Gene info: ID 3040

Gene: HBA2

GENE ID: 3040

Synonyms: HBA-T2|HBH

Description: hemoglobin subunit alpha 2

Gene type: protein-coding

Location: 16p13.3

dbXrefs: Ensembl:ENSG00000188536 MIM:141850 Vega:OTTHUMG00000059924 UniprotKB:P69905

RefSeq: NG_000006.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 3

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 7.792e-1 (AD) 6.641e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
HBB	0.953
HBA1	0.868
HBD	0.773
ALAS2	0.735
S100A9	0.618
S100A8	0.584
CST7	0.582
MYL12A	0.58
TAGLN2	0.577
IFITM2	0.577

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ZNF804A	-0.53
SLC32A1	-0.52
KCNG1	-0.52
RTP1	-0.517
RCOR2	-0.516
FADS6	-0.514
SIAH3	-0.513
OTUB2	-0.511
CALHM1	-0.51
MARCH4	-0.509

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00358	Mefloquine	Small Molecule	53230-10-7	Approved\|Investigational	Target
DB00893	Iron Dextran	Small Molecule	9004-66-4	Approved	Target
DB01592	Iron	Small Molecule	7439-89-6	Approved	Target
DB01593	Zinc	Small Molecule	7440-66-6	Approved\|Investigational	Target
DB02126	4-Carboxycinnamic Acid	Small Molecule		Experimental	Target
DB07427	2-[(2-methoxy-5-methylphenoxy)methyl]pyridine	Small Molecule		Experimental	Target
DB07428	4-[(5-methoxy-2-methylphenoxy)methyl]pyridine	Small Molecule		Experimental	Target
DB07645	SEBACIC ACID	Small Molecule		Experimental	Target
DB08077	2-[4-({[(3,5-DICHLOROPHENYL)AMINO]CARBONYL}AMINO)PHENOXY]-2-METHYLPROPANOIC ACID	Small Molecule		Experimental	Target
DB08262	2,6-dicarboxynaphthalene	Small Molecule	1141-38-4	Experimental	Target
DB08486	Efaproxiral	Small Molecule	131179-95-8	Investigational	Target
DB08632	1,3,5-BENZENETRICARBOXYLIC ACID	Small Molecule		Experimental	Target
DB09112	Nitrous acid	Small Molecule	7782-77-6	Approved\|Investigational	Target
DB09130	Copper	Small Molecule	7440-50-8	Approved\|Investigational	Target
DB09140	Oxygen	Small Molecule	7782-44-7	Approved	Target
DB09146	Iron saccharate	Small Molecule	8047-67-4	Approved	Target
DB09147	Ferric pyrophosphate	Small Molecule	10058-44-3	Experimental	Target
DB09517	Sodium ferric gluconate complex	Small Molecule	34089-81-1	Approved	Target
DB13995	Ferric pyrophosphate citrate	Small Molecule	1802359-96-1	Approved\|Investigational	Target

ID	Drug Name	Action	PubMed
C016583	4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone	[Benzo(a)pyrene co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in increased expression of HBA2 mRNA	20146248
D000082	Acetaminophen	Acetaminophen results in increased expression of HBA2 mRNA	26690555
D000447	Aldehydes	Aldehydes results in increased expression of HBA2 mRNA	25014914
D001564	Benzo(a)pyrene	[Benzo(a)pyrene co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in increased expression of HBA2 mRNA	20146248
D004958	Estradiol	[Progesterone co-treated with Estradiol] results in increased expression of HBA2 mRNA	17404688
C006780	bisphenol A	bisphenol A results in increased expression of HBA2 mRNA	28079927
C018475	butyraldehyde	butyraldehyde results in increased expression of HBA2 mRNA	26079696
D002104	Cadmium	HBA2 protein binds to Cadmium	23896426
D003300	Copper	HBA2 protein binds to Copper	23896426
D004026	Dieldrin	Dieldrin results in increased expression of HBA2 protein	20584760
C098607	JP8 aviation fuel	JP8 aviation fuel results in decreased expression of HBA2 mRNA	16835149
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of HBA2 mRNA	28001369
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in increased methylation of HBA2 protein	15655799
D008770	Methylnitrosourea	Methylnitrosourea results in increased carbamoylation of HBA2 protein	15655799
C028577	monobutyl phthalate	monobutyl phthalate results in increased expression of HBA2 mRNA	29162477
D009532	Nickel	HBA2 protein binds to Nickel	23896426
C017557	nickel subsulfide	nickel subsulfide results in decreased expression of HBA2 mRNA	21086188
C046012	pentanal	pentanal results in increased expression of HBA2 mRNA	26079696
C076994	perfluorooctane sulfonic acid	perfluorooctane sulfonic acid results in decreased expression of HBA2 mRNA	17560707\|1916217
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in decreased expression of HBA2 mRNA	17560707\|1916217
D011374	Progesterone	[Progesterone co-treated with Estradiol] results in increased expression of HBA2 mRNA	17404688
D011374	Progesterone	Progesterone results in increased expression of HBA2 mRNA	17404688
D011374	Progesterone	Progesterone results in decreased expression of HBA2 mRNA	19690047
C005556	propionaldehyde	propionaldehyde results in increased expression of HBA2 mRNA	26079696
D012643	Selenium	[Selenium co-treated with Vitamin E] results in decreased expression of HBA2 mRNA	19244175
D014028	Tobacco Smoke Pollution	Tobacco Smoke Pollution results in increased expression of HBA2 mRNA	28065790
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of HBA2 mRNA"	26179874
D014520	Urethane	Urethane results in increased expression of HBA2 mRNA	28818685
D014635	Valproic Acid	Valproic Acid results in increased expression of HBA2 mRNA	28001369
D014635	Valproic Acid	Valproic Acid results in decreased expression of HBA2 mRNA	23665938
D014810	Vitamin E	[Selenium co-treated with Vitamin E] results in decreased expression of HBA2 mRNA	19244175
D024483	Vitamin K 3	Vitamin K 3 affects the expression of HBA2 mRNA	20044591
D015032	Zinc	HBA2 protein binds to Zinc	23896426

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004601	peroxidase activity	CONTRIBUTES_TO	IBA	21873635
GO:0004601	peroxidase activity	contributes_to	IDA	19740759
GO:0005344	oxygen carrier activity	-	IBA	21873635
GO:0005344	oxygen carrier activity	-	IEA	-
GO:0005506	iron ion binding	-	IEA	-
GO:0005515	protein binding	-	IBA	21873635
GO:0005515	protein binding	-	IPI	881729 1552945 6683087 9441940 9830011 9894000 10390349 10930828 11159543 11724557 12072504 15550245 15835899 16169070 23123858 25156257 25416956
GO:0019825	oxygen binding	-	IBA	21873635
GO:0019825	oxygen binding	-	IEA	-
GO:0020037	heme binding	-	IBA	21873635
GO:0020037	heme binding	-	IEA	-
GO:0031720	haptoglobin binding	CONTRIBUTES_TO	IBA	21873635
GO:0031720	haptoglobin binding	contributes_to	IDA	19740759
GO:0043177	organic acid binding	-	IBA	21873635

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006898	receptor-mediated endocytosis	-	TAS	-
GO:0010942	positive regulation of cell death	-	IDA	19740759
GO:0015671	oxygen transport	-	TAS	7518430
GO:0015701	bicarbonate transport	-	TAS	-
GO:0042542	response to hydrogen peroxide	-	IDA	19740759
GO:0042744	hydrogen peroxide catabolic process	-	IBA	21873635
GO:0042744	hydrogen peroxide catabolic process	-	IDA	19740759
GO:0051291	protein heterooligomerization	-	IBA	21873635
GO:0051291	protein heterooligomerization	-	IDA	19740759
GO:0098869	cellular oxidant detoxification	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005576	extracellular region	-	TAS	-
GO:0005615	extracellular space	-	IDA	21805676
GO:0005829	cytosol	-	TAS	-
GO:0005833	hemoglobin complex	-	IBA	21873635
GO:0005833	hemoglobin complex	-	IDA	19740759
GO:0005833	hemoglobin complex	-	TAS	7555018
GO:0016020	membrane	-	HDA	19946888
GO:0022627	cytosolic small ribosomal subunit	-	IDA	8706699
GO:0031838	haptoglobin-hemoglobin complex	-	IBA	21873635
GO:0031838	haptoglobin-hemoglobin complex	-	IDA	19740759
GO:0070062	extracellular exosome	-	HDA	20458337 23533145
GO:0071682	endocytic vesicle lumen	-	TAS	-
GO:0072562	blood microparticle	-	HDA	22516433

KEGG ID	KEGG Term
hsa05143	African trypanosomiasis
hsa05144	Malaria

Reactome ID	Reactome Term	Evidence
R-HSA-1237044	Erythrocytes take up carbon dioxide and release oxygen	TAS
R-HSA-1247673	Erythrocytes take up oxygen and release carbon dioxide	TAS
R-HSA-1480926	O2/CO2 exchange in erythrocytes	TAS
R-HSA-2168880	Scavenging of heme from plasma	TAS
R-HSA-2173782	Binding and Uptake of Ligands by Scavenger Receptors	TAS
R-HSA-382551	Transport of small molecules	TAS
R-HSA-5653656	Vesicle-mediated transport	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
24482100	Hereditary gene mutations in Korean patients with isolated erythrocytosis. (2014 Jun)	Jang JH	Ann Hematol
18348310	Does cigarette smoking affect the diagnostic reliability of hemoglobin alpha 2 delta 2 (HbA2)? (2008)	Tarazi IS	J Clin Lab Anal
23577263	Hemoglobin A2 Lowered by Iron Deficiency and alpha -Thalassemia: Should Screening Recommendation for beta -Thalassemia Change? (2013)	Denic S	ISRN Hematol