Gene: HADHB

3032
ECHB|MSTP029|MTPB|TP-BETA
hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta
protein-coding
2p23.3
Ensembl:ENSG00000138029 MIM:143450 Vega:OTTHUMG00000096978 UniprotKB:P55084
NG_007294.1
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.698e-2 (AD)  9.753e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ACAA20.931
PON20.927
GLUD10.925
PSAT10.92
HADHA0.915
PTN0.912
HSDL20.908
ALDH9A10.908
ALDH20.905
RAB310.904

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.606
OR4F29-0.605
CACNA1F-0.398
IL12RB2-0.395
PROKR2-0.395
KCNH5-0.394
OPRD1-0.391
GABRG3-0.39
OSBPL10-0.39
KCNH1-0.39

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0142112,3,7,8-tetrachlorodibenzofuran"2,3,7,8-tetrachlorodibenzofuran affects the expression of HADHB mRNA"20702594
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of HADHB mRNA"21346803
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of HADHB mRNA]"19467301
C0179063-dinitrobenzene3-dinitrobenzene results in increased oxidation of HADHB protein25716674
C5756314-(4-(2,4-dioxothiazolidin-5-ylidenemethyl)-2-methoxyphenoxy)-3-trifluoromethylbenzonitrile"4-(4-(2,4-dioxothiazolidin-5-ylidenemethyl)-2-methoxyphenoxy)-3-trifluoromethylbenzonitrile affects the expression of HADHB mRNA"21218783
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of HADHB mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in increased expression of HADHB protein"25670856
D000082AcetaminophenAcetaminophen results in decreased expression of HADHB mRNA22230336
D000643Ammonium ChlorideAmmonium Chloride affects the expression of HADHB mRNA16483693
D001280AtrazineAtrazine results in increased expression of HADHB mRNA22982499
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of HADHB mRNA]22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of HADHB mRNA22228805
D004958EstradiolEstradiol results in decreased expression of HADHB mRNA19484750
D001629BezafibrateBezafibrate results in increased expression of HADHB mRNA17118139
C006780bisphenol Abisphenol A affects the expression of HADHB mRNA21786754
D002065BuspironeBuspirone results in increased expression of HADHB mRNA24136188
D002104CadmiumCadmium results in increased oxidation of HADHB protein24496640
D019256Cadmium ChlorideCadmium Chloride results in increased expression of HADHB mRNA23741332
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of HADHB mRNA15963342|1623916
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of HADHB mRNA23650126
C019304ciprofibrateciprofibrate results in increased expression of HADHB mRNA27225895
D002994ClofibrateClofibrate results in increased expression of HADHB mRNA23811191
D002994ClofibrateClofibrate results in decreased expression of HADHB protein20118634
D002994ClofibrateClofibrate results in increased expression of HADHB mRNA12851107|1867016
D003300CopperCopper deficiency results in decreased expression of HADHB mRNA19821111
C057862cyanoginosin LRcyanoginosin LR results in decreased expression of HADHB protein26984711
D016572CyclosporineCyclosporine results in decreased expression of HADHB mRNA19770486
D003687DehydroepiandrosteroneDehydroepiandrosterone results in increased expression of HADHB mRNA16940010
D003907Dexamethasone[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of HADHB mRNA23428407
D003907Dexamethasone[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased expression of HADHB mRNA24848799
C016366dibenzothiophenedibenzothiophene results in decreased expression of HADHB mRNA23656968
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of HADHB mRNA17361019
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of HADHB mRNA28962523
C000944dicrotophosdicrotophos results in decreased expression of HADHB mRNA28302478
D004041Dietary Fats"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of HADHB mRNA]"19467301
D004041Dietary FatsDietary Fats results in increased expression of HADHB mRNA16357043|1903023
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of HADHB mRNA19850644
D004051Diethylhexyl PhthalatePPARA protein promotes the reaction [Diethylhexyl Phthalate results in increased expression of HADHB mRNA]19850644
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of HADHB mRNA22672789
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of HADHB mRNA"22485181
D004317DoxorubicinDoxorubicin results in decreased expression of HADHB mRNA26873546
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of HADHB exon17116638
D011345FenofibrateFenofibrate results in increased expression of HADHB mRNA25572481
D011345FenofibrateFenofibrate results in increased expression of HADHB mRNA17118139
D011345FenofibrateFenofibrate affects the expression of HADHB mRNA20801182
D011345FenofibrateFenofibrate results in decreased expression of HADHB protein20118634
C006012fenofibric acid[fenofibric acid binds to PPARA protein] which results in increased expression of HADHB mRNA16197558
D018120FinasterideFinasteride results in increased expression of HADHB mRNA24136188
D005485FlutamideFlutamide analog results in decreased expression of HADHB mRNA17702527
D005485FlutamideFlutamide results in decreased expression of HADHB mRNA17702527|1944268
D005839GentamicinsGentamicins results in decreased expression of HADHB mRNA22061828
C492448ICG 001ICG 001 results in increased expression of HADHB mRNA26191083
D0150561-Methyl-3-isobutylxanthine[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of HADHB mRNA23428407
D0150561-Methyl-3-isobutylxanthine[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased expression of HADHB mRNA24848799
D007657Ketone BodiesKetone Bodies results in increased expression of HADHB mRNA16807920
D007854LeadLead results in decreased expression of HADHB mRNA19921347
C045463leflunomideleflunomide results in increased expression of HADHB mRNA24136188
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of HADHB mRNA"24972896
D008727MethotrexateMethotrexate results in increased expression of HADHB mRNA17400583
D008748MethylcholanthreneMethylcholanthrene results in increased expression of HADHB mRNA18804290
D008777MethyltestosteroneMethyltestosterone results in increased expression of HADHB mRNA29191790
C500085muraglitazarmuraglitazar results in increased expression of HADHB mRNA21515302
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of HADHB mRNA"25620056
C051752nefazodonenefazodone results in increased expression of HADHB mRNA24136188
C012655nimesulidenimesulide results in increased expression of HADHB mRNA24136188
C025589ochratoxin Aochratoxin A results in decreased expression of HADHB protein26861962
C539348perfluorobutanesulfonic acidperfluorobutanesulfonic acid results in increased expression of HADHB mRNA22071372
C033094perfluorobutyric acidperfluorobutyric acid results in decreased expression of HADHB mRNA22071372
C522391perfluorododecanoic acidperfluorododecanoic acid results in increased expression of HADHB mRNA22071372
C471071perfluorohexanesulfonic acidperfluorohexanesulfonic acid results in increased expression of HADHB mRNA22071372
C479228perfluorohexanoic acidperfluorohexanoic acid results in increased expression of HADHB mRNA22071372
C584865perfluorononanoic acidperfluorononanoic acid results in increased expression of HADHB mRNA22071372
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of HADHB mRNA19429403|2093613
C076994perfluorooctane sulfonic acidPPARA protein promotes the reaction [perfluorooctane sulfonic acid results in increased expression of HADHB mRNA]20936131
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of HADHB mRNA22071372
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of HADHB mRNA18692542|1916217
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of HADHB mRNA17681415|1846767
C023036perfluorooctanoic acidPPARA protein promotes the reaction [perfluorooctanoic acid results in increased expression of HADHB mRNA]18467677|2093613
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of HADHB mRNA18804290
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of HADHB mRNA16221955|1916217
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of HADHB mRNA26794494
C586085perfluoroundecanoic acidperfluoroundecanoic acid results in increased expression of HADHB mRNA22071372
D010634PhenobarbitalPhenobarbital results in decreased expression of HADHB mRNA19162173
D010695PhlorhizinPhlorhizin results in increased expression of HADHB mRNA22538082
D010852PicrotoxinPicrotoxin results in decreased expression of HADHB mRNA15170462
C006253pirinixic acidpirinixic acid results in increased expression of HADHB mRNA15375163|1635704
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in increased expression of HADHB mRNA]17950772|1846767
C006253pirinixic acidpirinixic acid results in increased expression of HADHB mRNA16940010|1916217
D017035PravastatinPravastatin results in decreased expression of HADHB mRNA27225895
D017035PravastatinPravastatin results in decreased expression of HADHB mRNA27225895
C045950propiconazolepropiconazole results in decreased expression of HADHB mRNA21278054
C059514resveratrolresveratrol results in increased expression of HADHB protein25505154
C089730rosiglitazonerosiglitazone results in increased expression of HADHB mRNA25572481
C089730rosiglitazonerosiglitazone affects the expression of HADHB mRNA22013433
C089730rosiglitazonerosiglitazone results in increased expression of HADHB mRNA24848799
C089730rosiglitazonerosiglitazone results in increased expression of HADHB mRNA21515302
D012402RotenoneRotenone results in decreased expression of HADHB mRNA17702527
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in increased expression of HADHB mRNA21427059
D012999SomanSoman results in decreased expression of HADHB mRNA19281266
C075117squalestatin 1squalestatin 1 affects the expression of HADHB mRNA27225895
C075117squalestatin 1squalestatin 1 affects the expression of HADHB mRNA27225895
D013467SulindacSulindac results in decreased expression of HADHB mRNA24136188
D016559TacrolimusTacrolimus results in decreased expression of HADHB mRNA25270620
C501413tesaglitazartesaglitazar results in increased expression of HADHB mRNA21515302
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of HADHB mRNA15716485
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of HADHB mRNA20702594|2157046
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of HADHB mRNA19770486
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of HADHB mRNA21215274
C009495titanium dioxidetitanium dioxide results in decreased expression of HADHB mRNA23557971
C011559tributyltintributyltin results in increased expression of HADHB mRNA23428407|2484879
D014241TrichloroethyleneTrichloroethylene results in decreased methylation of HADHB promoter27618143
D014241TrichloroethyleneTrichloroethylene results in increased expression of HADHB mRNA27618143
C057693troglitazonetroglitazone results in increased expression of HADHB mRNA21515302
D017974Uranium CompoundsUranium Compounds results in increased expression of HADHB mRNA19654044
D014635Valproic AcidValproic Acid results in decreased methylation of HADHB gene29154799
D014635Valproic AcidValproic Acid affects the expression of HADHB mRNA17292431
D014635Valproic AcidValproic Acid results in increased expression of HADHB mRNA21427059
C025643vinclozolinvinclozolin results in decreased expression of HADHB mRNA23555832

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003723RNA binding-HDA22658674  
GO:00038573-hydroxyacyl-CoA dehydrogenase activity-IBA21873635  
GO:00038573-hydroxyacyl-CoA dehydrogenase activity-TAS1550553  
GO:0003985acetyl-CoA C-acetyltransferase activity-IBA21873635  
GO:0003988acetyl-CoA C-acyltransferase activity-IBA21873635  
GO:0004300enoyl-CoA hydratase activity-IBA21873635  
GO:0004300enoyl-CoA hydratase activity-TAS1550553  
GO:0005515protein binding-IPI20562859  21527675  
GO:0016509long-chain-3-hydroxyacyl-CoA dehydrogenase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006635fatty acid beta-oxidation-IBA21873635  
GO:0006635fatty acid beta-oxidation-IEA-  
GO:0006696ergosterol biosynthetic process-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005739mitochondrion-IBA21873635  
GO:0005739mitochondrion-IDA-  
GO:0005739mitochondrion-NAS7958339  
GO:0005740mitochondrial envelope-TAS1550553  
GO:0005741mitochondrial outer membrane-IDA21527675  
GO:0005743mitochondrial inner membrane-IDA21527675  
GO:0005743mitochondrial inner membrane-TAS-  
GO:0005783endoplasmic reticulum-IDA21527675  
GO:0005829cytosol-IBA21873635  
GO:0042645mitochondrial nucleoid-IDA18063578  
KEGG ID KEGG Term
hsa00062Fatty acid elongation
hsa00071Fatty acid degradation
hsa00280Valine, leucine and isoleucine degradation
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1482798Acyl chain remodeling of CLTAS
R-HSA-1483206Glycerophospholipid biosynthesisTAS
R-HSA-1483257Phospholipid metabolismTAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-77285Beta oxidation of myristoyl-CoA to lauroyl-CoATAS
R-HSA-77286mitochondrial fatty acid beta-oxidation of saturated fatty acidsTAS
R-HSA-77288mitochondrial fatty acid beta-oxidation of unsaturated fatty acidsTAS
R-HSA-77289Mitochondrial Fatty Acid Beta-OxidationTAS
R-HSA-77305Beta oxidation of palmitoyl-CoA to myristoyl-CoATAS
R-HSA-77310Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoATAS
R-HSA-77346Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoATAS
R-HSA-77348Beta oxidation of octanoyl-CoA to hexanoyl-CoATAS
R-HSA-77350Beta oxidation of hexanoyl-CoA to butanoyl-CoATAS
R-HSA-8978868Fatty acid metabolismTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28550509Possible involvement of ACSS2 gene in alcoholism. (2017 Sep)Ribeiro AFJ Neural Transm (Vienna)