX protein modified form25533354
D052638Particulate MatterParticulate Matter results in increased phosphorylation of H2AFX protein23159502
C410127PCB 180Acetylcysteine inhibits the reaction [PCB 180 metabolite results in increased phosphorylation of H2AFX protein]26148434
C410127PCB 180Estradiol promotes the reaction [PCB 180 metabolite results in increased phosphorylation of H2AFX protein]26148434
C410127PCB 180PCB 180 metabolite promotes the reaction [Benzo(a)pyrene results in increased phosphorylation of H2AFX protein]26148434
C410127PCB 180PCB 180 metabolite results in increased phosphorylation of H2AFX protein26148434
C410127PCB 180PCB 180 results in increased phosphorylation of H2AFX protein26148434
D010416PentachlorophenolPentachlorophenol results in increased expression of H2AFX mRNA23892564
D010419PentamidinePentamidine affects the localization of H2AFX protein modified form20144237
D010634PhenobarbitalPhenobarbital affects the expression of H2AFX mRNA19159669
D010634PhenobarbitalPhenobarbital results in increased expression of H2AFX mRNA19363144|2309116
D019800PhenolPhenol affects the localization of H2AFX protein modified form20096274
C030090phosphoramide mustardphosphoramide mustard results in increased expression of H2AFX protein21439308
C030090phosphoramide mustardphosphoramide mustard results in increased expression of H2AFX protein21439308
C030090phosphoramide mustardphosphoramide mustard results in increased phosphorylation of and results in increased expression of H2AFX protein25497287
C032279phthalic acid"[Copper binds to phthalic acid binds to 1,10-phenanthroline] which results in increased expression of H2AFX protein modified form"22659117
C032279phthalic acid"[Copper binds to phthalic acid binds to 2,2'-Dipyridyl] which results in increased expression of H2AFX protein modified form"22659117
D010798PhycocyaninPhycocyanin inhibits the reaction [tributyltin results in increased expression of H2AFX protein modified form]26079211
C522973PI103PI103 promotes the reaction [Flavanones results in increased phosphorylation of H2AFX protein]21616090
C121565pifithrinpifithrin inhibits the reaction [decitabine results in increased phosphorylation of H2AFX protein]19732952
C121565pifithrinpifithrin promotes the reaction [Etoposide results in increased expression of H2AFX protein]26259609
C121565pifithrinpifithrin promotes the reaction [Mustard Gas results in increased phosphorylation of H2AFX protein]25448276
C121565pifithrin[pifithrin results in decreased phosphorylation of TP53 protein] inhibits the reaction [oxaliplatin results in increased expression of H2AFX protein modified form]19735649
D010882Piperonyl ButoxidePiperonyl Butoxide results in increased expression of H2AFX mRNA15890375
C006253pirinixic acidpirinixic acid results in decreased expression of H2AFX mRNA17426115
C006253pirinixic acidpirinixic acid results in increased expression of H2AFX mRNA15890375|1916217
D010894PiroxicamPiroxicam results in decreased expression of H2AFX mRNA21858171
D010936Plant ExtractsMIR23A promotes the reaction [Plant Extracts results in increased expression of H2AFX protein modified form]21750350
D010936Plant ExtractsPlant Extracts results in increased expression of H2AFX protein modified form21750350
D010936Plant ExtractsPlant Extracts results in increased expression of H2AFX protein24595819
D028321Plant PreparationsPlant Preparations results in increased expression of H2AFX protein modified form23747414
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls analog results in increased expression of H2AFX mRNA16474171
C060540polyhexamethyleneguanidinepolyhexamethyleneguanidine results in decreased expression of H2AFX mRNA24583197
C505150poly(N-vinylpyrrolidine)[Silver analog co-treated with poly(N-vinylpyrrolidine)] results in increased expression of H2AFX protein26028148
C019536potassium bromatebisphenol A inhibits the reaction [[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] which results in increased expression of H2AFX protein]25693136
C019536potassium bromate[XRCC6 gene mutant form results in increased susceptibility to potassium bromate] which results in increased expression of H2AFX protein25693136
C019536potassium bromateAzacitidine inhibits the reaction [potassium bromate results in increased phosphorylation of H2AFX protein]25015661
C019536potassium bromatepotassium bromate results in increased phosphorylation of H2AFX protein25015661
C019536potassium bromatetrichostatin A inhibits the reaction [potassium bromate results in increased phosphorylation of H2AFX protein]25015661
D011205Povidone[Silver co-treated with Povidone] results in increased expression of H2AFX protein modified form27387714
D011335Proadifen[Proadifen co-treated with Cisplatin] results in increased phosphorylation of H2AFX protein26721606
C035988procymidone[fludioxonil co-treated with cyprodinil co-treated with procymidone co-treated with iprodione co-treated with cyhalothrin] results in increased phosphorylation of H2AFX protein22389207
D011398PromethazinePromethazine results in decreased expression of H2AFX protein26011634
C045950propiconazolepropiconazole results in increased expression of H2AFX mRNA19363144|2127805
C004765propylene dichloride1-aminobenzotriazole inhibits the reaction [propylene dichloride results in increased phosphorylation of H2AFX protein]28300663
C004765propylene dichloride2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [propylene dichloride results in increased phosphorylation of H2AFX protein]28300663
C004765propylene dichlorideAcetylcysteine inhibits the reaction [propylene dichloride results in increased phosphorylation of H2AFX protein]28300663
C004765propylene dichlorideDisulfiram inhibits the reaction [propylene dichloride results in increased phosphorylation of H2AFX protein]28300663
C004765propylene dichloridefomepizole inhibits the reaction [propylene dichloride results in increased phosphorylation of H2AFX protein]28300663
C004765propylene dichloridepropylene dichloride results in increased phosphorylation of H2AFX protein28300663
C004765propylene dichloridepropylene dichloride results in increased phosphorylation of H2AFX protein28300663
D011435Propyl GallatePropyl Gallate results in decreased phosphorylation of H2AFX protein26928355
D011435Propyl Gallate[Propyl Gallate results in decreased phosphorylation of H2AFX protein] inhibits the reaction [Camptothecin results in increased activity of and affects the localization of MDC1 protein]26928355
D011441PropylthiouracilPropylthiouracil results in increased expression of H2AFX mRNA24780913
D047428Protein Kinase InhibitorsProtein Kinase Inhibitors results in increased phosphorylation of H2AFX protein21878655
C107773pterostilbene[resveratrol co-treated with pterostilbene] results in decreased expression of H2AFX protein modified form26459286
C432165pyrazolanthronepyrazolanthrone inhibits the reaction [resveratrol results in increased phosphorylation of H2AFX protein]25619392
C031280pyrazolepyrazole results in increased expression of H2AFX mRNA17945193
D011739PyrimethaminePyrimethamine results in increased phosphorylation of H2AFX protein19435820
C009131pyrimidin-2-one beta-ribofuranosidepyrimidin-2-one beta-ribofuranoside results in increased expression of H2AFX protein17991895
D011794QuercetinQuercetin inhibits the reaction [Cisplatin results in increased expression of H2AFX protein modified form]24999622
D011794QuercetinQuercetin results in increased phosphorylation of H2AFX protein15177039
D011794QuercetinQuercetin results in increased expression of H2AFX protein24595819
D011794QuercetinQuercetin inhibits the reaction [Doxorubicin results in increased expression of H2AFX protein modified form]24902966
C004532quinonequinone results in increased phosphorylation of H2AFX protein18835433
D011929RazoxaneRazoxane inhibits the reaction [Doxorubicin results in increased expression of H2AFX protein]17875725
D011929RazoxaneRazoxane inhibits the reaction [Etoposide results in increased expression of H2AFX protein]17875725
D017382Reactive Oxygen SpeciesH2AFX protein results in decreased susceptibility to Reactive Oxygen Species21555580
C031389resorcinolresorcinol results in increased expression of H2AFX mRNA22623647
C059514resveratrol4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [resveratrol results in increased phosphorylation of H2AFX protein]25619392
C059514resveratrolCaffeine inhibits the reaction [resveratrol results in increased phosphorylation of H2AFX protein]15975956
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of H2AFX mRNA19167446
C059514resveratrolErlotinib Hydrochloride promotes the reaction [resveratrol results in increased expression of H2AFX protein modified form]25895606
C059514resveratrolH2AFX protein results in increased susceptibility to resveratrol25619392
C059514resveratrolmanganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [resveratrol promotes the reaction [panobinostat results in increased expression of H2AFX protein]]22923501
C059514resveratrolpyrazolanthrone inhibits the reaction [resveratrol results in increased phosphorylation of H2AFX protein]25619392
C059514resveratrol[resveratrol co-treated with pterostilbene] results in decreased expression of H2AFX protein modified form26459286
C059514resveratrolresveratrol promotes the reaction [Erlotinib Hydrochloride results in increased expression of H2AFX protein modified form]25895606
C059514resveratrolresveratrol promotes the reaction [panobinostat results in increased expression of H2AFX protein]22923501
C059514resveratrolresveratrol promotes the reaction [vorinostat results in increased expression of H2AFX protein]22923501
C059514resveratrolresveratrol results in decreased expression of H2AFX protein23363784
C059514resveratrolresveratrol results in decreased expression of H2AFX protein modified form26459286
C059514resveratrol[resveratrol results in increased activity of [ATM protein co-treated with ATR protein]] which results in increased phosphorylation of H2AFX protein15975956
C059514resveratrolresveratrol results in increased expression of H2AFX protein22923501
C059514resveratrolresveratrol results in increased expression of H2AFX protein modified form23681230|2589560
C059514resveratrolresveratrol results in increased phosphorylation of H2AFX protein15975956|1955972
C059514resveratrol[temozolomide co-treated with resveratrol] results in increased phosphorylation of H2AFX protein23522185
D015474IsotretinoinIsotretinoin results in decreased expression of H2AFX mRNA20436886
D012176RetinoidsRetinoids analog results in increased phosphorylation of H2AFX protein17512204
C547185riccardin DCaffeine inhibits the reaction [riccardin D results in increased phosphorylation of H2AFX protein]24069304
C547185riccardin Driccardin D results in decreased expression of H2AFX mRNA24069304
C547185riccardin Driccardin D results in increased phosphorylation of H2AFX protein24069304
C087123romidepsinAcetylcysteine inhibits the reaction [[Bortezomib co-treated with romidepsin] results in increased phosphorylation of H2AFX protein]15173094
C087123romidepsin[Bortezomib co-treated with romidepsin] results in increased phosphorylation of H2AFX protein15173094
D012402RotenoneCASP1 gene mutant form inhibits the reaction [Rotenone results in increased phosphorylation of H2AFX protein]23619996
D012402RotenoneH2AFX protein results in decreased susceptibility to Rotenone21555580
D012402RotenoneNLRP3 gene mutant form inhibits the reaction [Rotenone results in increased phosphorylation of H2AFX protein]23619996
D012402RotenoneRotenone results in increased phosphorylation of H2AFX protein23619996
C028268satratoxin Gsatratoxin G results in increased activity of H2AFX protein20150440
C014184satratoxin Hsatratoxin H results in increased phosphorylation of H2AFX protein22863859
D012643SeleniumSelenium results in increased expression of H2AFX mRNA19244175
C078903seocalcitolseocalcitol results in decreased expression of H2AFX mRNA12040012
C040115shogaolshogaol analog inhibits the reaction [Doxorubicin results in increased phosphorylation of H2AFX protein]23899529
D012822Silicon DioxidePARP1 protein inhibits the reaction [Silicon Dioxide results in increased expression of H2AFX protein modified form]28757444
D012822Silicon DioxideSilicon Dioxide results in increased expression of H2AFX mRNA25351596
D012822Silicon DioxideSilicon Dioxide results in increased expression of H2AFX protein modified form28757444
D012822Silicon DioxideSilicon Dioxide results in increased phosphorylation of H2AFX protein23619996
D012822Silicon DioxideSilicon Dioxide results in increased phosphorylation of H2AFX protein23178243
D012834Silver[Silver analog co-treated with poly(N-vinylpyrrolidine)] results in increased expression of H2AFX protein26028148
D012834Silver[Silver co-treated with Povidone] results in increased expression of H2AFX protein modified form27387714
C440975silybinCaffeine inhibits the reaction [silybin results in increased phosphorylation of H2AFX protein]16777994
C440975silybinsilybin results in increased phosphorylation of H2AFX protein16777994
D019821SimvastatinSimvastatin results in increased phosphorylation of H2AFX protein20499237
D020123SirolimusSirolimus results in decreased expression of H2AFX protein23363784
C009277sodium arsenatesodium arsenate results in increased expression of H2AFX mRNA23922661
C017947sodium arsenitesodium arsenite results in increased expression of H2AFX mRNA28595984
C017947sodium arsenitesodium arsenite results in increased expression of H2AFX protein22706169|2486629
C017947sodium arsenitesodium arsenite results in increased phosphorylation of H2AFX protein20375080
C017947sodium arsenitesodium arsenite results in increased expression of H2AFX protein24866292
C017947sodium arsenitesodium arsenite results in decreased expression of H2AFX mRNA16014739
C017947sodium arsenitesodium arsenite results in increased expression of H2AFX protein modified form25787150
C028982sodium chromate(VI)MUS81 protein mutant form inhibits the reaction [sodium chromate(VI) results in increased expression of H2AFX protein modified form]28318385
C028982sodium chromate(VI)sodium chromate(VI) results in increased expression of H2AFX protein modified form28318385
D012969Sodium FluorideSodium Fluoride results in decreased expression of H2AFX protein28918527
D012969Sodium FluorideSodium Fluoride results in increased expression of H2AFX protein27548804
D012980Sodium SalicylateSodium Salicylate results in increased expression of H2AFX mRNA29117515
D018038Sodium SeleniteSodium Selenite results in increased expression of H2AFX mRNA18175754
D012989Soil PollutantsCHEK1 mutant form promotes the reaction [Soil Pollutants results in increased phosphorylation of H2AFX protein]22409540
D012989Soil PollutantsSoil Pollutants results in increased phosphorylation of H2AFX protein22409540
D012989Soil Pollutantswortmannin promotes the reaction [Soil Pollutants results in increased phosphorylation of H2AFX protein]22409540
D053260SootSoot results in increased expression of H2AFX mRNA22461453
D053260SootSoot results in increased phosphorylation of H2AFX protein23178243
C525423SRT2183panobinostat promotes the reaction [SRT2183 results in increased expression of H2AFX protein modified form]23681230
C525423SRT2183SRT2183 results in increased expression of H2AFX protein modified form23681230
D013241SterigmatocystinSterigmatocystin results in increased expression of H2AFX protein modified form26914363
D013467SulindacAcetylcysteine inhibits the reaction [Sulindac promotes the reaction [Bortezomib results in increased phosphorylation of H2AFX protein]]16033843
D013467Sulindacalpha-Tocopherol inhibits the reaction [Sulindac promotes the reaction [Bortezomib results in increased phosphorylation of H2AFX protein]]16033843
D013467SulindacSulindac promotes the reaction [Bortezomib results in increased phosphorylation of H2AFX protein]16033843
D013467Sulindac[arsenic trioxide co-treated with Sulindac] results in increased phosphorylation of H2AFX protein18636201
C473643sulphoraphenesulphoraphene results in increased expression of H2AFX protein28346727
D014284TriiodothyronineTriiodothyronine analog promotes the reaction [Cisplatin results in increased expression of H2AFX protein]22383522
D014284TriiodothyronineTriiodothyronine analog results in increased phosphorylation of H2AFX protein22383522
D013605T-2 Toxin2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [T-2 Toxin results in increased activity of H2AFX protein]20150440
D013605T-2 ToxinT-2 Toxin results in increased activity of H2AFX protein20150440
C047246temozolomidetemozolomide results in increased phosphorylation of H2AFX protein24743697
C047246temozolomide[temozolomide co-treated with resveratrol] results in increased phosphorylation of H2AFX protein23522185
C047246temozolomidetemozolomide results in increased phosphorylation of H2AFX protein23522185|2641895
C047246temozolomideH2AFX protein results in decreased susceptibility to temozolomide21555580
C003959TEMPOTEMPO results in increased expression of H2AFX protein25882087
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of H2AFX mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of H2AFX mRNA21592394
D013739Testosterone[bisphenol A co-treated with Testosterone] results in increased expression of H2AFX mRNA26496021
C000591600tetrachlorobenzoquinoneRAD51 protein inhibits the reaction [tetrachlorobenzoquinone results in increased expression of H2AFX protein modified form]27989139
C000591600tetrachlorobenzoquinonetetrachlorobenzoquinone results in increased expression of H2AFX protein modified form27989139
C000591600tetrachlorobenzoquinoneTP53 protein promotes the reaction [tetrachlorobenzoquinone results in increased expression of H2AFX protein modified form]27989139
D013749TetrachlorodibenzodioxinNFE2L2 gene mutant form promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of H2AFX protein]21846477
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of H2AFX mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [NFE2L2 gene mutant form results in increased expression of H2AFX protein]21846477
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of H2AFX protein21846477
D019284ThapsigarginThapsigargin results in increased expression of H2AFX mRNA19442820
D013853ThioacetamideThioacetamide results in increased expression of H2AFX protein26011634
C009495titanium dioxidetitanium dioxide results in increased expression of H2AFX mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of H2AFX mRNA27404394|2786577
D019772TopotecanTopotecan results in increased phosphorylation of H2AFX protein24743697
D019772TopotecanTopotecan results in increased phosphorylation of H2AFX protein16432175
D019772Topotecan[veliparib co-treated with Topotecan] results in increased expression of H2AFX protein21795476
D019772TopotecanAPAF1 promotes the reaction [Topotecan results in increased phosphorylation of H2AFX protein]19812371
D019772TopotecanTopotecan results in increased phosphorylation of H2AFX protein19812371
D019772TopotecanTRP53 inhibits the reaction [Topotecan results in increased phosphorylation of H2AFX protein]19812371
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of H2AFX mRNA25729387
D014112ToxapheneToxaphene results in decreased expression of H2AFX mRNA23153324
D014118Toxins, Biological"Toxins, Biological affects the expression of H2AFX mRNA"19682533
D014212TretinoinTretinoin results in decreased expression of H2AFX mRNA16249480
C032910triadimefontriadimefon results in increased expression of H2AFX mRNA19363144
C011559tributyltinAcetylcysteine inhibits the reaction [tributyltin results in increased expression of H2AFX protein modified form]26079211
C011559tributyltinPhycocyanin inhibits the reaction [tributyltin results in increased expression of H2AFX protein modified form]26079211
C011559tributyltintributyltin results in increased expression of H2AFX protein modified form26079211
C012589trichostatin Atrichostatin A results in increased expression of H2AFX mRNA15901671
C012589trichostatin Atrichostatin A affects the expression of H2AFX mRNA28542535
C012589trichostatin Atrichostatin A inhibits the reaction [potassium bromate results in increased phosphorylation of H2AFX protein]25015661
C023764triciribinetriciribine results in increased expression of H2AFX mRNA29117515
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of H2AFX mRNA19042947
D014303TrinitrotolueneTrinitrotoluene affects the expression of H2AFX mRNA21346803
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of H2AFX mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of H2AFX mRNA19140230
C080163trovafloxacinbenzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [[TNF protein co-treated with trovafloxacin] results in increased expression of H2AFX protein modified form]25748550
C080163trovafloxacinbenzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [trovafloxacin results in increased expression of H2AFX protein modified form]25748550
C080163trovafloxacin[TNF protein co-treated with trovafloxacin] results in increased expression of H2AFX protein modified form25748550
C080163trovafloxacinTNF protein promotes the reaction [trovafloxacin results in increased expression of H2AFX protein modified form]25748550
C080163trovafloxacintrovafloxacin results in increased expression of H2AFX protein modified form25748550
C080163trovafloxacintrovafloxacin results in increased phosphorylation of H2AFX protein24817034
C113580U 0126U 0126 promotes the reaction [Flavanones results in increased phosphorylation of H2AFX protein]21616090
D014527Uric AcidCASP1 gene mutant form inhibits the reaction [Uric Acid results in increased phosphorylation of H2AFX protein]23619996
D014527Uric AcidNLRP3 gene mutant form inhibits the reaction [Uric Acid results in increased phosphorylation of H2AFX protein]23619996
D014527Uric AcidUric Acid results in increased phosphorylation of H2AFX protein23619996
C073339usnic acidNFE2L2 protein inhibits the reaction [usnic acid results in increased expression of H2AFX protein modified form]27369375
C073339usnic acidusnic acid results in increased expression of H2AFX protein modified form27369375
D014635Valproic AcidValproic Acid results in increased expression of H2AFX mRNA15901671
D014635Valproic AcidValproic Acid affects the expression of H2AFX mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of H2AFX mRNA21427059
D014635Valproic AcidValproic Acid results in decreased expression of H2AFX protein21708246
D014635Valproic AcidValproic Acid results in increased expression of H2AFX protein21708246
D014640VancomycinVancomycin results in decreased expression of H2AFX mRNA18930951
C521013veliparibbenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [veliparib promotes the reaction [Camptothecin results in increased expression of H2AFX protein]]21227924
C521013veliparibERCC1 protein promotes the reaction [veliparib promotes the reaction [Camptothecin results in increased expression of H2AFX protein]]21227924
C521013veliparibERCC4 protein promotes the reaction [veliparib promotes the reaction [Camptothecin results in increased expression of H2AFX protein]]21227924
C521013veliparibTDP1 protein inhibits the reaction [veliparib promotes the reaction [Camptothecin results in increased expression of H2AFX protein]]21227924
C521013veliparib[veliparib co-treated with Topotecan] results in increased expression of H2AFX protein21795476
C521013veliparibveliparib inhibits the reaction [PARP1 protein mutant form results in increased expression of H2AFX protein modified form]27694308
C521013veliparibveliparib promotes the reaction [Camptothecin results in increased expression of H2AFX protein]21227924
C521013veliparibveliparib results in increased expression of H2AFX protein21917757
C521013veliparibveliparib results in increased expression of H2AFX protein modified form27694308
C521013veliparib[veliparib results in increased expression of PARP1 protein] which results in increased expression of H2AFX protein17505006
D002762CholecalciferolCholecalciferol results in decreased expression of H2AFX protein23363784
D024483Vitamin K 3[Ascorbic Acid results in increased reduction of Vitamin K 3] which results in increased phosphorylation of H2AFX protein19482829
C111237vorinostatresveratrol promotes the reaction [vorinostat results in increased expression of H2AFX protein]22923501
C111237vorinostatvorinostat results in increased activity of H2AFX protein20460513
C111237vorinostatvorinostat results in increased expression of H2AFX protein22923501
C111237vorinostatvorinostat results in increased expression of H2AFX protein modified form20679231
C111237vorinostatvorinostat results in increased phosphorylation of H2AFX protein20531243
C111237vorinostat[carfilzomib co-treated with vorinostat] results in increased expression of H2AFX protein20233973
C009687wortmanninwortmannin inhibits the reaction [decitabine results in increased expression of H2AFX protein]17991895
C009687wortmanninwortmannin promotes the reaction [docetaxel results in increased expression of H2AFX protein]20878124
C009687wortmanninwortmannin promotes the reaction [Soil Pollutants results in increased phosphorylation of H2AFX protein]22409540
C022186xanthatinxanthatin results in increased expression of H2AFX protein modified form29074359
D015032ZincZinc deficiency results in increased expression of H2AFX mRNA18356318
C016837zinc chloridezinc chloride results in increased expression of H2AFX mRNA18947441
D015034Zinc OxideAcetylcysteine inhibits the reaction [Zinc Oxide analog results in increased activity of H2AFX protein]24614525
D015034Zinc OxideZinc Oxide analog results in increased activity of H2AFX protein24614525
C088658zoledronic acidzoledronic acid results in increased expression of H2AFX mRNA20977926

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003677DNA binding-IBA21873635  
GO:0003677DNA binding-NAS2587254  
GO:0003684damaged DNA binding-IEA-  
GO:0005515protein binding-IPI12419185  12607005  15733840  16377563  16820410  17024177  
17498979  18001824  18001825  18583988  19234442  20000738  
20075863  20118229  20159462  20224553  20360685  20802463  
21044950  21293379  21317870  21824286  22064073  22157895  
22193777  22565321  23658700  25923214  
GO:0019899enzyme binding-IPI19234442  
GO:0042393histone binding-IPI19234442  
GO:0046982protein heterodimerization activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000077DNA damage checkpoint-IDA17974976  
GO:0000724double-strand break repair via homologous recombination-IEA-  
GO:0006302double-strand break repair-NAS19234442  
GO:0006303double-strand break repair via nonhomologous end joining-TAS-  
GO:0006325chromatin organization-IBA21873635  
GO:0006334nucleosome assembly-NAS2587254  
GO:0006342chromatin silencing-IBA21873635  
GO:0006974cellular response to DNA damage stimulus-IBA21873635  
GO:0006974cellular response to DNA damage stimulus-IDA15149599  
GO:0007283spermatogenesis-IEA-  
GO:0010212response to ionizing radiation-NAS19234442  
GO:0016032viral process-IEA-  
GO:0021987cerebral cortex development-IEA-  
GO:0045739positive regulation of DNA repair-NAS19234442  
GO:0051321meiotic cell cycle-IEA-  
GO:0071480cellular response to gamma radiation-IEA-  
GO:0090398cellular senescence-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000781chromosome, telomeric regioncolocalizes_withIDA15149599  
GO:0000786nucleosome-IEA-  
GO:0000790nuclear chromatin-IBA21873635  
GO:0000794condensed nuclear chromosome-IEA-  
GO:0001673male germ cell nucleus-IEA-  
GO:0001741XY body-IEA-  
GO:0005634nucleus-HDA21630459  
GO:0005634nucleus-IDA11331621  15604234  16319397  17974976  19734146  23235539  
GO:0005634nucleus-IMP24507776  
GO:0005654nucleoplasm-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005657replication fork-IEA-  
GO:0005813centrosome-IDA17498979  
GO:0016607nuclear speck-IDA-  
GO:0035861site of double-strand break-IDA21270334  
GO:0070062extracellular exosome-HDA23533145  
KEGG ID KEGG Term
hsa05322Systemic lupus erythematosus
Reactome ID Reactome Term Evidence
R-HSA-1221632Meiotic synapsisIEA
R-HSA-1266738Developmental BiologyIEA
R-HSA-1474165ReproductionIEA
R-HSA-1500620MeiosisIEA
R-HSA-157579Telomere MaintenanceTAS
R-HSA-162582Signal TransductionTAS
R-HSA-162582Signal TransductionIEA
R-HSA-1640170Cell CycleIEA
R-HSA-1640170Cell CycleTAS
R-HSA-171306Packaging Of Telomere EndsTAS
R-HSA-194315Signaling by Rho GTPasesTAS
R-HSA-195258RHO GTPase EffectorsTAS
R-HSA-195721Signaling by WNTIEA
R-HSA-195721Signaling by WNTTAS
R-HSA-201681TCF dependent signaling in response to WNTIEA
R-HSA-201681TCF dependent signaling in response to WNTTAS
R-HSA-201722Formation of the beta-catenin:TCF transactivating complexIEA
R-HSA-201722Formation of the beta-catenin:TCF transactivating complexTAS
R-HSA-211000Gene Silencing by RNATAS
R-HSA-212165Epigenetic regulation of gene expressionIEA
R-HSA-212165Epigenetic regulation of gene expressionTAS
R-HSA-212300PRC2 methylates histones and DNATAS
R-HSA-212436Generic Transcription PathwayIEA
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-2262752Cellular responses to stressTAS
R-HSA-2299718Condensation of Prophase ChromosomesTAS
R-HSA-2559580Oxidative Stress Induced SenescenceTAS
R-HSA-2559582Senescence-Associated Secretory Phenotype (SASP)TAS
R-HSA-2559583Cellular SenescenceTAS
R-HSA-2559586DNA Damage/Telomere Stress Induced SenescenceTAS
R-HSA-3214858RMTs methylate histone argininesTAS
R-HSA-3247509Chromatin modifying enzymesTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-427359SIRT1 negatively regulates rRNA expressionTAS
R-HSA-427389ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expressionIEA
R-HSA-427413NoRC negatively regulates rRNA expressionIEA
R-HSA-427413NoRC negatively regulates rRNA expressionTAS
R-HSA-4839726Chromatin organizationTAS
R-HSA-5250913Positive epigenetic regulation of rRNA expressionIEA
R-HSA-5250913Positive epigenetic regulation of rRNA expressionTAS
R-HSA-5250924B-WICH complex positively regulates rRNA expressionTAS
R-HSA-5250941Negative epigenetic regulation of rRNA expressionIEA
R-HSA-5250941Negative epigenetic regulation of rRNA expressionTAS
R-HSA-5334118DNA methylationIEA
R-HSA-5578749Transcriptional regulation by small RNAsTAS
R-HSA-5617472Activation of anterior HOX genes in hindbrain development during early embryogenesisIEA
R-HSA-5619507Activation of HOX genes during differentiationIEA
R-HSA-5625740RHO GTPases activate PKNsTAS
R-HSA-5625886Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3TAS
R-HSA-5693532DNA Double-Strand Break RepairTAS
R-HSA-5693538Homology Directed RepairTAS
R-HSA-5693565Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaksTAS
R-HSA-5693567HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)TAS
R-HSA-5693571Nonhomologous End-Joining (NHEJ)TAS
R-HSA-5693606DNA Double Strand Break ResponseTAS
R-HSA-5693607Processing of DNA double-strand break endsTAS
R-HSA-606279Deposition of new CENPA-containing nucleosomes at the centromereTAS
R-HSA-68875Mitotic ProphaseTAS
R-HSA-68886M PhaseTAS
R-HSA-69278Cell Cycle, MitoticTAS
R-HSA-69473G2/M DNA damage checkpointTAS
R-HSA-69481G2/M CheckpointsTAS
R-HSA-69620Cell Cycle CheckpointsTAS
R-HSA-73728RNA Polymerase I Promoter OpeningTAS
R-HSA-73777RNA Polymerase I Chain ElongationTAS
R-HSA-73854RNA Polymerase I Promoter ClearanceTAS
R-HSA-73857RNA Polymerase II TranscriptionIEA
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-73864RNA Polymerase I TranscriptionTAS
R-HSA-73886Chromosome MaintenanceTAS
R-HSA-73894DNA RepairTAS
R-HSA-74160Gene expression (Transcription)IEA
R-HSA-74160Gene expression (Transcription)TAS
R-HSA-774815Nucleosome assemblyTAS
R-HSA-8878171Transcriptional regulation by RUNX1IEA
R-HSA-8878171Transcriptional regulation by RUNX1TAS
R-HSA-8936459RUNX1 regulates genes involved in megakaryocyte differentiation and platelet functionTAS
R-HSA-8939211ESR-mediated signalingTAS
R-HSA-8939236RUNX1 regulates transcription of genes involved in differentiation of HSCsIEA
R-HSA-8953897Cellular responses to external stimuliTAS
R-HSA-9006931Signaling by Nuclear ReceptorsTAS
R-HSA-9018519Estrogen-dependent gene expressionTAS
R-HSA-912446Meiotic recombinationIEA
R-HSA-977225Amyloid fiber formationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21460372Unbalanced oxidant-induced DNA damage and repair in COPD: a link towards lung cancer. (2011 Jun)Caramori GThorax