Gene: HARS

3035
CMT2W|HRS|USH3B
histidyl-tRNA synthetase
protein-coding
5q31.3
Ensembl:ENSG00000170445 MIM:142810 Vega:OTTHUMG00000129502 UniprotKB:P12081
NG_032158.1
PubMed
0   ANCO-SNPs
ND|AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.951e-1 (AD)  5.581e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PRPF190.978
COPG10.971
PPME10.967
DDX240.966
PEX11B0.966
GOT20.966
TCF250.965
AP2M10.964
UBE2Q10.963
USP50.962

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.675
OR4F29-0.627
RAI14-0.366
MTRNR2L6-0.356
MBNL3-0.353
MTRNR2L9-0.35
HEY2-0.343
ASB4-0.337
REST-0.334
MTRNR2L10-0.33

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0364231-aminomethylphosphonic acid[Herbicides co-treated with 1-aminomethylphosphonic acid] results in decreased expression of HARS mRNA20566314
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of HARS mRNA"27291303
C0142112,3,7,8-tetrachlorodibenzofuran"2,3,7,8-tetrachlorodibenzofuran affects the expression of HARS mRNA"20702594
C5724913-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol results in increased expression of HARS protein26194647
C0326424-aminophenylarsenoxide4-aminophenylarsenoxide binds to HARS protein26598702
C0326424-aminophenylarsenoxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to HARS protein]26598702
D000082AcetaminophenAcetaminophen affects the expression of HARS mRNA17562736
D020106AcrylamideAcrylamide results in increased expression of HARS mRNA28959563
C006632arsenic trioxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to HARS protein]26598702
D004958Estradiol[bisphenol A co-treated with Estradiol] results in decreased expression of HARS mRNA26496021
C006780bisphenol Abisphenol A affects the expression of HARS mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of HARS mRNA26063408
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in decreased expression of HARS mRNA26496021
C006780bisphenol Abisphenol A results in increased expression of HARS mRNA25181051
C013418bromfenacoumbromfenacoum results in increased expression of HARS protein28903499
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of HARS mRNA18804290
D002104CadmiumCadmium results in decreased expression of HARS mRNA24084258
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of HARS mRNA18804290
C117342calfactant"[Nanotubes, Carbon co-treated with calfactant] results in increased expression of HARS protein"23026733
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of HARS mRNA27339419
C100187chloropicrinchloropicrin results in increased expression of HARS mRNA26352163
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of HARS mRNA28472532
D019327Copper SulfateCopper Sulfate results in increased expression of HARS mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of HARS mRNA25562108
D004147DioxinsDioxins affects the expression of HARS mRNA20463971
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of HARS protein23301498
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of HARS mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of HARS mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HARS mRNA17942748
C007738fluoranthene[fluoranthene co-treated with pyrene] results in decreased expression of HARS mRNA20117838
D005485FlutamideFlutamide results in decreased expression of HARS mRNA21126777
D005485FlutamideFlutamide results in increased expression of HARS mRNA24136188
D006540Herbicides[Herbicides co-treated with 1-aminomethylphosphonic acid] results in decreased expression of HARS mRNA20566314
D007213IndomethacinIndomethacin results in decreased expression of HARS mRNA28201806
D015759Ionomycinpyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of HARS mRNA]15477007
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of HARS mRNA15477007
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of HARS mRNA26011545
D037742Nanotubes, Carbon"[Nanotubes, Carbon co-treated with calfactant] results in increased expression of HARS protein"23026733
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of HARS mRNA"25554681
C051752nefazodonenefazodone results in increased expression of HARS mRNA24136188
C012655nimesulidenimesulide results in increased expression of HARS mRNA24136188
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of HARS mRNA25729387
C030110oxaliplatinoxaliplatin results in decreased expression of HARS mRNA25729387
C030984pyrene[fluoranthene co-treated with pyrene] results in decreased expression of HARS mRNA20117838
D011748PyrogallolPyrogallol results in decreased expression of HARS mRNA20362636
C020972pyrrolidine dithiocarbamic acidpyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of HARS mRNA]15477007
D012643SeleniumSelenium results in increased expression of HARS mRNA19244175
D013629TamoxifenTamoxifen affects the expression of HARS mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of HARS mRNA20702594
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HARS mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of HARS mRNA17942748
D013755Tetradecanoylphorbol Acetatepyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of HARS mRNA]15477007
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of HARS mRNA15477007
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of HARS mRNA25729387
D019772TopotecanTopotecan results in decreased expression of HARS mRNA25729387
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of HARS mRNA19042947
D014635Valproic AcidValproic Acid affects the expression of HARS mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of HARS mRNA23179753
D014635Valproic AcidValproic Acid results in increased methylation of HARS gene29154799
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of HARS gene25560391
C025643vinclozolinvinclozolin results in decreased expression of HARS mRNA21126777
C025643vinclozolinvinclozolin results in decreased expression of HARS mRNA23034163
C025643vinclozolinvinclozolin results in increased methylation of HARS promoter22570695
D014810Vitamin EVitamin E results in increased expression of HARS mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004821histidine-tRNA ligase activity-IBA21873635  
GO:0004821histidine-tRNA ligase activity-NAS1549469  7755634  
GO:0004821histidine-tRNA ligase activity-TAS-  
GO:0005524ATP binding-IEA-  
GO:0042802identical protein binding-IBA21873635  
GO:0042802identical protein binding-IPI22958643  
GO ID GO Term Qualifier Evidence PubMed
GO:0006412translation-NAS7755634  
GO:0006418tRNA aminoacylation for protein translation-TAS-  
GO:0006427histidyl-tRNA aminoacylation-IBA21873635  
GO:0006427histidyl-tRNA aminoacylation-IEA-  
GO:0032543mitochondrial translation-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IDA21464306  
GO:0005739mitochondrion-IBA21873635  
GO:0005829cytosol-IBA21873635  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa00970Aminoacyl-tRNA biosynthesis
Reactome ID Reactome Term Evidence
R-HSA-379716Cytosolic tRNA aminoacylationTAS
R-HSA-379724tRNA AminoacylationTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-72766TranslationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
12943960Alcohol detoxification and social anxiety symptoms: a preliminary study of the impact of mirtazapine administration. (2003 Sep)Liappas JJ Affect Disord