Gene: HAS2

3037
-
hyaluronan synthase 2
protein-coding
8q24.13
Ensembl:ENSG00000170961 MIM:601636 Vega:OTTHUMG00000164953 UniprotKB:Q92819
NC_000008.11
PubMed
0   ANCO-SNPs
ND
3   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.691e-1 (AD)  4.558e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
C9orf1350.852
IGF2BP20.786
PRRX20.775
RDH100.77
PIRT0.769
BEST30.759
SPOCD10.753
PCOLCE20.741
ZNF1140.739
PRPH0.737

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KCNA2-0.551
EIF4E1B-0.525
MPPED1-0.523
SCRT1-0.523
KCNS1-0.517
ADAM11-0.517
TESPA1-0.517
PVALB-0.511
NAT8L-0.509
ATP2B2-0.509

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C04676015-acetyldeoxynivalenol15-acetyldeoxynivalenol results in increased expression of HAS2 mRNA23792671
C0512461-methylanthracene[1-methylanthracene co-treated with fluoranthene] results in increased expression of HAS2 mRNA28329830
C0512461-methylanthraceneSB 203580 inhibits the reaction [[1-methylanthracene co-treated with fluoranthene] results in increased expression of HAS2 mRNA]28329830
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of HAS2 mRNA"25510870
C0131862,3-pentanedione"2,3-pentanedione results in increased expression of HAS2 mRNA"25710175
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of HAS2 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of HAS2 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of HAS2 mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of HAS2 mRNA"25510870
C0144643,4-dichloroaniline"3,4-dichloroaniline results in increased expression of HAS2 mRNA"24172598
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide results in decreased activity of [SMAD2 protein co-treated with SMAD3 protein]] inhibits the reaction [FSHB protein results in increased expression of HAS2 mRNA]"21520325
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HAS2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HAS2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HAS2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HAS2 mRNA"27188386
C0415944-nonylphenol[4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of HAS2 mRNA23626723
C1052604-tert-octylphenol[4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of HAS2 mRNA23626723
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HAS2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HAS2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HAS2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HAS2 mRNA"27188386
C5304757-(7-amino-7-methyl-5-azaspiro(2.4)heptan-5-yl)-6-fluoro-1-(2-fluoro-1-cyclopropyl)-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid"7-(7-amino-7-methyl-5-azaspiro(2.4)heptan-5-yl)-6-fluoro-1-(2-fluoro-1-cyclopropyl)-1,4-dihydro-8-methoxy-4-oxo-3-quinolinecarboxylic acid results in decreased expression of HAS2 mRNA"20688128
D000111AcetylcysteineAcetylcysteine inhibits the reaction [LHB protein results in increased abundance of HAS2 mRNA]21220312
D020106AcrylamideAcrylamide results in decreased expression of HAS2 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of HAS2 gene27153756
D000393Air PollutantsAir Pollutants analog results in increased expression of HAS2 mRNA21757418
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of HAS2 mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of HAS2 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of HAS2 mRNA24449571
C006632arsenic trioxidearsenic trioxide results in decreased expression of HAS2 mRNA25258189|2670570
C015001arsenite[arsenite co-treated with Benzo(a)pyrene] results in decreased expression of HAS2 mRNA15894712
C015001arsenitearsenite results in decreased expression of HAS2 mRNA15894712|1892958
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of HAS2 mRNA"25757056
D017638Asbestos, Crocidolite"Asbestos, Crocidolite results in increased expression of HAS2 mRNA"18687144|2416032
D001564Benzo(a)pyrene[arsenite co-treated with Benzo(a)pyrene] results in decreased expression of HAS2 mRNA15894712
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of HAS2 mRNA15894712
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of HAS2 mRNA"20382639
D004958EstradiolESR1 protein affects the reaction [Estradiol results in decreased expression of HAS2 mRNA]14699072
D004958EstradiolEstradiol affects the expression of HAS2 mRNA14699072
D004958Estradiol[bisphenol A co-treated with Estradiol] results in increased expression of HAS2 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of HAS2 mRNA27685785|2895115
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in increased expression of HAS2 mRNA26496021
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in increased expression of HAS2 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of HAS2 mRNA25181051
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of HAS2 mRNA20147733
D002083Butylated HydroxyanisoleButylated Hydroxyanisole inhibits the reaction [LHB protein results in increased abundance of HAS2 mRNA]21220312
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of HAS2 mRNA15336504
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of HAS2 mRNA27042213
D002251Carbon TetrachlorideHAS3 protein affects the reaction [Carbon Tetrachloride results in increased expression of HAS2 mRNA]27042213
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of HAS2 mRNA20971185
C402665CP 31398CP 31398 results in increased expression of HAS2 mRNA15155752
D003561CytarabineCytarabine results in decreased expression of HAS2 mRNA21198554
D000069439DasatinibDasatinib results in decreased expression of HAS2 mRNA20579391
C014347decitabinedecitabine affects the expression of HAS2 mRNA17145863
D003907DexamethasoneDexamethasone results in decreased expression of HAS2 mRNA19609316
D003907DexamethasoneDexamethasone results in decreased expression of HAS2 mRNA22733784
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of HAS2 mRNA24893172
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of HAS2 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of HAS2 mRNA27392435
D019422Dietary SucroseDietary Sucrose results in increased expression of HAS2 mRNA26033743
D002117CalcitriolCalcitriol results in increased expression of HAS2 mRNA16002434
D004237DiuronDiuron metabolite results in increased expression of HAS2 mRNA24172598
C505440DX 619DX 619 results in decreased expression of HAS2 mRNA20688128
D004656EnalaprilEnalapril results in increased expression of HAS2 mRNA20933085
C007738fluoranthene[1-methylanthracene co-treated with fluoranthene] results in increased expression of HAS2 mRNA28329830
C007738fluorantheneSB 203580 inhibits the reaction [[1-methylanthracene co-treated with fluoranthene] results in increased expression of HAS2 mRNA]28329830
D005557FormaldehydeFormaldehyde results in decreased expression of HAS2 mRNA17938736|2065599
D019833GenisteinGenistein results in decreased expression of HAS2 mRNA22228119
D005978GlutathioneGlutathione inhibits the reaction [LHB protein results in increased abundance of HAS2 mRNA]21220312
D006820Hyaluronic AcidHAS2 protein results in increased chemical synthesis of Hyaluronic Acid11318944
D006820Hyaluronic Acid[IL1B protein results in increased expression of HAS2 protein] which results in increased chemical synthesis of Hyaluronic Acid11318944
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of HAS2 mRNA21220312
D006861Hydrogen PeroxideN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Hydrogen Peroxide results in increased expression of HAS2 mRNA]21220312
D006861Hydrogen PeroxideU 0126 inhibits the reaction [Hydrogen Peroxide results in increased expression of HAS2 mRNA]21220312
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of HAS2 mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of HAS2 mRNA27392435
C561695(+)-JQ1 compound[(+)-JQ1 compound co-treated with PD 0325901] results in decreased expression of HAS2 mRNA25119042
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of HAS2 mRNA23129625|2479639
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of HAS2 mRNA24231268
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of HAS2 mRNA26644586
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of HAS2 mRNA23179753
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of HAS2 mRNA28496038
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of HAS2 protein28496038
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate affects the expression of HAS2 mRNA21195148
C028577monobutyl phthalatemonobutyl phthalate affects the expression of HAS2 mRNA21195148
C406082monomethylarsonous acidmonomethylarsonous acid results in decreased expression of HAS2 mRNA25145660
C063509N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamideN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Hydrogen Peroxide results in increased expression of HAS2 mRNA]21220312
C063509N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamideN-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [LHB protein results in increased abundance of HAS2 mRNA]21220312
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of HAS2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of HAS2 mRNA"25554681
C570897NSC668394NSC668394 results in decreased expression of HAS2 mRNA27137931
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of HAS2 mRNA20971185
D015242OfloxacinOfloxacin results in decreased expression of HAS2 mRNA23067722
C510784ormosil[ormosil binds to Polyethylene Glycols] which results in increased expression of HAS2 mRNA24888373
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of HAS2 mRNA25729387
D010100OxygenOxygen deficiency results in decreased expression of HAS2 mRNA24236059
D010121OxytocinOxytocin results in increased expression of HAS2 protein23707249
D010126Ozone[Ozone co-treated with NOTCH4 gene mutant form] affects the expression of HAS2 mRNA25658374
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HAS2 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of HAS2 mRNA26272509
D052638Particulate MatterParticulate Matter results in decreased expression of HAS2 mRNA22178795
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of HAS2 mRNA"25510870
C506614PD 0325901[(+)-JQ1 compound co-treated with PD 0325901] results in decreased expression of HAS2 mRNA25119042
C506614PD 0325901PD 0325901 results in decreased expression of HAS2 mRNA25119042
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in decreased expression of HAS2 mRNA23602845
D011092Polyethylene Glycols[ormosil binds to Polyethylene Glycols] which results in increased expression of HAS2 mRNA24888373
D059808PolyphenolsPolyphenols results in decreased expression of HAS2 mRNA16293270
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of HAS2 mRNA22714537
D011441PropylthiouracilPropylthiouracil results in increased expression of HAS2 mRNA24780913
C014175pyrazolo(3,4-d)pyrimidine"pyrazolo(3,4-d)pyrimidine analog affects the expression of HAS2 mRNA"21152443
D020849Raloxifene Hydrochloride[Raloxifene Hydrochloride co-treated with ESR1 protein] results in decreased expression of HAS2 mRNA19059307
C093642SB 203580SB 203580 inhibits the reaction [[1-methylanthracene co-treated with fluoranthene] results in increased expression of HAS2 mRNA]28329830
D017632Asbestos, Serpentine"Asbestos, Serpentine results in increased expression of HAS2 mRNA"24160326
D012834SilverSilver results in decreased expression of HAS2 mRNA27131904
C009277sodium arsenatesodium arsenate results in increased expression of HAS2 mRNA16882884
C017947sodium arsenitesodium arsenite results in increased expression of HAS2 mRNA28595984
C017947sodium arsenitesodium arsenite results in decreased expression of HAS2 mRNA18812580|2373208
D053260SootSoot results in increased expression of HAS2 mRNA26551751
D013605T-2 ToxinT-2 Toxin results in decreased expression of HAS2 mRNA18196609
D013629Tamoxifen[Tamoxifen co-treated with ESR1 protein] results in decreased expression of HAS2 mRNA19059307
D013739Testosterone[bisphenol A co-treated with Testosterone] results in increased expression of HAS2 mRNA26496021
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of HAS2 mRNA16443690
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of HAS2 mRNA25613284
C009495titanium dioxidetitanium dioxide results in increased expression of HAS2 mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of HAS2 mRNA27865774
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of HAS2 mRNA25729387
D019772TopotecanTopotecan results in increased expression of HAS2 mRNA25729387
D014212TretinoinTretinoin promotes the reaction [CREBBP protein binds to HAS2 promoter]17307735
D014212TretinoinTretinoin promotes the reaction [MED1 protein binds to HAS2 promoter]17307735
D014212TretinoinTretinoin promotes the reaction [NCOA3 protein binds to HAS2 promoter]17307735
D014212TretinoinTretinoin promotes the reaction [SP1 protein binds to HAS2 promoter]17307735
D014212TretinoinTretinoin results in decreased expression of HAS2 mRNA21934132
D014212TretinoinTretinoin results in increased expression of HAS2 mRNA17307735
D014212TretinoinTretinoin results in increased expression of HAS2 mRNA16604517
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HAS2 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of HAS2 mRNA24935251|2627250
C101044tyrphostin AG 1478tyrphostin AG 1478 inhibits the reaction [LHB protein results in increased expression of HAS2 mRNA]15459120
C113580U 0126U 0126 inhibits the reaction [Hydrogen Peroxide results in increased expression of HAS2 mRNA]21220312
C113580U 0126U 0126 inhibits the reaction [LHB protein results in increased abundance of HAS2 mRNA]21220312
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HAS2 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of HAS2 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of HAS2 mRNA23179753|2800136
D014635Valproic AcidValproic Acid results in increased expression of HAS2 mRNA23179753|2438349
D001335Vehicle EmissionsVehicle Emissions affects the methylation of HAS2 gene25560391
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of HAS2 mRNA"27188386
C111237vorinostatvorinostat results in increased expression of HAS2 mRNA26272509

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0050501hyaluronan synthase activity-IBA21873635  
GO:0050501hyaluronan synthase activity-IMP22016393  
GO:0050501hyaluronan synthase activity-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001570vasculogenesis-ISS-  
GO:0001822kidney development-ISS-  
GO:0008284positive regulation of cell proliferation-IMP22016393  
GO:0010838positive regulation of keratinocyte proliferation-IEA-  
GO:0014911positive regulation of smooth muscle cell migration-IEA-  
GO:0030213hyaluronan biosynthetic process-IBA21873635  
GO:0030213hyaluronan biosynthetic process-IDA17324121  
GO:0030213hyaluronan biosynthetic process-IEA-  
GO:0030213hyaluronan biosynthetic process-IMP22016393  
GO:0030213hyaluronan biosynthetic process-ISS-  
GO:0030335positive regulation of cell migration-IMP22016393  
GO:0035810positive regulation of urine volume-ISS-  
GO:0036120cellular response to platelet-derived growth factor stimulus-IDA17324121  
GO:0036302atrioventricular canal development-ISS-  
GO:0044849estrous cycle-IEA-  
GO:0045226extracellular polysaccharide biosynthetic process-IBA21873635  
GO:0045226extracellular polysaccharide biosynthetic process-ISS-  
GO:0051549positive regulation of keratinocyte migration-IEA-  
GO:0060349bone morphogenesis-IEA-  
GO:0070295renal water absorption-ISS-  
GO:0071347cellular response to interleukin-1-IEP20522558  
GO:0071356cellular response to tumor necrosis factor-IEP20522558  
GO:0071498cellular response to fluid shear stress-IEP21551265  
GO:0085029extracellular matrix assembly-IBA21873635  
GO:0085029extracellular matrix assembly-ISS-  
GO:0090500endocardial cushion to mesenchymal transition-ISS-  
GO:1900026positive regulation of substrate adhesion-dependent cell spreading-IEA-  
GO:1900127positive regulation of hyaluronan biosynthetic process-IEA-  
GO:1900625positive regulation of monocyte aggregation-IMP20522558  
GO:1901201regulation of extracellular matrix assembly-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IEA-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-IDA20522558  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-1630316Glycosaminoglycan metabolismTAS
R-HSA-2142845Hyaluronan metabolismTAS
R-HSA-2142850Hyaluronan biosynthesis and exportTAS
R-HSA-71387Metabolism of carbohydratesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25251750Genomewide association study identifies HAS2 as a novel susceptibility gene for adult asthma in a Japanese population. (2014 Nov)Yatagai YClin Exp Allergy
15610229Genome-wide linkage analysis to urinary microalbuminuria in a community-based sample: the Framingham Heart Study. (2005 Jan)Fox CSKidney Int
27829007Novel Gene Expression Profile of Women with Intrinsic Skin Youthfulness by Whole Transcriptome Sequencing. (2016)Xu JPLoS One