Gene: HBA1

3039
HBA-T3|HBH|METHBA
hemoglobin subunit alpha 1
protein-coding
16p13.3
Ensembl:ENSG00000206172 MIM:141800 Vega:OTTHUMG00000060138 UniprotKB:P69905
NG_000006.1
PubMed
ND|AD
50   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.436e-1 (AD)  5.703e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HBA20.868
HBB0.839
ALAS20.777
HBD0.731
SLC4A10.607
CST70.566
AHSP0.555
FCN10.554
S100A90.55
CA10.549

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GLRA3-0.456
ZNF804A-0.443
CBLN4-0.437
CNR1-0.435
VSTM2A-0.431
RTP1-0.428
NDST3-0.428
HAS1-0.427
KCNG1-0.426
C3orf80-0.425

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00358MefloquineSmall Molecule53230-10-7Approved|InvestigationalTarget
DB00893Iron DextranSmall Molecule9004-66-4ApprovedTarget
DB01592IronSmall Molecule7439-89-6ApprovedTarget
DB01593ZincSmall Molecule7440-66-6Approved|InvestigationalTarget
DB021264-Carboxycinnamic AcidSmall MoleculeExperimentalTarget
DB074272-[(2-methoxy-5-methylphenoxy)methyl]pyridineSmall MoleculeExperimentalTarget
DB074284-[(5-methoxy-2-methylphenoxy)methyl]pyridineSmall MoleculeExperimentalTarget
DB07645SEBACIC ACIDSmall MoleculeExperimentalTarget
DB080772-[4-({[(3,5-DICHLOROPHENYL)AMINO]CARBONYL}AMINO)PHENOXY]-2-METHYLPROPANOIC ACIDSmall MoleculeExperimentalTarget
DB082622,6-dicarboxynaphthaleneSmall Molecule1141-38-4ExperimentalTarget
DB08486EfaproxiralSmall Molecule131179-95-8InvestigationalTarget
DB086321,3,5-BENZENETRICARBOXYLIC ACIDSmall MoleculeExperimentalTarget
DB09112Nitrous acidSmall Molecule7782-77-6Approved|InvestigationalTarget
DB09130CopperSmall Molecule7440-50-8Approved|InvestigationalTarget
DB09140OxygenSmall Molecule7782-44-7ApprovedTarget
DB09146Iron saccharateSmall Molecule8047-67-4ApprovedTarget
DB09147Ferric pyrophosphateSmall Molecule10058-44-3ExperimentalTarget
DB09517Sodium ferric gluconate complexSmall Molecule34089-81-1ApprovedTarget
DB13995Ferric pyrophosphate citrateSmall Molecule1802359-96-1Approved|InvestigationalTarget
ID Drug Name Action PubMed
C0364231-aminomethylphosphonic acid[Herbicides co-treated with 1-aminomethylphosphonic acid] results in decreased expression of HBA1 mRNA20566314
C0164032,4-dinitrotoluene"2,4-dinitrotoluene results in increased expression of HBA1 mRNA"16917068
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in increased expression of HBA1 mRNA"19417177
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of HBA1 mRNA"12376462
C0303702-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone results in increased expression of HBA1 mRNA"20206263
D000082AcetaminophenAcetaminophen results in increased expression of HBA1 mRNA26690555
C038328BEP protocolBEP protocol results in increased expression of HBA1 mRNA18987330
D004958Estradiol[Progesterone co-treated with Estradiol] results in increased expression of HBA1 mRNA17404688
D001710Biotin[Chromium co-treated with Biotin] results in decreased expression of HBA1 protein modified form17684468
D001710Biotin[chromium tripicolinate co-treated with Biotin] results in decreased expression of HBA1 protein modified form17684468
C006780bisphenol Abisphenol A results in increased expression of HBA1 mRNA24988533
D002065BuspironeBuspirone results in decreased expression of HBA1 mRNA24136188
D019256Cadmium ChlorideCadmium Chloride results in increased expression of HBA1 mRNA18804290
C034939cadmium sulfide[cadmium telluride co-treated with cadmium sulfide] results in increased expression of HBA1 mRNA20596552
C028337cadmium telluride[cadmium telluride co-treated with cadmium sulfide] results in increased expression of HBA1 mRNA20596552
D000074262Canola OilCanola Oil metabolite results in increased expression of HBA1 mRNA27363782
C520092cetilistatcetilistat results in decreased expression of HBA1 protein modified form19461584
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of HBA1 mRNA18804290
D002857Chromium[Chromium co-treated with Biotin] results in decreased expression of HBA1 protein modified form17684468
D002857ChromiumChromium results in decreased glycation of HBA1 protein14658419
C079689chromium tripicolinate[chromium tripicolinate co-treated with Biotin] results in decreased expression of HBA1 protein modified form17684468
D003300Copper[Disulfiram binds to Copper] which results in decreased expression of HBA1 mRNA24690739
D003300CopperCopper results in decreased expression of HBA1 mRNA25646894
D003300CopperCopper results in increased expression of HBA1 mRNA25646894
C030123coumarincoumarin inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased glycosylation of HBA1 protein]19647726
D003471CuprizoneCuprizone results in increased expression of HBA1 mRNA26577399
C009160cyclonitecyclonite results in decreased expression of HBA1 mRNA20965580
D002945CisplatinCisplatin results in increased expression of HBA1 mRNA21603599
D004026DieldrinDieldrin results in decreased expression of HBA1 protein20584760
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of HBA1 mRNA21527772
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in decreased expression of HBA1 mRNA"12376462
D004221Disulfiram[Disulfiram binds to Copper] which results in decreased expression of HBA1 mRNA24690739
D052244Endocrine DisruptorsEndocrine Disruptors results in increased expression of HBA1 mRNA25198161
D005472FluorouracilTP53 protein affects the reaction [Fluorouracil results in decreased expression of HBA1 mRNA]15016801
D005485FlutamideFlutamide results in decreased expression of HBA1 mRNA24136188
D005947GlucoseGlucose results in increased glycation of HBA1 protein26163454
D006540Herbicides[Herbicides co-treated with 1-aminomethylphosphonic acid] results in decreased expression of HBA1 mRNA20566314
D006830Hydralazine[Hydralazine co-treated with Valproic Acid] results in decreased expression of HBA1 mRNA17183730
D007501IronAHSP protein binds to and affects the folding of and affects the stability of [HBA1 protein binds to Iron]16901899
D001556LindaneLindane results in decreased expression of HBA1 mRNA18804290
D008727MethotrexateMethotrexate results in decreased expression of HBA1 mRNA24136188
D008748MethylcholanthreneMethylcholanthrene results in decreased expression of HBA1 mRNA18804290
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased methylation of HBA1 protein15655799
D008769MethylnitronitrosoguanidineMethylnitronitrosoguanidine results in increased expression of HBA1 mRNA15120970
D008770MethylnitrosoureaMethylnitrosourea results in increased carbamoylation of HBA1 protein15655799
D009151Mustard GasMustard Gas affects the expression of HBA1 mRNA15651846
C051752nefazodonenefazodone results in decreased expression of HBA1 mRNA24136188
C017557nickel subsulfidenickel subsulfide results in decreased expression of HBA1 mRNA21086188
C012655nimesulidenimesulide results in decreased expression of HBA1 mRNA24136188
C055122orlistatorlistat results in decreased expression of HBA1 protein modified form19207292|1946158
D010100OxygenHBA1 protein binds to Oxygen1634355
D010100OxygenHBA1 protein polymorphism binds to Oxygen1634355
D052638Particulate MatterHBA1 alternative form promotes the reaction [Particulate Matter results in increased expression of CD40]21169129
D052638Particulate MatterHBA1 alternative form promotes the reaction [Particulate Matter results in increased expression of CD80]21169129
D052638Particulate MatterHBA1 alternative form promotes the reaction [Particulate Matter results in increased expression of CD86]21169129
D052638Particulate MatterHBA1 alternative form promotes the reaction [Particulate Matter results in increased expression of FCER2]21169129
D052638Particulate MatterHBA1 alternative form results in increased susceptibility to Particulate Matter21169129
C036567perfluorodecanoic acidperfluorodecanoic acid results in decreased expression of HBA1 mRNA21984479
C101816perfluoro-n-nonanoic acidperfluoro-n-nonanoic acid results in decreased expression of HBA1 mRNA21984479
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of HBA1 mRNA19162173
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of HBA1 mRNA19162173
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of HBA1 protein26879310
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of HBA1 mRNA21984479
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of HBA1 mRNA18804290
C030614picolinic acidpicolinic acid results in decreased glycation of HBA1 protein22944053
D010936Plant ExtractsPlant Extracts results in decreased glycation of HBA1 protein12236580
D011374Progesterone[Progesterone co-treated with Estradiol] results in increased expression of HBA1 mRNA17404688
D011374ProgesteroneProgesterone results in increased expression of HBA1 mRNA17404688
D011748PyrogallolPyrogallol results in increased expression of HBA1 mRNA20362636
D011794QuercetinQuercetin results in decreased expression of HBA1 protein19207037
C059514resveratrolresveratrol binds to and affects the folding of HBA1 protein17597382
C059514resveratrolresveratrol results in increased expression of HBA1 mRNA24526417
D012524SarinSarin results in decreased expression of HBA1 protein28973502
D012822Silicon DioxideSilicon Dioxide analog affects the secretion of HBA1 protein25895662
D013311Streptozocincoumarin inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased glycosylation of HBA1 protein]19647726
D013311Streptozocin[Streptozocin co-treated with Niacinamide] results in increased glycosylation of HBA1 protein19647726
D013311StreptozocinStreptozocin results in increased glycation of HBA1 protein21139377
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of HBA1 mRNA16054898
D014520UrethaneUrethane results in increased expression of HBA1 mRNA28818685
D014635Valproic Acid[Hydralazine co-treated with Valproic Acid] results in decreased expression of HBA1 mRNA17183730
C025643vinclozolinvinclozolin results in increased expression of HBA1 mRNA23034163
D009536Niacinamidecoumarin inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased glycosylation of HBA1 protein]19647726
D009536Niacinamide[Streptozocin co-treated with Niacinamide] results in increased glycosylation of HBA1 protein19647726
D014805Vitamin B 12Vitamin B 12 affects the expression of HBA1 protein modified form2299304
D014805Vitamin B 12Vitamin B 12 affects the glycosylation of HBA1 protein2299304
D014810Vitamin EVitamin E results in decreased expression of HBA1 protein1991440
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in increased expression of HBA1 mRNA"25198161
D019287Zinc SulfateZinc Sulfate results in decreased expression of HBA1 mRNA27215404

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004601peroxidase activityCONTRIBUTES_TOIBA21873635  
GO:0004601peroxidase activitycontributes_toIDA19740759  
GO:0005344oxygen carrier activity-IBA21873635  
GO:0005344oxygen carrier activity-IEA-  
GO:0005506iron ion binding-IEA-  
GO:0005515protein binding-IBA21873635  
GO:0005515protein binding-IPI881729  1552945  6683087  9441940  9830011  9894000  
10390349  10930828  11159543  11724557  12072504  15550245  
15835899  16169070  23123858  25156257  25416956  
GO:0019825oxygen binding-IBA21873635  
GO:0019825oxygen binding-IEA-  
GO:0020037heme binding-IBA21873635  
GO:0020037heme binding-IEA-  
GO:0031720haptoglobin bindingCONTRIBUTES_TOIBA21873635  
GO:0031720haptoglobin bindingcontributes_toIDA19740759  
GO:0043177organic acid binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0006898receptor-mediated endocytosis-TAS-  
GO:0010942positive regulation of cell death-IDA19740759  
GO:0015671oxygen transport-TAS7518430  
GO:0015701bicarbonate transport-TAS-  
GO:0042542response to hydrogen peroxide-IDA19740759  
GO:0042744hydrogen peroxide catabolic process-IBA21873635  
GO:0042744hydrogen peroxide catabolic process-IDA19740759  
GO:0051291protein heterooligomerization-IBA21873635  
GO:0051291protein heterooligomerization-IDA19740759  
GO:0098869cellular oxidant detoxification-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IDA21805676  
GO:0005829cytosol-TAS-  
GO:0005833hemoglobin complex-IBA21873635  
GO:0005833hemoglobin complex-IDA19740759  
GO:0005833hemoglobin complex-TAS7555018  
GO:0016020membrane-HDA19946888  
GO:0022627cytosolic small ribosomal subunit-IDA8706699  
GO:0031838haptoglobin-hemoglobin complex-IBA21873635  
GO:0031838haptoglobin-hemoglobin complex-IDA19740759  
GO:0070062extracellular exosome-HDA20458337  23533145  
GO:0071682endocytic vesicle lumen-TAS-  
GO:0072562blood microparticle-HDA22516433  
KEGG ID KEGG Term
hsa05143African trypanosomiasis
hsa05144Malaria
Reactome ID Reactome Term Evidence
R-HSA-1237044Erythrocytes take up carbon dioxide and release oxygenTAS
R-HSA-1247673Erythrocytes take up oxygen and release carbon dioxideTAS
R-HSA-1480926O2/CO2 exchange in erythrocytesTAS
R-HSA-2168880Scavenging of heme from plasmaTAS
R-HSA-2173782Binding and Uptake of Ligands by Scavenger ReceptorsTAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-5653656Vesicle-mediated transportTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
7044618Increased plasma renin activity in type 1 diabetes with microvascular disease. (1982 May)Drury PLClin Endocrinol (Oxf)
8910827Severe periodontitis and risk for poor glycemic control in patients with non-insulin-dependent diabetes mellitus. (1996 Oct)Taylor GWJ Periodontol
22396814Socioeconomic profile of diabetic patients with and without foot problems. (2010)Nather ADiabet Foot Ankle
10580182Are predictors of coronary heart disease and lower-extremity arterial disease in type 1 diabetes the same? A prospective study. (2000 Jan)Forrest KYAtherosclerosis
3391093Significance of high HbA1 levels in normal glucose tolerance. (1988 May)Modan MDiabetes Care
3528745Smoking and insulin sensitivity in type I diabetic patients. (1986 Sep)Helve EMetabolism
3104511Spontaneous platelet aggregation and coagulation parameters as risk factors for arterial occlusions in diabetics. Results of the PARD-study. (1986 Jul-Sep)Breddin HKInt Angiol
3471027Genetic and metabolic risk factors for the development of late complications in type I (insulin-dependent) diabetes. (1986 Oct-Dec)Pontiroli AEActa Diabetol Lat
3582077Black West Indian and matched white diabetics in Britain compared with diabetics in Jamaica: body mass, blood pressure, and vascular disease. (1987 Mar-Apr)Cruickshank JKDiabetes Care
16651834The prevalence of neuropathy and relationship with risk factors in diabetic patients: a single-center experience. (2006)Tamer AMed Princ Pract
9015687Why does diabetic autonomic neuropathy predict IDDM mortality? An analysis from the Pittsburgh Epidemiology of Diabetes Complications Study. (1996 Oct)Orchard TJDiabetes Res Clin Pract
11262670Incidence of and risk factors for proliferative retinopathy and its association with blindness among diabetes clinic attenders. (2000 Dec)Janghorbani MOphthalmic Epidemiol
18036065Dyslipidemia and other cardiovascular risk factors in a Canadian First Nation pediatric population with type 2 diabetes mellitus. (2007 Dec)Sellers EAPediatr Diabetes
17467846Cardiovascular disease risk prediction in type 1 diabetes: accounting for the differences. (2007 Nov)Ruppert KDiabetes Res Clin Pract
23092212No effect modification of serum bilirubin or coffee consumption on the association of gamma-glutamyltransferase with glycated hemoglobin in a cross-sectional study of Japanese men and women. (2012 Oct 23)Wang ZBMC Endocr Disord
8707978Medical status and complications in relation to periodontal disease experience in insulin-dependent diabetics. (1996 Mar)Thorstensson HJ Clin Periodontol
3119387Risk factors for micro- and macroangiopathic complications in type 2 diabetes: lack of association with acetylator phenotype, chlorpropamide alcohol flush and ABO and Rh blood groups. (1987 Jul-Aug)Pontiroli AEDiabete Metab
7955996Arterial wall changes in type 2 diabetic subjects. (1994 Aug-Sep)Geroulakos GDiabet Med
7074002HLA antigens and other risk factors in the development of retinopathy in type 1 diabetes. (1982 May)Gray RSBr J Ophthalmol
3073031Retinopathy in newly presenting non-insulin-dependent (type 2) diabetic patients. (1988 Oct)Owens DRDiabetes Res
8219732Does type II diabetes predispose to retinal vein occlusion? (1993 Jul-Sep)Dodson PMEur J Ophthalmol
11073184Geographic and social factors are related to increased morbidity and mortality rates in diabetic patients. (2000 Aug)Weng CDiabet Med
23418907Serum butyrylcholinesterase and the risk of future type 2 diabetes: the Kansai Healthcare Study. (2014 Mar)Sato KKClin Endocrinol (Oxf)
2180835Metabolic problems after gastric surgery. (1990 Jan-Mar)Harju EInt Surg
8088108Predictors of glycaemic control in type 1 diabetic patients after participation in an intensified treatment and teaching programme. (1994 May)Bott UDiabet Med
9802746Predictors of progression from normoalbuminuria to microalbuminuria in NIDDM. (1998 Nov)Forsblom CMDiabetes Care
1739347Limited joint mobility in subjects with insulin dependent diabetes mellitus: relationship with eye and kidney complications. (1992 Jan)Garg SKArch Dis Child
29539790Severe Periodontitis and Risk for Poor Glycemic Control in Patients with Non-Insulin-Dependent Diabetes Mellitus. (1996 Oct)Taylor GWJ Periodontol
8708424Vascular risk factors for atherosclerotic plaque progression in carotid artery. (1995 Dec)Delcker AInt Angiol
23347332A novel echocardiographic method for the detection of subclinical atherosclerosis in newly diagnosed, untreated type 2 diabetes. (2013 Jul)Simsek HEchocardiography
7851067Cholesterol rich apo B containing lipoproteins and smoking are independently associated with macrovascular disease in normotensive NIDDM patients. (1994 Oct)Dean JDDiabet Med
11276573Diabetes and social conditions in Estonia. A population-based study. (2001 Mar)Vides HEur J Public Health
6793437High-density lipoprotein cholesterol and apolipoprotein A-I levels at diagnosis in patients with non-insulin dependent diabetes. (1981 May)Taylor KGDiabetologia
8689845Risk factors for lower extremity arterial disease in non-insulin-dependent diabetic persons. (1996 Mar)Katsilambros NLDiabet Med
8279674Improved separation of acetaldehyde-induced hemoglobin. (1993 Oct)Hazelett SEAlcohol Clin Exp Res
1852860The determinants of early nephropathy in insulin-dependent diabetes mellitus: a prospective study based on the urinary excretion of albumin. (1991 Apr)Watts GFQ J Med
9678970Cardio vascular morbidity in proteinuric south Indian NIDDM patients. (1998 Jan)Viswanatham VDiabetes Res Clin Pract
1523737Prevalences of risk factors and angiopathy in diabetic patients in Uppsala. (1992)Cederholm JUps J Med Sci
11024584Epidemiologic study of type 2 diabetes in Taiwan. (2000 Oct)Chang CDiabetes Res Clin Pract
3723520Relationship between retinopathy and glycaemic control in insulin-dependent and non-insulin-dependent diabetes. (1986 May)Monson JPJ R Soc Med
2318103Cigarette smoking and neuropathy in diabetic patients. (1990 Apr)Mitchell BDDiabetes Care
8989741Renal findings in patients with short-term type 2 diabetes. (1996 Dec)Keller CKJ Am Soc Nephrol
3203570Psychosocial correlates of survival in diabetes. (1988 Jul-Aug)Davis WKDiabetes Care
9069569Autonomic neuropathy and cardiovascular risk factors in insulin-dependent and non insulin-dependent diabetes. (1997 Jan)Spallone VDiabetes Res Clin Pract
19082520Sulphonylureas and cancer: a case-control study. (2009 Dec)Monami MActa Diabetol
9507917Glycaemic control and development of retinopathy in type 2 diabetes mellitus: a longitudinal study. (1998 Feb)Guillausseau PJDiabet Med
7372025Glycosylated haemoglobin and relative polycythaemia in diabetes mellitus. (1980 Mar)Graham JJDiabetologia
1778113A comparison of the clinical features and vascular complications of diabetes between migrant Asians and Caucasians in Leicester, U.K. (1991 Dec)Samanta ADiabetes Res Clin Pract
7853131Association of the severity of periodontal disease with organ complications in type 1 diabetic patients. (1994 Nov)Karjalainen KMJ Periodontol
2620781Epidemiological correlates of diabetic neuropathy. Report from Pittsburgh Epidemiology of Diabetes Complications Study. (1989 Nov)Maser REDiabetes