Gene: HAL

3034
HIS|HSTD
histidine ammonia-lyase
protein-coding
12q23.1
Ensembl:ENSG00000084110 MIM:609457 Vega:OTTHUMG00000170354 UniprotKB:P42357
NG_008180.1
PubMed
0   ANCO-SNPs
CD|ND
7   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.579e-1 (AD)  6.459e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LILRB20.743
NFE20.738
CLEC4D0.732
TMEM710.722
CLEC2D0.718
TREML20.713
CR10.707
CEACAM40.706
CSF3R0.693
CFI0.69

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ZNF835-0.474
KCNG1-0.464
TMEM151B-0.463
MARCH4-0.46
HAS1-0.46
CYP46A1-0.454
FLRT1-0.453
SVOP-0.453
LRTM2-0.452
PRDM11-0.446

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00117HistidineSmall Molecule71-00-1Approved|NutraceuticalTarget
ID Drug Name Action PubMed
C0364231-aminomethylphosphonic acid[Herbicides co-treated with 1-aminomethylphosphonic acid] results in decreased expression of HAL mRNA20566314
C0291412,2,5,7,8-pentamethyl-1-hydroxychroman"2,2,5,7,8-pentamethyl-1-hydroxychroman results in decreased expression of HAL mRNA"21920950
C0142112,3,7,8-tetrachlorodibenzofuran"2,3,7,8-tetrachlorodibenzofuran affects the expression of HAL mRNA"18343893
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] results in decreased expression of HAL mRNA"16984957
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of HAL mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in decreased expression of HAL mRNA"20406850
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of HAL mRNA"19692669
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of HAL mRNA"23994337
C0230353,4,5,3',4'-pentachlorobiphenyl"[3,4,5,3',4'-pentachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl] results in decreased expression of HAL mRNA"16984957
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of HAL mRNA"20959002
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of HAL mRNA"19692669
C0261373-hydroxyacetanilide3-hydroxyacetanilide results in decreased expression of HAL mRNA18544908
C4734844-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine4-(2-bromo-6-pyrrolidin-1-ylpyridine-4-sulfonyl)phenylamine affects the expression of HAL mRNA14610520
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of HAL mRNA"18648102
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of HAL mRNA"25380136
D000082AcetaminophenAcetaminophen results in decreased expression of HAL mRNA29067470
D000082Acetaminophen[Dietary Carbohydrates co-treated with Acetaminophen] results in increased expression of HAL mRNA17093179
D000082AcetaminophenAcetaminophen affects the expression of HAL mRNA17562736
D000082AcetaminophenAcetaminophen results in decreased expression of HAL mRNA18544908
D000082AcetaminophenAcetaminophen affects the expression of HAL protein16687475
D000082AcetaminophenAcetaminophen results in decreased expression of HAL mRNA18346771
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of HAL mRNA27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of HAL mRNA19770486
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of HAL mRNA"23195993
D019386AlendronateAlendronate affects the expression of HAL mRNA16079270
D000517alpha-Chlorohydrinalpha-Chlorohydrin analog results in decreased expression of HAL protein26597043
D024502alpha-Tocopherolalpha-Tocopherol results in increased expression of HAL mRNA16908007
D000638AmiodaroneAmiodarone affects the expression of HAL mRNA18355885|1948338
D000639AmitriptylineAmitriptyline affects the expression of HAL mRNA18355885
D000643Ammonium ChlorideAmmonium Chloride affects the expression of HAL mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of HAL mRNA24449571
C030610argemone oil"[[9,10-Dimethyl-1,2-benzanthracene co-treated with Tetradecanoylphorbol Acetate] co-treated with argemone oil] results in decreased activity of HAL protein"20691676
C030610argemone oil"[9,10-Dimethyl-1,2-benzanthracene co-treated with [Tetradecanoylphorbol Acetate co-treated with argemone oil]] results in decreased activity of HAL protein"20691676
D001553BenzbromaroneBenzbromarone affects the expression of HAL mRNA19483382
D019324beta-Naphthoflavonebeta-Naphthoflavone results in decreased expression of HAL mRNA23994337
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of HAL mRNA18164116
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of HAL mRNA21632981
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of HAL mRNA22316170
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of HAL mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of HAL mRNA22228805
D004958EstradiolEstradiol results in decreased expression of HAL mRNA20106945|2163298
C006780bisphenol Abisphenol A results in decreased expression of HAL mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of HAL mRNA25993096
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of HAL mRNA27339419
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of HAL mRNA18346771
D002994ClofibrateClofibrate results in decreased expression of HAL mRNA23811191|2527062
D002994ClofibrateClofibrate affects the expression of HAL mRNA19483382
D002994ClofibrateClofibrate results in decreased expression of HAL mRNA12851107
D002995Clofibric Acid[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of HAL mRNA17602206
D002997ClomipramineClomipramine affects the expression of HAL mRNA18355885
C018021cobaltous chloridecobaltous chloride results in decreased expression of HAL mRNA24386269
D003300CopperCopper results in decreased expression of HAL mRNA18522721
D003314Corn OilCorn Oil affects the expression of HAL mRNA16360708
C030123coumarincoumarin results in decreased expression of HAL mRNA18480146
D016572CyclosporineCyclosporine results in decreased expression of HAL mRNA20106945|2556210
D016572CyclosporineCyclosporine results in increased expression of HAL mRNA27989131
C093628cyproconazolecyproconazole results in decreased expression of HAL mRNA22334560
D002945CisplatinCisplatin results in increased expression of HAL mRNA27594783
D004040Dietary Carbohydrates[Dietary Carbohydrates co-treated with Acetaminophen] results in increased expression of HAL mRNA17093179
D004041Dietary FatsDietary Fats results in decreased expression of HAL mRNA22609946
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of HAL mRNA24535843
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of HAL mRNA18164116
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of HAL mRNA17602206
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of HAL mRNA28943392
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of HAL mRNA19638242
D002117CalcitriolCalcitriol results in increased expression of HAL mRNA12798352
D0151279,10-Dimethyl-1,2-benzanthracene"[[9,10-Dimethyl-1,2-benzanthracene co-treated with Tetradecanoylphorbol Acetate] co-treated with argemone oil] results in decreased activity of HAL protein"20691676
D0151279,10-Dimethyl-1,2-benzanthracene"[9,10-Dimethyl-1,2-benzanthracene co-treated with [Tetradecanoylphorbol Acetate co-treated with argemone oil]] results in decreased activity of HAL protein"20691676
D0151279,10-Dimethyl-1,2-benzanthracene"[[9,10-Dimethyl-1,2-benzanthracene co-treated with Tetradecanoylphorbol Acetate] co-treated with sanguinarine] results in decreased activity of HAL protein"20691676
D0151279,10-Dimethyl-1,2-benzanthracene"[9,10-Dimethyl-1,2-benzanthracene co-treated with [Tetradecanoylphorbol Acetate co-treated with sanguinarine]] results in decreased activity of HAL protein"20691676
D0151279,10-Dimethyl-1,2-benzanthracene"[9,10-Dimethyl-1,2-benzanthracene co-treated with Tetradecanoylphorbol Acetate] results in decreased activity of HAL protein"20691676
D004128DimethylnitrosamineDimethylnitrosamine results in decreased expression of HAL mRNA25380136
C109476epoxiconazoleepoxiconazole results in decreased expression of HAL mRNA22334560
D000431Ethanol[Fish Oils co-treated with Ethanol] results in increased expression of HAL mRNA17347304
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of HAL mRNA17555576
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HAL mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of HAL mRNA16079270
D005001EthionineEthionine affects the expression of HAL mRNA19483382
D005047EtoposideEtoposide results in decreased expression of HAL mRNA25270620
C082360fipronilfipronil results in decreased expression of HAL mRNA23962444
D005395Fish Oils[Fish Oils co-treated with Ethanol] results in increased expression of HAL mRNA17347304
D005485FlutamideFlutamide results in decreased expression of HAL mRNA24136188
D004397FonofosFonofos results in increased methylation of HAL promoter22847954
C056933fumonisin B1fumonisin B1 results in decreased expression of HAL mRNA16221962
D005839GentamicinsGentamicins results in decreased expression of HAL mRNA22061828
D005897GlafenineGlafenine results in decreased expression of HAL mRNA24136188
D005912GliotoxinGliotoxin results in decreased expression of HAL mRNA18346771
D006540Herbicides[Herbicides co-treated with 1-aminomethylphosphonic acid] results in decreased expression of HAL mRNA20566314
D017313FenretinideFenretinide results in decreased expression of HAL mRNA28973697
D007099ImipramineImipramine affects the expression of HAL mRNA18355885
C016517indole-3-carbinolindole-3-carbinol affects the expression of HAL mRNA21396975
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of HAL mRNA27432991
D007654KetoconazoleKetoconazole affects the expression of HAL mRNA18355885
C045463leflunomideleflunomide results in decreased expression of HAL mRNA24136188
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of HAL mRNA"18346771
D008730MethoxsalenMethoxsalen results in decreased activity of HAL protein20880231
C517284monomethyl phthalatemonomethyl phthalate affects the expression of HAL mRNA26924002
C523799MRK 003HAL results in increased susceptibility to MRK 00319903844
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in decreased expression of HAL mRNA25380136
C051752nefazodonenefazodone results in decreased expression of HAL mRNA24136188
D009532NickelNickel results in decreased expression of HAL mRNA23195993
C022838nickel chloridenickel chloride results in decreased expression of HAL mRNA24612858
D009534NiclosamideNiclosamide results in increased expression of HAL mRNA26452273
C012655nimesulidenimesulide results in decreased expression of HAL mRNA24136188
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in increased expression of HAL mRNA17616710
C002741N-nitrosomorpholineN-nitrosomorpholine affects the expression of HAL protein19716841
D009853OmeprazoleOmeprazole affects the expression of HAL mRNA19483382
D009966OrphenadrineOrphenadrine affects the expression of HAL mRNA23665939
D019308Palmitic AcidPalmitic Acid results in increased expression of HAL mRNA17658692
D010278ParathionParathion results in increased methylation of HAL promoter22847954
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of HAL mRNA23948077
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of HAL mRNA19162173
C023036perfluorooctanoic acidperfluorooctanoic acid affects the expression of HAL mRNA18281256
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of HAL mRNA19162173
C027579periodate-oxidized adenosineperiodate-oxidized adenosine affects the expression of HAL mRNA17097637
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of HAL mRNA24535843
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in decreased expression of HAL mRNA]19482888
D010634PhenobarbitalPhenobarbital results in decreased expression of HAL mRNA19482888
D010634PhenobarbitalPhenobarbital results in decreased expression of HAL mRNA19162173
C049032pinosylvinpinosylvin results in increased expression of HAL mRNA23333577
D010882Piperonyl ButoxidePiperonyl Butoxide results in decreased expression of HAL mRNA22484513
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of HAL mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of HAL mRNA16221962|1844570
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in decreased expression of HAL mRNA]20059764
C006253pirinixic acidpirinixic acid affects the expression of HAL mRNA19483382
C006253pirinixic acidpirinixic acid results in decreased expression of HAL mRNA17164430|1916217
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of HAL mRNA19162173
C045950propiconazolepropiconazole results in decreased expression of HAL mRNA21278054|2233456
D011441PropylthiouracilPropylthiouracil affects the expression of HAL mRNA19483382
D011794QuercetinQuercetin results in decreased expression of HAL mRNA21632981
D015125OxyquinolineOxyquinoline results in decreased expression of HAL mRNA21632981
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride affects the expression of HAL mRNA16079270
C488333Ro 65-7199Ro 65-7199 results in decreased expression of HAL mRNA14610520
C089730rosiglitazonerosiglitazone results in decreased expression of HAL mRNA21515302
C005705sanguinarine"[[9,10-Dimethyl-1,2-benzanthracene co-treated with Tetradecanoylphorbol Acetate] co-treated with sanguinarine] results in decreased activity of HAL protein"20691676
C005705sanguinarine"[9,10-Dimethyl-1,2-benzanthracene co-treated with [Tetradecanoylphorbol Acetate co-treated with sanguinarine]] results in decreased activity of HAL protein"20691676
D012822Silicon DioxideSilicon Dioxide results in decreased expression of HAL mRNA23221170
C009277sodium arsenatesodium arsenate results in decreased expression of HAL mRNA23922661
C016104sodium bichromatesodium bichromate results in decreased expression of HAL mRNA24612858
C016104sodium bichromatesodium bichromate affects the expression of HAL mRNA22110744
C012568terbufosterbufos results in increased methylation of HAL promoter22847954
C501413tesaglitazartesaglitazar results in decreased expression of HAL mRNA21515302
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of HAL mRNA27914987
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of HAL mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of HAL mRNA11489354|1969266
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of HAL mRNA23152189
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of HAL mRNA18343893
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HAL mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of HAL mRNA11906171|1696003
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of HAL mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of HAL mRNA16054898|1696003
D013755Tetradecanoylphorbol Acetate"[[9,10-Dimethyl-1,2-benzanthracene co-treated with Tetradecanoylphorbol Acetate] co-treated with argemone oil] results in decreased activity of HAL protein"20691676
D013755Tetradecanoylphorbol Acetate"[9,10-Dimethyl-1,2-benzanthracene co-treated with [Tetradecanoylphorbol Acetate co-treated with argemone oil]] results in decreased activity of HAL protein"20691676
D013755Tetradecanoylphorbol Acetate"[[9,10-Dimethyl-1,2-benzanthracene co-treated with Tetradecanoylphorbol Acetate] co-treated with sanguinarine] results in decreased activity of HAL protein"20691676
D013755Tetradecanoylphorbol Acetate"[9,10-Dimethyl-1,2-benzanthracene co-treated with [Tetradecanoylphorbol Acetate co-treated with sanguinarine]] results in decreased activity of HAL protein"20691676
D013755Tetradecanoylphorbol Acetate"[9,10-Dimethyl-1,2-benzanthracene co-treated with Tetradecanoylphorbol Acetate] results in decreased activity of HAL protein"20691676
D013853Thioacetamide[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of HAL mRNA28943392
D013853ThioacetamideThioacetamide affects the expression of HAL mRNA19483382
C009495titanium dioxidetitanium dioxide results in increased expression of HAL mRNA19464567
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of HAL mRNA20133372
D014212TretinoinTretinoin results in increased expression of HAL mRNA16604517
D014241TrichloroethyleneTrichloroethylene results in decreased expression of HAL mRNA25549359
C012589trichostatin Atrichostatin A results in decreased expression of HAL mRNA15901671
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of HAL mRNA"26179874
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of HAL mRNA29024780
C057693troglitazonetroglitazone results in increased expression of HAL mRNA28973697
C057693troglitazonetroglitazone results in increased expression of HAL protein21315101
D014520UrethaneUrethane results in increased expression of HAL mRNA28818685
D014635Valproic AcidValproic Acid results in decreased expression of HAL mRNA29154799
D014635Valproic AcidValproic Acid results in decreased expression of HAL mRNA15901671
C034028vanadyl sulfatevanadyl sulfate results in increased expression of HAL mRNA16330358
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of HAL gene25560391
D015032ZincZinc deficiency results in decreased expression of HAL mRNA18356318

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004397histidine ammonia-lyase activity-EXP15806399  
GO:0004397histidine ammonia-lyase activity-IBA21873635  
GO:0016841ammonia-lyase activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006548histidine catabolic process-IBA21873635  
GO:0006548histidine catabolic process-TAS-  
GO:0019556histidine catabolic process to glutamate and formamide-IEA-  
GO:0019557histidine catabolic process to glutamate and formate-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa00340Histidine metabolism
hsa00910Nitrogen metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-6788656Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolismTAS
R-HSA-70921Histidine catabolismTAS
R-HSA-71291Metabolism of amino acids and derivativesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
14499311Effects of smoking and cytochrome P450 2D6*10 allele on the plasma haloperidol concentration/dose ratio. (2003 Sep)Ohara KProg Neuropsychopharmacol Biol Psychiatry
1811758Measuring outcome in the treatment of cocaine abuse: the Drug Impairment Rating Scale for cocaine. (1991)Halikas JAJ Addict Dis
11817502Lack of impact of CYP1A2 genetic polymorphism (C/A polymorphism at position 734 in intron 1 and G/A polymorphism at position -2964 in the 5'-flanking region of CYP1A2) on the plasma concentration of haloperidol in smoking male Japanese with schizophrenia. (2002 Feb)Shimoda KProg Neuropsychopharmacol Biol Psychiatry
25690673Development and validation of a risk stratification score for ventral incisional hernia after abdominal surgery: hernia expectation rates in intra-abdominal surgery (the HERNIA Project). (2015 Apr)Goodenough CJJ Am Coll Surg
10833286The response of human buccal maxillary furcation defects to combined regenerative techniques--two controlled clinical studies. (1999 Jul)de Santana RBJ Int Acad Periodontol
15164612[Effect of smoking on pharmacokinetics of antipsychotics]. (2004 Apr)Shimoda KNihon Shinkei Seishin Yakurigaku Zasshi
10519444Effects of smoking, CYP2D6 genotype, and concomitant drug intake on the steady state plasma concentrations of haloperidol and reduced haloperidol in schizophrenic inpatients. (1999 Oct)Pan LTher Drug Monit